null
ChEBI ID: 25605
| Member | Definition | Class |
|---|---|---|
| cordycepin | cordycepin | |
| nucleocidin | A nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness. | nucleocidin |
| puromycin | An aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome. | puromycin |
| vidarabine | A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. | adenine arabinoside |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,562 (50.50) | 18.7374 |
| 1990's | 1,137 (10.32) | 18.2507 |
| 2000's | 1,898 (17.23) | 29.6817 |
| 2010's | 1,929 (17.51) | 24.3611 |
| 2020's | 488 (4.43) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 976 (8.55%) | 5.53% |
| Reviews | 692 (6.06%) | 6.00% |
| Case Studies | 772 (6.76%) | 4.05% |
| Observational | 17 (0.15%) | 0.25% |
| Other | 8,956 (78.47%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 28.1838 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 9.5221 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 9.2089 | 4 | 4 |
| G | Vesicular stomatitis virus | Potency | 23.9185 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 4.6516 | 2 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 23.9185 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.5280 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.0837 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 89.1251 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.5280 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.5280 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 30S ribosomal protein S1 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S6 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | IC50 | 0.9000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 9.8133 | 3 | 3 |
| Adenosylhomocysteinase | Mus musculus (house mouse) | Ki | 30.0000 | 1 | 1 |
| Aminopeptidase N | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Aminopeptidase N | Sus scrofa (pig) | IC50 | 100.0000 | 1 | 1 |
| Carnitine O-palmitoyltransferase 1, muscle isoform | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| Puromycin-sensitive aminopeptidase | Homo sapiens (human) | IC50 | 6.0750 | 2 | 2 |
| RNA-directed RNA polymerase | IC50 | 36.0000 | 1 | 2 | |
| Sterol 14-alpha demethylase | Trypanosoma cruzi strain CL Brener | IC50 | 100.0000 | 1 | 1 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 14.0000 | 1 | 1 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 18,000.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| heat shock protein 90 | Candida albicans | EC50 | 150.0000 | 1 | 1 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | EC50 | 48.0000 | 1 | 2 |
| RNA-directed RNA polymerase | EC50 | 48.0000 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 30S ribosomal protein S1 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S6 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | Km | 234.0000 | 1 | 1 |
| Adenosine deaminase | Bos taurus (cattle) | Km | 81.5000 | 2 | 2 |
| Thymidine kinase, cytosolic | Homo sapiens (human) | Km | 1.5000 | 1 | 1 |