ascorbic-acid and Peptic-Ulcer

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Ascorbic Acid; Brain Diseases; Collagen Diseases; Cortisone; Glucocorticoids; Humans; Peptic Ulcer; Rheumatic Fever; Water-Electrolyte Balance

In 33 patients undergoing surgery for peptic ulcer it was found that both the dietary and the leucocyte ascorbic acid levels fell below the accepted normal values. Although after vagotomy the dietary intake improved dramatically, this was accompanied by only a small rise in leucocyte ascorbic acid levels. Evidence has been presented that the reduction in gastric acid output after vagotomy might be responsible for this paradox.

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Diet; Female; Gastric Juice; Humans; Insulin; Leukocytes; Male; Middle Aged; Nutrition Disorders; Pentagastrin; Peptic Ulcer; Vagotomy

Topics: Adult; Ascorbic Acid; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Parasympatholytics; Peptic Ulcer

The circadian rhythm, as part of a broad time structure (chronome) of lipid peroxides and antioxidant defense mechanisms may relate to prevention, efficacy and management of preventive and curative chronotherapy.. Fifty newly diagnosed patients with peptic ulcers, 30-45 years of age, and 60 age-matched clinically healthy volunteers were synchronized for one week with diurnal activity from about 06:00 to about 22:00 and nocturnal rest. Breakfast was served around 08:30, lunch around 13:30 and dinner around 20:30. Drugs known to affect the free-radical systems were not taken. Blood samples were collected at 6-hour intervals for 24h under standardized, presumably 24-hour synchronized conditions. Plasma lipid peroxides, in the form of malondialdehyde (MDA), blood superoxide dismutase (SOD), glutathione peroxide (GPx), glutathione reductase (GR), catalase (CAT) activities, and serum total protein, albumin, ascorbic acid, total serum cholesterol, and HDL-cholesterol concentrations were determined.. By population-mean cosinor analysis, a marked circadian variation was demonstrated for all variables in healthy subjects and in ulcer patients (p<0.001). As compared to controls, patients had a lower MESOR of MDA, SOD, GPx, GR, ascorbic acid, and HDL-C. They also had smaller circadian amplitude of SOD, CAT, GPx, GR, ascorbic acid, T-C, and HDL-C, but larger circadian amplitude of MDA and albumin. As compared to healthy subjects, the circadian acrophase of ulcer patients occurred later for MDA and GR and earlier for GPx.. Mapping circadian rhythms, important chronome components that include trends with age and extra-circadian components characterizing antioxidants and pro-oxidants, is needed for exploring their putative role as markers in the treatment and management of peptic ulcers.

Topics: Adult; Albumins; Antioxidants; Ascorbic Acid; Blood Proteins; Catalase; Cholesterol; Circadian Rhythm; Glutathione Reductase; Humans; Lipid Peroxides; Malondialdehyde; Middle Aged; Peptic Ulcer; Superoxide Dismutase; Young Adult

We investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p<0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.

Topics: Adult; Aged; Aged, 80 and over; Ascorbic Acid; Cohort Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Japan; Male; Middle Aged; Peptic Ulcer; Prospective Studies; Riboflavin; Thiamine; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency

Topics: Ascorbic Acid; Combined Modality Therapy; Female; Humans; Male; Niacinamide; Peptic Ulcer; Pyridoxine; Thiamine; Time Factors

Topics: Ascorbic Acid; Dehydroascorbic Acid; Glutathione; Histamine; Humans; Leukocytes; Peptic Ulcer

Topics: Adult; Ascorbic Acid; Female; Hepatitis; Humans; Male; Middle Aged; Pancreatitis; Peptic Ulcer; Thiamine

Topics: Adult; Ascorbic Acid; Female; Humans; Male; Middle Aged; Niacinamide; Peptic Ulcer; Pyridoxine; Thiamine

Blood was obtained from 11 healthy voluteers, mixed with two standard types of anticoagulant used in blood transfusion centres and stored for 21-28 days at 4 degrees C. Leucocyte ascorbic acid (LAA) fell to deficient levels after 7 days in all cases. There were no corresponding changes in plasma ascorbic acid (PAA) levels. LAA and PAA were measured before, during and after surgery in 5 control patients who underwent definitive operations for benign peptic ulceration and in 4 patients under-going surgery for bleeding peptic ulceration. The average amount of blood administered to the latter group was 10 units. There was a fall in LAA and PAA in both groups of patients after operation. This fall had returned to normal by 7 days in the controls, but the LAA remained at a deficient level at 7 days in the patients who had bled. Deficient ascorbic acid in stored blood may contribute to low leucocyte ascorbic acid levels in patients after blood transfusion and may contribute to the increased complication rate when surgery is undertaken in these patients.

