ion transport inhibitor

A compound which inhibits the movement of an ion across an energy-transducing cell membrane.

ChEBI ID: 50184

Members (3)

Member	Definition	Class
ethacrynic acid	An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.	etacrynic acid
metolazone	A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.	metolazone
ouabain	A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.	ouabain

Research

Studies (17,813)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	11,859 (66.57)	18.7374
1990's	3,334 (18.72)	18.2507
2000's	1,572 (8.83)	29.6817
2010's	910 (5.11)	24.3611
2020's	138 (0.77)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	168 (0.89%)	5.53%
Reviews	544 (2.88%)	6.00%
Case Studies	85 (0.45%)	4.05%
Observational	2 (0.01%)	0.25%
Other	18,086 (95.77%)	84.16%

Protein Targets (195)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	20.2676	1	2
67.9K protein	Vaccinia virus	Potency	14.5791	2	4
acid sphingomyelinase	Homo sapiens (human)	Potency	31.6228	1	1
activating transcription factor 6	Homo sapiens (human)	Potency	3.6379	1	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	28.4357	1	4
AR protein	Homo sapiens (human)	Potency	11.5122	11	36
ATAD5 protein, partial	Homo sapiens (human)	Potency	9.5077	4	5
Ataxin-2	Homo sapiens (human)	Potency	17.0573	1	4
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	11.2215	2	7
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	0.0006	2	2
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	40.8519	1	2
caspase-3	Homo sapiens (human)	Potency	40.8519	1	2
Cellular tumor antigen p53	Homo sapiens (human)	Potency	9.1685	2	6
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	39.8107	1	1
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	31.6228	1	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	35.4813	1	1
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	25.1189	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	39.8107	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	29.4548	2	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	17.7407	1	1
Chain B, HADH2 protein	Homo sapiens (human)	Potency	29.4548	2	3
chromobox protein homolog 1	Homo sapiens (human)	Potency	39.8107	1	1
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	0.6310	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	3.8902	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	26.2000	2	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	1.6315	1	5
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	6.0457	1	2
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	79.4328	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	9.4562	1	2
endonuclease IV	Escherichia coli	Potency	177.8280	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	12.9971	10	34
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	21.9499	2	8
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	17.2547	10	28
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	33.7084	1	3
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	9.8881	3	8
flap endonuclease 1	Homo sapiens (human)	Potency	29.9349	1	1
G	Vesicular stomatitis virus	Potency	3.8902	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	26.2000	1	2
geminin	Homo sapiens (human)	Potency	14.3350	2	8
GLI family zinc finger 3	Homo sapiens (human)	Potency	18.3133	3	5
GLS protein	Homo sapiens (human)	Potency	35.4813	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	21.8278	3	9
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	8.0876	1	3
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	39.8107	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	33.6675	1	4
heat shock protein beta-1	Homo sapiens (human)	Potency	22.2036	2	4
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	0.6310	1	3
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	17.7828	1	1
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	54.0951	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	3.8902	1	1
huntingtin isoform 2	Homo sapiens (human)	Potency	5.6234	1	1
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	32.8564	2	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	34.8705	3	3
IDH1	Homo sapiens (human)	Potency	18.3564	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	3.8902	1	2
Interferon beta	Homo sapiens (human)	Potency	0.8108	3	5
interleukin 8	Homo sapiens (human)	Potency	66.8242	1	1
isocitrate dehydrogenase 1, partial	Homo sapiens (human)	Potency	50.1187	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	3.1011	1	4
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	11.0792	1	2
Luciferase	Photinus pyralis (common eastern firefly)	Potency	47.1114	2	2
Microtubule-associated protein tau	Homo sapiens (human)	Potency	14.4326	1	2
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	44.6684	1	1
