Dysthymia

Synonym
Dysthymia and Chronic Depression
Dysthymia
Persistent Depressive Disorder, Dysthymia
Neurotic Depression, Persistent Depressive Disorder

Excerpt	Reference
"Dysthymia is a chronic depressive condition that is quite prevalent."	( Davidson, J; Halbreich, U; Koran, L; Pearlstein, T; Shelton, RC; Thase, ME; Yonkers, KA, 1997)
"Dysthymia is a disabling condition and high doses of antidepressants are needed to achieve full recovery."	( Versiani, M, 1998)
"While dysthymia is associated with elevated IL-1 beta production, the failure for the cytokine to normalize following symptom alleviation suggests that either the IL-1 beta may be a trait marker of the illness, or that more sustained treatment is necessary to reduce cytokine production."	( Anisman, H; Griffiths, J; Merali, Z; Ravindran, AV, 1999)
"Remission of dysthymia is associated with improvement in this aspect of temperament."	( Chapman, D; Harrison, W; Hellerstein, DJ; Kocsis, JH; Stewart, JW, 2000)
"Dysthymia is a prevalent form of subthreshold depressive disorder, associated with considerable disability and high co-morbidity."	( De Lima, MS; Hotopf, M, 2003)

Excerpt	Reference
"Patients with dysthymia have been shown to respond to treatment with antidepressant medications, and to some degree to psychotherapy."	( Batchelder, S; Fedak, M; Hellerstein, DJ; Kreditor, D; Little, SA; Muran, JC; Rosenthal, RN; Samstag, LW; Winston, A, 2001)

Excerpt	Reference
"Forty-six subjects with DSM-III-R dysthymia (70% with superimposed major depression) who had responded to 10 weeks of open-label desipramine (DMI) treatment received 16 additional weeks of continuation DMI."	( Friedman, RA; Gniwesch, L; Kocsis, JH; Markowitz, JC; Parides, M, 1999)
"More provocatively, patients with dysthymia who had required extensive psychotherapeutic attention prior to state-of-the-art pharmacotherapy no longer required such therapy."	( Akiskal, HS; Haykal, RF, 1999)
"Patients suffering from BPD and dysthymia were included in an 8-week, open-label study of olanzapine monotherapy."	( Berry, SA; Camlin, KL; Jesberger, JA; Schulz, SC, 1999)
"While dysthymia is associated with elevated IL-1 beta production, the failure for the cytokine to normalize following symptom alleviation suggests that either the IL-1 beta may be a trait marker of the illness, or that more sustained treatment is necessary to reduce cytokine production."	( Anisman, H; Griffiths, J; Merali, Z; Ravindran, AV, 1999)
"Remission of dysthymia was associated with significantly greater improvement in harm avoidance, with the greatest numerical change found in the patients treated with sertraline."	( Chapman, D; Harrison, W; Hellerstein, DJ; Kocsis, JH; Stewart, JW, 2000)
"While dysthymia responds to antidepressant treatment similarly to depressive episodes, treatment must be carried out for a considerably longer period."	( Pöldinger, W, 2000)
"Patients with dysthymia have been shown to respond to treatment with antidepressant medications, and to some degree to psychotherapy."	( Batchelder, S; Fedak, M; Hellerstein, DJ; Kreditor, D; Little, SA; Muran, JC; Rosenthal, RN; Samstag, LW; Winston, A, 2001)
"Primary care patients (n = 96) with dysthymia or minor depression were randomly assigned to problem-solving therapy, paroxetine, or placebo."	( Dimidjian, S; Katon, W; Schmaling, KB; Sullivan, M, 2002)
"Pharmacotherapy for dysthymia appears to be an effective short-term treatment for dysthymic disorder."	( De Lima, MS; Hotopf, M, 2003)
"The treatment of dysthymia in itself poses a problem in the everyday psychiatric practice and it can be further hindered when accompanied by pronounced personality traits (which are indicative of disorder)."	( Dadić-Hero, E; Grahovac, T; Graovac, M; Palijan, TZ; Ružić, K; Sepić-Grahovac, D, 2011)
