Cerebromalacia

Softening or loss of brain tissue following CEREBRAL INFARCTION; cerebral ischemia (see BRAIN ISCHEMIA), infection, CRANIOCEREBRAL TRAUMA, or other injury. The term is often used during gross pathologic inspection to describe blurred cortical margins and decreased consistency of brain tissue following infarction. Multicystic encephalomalacia refers to the formation of multiple cystic cavities of various sizes in the cerebral cortex of neonates and infants following injury, most notably perinatal hypoxia-ischemic events. (From Davis et al., Textbook of Neuropathology, 2nd ed, p665; J Neuropathol Exp Neurol, 1995 Mar;54(2):268-75)

Synonym
Encephalomalacia, Multicystic
Multicystic Encephalomalacia
Encephalomalacia
Cerebromalacia

Excerpt	Reference
"Sulfur-related polioencephalomalacia is frequently associated with a high total sulfur intake by ruminants."	( Gould, DH, 2000)

Excerpt	Reference
"An outbreak of polioencephalomalacia affected 16 of 46 Swaledale lambs and five of 25 Scottish blackface lambs 15 to 32 days after they were introduced to an ad libitum concentrate ration containing 0."	( FitzSimons, J; Howie, F; Lewis, M; Low, JC; Scott, PR; Spence, JA, 1996)

