ascorbic-acid and bakuchiol

Changes induced by intrinsic and extrinsic photoaging result in signs of skin aging including altered pigmentation and wrinkles. A 3-in-1 night facial serum (NFS) was developed to treat skin aging by antioxidative and retinoid-like mechanisms.. To determine the clinical and histological effects of the 3-in-1 NFS on signs of skin aging, clinically and histologically.. Twenty-four subjects applied serum nightly for 12 weeks, and 12 subjects continued an extension study to 24 weeks. Clinical assessment of skin quality was performed by dermatologists. Skin biopsy was performed at 12 weeks to assess histological changes.. There was a global aesthetic improvement over the duration of the study: +1.21 points at 12 weeks; +1.25 at 24 weeks. Skin texture, pigmentation, erythema, skin tone, complexion, lines, and wrinkles all significantly improved (P < .05). There was also a significant reduction in photodamage, hyperpigmentation, and wrinkle scores, most notably horizontal forehead expression lines, and marionette lines (P < .05 for all). Dermal and epidermal thickness increased without reaching statistical significance.. The 3-in-1 NFS had clinically and statistically significant effects on signs of skin aging after 12 weeks, which became more pronounced after 24 weeks.

Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cosmeceuticals; Decanoic Acids; Drug Administration Schedule; Face; Female; Humans; Male; Melatonin; Middle Aged; Phenols; Prospective Studies; Skin; Skin Aging; Skin Pigmentation; Treatment Outcome

Topical melatonin is a potent antioxidant, yet there have been few clinical studies on its anti-aging effects on the skin.. To clinically assess the anti-aging efficacy and safety of a new 3-in-1 night facial serum (NFS) combining melatonin with bakuchiol, a novel retinol-like ingredient, and ascorbyl tetraisopalmitate, in all skin types.. Five clinical studies were performed, with a total of 103 subjects treated from 28 to 84 days. Under dermatologist supervision, a 3-month efficacy and safety study evaluated anti-aging properties by clinical scoring and instrumental evaluations. Two studies evaluated skin hydration properties for 12 hours after a single application of NFS. Two studies were performed in oily skin: a 1-month efficacy and safety study and a 1-month comedogenesis study.. After 12 weeks, clinical evaluation showed a statistically significant decrease in wrinkles (11%), an increase in skin firmness (8%), a reduction in redness (70%; P < 0.01 for all), and an overall improvement in skin quality and complexion. The reduction in wrinkles and the increase in skin firmness were also supported by instrumental evaluations (Dermatop and Dynaskin). Hydration levels increased significantly from 30 minutes until 12 hours and transepidermal water loss significantly decreased after 4H and 6H. Subjects favorably evaluated the efficacy and cosmetic properties of the serum, and it was well tolerated in all skin types including oily skin.. This 3-in-1 NFS showed significant clinical anti-aging effects when applied once daily and was well tolerated.

Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Ascorbic Acid; Cosmetics; Face; Female; Healthy Volunteers; Humans; Male; Melatonin; Middle Aged; Palmitates; Phenols; Prospective Studies; Skin; Skin Aging; Skin Care; Treatment Outcome; Water Loss, Insensible; Young Adult