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	12.5893	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	14.1254	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	3.9811	1	1
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	77.2668	1	3
Nrf2	Homo sapiens (human)	Potency	3.5481	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	12.0953	4	9
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	14.5810	1	1
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	Potency	44.6684	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	0.0290	1	2
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	37.5780	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	28.3627	2	3
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	12.6189	3	11
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	89.1251	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	79.4328	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	4.5479	1	1
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	63.7414	1	2
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	12.0691	4	11
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	19.8572	5	11
phosphopantetheinyl transferase	Bacillus subtilis	Potency	29.0027	1	3
plasminogen precursor	Mus musculus (house mouse)	Potency	4.4668	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	0.1122	1	1
PPM1D protein	Homo sapiens (human)	Potency	0.0370	1	2
pregnane X nuclear receptor	Homo sapiens (human)	Potency	10.4102	1	5
progesterone receptor	Homo sapiens (human)	Potency	16.4143	2	6
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	41.5649	2	6
ras-related protein Rab-9A	Homo sapiens (human)	Potency	14.6094	1	2
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	46.9420	1	2
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	43.0527	3	6
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	15.6255	4	10
serine-protein kinase ATM isoform a	Homo sapiens (human)	Potency	39.8107	1	1
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	26.6795	1	1
SMAD family member 2	Homo sapiens (human)	Potency	14.2192	2	8
SMAD family member 3	Homo sapiens (human)	Potency	14.2192	2	8
Smad3	Homo sapiens (human)	Potency	30.3001	1	2
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	0.2239	1	1
TDP1 protein	Homo sapiens (human)	Potency	13.5990	2	12
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	35.4813	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	37.1493	3	9
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	40.5062	2	4
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	39.8107	1	1
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	6.3543	5	6
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	4.4668	1	1
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	4.4668	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	27.4436	1	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	17.0210	4	9
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	10.0449	1	3
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	8.0876	1	3
WRN	Homo sapiens (human)	Potency	2.6679	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	Homo sapiens (human)	IC50	4.5110	2	2
10 kDa chaperonin	Escherichia coli	IC50	4.9500	2	2
10 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	8.5000	1	1
14 kDa phosphohistidine phosphatase	Homo sapiens (human)	IC50	18.3000	1	1
14 kDa phosphohistidine phosphatase	Homo sapiens (human)	Ki	183.0000	1	1
60 kDa chaperonin	Escherichia coli K-12	IC50	250.0000	1	1
60 kDa chaperonin	Escherichia coli	IC50	4.9500	2	2
60 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	8.5000	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	95.9000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	566.5000	2	2
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	3.8500	1	1
Carbonic anhydrase 1	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 12	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	22.0639	1	12
Carbonic anhydrase 14	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 2	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 3	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 4	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 6	Homo sapiens (human)	Ki	22.0639	1	12
Carbonic anhydrase 7	Homo sapiens (human)	Ki	20.3668	2	13
Carbonic anhydrase 9	Homo sapiens (human)	Ki	22.0639	1	12
Chain A, Glutathione S-transferase P1-1	Homo sapiens (human)	Ki	11.5000	1	2
Chain A, GLUTATHIONE TRANSFERASE A1-1	Homo sapiens (human)	IC50	10.0000	1	1
Chain B, Glutathione S-transferase P1-1	Homo sapiens (human)	Ki	11.5000	1	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	Mus musculus (house mouse)	Ki	0.0028	1	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	Mus musculus (house mouse)	Ki	0.0028	1	1
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	IC50	4.5000	1	1
Glutathione S-transferase A1	Homo sapiens (human)	IC50	5.0000	1	1
