ascorbic-acid and Conjunctival-Diseases

To report the presence of an asymptomatic cilium in the subconjunctival area and an adjacent sterile scleral ulcer, together as a complication of subtenon injection of steroids, and the resolution of the ulcer despite the in situ cilium.. Medical management of a 51-year-old man, who was a known case of ankylosing spondylitis, with a 3-mm scleral ulcer located in the inferior palpebral area with one adjacent fully embedded cilium at the probable site of subtenon injection given for suspected acute iridocyclitis.. On altering the medication, the ulcer resolved completely. This occurred despite the in situ cilium, which did not act as a nidus for infection or inflammation.. The presence of cilia did not adversely affect the outcome of treatment of the adjacent ulcer. Therefore, if there is no exposure of the entrapped cilium through the conjunctiva, as was in this case, conservative management of the ulcer and not trying to remove the cilium seems to be a good alternative as opposed to reports in literature, which warrant its removal in most cases.

Topics: Anti-Bacterial Agents; Ascorbic Acid; Carboxymethylcellulose Sodium; Chloramphenicol; Cilia; Conjunctival Diseases; Drug Therapy, Combination; Eye Foreign Bodies; Humans; Iatrogenic Disease; Injections, Intraocular; Iridocyclitis; Male; Middle Aged; Scleral Diseases; Spondylitis, Ankylosing; Steroids; Tetracycline; Ulcer; Vitamins

The purpose of our research was to investigate the effect of supplementation with vitamin C and E on ocular surface cytology specimens and related parameters in diabetic patients.. 60 patients were enrolled in the study. The patients were given vitamin C (1000 mg/day) and vitamin E (400 IU/day) for 10 days. Conjunctival brush cytology specimens were obtained before and after treatment. Schirmer tests, break-up time and ocular ferning tests were also performed.. Goblet cell densities were 50 cells/per field before and 59 cells/per field after supplementation (p=0.002). The stage of squamous metaplasia was 1.12+/-0.42 before and 0.88+/-0.41 after supplementation (p=0.011). The changes were accompanied with improved values for the Schirmer test (p<0.001), break up time (p=0.001), and ocular ferning (p<0.001).. Diabetes mellitus is associated with increased oxidative stress. Our study suggests that supplementation with antioxidant vitamins C and E probably plays an important role in improving the ocular surface milieu.

Topics: Antioxidants; Ascorbic Acid; Conjunctiva; Conjunctival Diseases; Diabetes Mellitus, Type 2; Goblet Cells; Humans; Oxidative Stress; Tears; Time Factors; Vitamin E

Topics: Amyloidosis; Ascorbic Acid; Conjunctiva; Conjunctival Diseases; Conjunctivitis; Deficiency Diseases; Diagnosis; Eye Diseases; Humans; Immunoglobulin Light-chain Amyloidosis; Liver Extracts; Surgical Procedures, Operative; Triamcinolone; Vitamin A