Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups.
| Member | Definition | Role |
|---|
| 1-(3-cyano-7-methoxy-2-quinolinyl)-4-piperidinecarboxylic acid ethyl ester | | 1-(3-cyano-7-methoxy-2-quinolinyl)-4-piperidinecarboxylic acid ethyl ester |
| 1-(4-amino-2-methyl-3-quinolinyl)ethanone | | 1-(4-amino-2-methyl-3-quinolinyl)ethanone |
| 1-[2-[(3-cyano-5,7-dimethyl-2-quinolinyl)amino]ethyl]-3-(3-methoxypropyl)thiourea | | 1-[2-[(3-cyano-5,7-dimethyl-2-quinolinyl)amino]ethyl]-3-(3-methoxypropyl)thiourea |
| 1-[2-[(3-cyano-7-methyl-2-quinolinyl)amino]ethyl]-3-[3-(4-morpholinyl)propyl]thiourea | | 1-[2-[(3-cyano-7-methyl-2-quinolinyl)amino]ethyl]-3-[3-(4-morpholinyl)propyl]thiourea |
| 1-[3-[(7-cyano-[1,3]dioxolo[4,5-g]quinolin-6-yl)amino]propyl]-3-(3-ethoxypropyl)thiourea | | 1-[3-[(7-cyano-[1,3]dioxolo[4,5-g]quinolin-6-yl)amino]propyl]-3-(3-ethoxypropyl)thiourea |
| 1-[3-[(7-cyano-[1,3]dioxolo[4,5-g]quinolin-6-yl)amino]propyl]-3-(3-methoxypropyl)thiourea | | 1-[3-[(7-cyano-[1,3]dioxolo[4,5-g]quinolin-6-yl)amino]propyl]-3-(3-methoxypropyl)thiourea |
| 1,2-Dihydroquinolin-2-imine | | 1,2-Dihydroquinolin-2-imine |
| 1,4,8-trimethyl-12-quinolino[2,3-b]quinolinamine | | 1,4,8-trimethyl-12-quinolino[2,3-b]quinolinamine |
| 2-amino-3,4-dimethylimidazo(4,5-f)quinoline | | MeIQ |
| 2-methyl-8-quinolinamine | | 2-methyl-8-quinolinamine |
| 2,4-dibromo-6-[(3-quinolinylamino)methyl]phenol | | 2,4-dibromo-6-[(3-quinolinylamino)methyl]phenol |
| 2,6-dimethyl-N-(4-methylphenyl)-4-quinolinamine | | 2,6-dimethyl-N-(4-methylphenyl)-4-quinolinamine |
| 3-methoxy-N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]benzamide | | 3-methoxy-N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]benzamide |
| 4-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-3-quinolinecarboxylic acid ethyl ester | | 4-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-3-quinolinecarboxylic acid ethyl ester |
| 4-[2-(dimethylamino)ethylamino]-3-benzo[h]quinolinecarboxylic acid ethyl ester | | 4-[2-(dimethylamino)ethylamino]-3-benzo[h]quinolinecarboxylic acid ethyl ester |
| 4-amino-5,8-dimethoxy-2-(1,1,2,2,2-pentafluoroethyl)-3-quinolinecarbonitrile | | 4-amino-5,8-dimethoxy-2-(1,1,2,2,2-pentafluoroethyl)-3-quinolinecarbonitrile |
| 4,6-dimethyl-N-phenyl-2-quinolinamine | | 4,6-dimethyl-N-phenyl-2-quinolinamine |
| 5-hydroxyprimaquine | | 5-Hydroxyprimaquine |
| 5,7-dimethyl-2-(1-pyrrolidinyl)-3-quinolinecarbonitrile | | 5,7-dimethyl-2-(1-pyrrolidinyl)-3-quinolinecarbonitrile |
| 6-anilino-5,8-quinolinedione | A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group. | 6-anilino-5,8-quinolinedione |
| 6-methoxy-2-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-4-quinolinamine | | 6-methoxy-2-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-4-quinolinamine |
| 6-methoxy-8-(3-diethylaminopropylamino)quinoline | | rhodoquine |
| 6,7-dimethyl-2H-pyrazolo[3,4-b]quinolin-3-amine | | 6,7-dimethyl-2H-pyrazolo[3,4-b]quinolin-3-amine |
| 7-chloro-4-aminoquinoline | | 4-Amino-7-chloroquinoline |
| 7-chloro-N-(phenylmethyl)-4-quinolinamine | | 7-chloro-N-(phenylmethyl)-4-quinolinamine |
| 7-methoxy-2-(3-methoxyanilino)-3-quinolinecarbonitrile | | 7-methoxy-2-(3-methoxyanilino)-3-quinolinecarbonitrile |