Excerpt	Reference
"Of six goats with polioencephalomalacia, three responded to thiamin therapy, whereas three died 2 to 7 days after onset of signs."	( Smith, MC, 1979)
"Leukoencephalomalacia (LEM) was induced by the oral administration of fumonisin B1 (FB1) to 2 horses: a filly received 59."	( Cawood, M; Coetzer, JA; Gelderblom, WC; Kellerman, TS; Marasas, WF; Thiel, PG, 1990)
"Polioencephalomalacia that was unresponsive to thiamine treatment developed in another 40 (2%) of the ewes; 28 (70%) of the ewes with polioencephalomalacia recovered."	( Bulgin, MS; Lincoln, SD; Mather, G, 1996)
"Clinical polioencephalomalacia occurred in all calves assigned to the moderately high and high treatments."	( Edwards, WC; Lalman, D; Morgan, S; Niles, GA, 2002)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	235 (69.94)	23.3326
1990's	66 (19.64)	12.5806
2000's	21 (6.25)	18.1394
2010's	11 (3.27)	28.8240
2020's	3 (0.89)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	1	0
hydrogen sulfide	low	8	0
3,4-dihydroxyphenylacetic acid	low	1	0
lactic acid	low	2	0
glutaric acid	low	1	0
hydrogen carbonate	low	4	0
histamine	low	1	0
iodine	low	1	0
thioctic acid	low	4	0
inositol	low	1	0
niacinamide	low	1	0
niacin	low	1	0
pteridines	low	2	0
pyridoxine	low	3	0
pyruvic acid	low	1	0
thiosulfates	low	1	0
sulfites	low	1	0
thiamine	medium	70	2
uric acid	low	3	0
urea	low	2	0
ibotenic acid	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
phenytoin	low	2	0
theophylline	medium	3	1
amprolium	low	7	0
aspirin	low	2	0
carbamazepine	low	1	0
carmofur	low	1	0
chlorothiazide	low	1	0
clonidine	low	1	0
diazepam	low	3	0
ddt	low	1	0
valproic acid	low	1	0
erythrosine	low	1	0
ethoxyquin	low	1	0
fluorouracil	low	1	0
hexachlorophene	low	1	0
hexobarbital	low	1	0
indomethacin	low	1	0
isoniazid	low	2	0
2-propanol	low	1	0
lamotrigine	low	1	0
metyrapone	low	1	0
apnea	low	2	0
papaverine	low	1	0
phenobarbital	low	1	0
piribedil	low	1	0
promethazine	low	1	0
pyrimethamine	low	1	0
sulfadiazine	low	1	0
thiabendazole	low	1	0
trihexyphenidyl	low	2	0
prednisolone	low	1	0
prednisone	low	3	0
alanine	low	6	0
aspartic acid	low	2	0
glutamine	low	4	0
cyanides	low	1	0
adenosine diphosphate	low	1	0
uridine	low	1	0
levodopa	low	1	0
methylene blue	low	1	0
methionine	low	1	0
dichlorodiphenyldichloroethane	low	1	0
soman	low	1	0
nitrobenzene	low	1	0
dodecanol	low	2	0
ergotamine	low	1	0
thiamine pyrophosphate	low	15	0
aminophylline	low	1	0
dextropropoxyphene	low	1	0
fusarium	low	26	0
thiamine monophosphate	low	1	0
chlormethiazole	low	1	0
malondialdehyde	low	1	0
thorium dioxide	low	1	0
d-alpha tocopherol	low	35	0
tocopherols	low	3	0
ethamsylate	medium	1	1
streptomycin	low	1	0
manganese	low	1	0
mercury	low	1	0
molybdenum	low	1	0
technetium	low	9	0
gold	low	1	0
magnesium sulfate	low	1	0
calcium sulfate	low	1	0
chlormerodrin	low	2	0
levamisole	low	1	0
daunorubicin	low	1	0
bromocriptine	low	1	0
phenyl acetate	low	1	0
4-methoxyamphetamine	low	1	0
transferrin	low	1	0
closantel	low	1	0
propiconazole	low	4	0
3-iodobenzylguanidine	low	1	0
dexamethasone 21-palmitate	low	1	0
xenon radioisotopes	low	1	0
coenzyme a	low	1	0
fibrinogen	low	2	0
foxes	low	1	0
cobalt	low	1	0
thromboxanes	low	1	0
n,n,n'-trimethyl-n'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine	low	1	0
methotrexate	low	1	0
biotin	low	2	0
cortisone	low	3	0
glycogen	low	6	0
inositol 3-phosphate	low	1	0
digitoxin	low	1	0
metrizamide	low	1	0
arachidonic acid	low	4	0
retinol	low	5	0
oleic acid	low	2	0
cocaine	low	1	0
potassium permanganate	low	1	0
pyrophosphate	low	1	0
sesquiterpenes	low	2	0
dieldrin	low	1	0
fumonisin b1	low	22	0
fumonisin b2	low	11	0
cystine	low	1	0
17-ketosteroids	low	2	0
naphthoquinones	low	1	0
myelin basic protein	low	2	0
sphingosine	low	1	0
bilirubin	low	3	0
dinoprostone	low	1	0
linoleic acid	low	4	0
5-hydroxy-6,8,11,14-eicosatetraenoic acid	low	1	0
alpha-linolenic acid	low	2	0
zearalenone	low	1	0
thromboxane b2	low	1	0
phenylephrine hydrochloride	low	1	0
lead	low	1	0
15-hydroxy-5,8,11,13-eicosatetraenoic acid	low	1	0
aluminum	low	1	0
indium	low	1	0
dextromethorphan	low	1	0
sulfur	medium	17	2
phosphorus	low	1	0
fumonisin a1	low	1	0
ammonium sulfate	low	2	0
selenium	low	14	0
oxalates	low	1	0
clinoptilolite	medium	1	1
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid	low	1	0
ubichromenol	low	1	0
zeolites	medium	1	1
alpha-synuclein	low	1	0
acid phosphatase	low	3	0
thiamine pyrophosphate	low	1	0
phosphatidylcholines	low	2	0
ubiquinone	low	1	0
sodium pertechnetate tc 99m	low	1	0
sodium ethylxanthate	low	1	0
quetiapine fumarate	low	1	0
fumonisin b4	low	2	0
glycolipids	low	1	0
heme	low	1	0
ascorbic acid	low	2	0
caseins	low	1	0
fumonisin b3	low	2	0
t-2 toxin	low	2	0
muramidase	low	1	0
acyclovir	low	2	0
levoleucovorin	low	1	0
trypan blue	low	1	0
5-methyltetrahydrofolate	low	1	0
molybdenum cofactor	low	2	0
eye	low	1	0
repin	low	1	0

Protein Targets (1,244)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	11	0	0	11
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	29	0	0	29
USP1 protein, partial	21	0	0	21
TDP1 protein	38	0	0	38
vitamin D3 receptor isoform VDRA	22	0	0	22
importin subunit beta-1 isoform 1	7	0	0	7
flap endonuclease 1	14	0	0	14
serine/threonine-protein kinase PLK1	5	0	0	5
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
DNA polymerase eta isoform 1	8	0	0	8
DNA polymerase iota isoform a (long)	18	0	0	18
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
geminin	38	0	0	38
DNA polymerase kappa isoform 1	16	0	0	16
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	2
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	6	2	8
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	2	3
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	6	0	0	6
Fatty acid-binding protein 5	0	3	1	4
Fatty acid-binding protein 5	0	0	2	2
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	4	0	4
hypoxia-inducible factor 1 alpha subunit	19	0	0	19
RAR-related orphan receptor gamma	41	0	0	41
GLI family zinc finger 3	36	0	0	36
AR protein	49	0	0	49
aldehyde dehydrogenase 1 family, member A1	31	0	0	31
retinoic acid nuclear receptor alpha variant 1	47	0	0	47
retinoid X nuclear receptor alpha	34	0	0	34
estrogen nuclear receptor alpha	60	0	0	60
peroxisome proliferator-activated receptor delta	26	0	0	26
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	26	0	0	26
activating transcription factor 6	19	0	0	19
v-jun sarcoma virus 17 oncogene homolog (avian)	27	0	0	27
Histone H2A.x	18	0	0	18
thyroid hormone receptor beta isoform a	20	0	0	20
heat shock protein beta-1	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 1	43	0	0	43
lamin isoform A-delta10	43	0	0	43
Voltage-dependent calcium channel gamma-2 subunit	24	0	0	24
Glutamate receptor 2	25	1	0	26
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	30	0	0	30
67.9K protein	9	0	0	9
thyroid stimulating hormone receptor	15	0	0	15
Nuclear receptor ROR-gamma	17	0	0	17
ORF73	0	0	2	2
dopamine D1 receptor	7	0	0	7
GLS protein	21	0	0	21
Thrombopoietin	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	16	0	0	16
cytochrome P450 2D6 isoform 1	13	0	0	13
cytochrome P450 2C19 precursor	9	0	0	9
ras-related protein Rab-9A	5	0	0	5
histone acetyltransferase KAT2A isoform 1	16	0	0	16
lethal factor (plasmid)	13	0	0	13
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	15	2	1	18
ATP-dependent phosphofructokinase	19	0	0	19
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	25	0	0	25
Chain A, HADH2 protein	20	0	0	20
Chain B, HADH2 protein	20	0	0	20
Chain A, 2-oxoglutarate Oxygenase	18	0	0	18
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	21	0	0	21
endonuclease IV	6	0	0	6
RGS12	1	0	0	1
phosphopantetheinyl transferase	26	0	0	26
NFKB1 protein, partial	5	0	0	5
Microtubule-associated protein tau	20	0	0	20
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	9	0	0	9
apical membrane antigen 1, AMA1	6	0	0	6
thyroid stimulating hormone receptor	22	0	0	22
hypothetical protein, conserved	6	0	0	6
regulator of G-protein signaling 4	16	0	0	16
euchromatic histone-lysine N-methyltransferase 2	42	0	0	42
Bloom syndrome protein isoform 1	22	0	0	22
lysosomal alpha-glucosidase preproprotein	4	0	0	4
peripheral myelin protein 22 isoform 1	8	0	0	8
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	15	0	0	15
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	20	0	0	20
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	7	0	0	7
M-phase phosphoprotein 8	7	0	0	7
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	3	3
muscarinic acetylcholine receptor M1	13	0	0	13
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	3	7
Zinc finger protein mex-5	0	0	3	3
5-hydroxytryptamine receptor 2C	0	4	1	6
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 1A	0	13	2	15
5-hydroxytryptamine receptor 1B	0	10	1	11
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	8	1	9
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Inositol monophosphatase 1	11	0	0	11
caspase 7, apoptosis-related cysteine protease	9	0	0	9
glucocorticoid receptor [Homo sapiens]	35	0	0	35
estrogen-related nuclear receptor alpha	47	0	0	47
pregnane X nuclear receptor	34	0	0	34
vitamin D (1,25- dihydroxyvitamin D3) receptor	29	0	0	29