"HDRS, Cornell Dysthymia Rating Scale (CDRS), Clinical Global Impressions (CGI), Beck Depression Inventory (BDI), Global Assessment of Functioning (GAF), Social Adjustment Scale (SAS), and other assessments were administered at each visit."	( Batchelder, ST; Black, SR; Chen, Y; Deliyannides, DA; Hellerstein, DJ; McGrath, PJ; O'Shea, D; Stewart, JW; Withers, A, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	66 (27.97)	12.5806
2000's	126 (53.39)	18.1394
2010's	42 (17.80)	28.8240
2020's	2 (0.85)	9.53

Drug	Relationship Strength	Studies	Trials
acetylcarnitine	medium	2	2
gamma-aminobutyric acid	medium	2	1
choline	low	1	0
bupropion	medium	7	2
creatine	low	1	0
inositol	low	1	0
picolinic acid	medium	1	1
normetanephrine	low	1	0
amitrole	medium	1	1
homovanillic acid	low	1	0
hydroxyindoleacetic acid	low	3	0
alprazolam	medium	1	1
dan 2163	medium	12	7
amitriptyline	medium	3	3
aspirin	low	1	0
buspirone	low	1	0
carbamazepine	low	3	0
chlorpromazine	low	1	0
citalopram	medium	11	6
clonazepam	low	1	0
desipramine	medium	2	2
amphetamine	low	1	0
diazepam	low	1	0
disulfiram	low	1	0
valproic acid	medium	4	2
doxepin	low	1	0
fentanyl	low	1	0
fluoxetine	medium	21	14
phenelzine	low	1	0
imipramine	medium	20	16
ketamine	low	1	0
methadone	low	5	0
methylphenidate	low	3	0
mianserin	medium	8	2
midazolam	low	1	0
mirtazapine	medium	9	2
moclobemide	medium	6	2
modafinil	medium	2	1
nefazodone	medium	7	4
nortriptyline	medium	2	1
pirenzepine	medium	1	1
propranolol	low	1	0
risperidone	medium	4	1
ritanserin	low	1	0
ropinirole	low	1	0
succinylcholine	low	1	0
sulpiride	medium	12	7
trazodone	medium	3	2
zolpidem	low	1	0
thyroxine	medium	1	1
dextroamphetamine	low	2	0
prednisone	low	1	0
dehydroepiandrosterone	medium	2	2
aspartic acid	low	1	0
carbostyril	low	1	0
tryptophan	low	1	0
cyclohexanol	medium	19	10
thiophenes	medium	5	3
1-naphthylamine	medium	7	4
thiazoles	low	1	0
methoxyhydroxyphenylglycol	low	1	0
lithium carbonate	medium	4	2
acetylcysteine	low	1	0
dehydroepiandrosterone sulfate	low	2	0
s,n,n'-tripropylthiocarbamate	low	3	0
metanephrine	low	1	0
chromium	medium	1	1
glutamic acid	medium	2	1
amineptin	medium	2	1
paroxetine	medium	16	12
fenoxycarb	low	1	0
aripiprazole	low	1	0
duloxetine hydrochloride	medium	7	5
venlafaxine hydrochloride	medium	19	10
n-acetylaspartic acid	low	1	0
triazoles	medium	7	4
fluorodeoxyglucose f18	low	1	0
sertraline	medium	35	26
delta sleep-inducing peptide	low	1	0
homocysteine	low	2	0
pramipexole	low	1	0
reboxetine	medium	5	2
cocaine	low	2	0
thiopental	low	1	0
pica	low	1	0
freedom	low	1	0
fluvoxamine	medium	2	1
naltrexone	low	1	0
hypericum	medium	3	1
technetium tc 99m exametazime	low	1	0
quetiapine fumarate	low	1	0
ascorbic acid	medium	1	1
phenprocoumon	low	1	0
rome	low	1	0
vitamin b 12	low	2	0
exudates	low	1	0
folic acid	low	2	0
neopterin	low	1	0
clozapine	low	1	0
olanzapine	medium	2	1
sildenafil citrate	medium	2	1
ego	low	2	0
leptin	low	1	0

Protein Targets (955)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
RAR-related orphan receptor gamma	20	0	0	20
GLI family zinc finger 3	27	0	0	27
AR protein	33	0	0	33
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
thyroid stimulating hormone receptor	18	0	0	18
estrogen receptor 2 (ER beta)	17	0	0	17
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
progesterone receptor	20	0	0	20
glucocorticoid receptor [Homo sapiens]	29	0	0	29
retinoic acid nuclear receptor alpha variant 1	29	0	0	29
estrogen-related nuclear receptor alpha	31	0	0	31
pregnane X nuclear receptor	26	0	0	26
estrogen nuclear receptor alpha	40	0	0	40
aryl hydrocarbon receptor	13	0	0	13
thyroid stimulating hormone receptor	11	0	0	11
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	18	0	0	18
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
thyroid hormone receptor beta isoform 2	26	0	0	26
nuclear factor erythroid 2-related factor 2 isoform 1	24	0	0	24
cytochrome P450 3A4 isoform 1	14	0	0	14
Gamma-aminobutyric acid receptor subunit pi	14	13	3	30
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Gamma-aminobutyric acid receptor subunit beta-1	14	13	3	30
Gamma-aminobutyric acid receptor subunit delta	14	13	3	30
Gamma-aminobutyric acid receptor subunit gamma-2	14	13	4	31
Glutamate receptor 2	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-5	14	13	3	30
Gamma-aminobutyric acid receptor subunit alpha-3	14	13	3	30
Gamma-aminobutyric acid receptor subunit gamma-1	14	13	3	30
Gamma-aminobutyric acid receptor subunit alpha-2	14	13	3	30
Gamma-aminobutyric acid receptor subunit alpha-4	14	13	3	30
Gamma-aminobutyric acid receptor subunit gamma-3	14	13	3	30
Gamma-aminobutyric acid receptor subunit alpha-6	14	13	3	30
Gamma-aminobutyric acid receptor subunit alpha-1	14	14	4	32
Gamma-aminobutyric acid receptor subunit beta-3	14	13	3	30
Gamma-aminobutyric acid receptor subunit beta-2	14	13	4	31
Kelch-like ECH-associated protein 1	0	0	1	1
GABA theta subunit	14	13	3	30
Gamma-aminobutyric acid receptor subunit epsilon	14	13	3	30
Histone acetyltransferase KAT8	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
acetylcholinesterase	16	0	0	16
dopamine D1 receptor	4	0	0	4
15-lipoxygenase, partial	4	0	0	4
pregnane X receptor	4	0	0	4
phosphopantetheinyl transferase	11	0	0	11
USP1 protein, partial	17	0	0	17
NFKB1 protein, partial	11	0	0	11
Microtubule-associated protein tau	9	0	0	9
Thrombopoietin	6	0	0	6
regulator of G-protein signaling 4	15	0	0	15
retinoid X nuclear receptor alpha	17	0	0	17
farnesoid X nuclear receptor	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
arylsulfatase A	19	0	0	19
euchromatic histone-lysine N-methyltransferase 2	40	0	0	40
Bloom syndrome protein isoform 1	8	0	0	8
D(1A) dopamine receptor	25	0	0	25
thyroid hormone receptor beta isoform a	7	0	0	7
heat shock protein beta-1	6	0	0	6
flap endonuclease 1	6	0	0	6
geminin	30	0	0	30
peripheral myelin protein 22	20	0	0	20
survival motor neuron protein isoform d	9	0	0	9
muscarinic acetylcholine receptor M1	18	0	0	18
Histone deacetylase 3	0	4	0	4
Solute carrier family 22 member 6	0	2	0	2
Histone deacetylase 4	0	4	0	4
Guanine nucleotide-binding protein G	2	0	0	2
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Ataxin-2	24	0	0	24
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
ATP-dependent phosphofructokinase	18	0	0	18
TDP1 protein	33	0	0	33
peroxisome proliferator activated receptor gamma	17	0	0	17
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
nuclear receptor ROR-gamma isoform 1	9	0	0	9
lamin isoform A-delta10	30	0	0	30
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	10	5	15
Gamma-aminobutyric acid receptor subunit gamma-2	0	10	3	13
Cholecystokinin receptor type A	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	10	5	15
Gamma-aminobutyric acid receptor subunit alpha-3	0	10	4	14
Gamma-aminobutyric acid receptor subunit alpha-2	0	10	4	14
Gamma-aminobutyric acid receptor subunit beta-2	0	10	3	13
Cholecystokinin receptor type A	0	2	0	2
ATPase family AAA domain-containing protein 5	8	0	0	8
Luciferase	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	30	0	0	30
cytochrome P450 2D6	28	0	0	28
peroxisome proliferator-activated receptor delta	12	0	0	12
Snq2p	0	0	0	3
Cellular tumor antigen p53	21	0	0	21
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
thioredoxin reductase	24	0	0	24
GLS protein	24	0	0	24
cytochrome P450 2D6 isoform 1	16	0	0	16
chromobox protein homolog 1	20	0	0	20
atrial natriuretic peptide receptor 2 precursor	10	0	0	10
serine/threonine-protein kinase mTOR isoform 1	11	0	0	11
Solute carrier family 22 member 1	0	11	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15B	9	0	0	9
ATP-binding cassette sub-family C member 3	0	29	0	29
Multidrug resistance-associated protein 4	0	30	0	32
Voltage-dependent L-type calcium channel subunit alpha-1F	0	8	0	8
5-hydroxytryptamine receptor 4	0	28	0	28
Bile salt export pump	0	41	0	41
Albumin	0	0	8	8
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	25	0	25
Muscarinic acetylcholine receptor M2	0	24	2	26
Muscarinic acetylcholine receptor M4	0	23	1	24
Muscarinic acetylcholine receptor M1	0	7	0	7
Muscarinic acetylcholine receptor M3	0	6	0	6
Muscarinic acetylcholine receptor M4	0	6	0	6
5-hydroxytryptamine receptor 2C	0	26	3	29
Muscarinic acetylcholine receptor M5	0	8	0	8
Muscarinic acetylcholine receptor M5	0	25	0	25
Alpha-2A adrenergic receptor	0	32	2	35
Muscarinic acetylcholine receptor M2	0	6	0	6
Muscarinic acetylcholine receptor M1	0	26	4	31
Angiotensin-converting enzyme	0	19	0	19
D(2) dopamine receptor	0	35	6	46
5-hydroxytryptamine receptor 2A	0	28	3	31
Alpha-2B adrenergic receptor	0	29	2	32
Alpha-2C adrenergic receptor	0	28	2	31
5-hydroxytryptamine receptor 1A	0	32	4	37
Muscarinic acetylcholine receptor M3	0	27	2	29
D(1A) dopamine receptor	0	23	3	28
D(1B) dopamine receptor	0	6	1	9
UDP-glucuronosyltransferase 1A4	0	2	0	7
Sodium-dependent noradrenaline transporter	0	43	6	49
Histamine H2 receptor	0	17	2	19
Alpha-1D adrenergic receptor	0	25	1	27
5-hydroxytryptamine receptor 2A	0	38	3	43
5-hydroxytryptamine receptor 2C	0	35	2	37
5-hydroxytryptamine receptor 1B	0	24	2	26
5-hydroxytryptamine receptor 1D	0	12	2	14
5-hydroxytryptamine receptor 1F	0	12	2	14
5-hydroxytryptamine receptor 2B	0	24	4	28
5-hydroxytryptamine receptor 6	0	7	2	9
Histamine H1 receptor	0	8	0	8
Sodium-dependent serotonin transporter	0	45	7	52
5-hydroxytryptamine receptor 7	0	13	2	15
5-hydroxytryptamine receptor 5A	0	7	2	9
5-hydroxytryptamine receptor 5B	0	7	2	9
Histamine H1 receptor	0	28	4	34
D(3) dopamine receptor	0	34	5	45
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	5	0	6
UDP-glucuronosyltransferase 1A3	0	0	0	2
5-hydroxytryptamine receptor 3A	0	9	2	11
5-hydroxytryptamine receptor 2B	0	33	2	35
Alpha-1A adrenergic receptor	0	28	5	33
Histamine H2 receptor	15	6	0	26
D(1A) dopamine receptor	10	0	0	10
5-hydroxytryptamine receptor 6	0	27	1	30
5-hydroxytryptamine receptor 7	0	6	0	6
Voltage-dependent N-type calcium channel subunit alpha-1B	0	5	0	5
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	8	0	8
Sodium-dependent dopamine transporter	0	33	5	38
Potassium voltage-gated channel subfamily H member 2	0	31	0	31
Voltage-dependent L-type calcium channel subunit alpha-1S	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	9	0	9
Sodium channel protein type 5 subunit alpha	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	7	2	9
5-hydroxytryptamine receptor 4	0	7	2	9
Nuclear receptor subfamily 3 group C member 3	0	19	0	19
Canalicular multispecific organic anion transporter 1	0	27	0	27
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	28	1	29
5-hydroxytryptamine receptor 3B	0	9	2	11
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	8	0	8
Sodium channel protein type 10 subunit alpha	0	3	0	3
Integrase	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Phenylethanolamine N-methyltransferase	0	3	0	3
Cytochrome P450 2A6	0	2	0	2
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	22	2	24
Beta-2 adrenergic receptor	0	3	1	5
Sigma non-opioid intracellular receptor 1	0	8	2	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
5-hydroxytryptamine receptor 3E	0	5	0	5
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
SMAD family member 2	4	0	0	4
Fumarate hydratase	11	0	0	11
PPM1D protein	3	0	0	3
SMAD family member 3	4	0	0	4
EWS/FLI fusion protein	14	0	0	14
G	12	0	0	12
polyprotein	11	0	0	11
67.9K protein	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
lysosomal alpha-glucosidase preproprotein	4	0	0	4
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	19	0	0	19
transcriptional regulator ERG isoform 3	4	0	0	4
histone acetyltransferase KAT2A isoform 1	11	0	0	11
5-hydroxytryptamine receptor 2A	0	0	1	1
neuropeptide S receptor isoform A	6	0	0	6
Solute carrier family 22 member 2	0	5	0	6
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3B	0	5	0	5
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
ATP-dependent translocase ABCB1	0	11	0	16
Cytochrome P450 3A4	0	12	0	14
5-hydroxytryptamine receptor 1A	0	16	13	29
Neuronal acetylcholine receptor subunit alpha-4	1	3	0	4
Neuronal acetylcholine receptor subunit beta-2	1	3	0	4
Alpha-1B adrenergic receptor	0	25	5	30
D	0	16	0	16
D(4) dopamine receptor	0	17	2	22
Alpha-1D adrenergic receptor	0	22	5	27
D(4) dopamine receptor	0	11	0	11
Histamine H1 receptor	0	6	0	7
5-hydroxytryptamine receptor 7	0	15	1	16
Alpha-1A adrenergic receptor	0	10	2	13
Alpha-1B adrenergic receptor	0	4	1	6
5-hydroxytryptamine receptor 3A	0	8	0	8
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Spike glycoprotein	19	2	1	22
D(2) dopamine receptor	0	26	1	28
Inositol monophosphatase 1	9	0	0	9
5-hydroxytryptamine receptor 3D	0	5	0	5
Multidrug and toxin extrusion protein 2	0	4	0	4
5-hydroxytryptamine receptor 3C	0	5	0	5
Inositol hexakisphosphate kinase 1	12	0	0	12
Multidrug and toxin extrusion protein 1	0	4	0	4
cytochrome P450 2C9, partial	12	0	0	12
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	5	0	0	5
IDH1	12	0	0	12
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lethal factor (plasmid)	8	0	0	8
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	6	0	0	6
cytochrome P450 2C19 precursor	10	0	0	10
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	7	0	13
Carbonic anhydrase 2	0	7	1	14
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	8	1	10
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	8	1	10
Glutamate receptor ionotropic, NMDA 2B	0	9	1	11
Glutamate receptor ionotropic, NMDA 2C	0	8	1	10
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	8	1	10
Glutamate receptor ionotropic, NMDA 3B	0	8	1	10
Carbonic anhydrase 4	0	3	0	4
Glutamate receptor ionotropic, NMDA 3A	0	8	1	10
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
hypothetical protein, conserved	3	0	0	3
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase iota isoform a (long)	7	0	0	7
DNA polymerase kappa isoform 1	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	5	1	1	7
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	5	1	1	7
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	3	0	3
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	3	0	5
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	2	0	3
Cytochrome P450 2B6	0	1	1	4
UDP-glucuronosyltransferase 1A1	0	3	0	4
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2C19	0	8	0	10
UDP-glucuronosyltransferase 2B10	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
cytochrome P450 2C9 precursor	9	0	0	9
Bile salt export pump	0	8	0	8
Beta-2 adrenergic receptor	0	5	0	6
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	5	1	7
D(3) dopamine receptor	0	15	1	16
Alpha-2B adrenergic receptor	0	14	3	17
D(2) dopamine receptor	0	5	0	5
Alpha-2C adrenergic receptor	0	14	3	17
Alpha-2A adrenergic receptor	0	14	3	17
D(1B) dopamine receptor	0	9	0	9
Beta-3 adrenergic receptor	0	4	0	4
Alpha-2A adrenergic receptor	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D	0	5	0	5
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Beta-lactamase	6	0	0	6
mitogen-activated protein kinase 1	9	0	0	9
Vpr	2	0	0	2
Major prion protein	0	0	3	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	11	0	12
Cytochrome P450 2J2	0	9	0	10
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	3	0	6
Carbonic anhydrase 3	0	3	0	5
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	2	0	5
Carbonic anhydrase 6	0	3	0	6
Carbonic anhydrase 5A, mitochondrial	0	3	1	7
Carbonic anhydrase 7	0	3	0	6