Topics: Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Preservation; Female; Humans; Leukocytes; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Stomach Ulcer; Transfusion Reaction

The complications of emergency surgery for acute upper gastro-intestinal haemorrhage in 95 patients were compared with those of surgery for non-bleeding benign peptic ulceration in 380 patients. There was a significantly higher number of senior surgeons performing emergency surgery for haemorrhage. There was a significantly higher mortality (10-5 %), wound dehiscence rate (12-6 %) and wound complication rate with re-bleeding (33-7 %) in the post-haemorrhage patients compared with the non-bleeding group (1-3, 1-8 and 11-6 % respectively). There was no significant difference in the incidence of chest infection in the two groups. Mortality and morbidity after haemorrhage were correlated directly with the amount of blood transfused before surgery. Rats were used to study the effect of the removal of 13 % of the blood volume, and its restoration after varying time intervals, upon subsequent wound healing. Abdominal wounds were tested at 7 days for breaking and bursting strength. There was no difference between the wound strength of the control animals and animals which had been bled for 4 minutes before wounding. A significant reduction of wound strength occurred in animals which had been bled for 30-60 minutes before wounding. Prolonged blood loss was associated with deficient wound healing even if blood loss was restored before the wounds were made. Stored blood may be deficient in a factor which is necessary for normal wound healing.

Topics: Adolescent; Adult; Age Factors; Aged; Animals; Ascorbic Acid; Blood Pressure; Blood Transfusion; Blood Volume; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Peptic Ulcer; Postoperative Complications; Rats; Shock, Hemorrhagic; Surgical Wound Dehiscence; Wound Healing

Topics: Acidosis; Adrenocortical Hyperfunction; Ascorbic Acid; Ascorbic Acid Deficiency; Peptic Ulcer; Postoperative Care; Postoperative Complications; Preoperative Care

Topics: Adolescent; Adult; Ascorbic Acid; Atropine; Avitaminosis; Drug Therapy, Combination; Female; Hexamethonium Compounds; Humans; Male; Middle Aged; Niacinamide; Peptic Ulcer; Pyridoxine; Thiamine; Vitamins

Topics: Adolescent; Adult; Aged; Alcoholism; Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Female; Hair; Hemoglobins; Hospitalization; Humans; Liver Diseases; Male; Middle Aged; Nutrition Disorders; Peptic Ulcer; Protein Deficiency; Proteins; Rehabilitation, Vocational; Serum Albumin; Vitamin A; Vitamin A Deficiency; Vitamin E; Vitamin E Deficiency

Topics: Adult; Age Factors; Aged; Animals; Ascorbic Acid; Aspirin; Diet Therapy; Drainage; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Milk; Peptic Ulcer; Potassium; Pyloric Stenosis; Sex Factors; Sodium Chloride; Stomach Neoplasms; Time Factors

Topics: Adolescent; Adult; Ascorbic Acid; Female; Ganglionic Blockers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Parasympatholytics; Peptic Ulcer

Topics: Adult; Anemia; Ascorbic Acid; Blood Transfusion; Carcinoma, Squamous Cell; Citrus; Diet; Epistaxis; Female; Gastrointestinal Diseases; Hemoglobins; Humans; Intestinal Absorption; Iron; Leukocytes; Male; Middle Aged; Peptic Ulcer; Pharyngeal Neoplasms; Scurvy; Smoking; Stomatitis, Aphthous

Topics: Adult; Aged; Anticoagulants; Ascorbic Acid; Atropine; Autopsy; Disseminated Intravascular Coagulation; Female; Glucocorticoids; Humans; Iatrogenic Disease; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrhage; Reserpine; Respiration, Artificial; Resuscitation