caspase-3	9	0	0	9
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Cellular tumor antigen p53	38	0	0	38
Fibroblast growth factor receptor 4	0	1	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	9	0	0	9
Chain A, Ferritin light chain	9	0	0	9
Thymidine kinase	0	1	0	1
Smad3	9	0	0	9
EWS/FLI fusion protein	14	0	0	14
arylsulfatase A	12	0	0	12
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	7	0	0	7
ubiquitin carboxyl-terminal hydrolase 2 isoform a	9	0	0	9
Solute carrier family 22 member 1	0	7	0	12
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	21
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	7	0	7
Bile salt export pump	0	34	0	34
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	9	1	10
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	6	0	0	6
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	7
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	5
Canalicular multispecific organic anion transporter 1	0	19	0	19
Thymidine kinase	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	1	1	2
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	1	1	2
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Carbonic anhydrase 1	0	10	0	16
Carbonic anhydrase 2	0	10	1	18
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	4
Glutamate receptor ionotropic, NMDA 1	0	5	0	7
Proton-coupled amino acid transporter 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
Chain A, Beta-lactamase	12	0	0	12
Chain A, Cruzipain	14	0	0	14
15-lipoxygenase, partial	12	0	0	12
WRN	2	0	0	2
SMAD family member 2	17	0	0	17
SMAD family member 3	17	0	0	17
estrogen receptor 2 (ER beta)	26	0	0	26
progesterone receptor	27	0	0	27
farnesoid X nuclear receptor	27	0	0	27
peroxisome proliferator activated receptor gamma	29	0	0	29
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	17	0	0	17
Caspase-7	9	0	0	9
phospholipase A2 precursor	0	1	0	1
caspase-3	9	0	0	9
thyroid hormone receptor beta isoform 2	36	0	0	36
cysteine protease ATG4B isoform a	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	6	0	0	6
cytochrome P450 3A4 isoform 1	18	0	0	18
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	1	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	18	3	1	22
Free fatty acid receptor 1	0	0	2	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Prostaglandin G/H synthase 1	0	5	0	7
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Trypsin	0	4	0	4
Coagulation factor VII	0	5	0	5
Aromatase	0	6	0	6
Tissue factor	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	18	3	1	22
Gamma-aminobutyric acid receptor subunit delta	18	3	1	22
Gamma-aminobutyric acid receptor subunit gamma-2	18	3	1	22
Gamma-aminobutyric acid receptor subunit alpha-5	18	3	1	22
Gamma-aminobutyric acid receptor subunit alpha-3	18	3	1	22
Prostaglandin G/H synthase 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	18	3	1	22
Gamma-aminobutyric acid receptor subunit alpha-2	18	3	1	22
Gamma-aminobutyric acid receptor subunit alpha-4	18	3	1	22
Gamma-aminobutyric acid receptor subunit gamma-3	18	3	1	22
Gamma-aminobutyric acid receptor subunit alpha-6	18	3	1	22
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Histamine H2 receptor	12	0	1	13
Gamma-aminobutyric acid receptor subunit alpha-1	18	4	1	23
Gamma-aminobutyric acid receptor subunit beta-3	18	3	1	22
Gamma-aminobutyric acid receptor subunit beta-2	18	3	1	22
Prostaglandin G/H synthase 2	0	6	0	7
Free fatty acid receptor 4	0	0	2	2
GABA theta subunit	18	3	1	22
Gamma-aminobutyric acid receptor subunit epsilon	18	3	1	22
ATAD5 protein, partial	13	0	0	13
D(1A) dopamine receptor	5	0	0	5
neuropeptide S receptor isoform A	4	0	0	4
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, SERUM ALBUMIN	0	0	2	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
cellular tumor antigen p53 isoform a	8	0	0	8
nuclear receptor ROR-gamma isoform 1	17	0	0	17
caspase-1 isoform alpha precursor	3	0	0	3
Fatty-acid amide hydrolase 1	0	2	0	2
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	7	2	10
Nuclear receptor subfamily 4 group A member 2	0	0	3	3
10 kDa heat shock protein, mitochondrial	0	3	0	3
Calmodulin	0	0	1	2
Solute carrier organic anion transporter family member 2A1	0	0	0	3
Thiosulfate sulfurtransferase	0	3	0	3
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	6	0	7
