ascorbic-acid and Prostatitis

To investigate whether chronic bacterial prostatitis might increase oxidative stress and oxidative damage in chronic bacterial prostatitis patients (CBPP), and to explore its possible mechanism.. Enrolled in a case-control study were 70 randomly sampled CBPP and 70 randomly sampled healthy adult volunteers (HAV), on whom plasma nitric oxide (NO), vitamin C (VC), vitamin E (VE) and beta-carotene (beta-CAR) level, erythrocyte malondialdehyde (MDA) level, as well as erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities were determined by spectrophotometry.. Compared with the HAV group, values of plasma NO and erythrocyte MDA in the CBPP group were significantly increased (P < 0.001); those of plasma VC, VE and beta-CAR as well as erythrocyte SOD, CAT and GPX activities in the CBPP group were significantly decreased (P < 0.001). Findings from partial correlation for the 70 CBPP showed that with prolonged course of disease, values of NO and MDA were gradually increased (P < 0.001), and those of VC, VE, beta-CAR, SOD, CAT and GPX were gradually decreased (P < 0.05-0.001). The findings from stepwise regression for the 70 CBPP suggested that the model was Y = -13.2077 + 0.1894MDA + 0.0415NO - 0.1999GPX, F = 18.2047, P < 0.001, r = 0.6729, P < 0.001.. The findings suggest that there exist increased oxidative stress and oxidative damage induced by chronic bacterial prostatitis in the patients, and such phenomenon was closely related to the course of disease.

Topics: Adult; Ascorbic Acid; Bacterial Infections; beta Carotene; Case-Control Studies; Catalase; Erythrocytes; Glutathione Peroxidase; Humans; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Prostatitis; Reference Values; Superoxide Dismutase; Vitamin E

Background: Prostatitis-like symptoms (PLS) lead to severe discomfort in males in their daily lives. Diet has been established as affecting PLS in our prior study, but the effect of nutrients, particularly for micronutrients remains largely unclear. Methods: This study enrolled 1284 participants from August 2020 to March 2021. The National Institute of Health−Chronic Prostatitis Symptom Index was used to assess PLS. The diet composition was evaluated by the Chinese Food Composition Tables. Results: Participants were separated into PLS (n = 216), control (n = 432), and noninflammatory-abnormal symptoms (NIANS) (n = 608) groups. We observed higher levels of carotene, vitamin C, vitamin E-(β+γ) and subclass, zinc, magnesium, selenium, potassium, sodium, iron and manganese in the PLS group than in the control group. After adjustment for the potential confounders, the elevated risk from IQR2 to IQR4 of fat (P for trend = 0.011), vitamin E-(β+γ) (P for trend = 0.003), magnesium (P for trend = 0.004), sodium (P for trend = 0.001) and copper (P for trend < 0.001) was identified. Conclusions: This is the first study to evaluate the nutrient distribution in PLS patients and reveal that the higher intake of fat, vitamin E-(β+γ), magnesium, sodium, and copper is associated with a risk of PLS.

Topics: Adult; Ascorbic Acid; Carotenoids; China; Copper; Diet; Energy Intake; Humans; Iron; Magnesium; Male; Manganese; Micronutrients; Potassium; Prostatitis; Selenium; Sodium; Vitamin E; Zinc

The aim of this study was to contribute to the knowledge concerning pathogenesis of inflammatory chronic prostatitis by revealing possible shifts in the balance of markers of oxidative stress and anti-oxidative activity in case of leucocytospermic prostatitis. We also attempted to identify possible relations between seminal micro-organisms and oxidative stress parameters. A many-sided complex of local (spermatozoa, seminal plasma) and general (blood, urine) markers in 21 prostatitis patients and nine controls was compared. In both spermatozoa and seminal plasma, the content of diene conjugates was significantly higher in prostatitis patients compared with healthy controls. At the same time total anti-oxidative status in spermatozoa and total anti-oxidative activity in seminal plasma were lower in prostatitis patients than in controls. In urine, the level of 8-isoprostanes was significantly higher in prostatitis patients than in healthy controls, correlating well with 8-hydroxy-2'-deoxyguanosine. The latter correlated with cellular Fe and Ni contents as well, confirming that these metals with varying valency may cause DNA damage. Reduced glutathione showed higher levels in blood of controls than in prostatitis patients. Coryneform bacteria appeared to be associated with prostatitis-related oxidative stress. In conclusion, leucocytospermic prostatitis patients are characterised by oxidative stress at all levels: systemic (general), seminal plasma and cellular.

Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Ascorbic Acid; Case-Control Studies; Chronic Disease; Corynebacterium; Deoxyguanosine; Dinoprost; Glutathione; Humans; Interleukin-6; Leukocytes; Male; Metals; Oxidation-Reduction; Oxidative Stress; Prospective Studies; Prostatitis; Reactive Oxygen Species; Semen; Spermatozoa

To investigate whether chronic bacterial prostatitis (CBP) increases oxidative stress and damage in patients with CBP, and to explore its possible mechanism.. Eighty patients with CBP and 80 healthy adults as controls were enrolled in a case-control study, in which levels of nitric oxide (NO), vitamin C (VC), and vitamin E (VE) in plasma, as well as malondialdehyde (MDA), activities of superoxide dismutase (SOD), and catalase (CAT) in erythrocytes were determined by spectrophotometry.. Compared with the average values of NO, VC, VE, MDA, SOD, and CAT in the healthy control group, those of plasma NO and erythrocyte MDA in the CBP group were significantly increased (P < 0.001), and those of plasma VC and VE as well as erythrocyte SOD and CAT in the CBP group were significantly decreased (P < 0.001). Findings from partial correlation analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in 80 patients with CBP, adjusted for age, suggested that with prolonged course of the disease, values of NO and MDA were gradually increased (P < 0.001), and those of VC, VE, SOD, and CAT were gradually decreased (P < 0.05-0.001). The findings from stepwise regression analysis for course of the disease and NO, VC, VE, MDA, SOD, and CAT in CBP group suggested that the model of stepwise regression was Y = -19.1160 + 0.3112MDA + 0.0337NO, F = 22.1734, P < 0.001, r = 0.6045, P < 0.001. The findings from the reliability analysis for VC, VE, SOD, CAT, NO, and MDA in the CBP group showed that the reliability coefficients' alpha (6 items) was 0.7195, P < 0.0001, and the standardized item alpha was 0.9307, P < 0.0001.. There exist increased oxidative stress and damage induced by chronic bacterial prostatitis in patients, and such a phenomenon is closely related to the course of disease.

Topics: Adult; Ascorbic Acid; Case-Control Studies; Catalase; Erythrocytes; Humans; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Prostatitis; Spectrophotometry; Superoxide Dismutase; Vitamin E

To evaluate the efficacy of free-radical scavenger in the treatment of chronic bacterial prostatitis (CBP).. Fifty-eight healthy male rats were randomly divided into a control group and four model groups (Groups A, B, C and D). The chronic prostatitis model was established in the latter groups through injecting E. coli into the ventral robe of the prostate according to document. Group A was untreated, Group B treated with free-radical scavenger vitamin C, Group C with salicylazosulfapyridine (SASP), Group D with SASP and vitamin C. Superoxide dismutase (SOD) and malondialdehyde (MDA) examinations were conducted in each group 2 months later.. Vitamin C could significantly increase the level of SOD and decrease the level of MDA. There was significant difference between the model groups and the control one, as well as between the treated groups and the untreated one, but none among the treated groups.. Free-radical scavenger may be useful for the treatment of chronic bacterial prostatitis.

Topics: Animals; Ascorbic Acid; Chronic Disease; Free Radical Scavengers; Male; Malondialdehyde; Prostatitis; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfasalazine; Superoxide Dismutase

Two hundred and eighty-eight samples of patients with nongonococcal urethritis (NGU) and prostatitis were detected by cell culture and immunofluorescence assay for Chlamydia trachomatis (CT) and the effects of ascorbic acid(vitC) on the formation rate of inclusion of CT in positive samples were also studied. The results showed that the formation rate of inclusion of CT was 29.5% when the concentration of vitC was 5 micrograms.ml-1. The difference between test group and control group which contained cycloheximide in the media was insignificant (P > 0.05). The results suggested that vitC was a kind of nutrient needed for CT. The proliferation of CT in the cell can be promoted by vitC. We can replace cycloheximide by vitC in McCoy cell culture to detect clinic samples with CT.

Topics: Adult; Aged; Ascorbic Acid; Chlamydia Infections; Chlamydia trachomatis; Female; Humans; Inclusion Bodies; Male; Middle Aged; Prostatitis; Urethritis; Uterine Cervicitis

Seventy infertile men with chronic prostatitis were treated by prostatic massage and wide-spectrum chemotherapy as basic treatment to which intraprostatic injection of zinc or vitamin C with or without ultrasound application was added as a new line of treatment. Comparison showed no significant improvement of the additive treatment over the conventional treatment used alone. Pus cells in the expressed prostatic smear diminished significantly after treatment, which was associated with significant increase of percentage of motile spermatozoa and significant decrease of abnormal forms. Bacterial flora was studied in comparison with findings in 20 cases of infertile males without prostatitis; staphylococci predominated in both patient and control groups.

Topics: Adult; Ascorbic Acid; Chronic Disease; Escherichia coli; Humans; Infertility, Male; Male; Middle Aged; Prostate; Prostatitis; Semen; Staphylococcus; Streptococcus; Ultrasonic Therapy; Zinc