Glutathione S-transferase omega-1	Homo sapiens (human)	IC50	25.0000	1	1
Glutathione S-transferase P	Homo sapiens (human)	IC50	11.1333	3	3
Hematopoietic prostaglandin D synthase	Homo sapiens (human)	IC50	122.3000	1	1
Kruppel-like factor 5	Homo sapiens (human)	IC50	0.0832	3	3
large T antigen	Betapolyomavirus macacae	IC50	100.0000	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	133.0000	1	1
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	IC50	0.1646	1	1
perilipin-1	Homo sapiens (human)	IC50	4.1900	1	1
perilipin-5	Homo sapiens (human)	IC50	4.8320	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	5.8000	1	1
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	Ki	375.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	0.0970	1	1
Replicase polyprotein 1ab	Human coronavirus 229E	Ki	375.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	Ki	375.0000	1	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	Homo sapiens (human)	IC50	55.7000	1	1
Sodium/potassium-transporting ATPase subunit alpha-1	Homo sapiens (human)	IC50	6.0000	1	1
Sodium/potassium-transporting ATPase subunit alpha-1	Rattus norvegicus (Norway rat)	IC50	4.3000	1	1
Sodium/potassium-transporting ATPase subunit alpha-1	Homo sapiens (human)	Ki	0.0935	1	2
Sodium/potassium-transporting ATPase subunit alpha-2	Homo sapiens (human)	IC50	6.0000	1	1
Sodium/potassium-transporting ATPase subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	0.1700	1	1
Sodium/potassium-transporting ATPase subunit alpha-2	Homo sapiens (human)	Ki	0.0935	1	2
Sodium/potassium-transporting ATPase subunit alpha-3	Homo sapiens (human)	IC50	6.0000	1	1
Sodium/potassium-transporting ATPase subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	0.0310	1	1
Sodium/potassium-transporting ATPase subunit alpha-4	Homo sapiens (human)	IC50	6.0000	1	1
Sodium/potassium-transporting ATPase subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.0030	2	2
Sodium/potassium-transporting ATPase subunit beta-1	Homo sapiens (human)	IC50	6.0000	1	1
Sodium/potassium-transporting ATPase subunit beta-1	Homo sapiens (human)	Ki	0.0935	1	2
Sodium/potassium-transporting ATPase subunit beta-1	Rattus norvegicus (Norway rat)	IC50	1.1263	4	4
Sodium/potassium-transporting ATPase subunit beta-2	Homo sapiens (human)	IC50	6.0000	1	1
Sodium/potassium-transporting ATPase subunit beta-3	Homo sapiens (human)	IC50	6.0000	1	1
Sodium/potassium-transporting ATPase subunit beta-3	Rattus norvegicus (Norway rat)	IC50	0.0018	1	1
Sodium/potassium-transporting ATPase subunit gamma	Homo sapiens (human)	IC50	6.0000	1	1
STAT3, partial	Homo sapiens (human)	IC50	1.1540	1	1
Thiosulfate sulfurtransferase	Homo sapiens (human)	IC50	100.0000	1	1
UDP-glucose 4-epimerase	Homo sapiens (human)	IC50	14.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Chain A, Na, K-ATPase alpha subunit	Squalus acanthias (spiny dogfish)	Kd	0.0007	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Carbonic anhydrase 1	Homo sapiens (human)	Kinact	54.0000	1	1
Carbonic anhydrase 12	Homo sapiens (human)	Kinact	0.0054	1	1
Carbonic anhydrase 13	Mus musculus (house mouse)	Kinact	0.0150	1	1
Carbonic anhydrase 14	Homo sapiens (human)	Kinact	5.4320	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Kinact	2.0000	1	1
Carbonic anhydrase 4	Homo sapiens (human)	Kinact	0.2160	1	1
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Kinact	0.7500	1	1
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Kinact	0.3120	1	1
Carbonic anhydrase 6	Homo sapiens (human)	Kinact	1.7140	1	1
Carbonic anhydrase 7	Homo sapiens (human)	Kinact	0.0021	1	1
Carbonic anhydrase 9	Homo sapiens (human)	Kinact	0.3200	1	1
Sodium/potassium-transporting ATPase subunit alpha-1	Homo sapiens (human)	LC50	9.4000	1	1
Sodium/potassium-transporting ATPase subunit alpha-2	Homo sapiens (human)	LC50	9.4000	1	1
Sodium/potassium-transporting ATPase subunit alpha-3	Homo sapiens (human)	LC50	9.4000	1	1
Sodium/potassium-transporting ATPase subunit alpha-4	Homo sapiens (human)	LC50	9.4000	1	1
Sodium/potassium-transporting ATPase subunit beta-1	Homo sapiens (human)	LC50	9.4000	1	1
Sodium/potassium-transporting ATPase subunit beta-2	Homo sapiens (human)	LC50	9.4000	1	1
Sodium/potassium-transporting ATPase subunit beta-3	Homo sapiens (human)	LC50	9.4000	1	1
Sodium/potassium-transporting ATPase subunit gamma	Homo sapiens (human)	LC50	9.4000	1	1
Solute carrier organic anion transporter family member 1A1	Rattus norvegicus (Norway rat)	Km	2,350.0000	2	2
Solute carrier organic anion transporter family member 1A2	Homo sapiens (human)	Km	5,500.0000	1	1
Solute carrier organic anion transporter family member 1A4	Rattus norvegicus (Norway rat)	Km	470.0000	1	1
Solute carrier organic anion transporter family member 1A5	Rattus norvegicus (Norway rat)	Km	1,571.0000	1	1
Solute carrier organic anion transporter family member 4C1	Homo sapiens (human)	Km	0.3800	1	1