A EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor that interferes with the action of channel-conductance-controlling ATPase (EC 3.6.3.49, also known as cystic fibrosis conductance regulator, CFCR).
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 21.5855 | 1 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 23.2662 | 1 | 6 |
| AR protein | Homo sapiens (human) | Potency | 35.8370 | 4 | 5 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 6.5104 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.4632 | 1 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 59.9763 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 23.5190 | 1 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 39.8107 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 28.1003 | 2 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 1.5266 | 1 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 19.0728 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 28.1003 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 94.5626 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 4.1502 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 8.4230 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 26.8358 | 1 | 3 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 5.7008 | 2 | 7 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 4.6058 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.4483 | 1 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.2626 | 3 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 58.9146 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 39.9336 | 1 | 4 |
| G | Vesicular stomatitis virus | Potency | 8.4230 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 5.4858 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 0.1458 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 1.2474 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 13.6108 | 3 | 4 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 4.1502 | 1 | 9 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 23.4451 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 8.4230 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.3036 | 2 | 10 |
| IDH1 | Homo sapiens (human) | Potency | 12.9953 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 8.4230 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 8.4230 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.5854 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 9.0038 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 17.7828 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 43.8679 | 3 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 6.1590 | 2 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 31.6228 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 29.8493 | 2 | 3 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0023 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 20.4485 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 13.7187 | 3 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 29.7790 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 34.3762 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 30.2562 | 2 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 2.1192 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 33.2704 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 24.6571 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 24.6571 | 2 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 29.8554 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 24.6978 | 3 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 4.2484 | 2 | 3 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |