Roles > antigen
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antigen

Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).

ChEBI ID: 59132

Members (11)

MemberDefinitionClass
benzyl cinnamateThe cinnamate ester derived from cinnamic acid and benzyl alcohol. Occuring in Balsam of Peru and Tolu balsam, in Sumatra and Penang benzoin, and as the main constituent of copaiba balsam, it is used in heavy oriental perfumes, as a fixative and as a flavouring agent.benzyl cinnamate
blood group a trisaccharideA branched amino trisaccharide consisting of beta-D-galactose having an alpha-L-fucosyl residue at the 2-position and an N-acetyl-alpha-D-galactosaminyl residue at the 3-position.3)-[alpha-L-Fucp-(1->2)]-beta-D-Galp.html>alpha-D-GalpNAc-(1->3)-[alpha-L-Fucp-(1->2)]-beta-D-Galp
dimyristoylphosphatidylcholineA 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).1,2-di-O-myristoyl-sn-glycero-3-phosphocholine
dimyristoylphosphatidylsulfocholineA 1,2-diacyl-sn-glycero-3-phosphosulfocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).1,2-di-O-myristoyl-sn-glycero-3-phosphosulfocholine
g(m2) gangliosideA sialotriaosylceramide that is N-acetyl-beta-D-galactosaminyl-(1->4)-alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine in which the acyl group on the sphingosine nitrogen is octadecanoyl. A constituent of natural ganglioside GM2.ganglioside GM2 (18:0)
isoglobotrihexosylceramideThe N-hexacosanoyl derivative of isoglobotriaosyl ceramide.N-hexacosanoylisoglobotriaosyl ceramide
isopentenyl pyrophosphateA prenol phosphate comprising 3-methylbut-3-en-1-ol having an O-diphosphate substituent.isopentenyl diphosphate
krn 7000A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine
n(6)-carboxymethyllysineAn L-lysine derivative with a carboxymethyl substituent at the N(6)-position.N(6)-carboxymethyl-L-lysine
nitrohydroxyiodophenylacetateA member of the class of phenylacetic acids that is phenylacetic acid in which the phenyl group is substituted by iodo, hydroxy and nitro groups at positions 3, 4 and 5 respectively.(4-hydroxy-3-iodo-5-nitrophenyl)acetic acid
ribothymidineA methyluridine having a single methyl substituent at the 5-position on the uracil ring.ribothymidine

Research

Studies (6,405)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990970 (15.14)18.7374
1990's1,193 (18.63)18.2507
2000's2,000 (31.23)29.6817
2010's1,880 (29.35)24.3611
2020's362 (5.65)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials83 (1.26%)5.53%
Reviews232 (3.52%)6.00%
Case Studies83 (1.26%)4.05%
Observational8 (0.12%)0.25%
Other6,182 (93.84%)84.16%

Protein Targets (35)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency42.161644
aryl hydrocarbon receptorHomo sapiens (human)Potency26.603211
Ataxin-2Homo sapiens (human)Potency6.859011
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency6.859011
Cellular tumor antigen p53Homo sapiens (human)Potency27.306011
cytochrome P450 2C9, partialHomo sapiens (human)Potency12.301811
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency3.682222
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency17.228911
estrogen nuclear receptor alphaHomo sapiens (human)Potency29.186256
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency22.1360612
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency31.622811
farnesoid X nuclear receptorHomo sapiens (human)Potency26.601111
GVesicular stomatitis virusPotency12.301811
GLI family zinc finger 3Homo sapiens (human)Potency6.955023
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency15.157712
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency12.301811
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency12.301812
Interferon betaHomo sapiens (human)Potency12.301811
lamin isoform A-delta10Homo sapiens (human)Potency0.035511
LuciferasePhotinus pyralis (common eastern firefly)Potency13.994323
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency14.283324
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency11.990036
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency11.882311
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency35.481311
RAR-related orphan receptor gammaMus musculus (house mouse)Potency21.453124
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency18.803736
retinoid X nuclear receptor alphaHomo sapiens (human)Potency14.204524
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency5.011911
TDP1 proteinHomo sapiens (human)Potency3.349811
thyroid stimulating hormone receptorHomo sapiens (human)Potency7.695922
USP1 protein, partialHomo sapiens (human)Potency10.000011
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency15.157712

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
17beta-hydroxysteroid dehydrogenaseCurvularia lunataIC503.850022
Butyrophilin subfamily 3 member A1Homo sapiens (human)IC50513.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Butyrophilin subfamily 3 member A1Homo sapiens (human)EC5036.000033
Chain A, PROBABLE SUGAR ABC TRANSPORTER, SUGAR-BINDING PROTEINStreptococcus pneumoniae SP3-BS71Kd0.830011