| 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethyl-4-piperidinyl)-4-triazolyl]methylamino]-3-quinolinecarbonitrile | | 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethyl-4-piperidinyl)-4-triazolyl]methylamino]-3-quinolinecarbonitrile |
| amd 070 | | AMD 070 |
| amiridine | | 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine |
| amodiaquine | A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position. | amodiaquine |
| bosutinib | An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively. | bosutinib |
| bulaquine | | bulaquine |
| chloroquine | An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. | chloroquine |
| ciprofloxacin | A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. | ciprofloxacin zwitterion; ciprofloxacin |
| cp-673,451 | | 1-[2-[5-(2-methoxyethoxy)-1-benzimidazolyl]-8-quinolinyl]-4-piperidinamine |
| desethylchloroquine | | Desethylchloroquine |
| ekb 569 | | pelitinib |
| glafenine | A carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market. | glafenine |
| hydroxychloroquine | An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions. | hydroxychloroquine |
| LSM-6401 | | LSM-6401 |
| n-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide | | N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide |
| N-(4-methoxyphenyl)-3,4-dihydroquinolin-2-amine | | N-(4-methoxyphenyl)-3,4-dihydroquinolin-2-amine |
| N-[2-[(3-cyano-6-ethoxy-2-quinolinyl)amino]ethyl]propanamide | | N-[2-[(3-cyano-6-ethoxy-2-quinolinyl)amino]ethyl]propanamide |
| N-[2-[(3-cyano-8-methyl-2-quinolinyl)amino]ethyl]benzenesulfonamide | | N-[2-[(3-cyano-8-methyl-2-quinolinyl)amino]ethyl]benzenesulfonamide |
| N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide | | N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide |
| N-[4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide | | N-[4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide |
| N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamide | | N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]cyclohexanecarboxamide |
| n-methylquipazine | An aminoquinoline that consists of quinoline in which the hydrogen at position 2 is substituted by a 4-methylpiperazin-1-yl group. A 5-HT3 agonist. Has almost the same affinity for 5-HT3 sites as quipazine but unlike the latter, does not bind to 5-HT1B sites. | N-methylquipazine |
| N'-butan-2-yl-N-[2-(3,5-dimethyl-1-piperidinyl)-4-methyl-6-quinolinyl]butanediamide | | N'-butan-2-yl-N-[2-(3,5-dimethyl-1-piperidinyl)-4-methyl-6-quinolinyl]butanediamide |
| nsc 23766 | An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1). | NSC 23766 |
| pamaquine | | pamaquine |
| piperaquine | An aminoquinoline that is 1,3-di(piperazin-1-yl)propane in which the nitrogen at position 4 of each of the piperazine moieties is replaced by a 7-chloroquinolin-4-yl group. | piperaquine |
| primaquine | An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia. | primaquine |
| pyronaridine | | pyronaridine |
| tafenoquine | An aminoquinoline that is 8-aminoquinoline which is substituted by methoxy groups at positions 2 and 6, a methyl group at position 4, and a m-(trifluoromethyl)phenoxy group at position 5, and in which the amino substituent at position 8 is itself substituted by a 5-aminopentan-2-yl group. | N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine |