Page last updated: 2024-12-05

ethylene urea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Ethylene urea is a cyclic organic compound with the formula (CH2)2NHCONH. It is a white solid that is soluble in water and some organic solvents. Ethylene urea is used as an intermediate in the synthesis of other chemicals, including herbicides, fungicides, and pharmaceuticals. It is also used as a corrosion inhibitor and a stabilizer for polymers. Ethylene urea is synthesized by the reaction of ethylene diamine with urea. It has been studied for its potential anti-cancer activity, as well as its ability to inhibit the growth of fungi and bacteria. It is also being investigated as a potential fertilizer. Ethylene urea is a relatively safe compound, but it can cause skin and eye irritation.'

ethylene urea: used in manufacture of polymers, finishing agents for textiles & leather, in formulation of plasticizers, lacquers & adhesives; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

imidazolidinone : An imidazolidine containing one or more oxo groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID8453
CHEMBL ID12034
CHEBI ID37001
MeSH IDM0046117

Synonyms (70)

Synonym
120-93-4
sd 6073
2-oxoimidazolidine
1,3-ethyleneurea
2-imidazolidone
2-imidazolidinone
urea,3-ethylene-
ethyleneurea
nsc3338
n,n'-ethyleneurea
imidazolid-2-one
nsc-3338
urea,n'-(1,2-ethanediyl)-
wln: t5mvmtj
nsc21314
nsc-21314
urea, n,n'-(1,2-ethanediyl)-
ai3-22151
nsc 21314
einecs 204-436-4
hsdb 4021
urea, 1,3-ethylene-
2-oxomidazolidine
ethylene urea
monoethyleneurea
CHEBI:37001 ,
imidazolidin-2-one ,
inchi=1/c3h6n2o/c6-3-4-1-2-5-3/h1-2h2,(h2,4,5,6
2-imidazolidone, 96%
CHEMBL12034
FT-0668259
I0005
AKOS000121325
A804620
NCGC00248832-01
7-benzyloxy-1h-indole-3-carboxylicacid
tox21_200783
cas-120-93-4
NCGC00258337-01
dtxsid0020602 ,
dtxcid20602
imidazolidinone
unii-2k48456n55
ec 204-436-4
2k48456n55 ,
FT-0626340
AM20080146
BP-21148
imidazolidone
2-oxo-imidazolidine
imidazolin-2-one
ethyleneurea [hsdb]
2-imidazolidinone [mi]
imidazolidinone [inci]
2-imidazolinone
Q-200290
imidazoliden-2-one
mfcd00005257
F0001-0335
2-imidazolidone, pestanal(r), analytical standard
2-imidazolidinon
mancozeb tp2
Q2813813
CS-0075560
AS-13128
EN300-21266
D71145
2-imidazolidinon 100 microg/ml in acetonitrile
Z104494954
PD065555
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
ureas
imidazolidinoneAn imidazolidine containing one or more oxo groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
retinoid X nuclear receptor alphaHomo sapiens (human)Potency29.59610.000817.505159.3239AID1159527
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID71654The degree of erythroid maturation was measured by assessing the proportion of benzidine-positive cells at a concentration of 4 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
AID71665Cell growth of friend erythroleukemia cells measured as percentage of control on day 6 at a concentration of 4 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
AID71775Percent of untreated control cell growth evaluated in friend leukemia cells on day 3 at a concentration of 4 mM1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Cyclic urea and thiourea derivatives as inducers of murine erythroleukemia differentiation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (40)

TimeframeStudies, This Drug (%)All Drugs %
pre-199012 (30.00)18.7374
1990's1 (2.50)18.2507
2000's2 (5.00)29.6817
2010's19 (47.50)24.3611
2020's6 (15.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.89 (24.57)
Research Supply Index3.76 (2.92)
Research Growth Index5.45 (4.65)
Search Engine Demand Index44.07 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (2.38%)4.05%
Observational0 (0.00%)0.25%
Other41 (97.62%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]