Topics: Amino Acids; Analgesics; Anti-Inflammatory Agents; Ascorbic Acid; Atropine; Bismuth; Carbonates; Diet Therapy; Gastric Mucins; Humans; Imipramine; Injections, Intravenous; Muscles; Nitrates; Parasympatholytics; Parathyroid Hormone; Peptic Ulcer; Piperazines; Polysaccharides; Proteins; Secretin; Tissue Extracts

Topics: Adult; Alloxan; Anti-Inflammatory Agents; Ascorbic Acid; Female; Gastrointestinal Diseases; Humans; Iron; Male; Middle Aged; Peptic Ulcer; Sodium

Topics: Ascorbic Acid; Gastric Juice; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage

Topics: Adult; Antihypertensive Agents; Ascorbic Acid; Bismuth; Bromides; Carbonates; Female; Ganglionic Blockers; Humans; Magnesium; Male; Middle Aged; Papaverine; Peptic Ulcer; Plants, Toxic; Senecio; Vitamin B Complex

Topics: Adult; Ascorbic Acid; Gastric Mucosa; Humans; Middle Aged; Peptic Ulcer; Sulfhydryl Compounds

Topics: Adult; Aged; Arthritis, Rheumatoid; Ascorbic Acid; Female; Humans; Iron; Male; Peptic Ulcer; Romania

Topics: Adult; Anti-Inflammatory Agents; Ascorbic Acid; Dyspepsia; Gastrointestinal Diseases; Humans; Iron; Male; Middle Aged; Peptic Ulcer; Tuberculosis, Pulmonary

Topics: Achlorhydria; Ascorbic Acid; Body Fluids; Gastrectomy; Gastric Juice; Humans; Peptic Ulcer; Vitamins

Topics: Anemia; Anemia, Hypochromic; Anemia, Iron-Deficiency; Ascorbic Acid; Humans; Iron; Peptic Ulcer; Vitamins

Topics: Achlorhydria; Ascorbic Acid; Gastrectomy; Humans; Peptic Ulcer; Vitamins

Topics: Ascorbic Acid; Cortisone; Humans; Peptic Ulcer; Phenylbutazone

Topics: Ascorbic Acid; Carbohydrate Metabolism; Duodenal Ulcer; Humans; Niacin; Nicotinic Acids; Peptic Ulcer; Vitamin A

Topics: Animals; Ascorbic Acid; Flavonoids; Guinea Pigs; Hesperidin; Histamine; Histamine Agents; Humans; Peptic Ulcer; Stomach Ulcer; Vitamins

Topics: Antacids; Ascorbic Acid; Diet; Disease Management; Humans; Peptic Ulcer; Scopolamine Derivatives

Topics: Ascorbic Acid; Atropine; Hormones; Humans; Peptic Ulcer; Vitamins

Topics: Ascorbic Acid; Flavonoids; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Vitamins

Topics: Adrenal Cortex; Adrenal Cortex Diseases; Ascorbic Acid; Cerebral Cortex; Nicotiana; Peptic Ulcer; Smoking

Topics: Ascorbic Acid; Hospitalization; Humans; Peptic Ulcer; Phenobarbital; Stomach Ulcer; Wound Healing

Topics: Antacids; Anti-Ulcer Agents; Ascorbic Acid; Peptic Ulcer; Vitamins

Topics: Ascorbic Acid; Humans; Niacin; Nicotinic Acids; Peptic Ulcer; Vitamins

Topics: Ascorbic Acid; Blood; Bone Marrow; Humans; Peptic Ulcer; Vitamins

Topics: Ascorbic Acid; Histidine; Humans; Peptic Ulcer; Vitamins

Topics: Alloxan; Ascorbic Acid; Peptic Ulcer

Topics: Ascorbic Acid; Humans; Peptic Ulcer

Topics: Ascorbic Acid; Gastrectomy; Humans; Peptic Ulcer; Stomach; Vitamins

Topics: Ascorbic Acid; Humans; Peptic Ulcer; Quinolines