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	18	0	0	18
cytochrome P450 family 3 subfamily A polypeptide 4	26	0	0	26
IDH1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	15
Polyphenol oxidase 2	0	3	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	10	2	12
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	0	6
Glutamate receptor ionotropic, NMDA 2B	0	4	0	6
Glutamate receptor ionotropic, NMDA 2C	0	4	0	6
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	1	2	3
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	4	0	6
Glutamate receptor ionotropic, NMDA 3B	0	4	0	6
Glutamate receptor ionotropic, NMDA 3A	0	4	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	6	0	0	6
cytochrome P450 2D6	15	0	0	15
glucocerebrosidase	4	0	0	4
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	3
Epidermal growth factor receptor	0	6	0	6
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	6	1	0	7
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	4
Seed linoleate 13S-lipoxygenase-1	0	4	0	4
Integrin alpha-IIb	6	1	0	7
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	1	7	0	12
Adenosine receptor A2a	0	5	1	12
Substance-P receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	7	1	8
Sigma non-opioid intracellular receptor 1	0	2	1	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
Caspase-7	3	0	0	3
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Genome polyprotein	0	2	2	4
Fumarate hydratase	8	0	0	8
G	12	0	0	12
polyprotein	8	0	0	8
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
5-hydroxytryptamine receptor 4	0	8	0	8
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	4	0	6
Beta-1 adrenergic receptor	0	4	0	4
Cytochrome P450 3A4	0	6	1	7
5-hydroxytryptamine receptor 1A	0	3	0	3
Alpha-2A adrenergic receptor	0	10	1	11
D(2) dopamine receptor	0	6	1	7
Androgen receptor	0	9	0	9
Alpha-2C adrenergic receptor	0	12	1	13
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	0	4
ATP-dependent translocase ABCB1	0	2	0	2
D(1A) dopamine receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	8	1	9
D(1B) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	8	1	9
D(4) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	6	0	6
Alpha-synuclein	3	2	0	5
5-hydroxytryptamine receptor 2B	0	8	0	8
5-hydroxytryptamine receptor 6	0	6	0	6
D(2) dopamine receptor	0	3	1	4
Inositol hexakisphosphate kinase 1	12	0	0	12
ATPase family AAA domain-containing protein 5	18	0	0	18
Ataxin-2	20	0	0	20
cytochrome P450 2C9, partial	12	0	0	12
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
nuclear receptor subfamily 1, group I, member 3	29	0	0	29
Potassium channel subfamily K member 2	0	0	2	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	5	2	7
Adenosine receptor A3	0	6	0	6
Replicase polyprotein 1ab	0	6	3	9
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	5	0	5
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	5	0	5
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	6	3	11
Adenosine receptor A2b	0	2	0	4
Adenosine receptor A2b	0	3	1	6
Adenosine receptor A1	0	3	2	9
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	2	0	2
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	3
Guanine deaminase	0	2	0	2
mitogen-activated protein kinase 1	13	0	0	13
Vpr	6	0	0	6
Albumin	0	0	2	2
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	2	0	4
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	3	0	6
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	4	0	4
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Spike glycoprotein	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
potassium voltage-gated channel subfamily H member 2 isoform d	16	0	0	16
peripheral myelin protein 22	20	0	0	20
survival motor neuron protein isoform d	11	0	0	11
Transmembrane protease serine 2	0	2	1	3
Procathepsin L	0	3	1	4
Replicase polyprotein 1a	0	3	1	4
Replicase polyprotein 1ab	0	2	1	3
Cytochrome P450 2D6	0	4	0	5
Mitogen-activated protein kinase 3	0	2	0	2
Fatty-acid amide hydrolase 1	0	3	0	3
Acid ceramidase	0	1	0	1
Acid ceramidase	0	1	0	1
Angiotensin-converting enzyme 2	0	2	1	3
Sulfide:quinone oxidoreductase, mitochondrial	0	1	0	1
Carbonic anhydrase 4	0	4	0	7
Carbonic anhydrase	0	5	0	7
Carbonic anhydrase 15	0	4	0	6
cytochrome P450 2C9 precursor	7	0	0	7