Carbonic anhydrase 9	0	3	0	7
Carbonic anhydrase 13	0	2	0	2
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	3	0	6
Proteasome subunit beta type-11	0	0	0	1
ATAD5 protein, partial	16	0	0	16
Smad3	9	0	0	9
caspase 7, apoptosis-related cysteine protease	6	0	0	6
NADPH oxidase 1	0	1	0	1
caspase-3	6	0	0	6
Adenylate cyclase type 1	0	3	0	3
Histone H2A.x	4	0	0	4
Caspase-7	3	0	0	3
Spike glycoprotein	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
cellular tumor antigen p53 isoform a	6	0	0	6
vitamin D3 receptor isoform VDRA	10	0	0	10
caspase-3	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
ras-related protein Rab-9A	9	0	0	9
M-phase phosphoprotein 8	10	0	0	10
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	2	1	3
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	0	5	6
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	2	1	4
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	2	1	3
Replicase polyprotein 1a	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	3	1	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Replicase polyprotein 1ab	0	3	1	4
Cytochrome P450 2D6	0	13	1	16
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	2	0	2
Adenylate cyclase type 3	0	3	0	3
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	3	0	3
Adenylate cyclase type 4	0	3	0	3
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Mu-type opioid receptor	0	11	4	17
Adenylate cyclase type 8	0	3	0	3
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	9	3	14
Kappa-type opioid receptor	0	10	2	15
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	2	0	2
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Adenylate cyclase type 6	0	3	0	3
Adenylate cyclase type 5	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Adenylyl cyclase 7	0	3	0	3
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	1	3
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	4	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	4	0	4
Solute carrier family 22 member 1	0	4	0	6
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	3	0	5
NPC intracellular cholesterol transporter 1 precursor	8	0	0	8
Sodium-dependent noradrenaline transporter	0	4	0	4
Tryptophan 5-hydroxylase 1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	2	0	2
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	18	2	21
Sigma intracellular receptor 2	0	6	0	6
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	6	0	6
Transporter	0	22	0	22
Gamma-aminobutyric acid receptor subunit pi	0	8	0	8
Gamma-aminobutyric acid receptor subunit delta	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	9	1	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	9	2	11
Translocator protein	0	2	0	2
Translocator protein	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	9	1	10
Gamma-aminobutyric acid receptor subunit epsilon	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	0	9	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	0	8	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	0	8	0	8
Gamma-aminobutyric acid receptor subunit theta	0	8	0	8
Beta-1 adrenergic receptor	0	2	1	4
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
peripheral myelin protein 22 isoform 1	6	0	0	6
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Endothelin receptor type B	0	3	0	3
5-hydroxytryptamine receptor 3A	0	3	0	3
Endothelin receptor type B	0	3	0	3
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	2	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	1	0	1
Transporter	0	5	0	5
5-hydroxytryptamine receptor 1A	0	2	0	2
Histamine H4 receptor	0	2	2	4
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	1	2	0	3
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	3
GALC protein	3	0	0	3
Sex hormone-binding globulin	0	0	1	1
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Alpha-synuclein	6	0	0	6
TAR DNA-binding protein 43	5	0	0	5