UDP-glucuronosyltransferase 1-6	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
nonstructural protein 1	7	0	0	7
transcriptional regulator ERG isoform 3	6	0	0	6
glp-1 receptor, partial	12	0	0	12
mu opioid receptor, partial	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
bromodomain adjacent to zinc finger domain 2B	14	0	0	14
LAP4	0	0	1	1
MEP2	0	0	1	1
aryl hydrocarbon receptor	16	0	0	16
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
delta-type opioid receptor	0	1	1	2
kappa-type opioid receptor isoform 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
huntingtin isoform 2	6	0	0	6
nuclear factor NF-kappa-B p105 subunit isoform 1	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	2	0	5
Histone deacetylase 3	0	3	0	3
Carbonic anhydrase 12	0	0	0	3
Amyloid-beta precursor protein	1	6	0	7
Carbonic anhydrase 3	0	0	0	3
Botulinum neurotoxin type A	0	1	0	1
Spike glycoprotein	0	1	0	1
Alpha-1B adrenergic receptor	0	6	1	7
Catechol O-methyltransferase	0	1	0	1
Carbonic anhydrase 6	0	3	0	6
Alpha-1D adrenergic receptor	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
Alpha-1A adrenergic receptor	0	6	2	8
Carbonic anhydrase 7	0	1	0	4
Histone deacetylase 4	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	5	0	5
TAR DNA-binding protein 43	10	0	0	10
Histone deacetylase 1	0	4	0	4
Carbonic anhydrase 9	0	1	0	4
Beta-galactosidase	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	4	0	4
Carbonic anhydrase 13	0	1	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Carbonic anhydrase 14	0	0	0	3
Histone deacetylase 5	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	3
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	3	0	4
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	3	0	4
Multidrug and toxin extrusion protein 1	0	5	0	5
Nischarin	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
glucose-6-phosphate dehydrogenase	0	1	0	1
SUMO-1	0	2	0	2
TSHR protein	3	0	0	3
PINK1	2	0	0	2
Parkin	3	0	0	3
hexokinase	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
streptokinase A precursor	0	0	4	4
bcl-2-like protein 11 isoform 1	0	0	2	2
Long-chain-fatty-acid--AMP ligase FadD32	0	1	0	1
Rap guanine nucleotide exchange factor 3	6	0	0	6
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Tyrosine-protein kinase Lck	0	4	0	4
Tyrosine-protein kinase Fyn	0	4	0	4
Sporulation initiation phosphotransferase F	0	1	0	1
Neutrophil elastase	0	1	0	1
Sporulation kinase A	0	1	0	1
Thromboxane-A synthase	0	4	0	4
Mitogen-activated protein kinase 1	0	2	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Chitinase	0	2	0	2
Rap guanine nucleotide exchange factor 4	3	0	0	3
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	3	0	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Fatty acid-binding protein, heart	0	3	0	3
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	1	5
Liver carboxylesterase 1	0	1	0	2
Sodium-dependent dopamine transporter	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	1	5
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-2	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
Transporter	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
pregnane X receptor	13	0	0	13
Glucocorticoid receptor	0	6	2	13
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
PPM1D protein	3	0	0	3
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	2	1	0	3
Glutamate receptor 3	2	1	0	3
Glutamate receptor 4	2	1	0	3
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	3	0	5
Reverse transcriptase/RNaseH	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Cytochrome P450 2D4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Gamma-aminobutyric acid	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	2	2	5
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	3	2	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	3	2	0	5
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Peroxisome proliferator-activated receptor alpha	3	0	1	4
thyrotropin-releasing hormone receptor	4	0	0	4
STAT3, partial	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Adenylate cyclase	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	2	0	2
Nrf2	1	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	3	0	3
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
calpain II, partial	0	1	0	1
PAX8	0	0	0	1
Mcl-1	0	1	0	1
Valosin-containing protein	0	1	0	1
Estrogen receptor 1	0	1	0	1
envelope glycoprotein	0	1	0	1
heat shock protein 90	0	0	1	1
heat shock 70kDa protein 1A	0	1	0	1
galactokinase	1	0	0	1
tumor necrosis factor	1	0	0	1
neuropeptide Y receptor type 1	0	0	1	1
neuropeptide Y receptor type 2	0	0	1	1
small ubiquitin-related modifier 2 isoform b precursor	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
enteropeptidase precursor	1	0	0	1
fatty acid synthase	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	2	0	2
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	2	0	2
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase	1	0	0	1
replicative DNA helicase	0	0	0	2
recombinase A	0	0	2	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Cytochrome P450 1A2	0	4	0	4
Estrogen receptor	0	0	3	3
Urokinase-type plasminogen activator	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Macrophage migration inhibitory factor	0	5	0	5
Substance-K receptor	0	2	0	2
Cytochrome P450 2C19	0	4	0	4
Estrogen receptor beta	0	0	3	3
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
phosphoglycerate kinase	3	0	0	3
M1-family alanyl aminopeptidase	0	1	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
BZLF2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	6	0	0	6
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	2
Histamine H2 receptor	0	3	2	5
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H1 receptor	0	4	2	6
Carbonic anhydrase	0	0	0	3
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	1	0	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	3
Histamine H3 receptor	0	1	2	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
alpha-galactosidase	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	0	1	0	1
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 5	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Metabotropic glutamate receptor 4	0	1	1	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
histone deacetylase 9 isoform 3	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Dihydrofolate reductase	0	6	3	10
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	4	0	4
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	2	0	2
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
pyruvate kinase	2	0	0	2
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	2	0	2
Dual specificity protein phosphatase 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Pteridine reductase 1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Protein-arginine deiminase type-4	0	3	0	3
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Cruzipain	0	1	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
putative potassium channel subunit	0	0	1	1
Fatty acid-binding protein, liver	0	0	1	1
DNA topoisomerase 1	0	1	0	1
Protein kinase C alpha type	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	3	0	3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	1	3
Snq2p	0	0	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	4	0	4
Calmodulin-1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	4	0	4
Muscarinic acetylcholine receptor M3	0	4	0	4
Trypanothione reductase	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
D(1A) dopamine receptor	1	0	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Pyridoxal kinase	0	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Acetylcholinesterase	0	2	1	3
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Aurora kinase A	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
BRCA1	1	0	0	1
P53	1	0	0	1
Methionine aminopeptidase	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Methionine aminopeptidase 2	0	1	0	1
Methionine aminopeptidase 1	0	1	1	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
Vif	0	1	0	1
Tat	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Protein cereblon	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
PTK2B protein tyrosine kinase 2 beta	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

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Overview

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Treatment

Research

Studies (336)

Protein Targets (1,244)

Cerebromalacia

Synonyms(4)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (336)

Drugs Studied (205)

Protein Targets (1,244)