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	1	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Solute carrier organic anion transporter family member 1A3	0	1	0	4
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	2
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	3
huntingtin isoform 2	5	0	0	5
Solute carrier family 22 member 3	0	2	0	2
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] A	0	7	0	7
Amine oxidase [flavin-containing] B	0	6	0	6
Amine oxidase [flavin-containing] B	0	3	0	3
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	10	0	0	10
Alpha-1-acid glycoprotein 1	0	0	0	1
Translocator protein	0	3	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Chain A, Cruzipain	2	0	0	2
apical membrane antigen 1, AMA1	4	0	0	4
nonstructural protein 1	3	0	0	3
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
LacZ protein (plasmid)	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
beta-2 adrenergic receptor	2	0	0	2
type-1 angiotensin II receptor	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
perilipin-5	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	1	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	2	0	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Ornithine decarboxylase	2	0	0	2
Fructose-1,6-bisphosphatase 1	0	1	0	1
Adenosine receptor A3	0	3	1	4
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	1	0	1
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
heat shock protein 90, putative	0	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Histamine H3 receptor	0	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Delta-type opioid receptor	0	6	1	8
Delta-type opioid receptor	0	6	1	7
Mu-type opioid receptor	0	6	2	8
Kappa-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	4	0	5
Mu-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	6	1	8
Cytochrome P450 2C8	0	5	0	5
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
alpha-galactosidase	3	0	0	3
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
ClpP	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
endonuclease IV	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Envelope glycoprotein	0	0	3	3
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Sodium/myo-inositol cotransporter 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Cholinesterase	0	1	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Aldehyde oxidase 1	0	1	0	1
Endothelin-1 receptor	0	2	1	3
Type-2 angiotensin II receptor	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Histidine decarboxylase	0	0	1	1
Kappa-type opioid receptor	0	2	1	3
Nociceptin receptor	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Membrane primary amine oxidase	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	1	2
Transmembrane prolyl 4-hydroxylase	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Beta-2 adrenergic receptor	0	3	1	4
Beta-3 adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 1E	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	2	0	2
Beta-1 adrenergic receptor	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Glycine receptor subunit alpha-1	0	0	1	1
DNA polymerase III, partial	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
Diacylglycerol kinase alpha	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Carbonic anhydrase 13	0	1	0	4
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	3
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 15	0	2	0	3
D(2) dopamine receptor	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
DNA polymerase eta isoform 1	1	0	0	1
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	2
Androgen receptor	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (236)

Protein Targets (955)

Dysthymia

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (236)

Drugs Studied (123)

Protein Targets (955)