An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule.
| Member | Definition | Class |
|---|
| acetazolamide | | acetazolamide |
| astragaloside IV | A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from Astragalus membranaceus var mongholicus. | astragaloside IV |
| brinzolamide | | brinzolamide |
| dichlorphenamide | A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma. | diclofenamide |
| dorzolamide | 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension. | dorzolamide |
| ethoxzolamide | A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic. | ethoxzolamide |
| l 671152 | The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension. | dorzolamide hydrochloride |
| latanoprost | A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension. | latanoprost |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | A chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. | indisulam |
| phxa 85 | A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension. | latanoprost free acid |
| sulfanilamide | A sulfonamide in which the sulfamoyl functional group is attached to aniline at the 4-position. | sulfanilamide |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| AR protein | Homo sapiens (human) | Potency | 22.5373 | 5 | 9 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 24.7103 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 21.3313 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 68.9385 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 23.7531 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 24.4305 | 2 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.5628 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 53.1942 | 1 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 92.1395 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 16.0546 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 24.9071 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 46.3243 | 1 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 30.3710 | 6 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 36.3822 | 5 | 16 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.0224 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 13.4096 | 2 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 0.0042 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 16.0546 | 1 | 2 |
| GALC protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 2.2483 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 34.8063 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.9294 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 34.4696 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 0.6310 | 1 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 16.0546 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.0100 | 2 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 16.0546 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 16.0546 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 10.1537 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 30.1230 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 630.9570 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 36.6991 | 2 | 5 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 14.5810 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 18.5518 | 3 | 7 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 28.9466 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 3.6225 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 2.6601 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 42.3046 | 1 | 2 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 6.4466 | 2 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 27.6068 | 3 | 8 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 11.7317 | 2 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 8.9125 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.8948 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.9275 | 2 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 9.7378 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.8914 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 1.0000 | 2 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 34.4696 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 3 | 14 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 3 | 14 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0632 | 5 | 16 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 145.2400 | 1 | 1 |
| Acidic mammalian chitinase | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.0336 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 0.0185 | 3 | 3 |
| Androgen receptor | Homo sapiens (human) | IC50 | 0.0650 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0115 | 2 | 2 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | Ki | 0.0025 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 3.3852 | 10 | 29 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 266.6000 | 3 | 5 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0337 | 2 | 3 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 1.6549 | 8 | 37 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 5.7200 | 1 | 1 |
| Carbonic anhydrase | Flaveria bidentis | Ki | 0.0270 | 4 | 4 |
| Carbonic anhydrase | Helicobacter pylori 26695 | Ki | 0.8563 | 2 | 14 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 0.6161 | 8 | 16 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 30.9062 | 4 | 8 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ki | 4.2822 | 5 | 12 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.1763 | 1 | 7 |
| Carbonic anhydrase | Anopheles gambiae (African malaria mosquito) | Ki | 0.3195 | 1 | 7 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 1.1540 | 2 | 8 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 0.7952 | 9 | 17 |
| Carbonic anhydrase | Drosophila melanogaster (fruit fly) | Ki | 0.1060 | 1 | 1 |
| Carbonic anhydrase | Mycobacterium tuberculosis H37Rv | Ki | 1.2937 | 6 | 11 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 2.0347 | 5 | 11 |
| Carbonic anhydrase | Pseudomonas aeruginosa PAO1 | Ki | 0.0759 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.1542 | 2 | 14 |
| Carbonic anhydrase | Sulfurihydrogenibium sp. YO3AOP1 | Ki | 0.1112 | 1 | 7 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 4.0135 | 43 | 65 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 86,685,805.8088 | 498 | 1225 |
| Carbonic anhydrase 12 | Homo sapiens (human) | IC50 | 0.3178 | 7 | 7 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 5.5873 | 245 | 476 |
| Carbonic anhydrase 13 | Homo sapiens (human) | IC50 | 0.2300 | 2 | 2 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | IC50 | 0.7700 | 2 | 2 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 9.6130 | 22 | 74 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 17.1340 | 20 | 108 |
| Carbonic anhydrase 14 | Homo sapiens (human) | IC50 | 0.1830 | 4 | 4 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 13.8460 | 50 | 186 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 1.0482 | 9 | 30 |
| Carbonic anhydrase 2 | Bos taurus (cattle) | IC50 | 0.7000 | 3 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 1.6703 | 102 | 141 |
| Carbonic anhydrase 2 | Bos taurus (cattle) | Ki | 8.7023 | 2 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 332.7015 | 526 | 1329 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 7.9139 | 2 | 10 |
| Carbonic anhydrase 2, isoform A | Drosophila melanogaster (fruit fly) | Ki | 0.0780 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | IC50 | 1.9500 | 4 | 4 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 63.5341 | 4 | 20 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 155.8180 | 39 | 134 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | IC50 | 0.1680 | 2 | 6 |
| Carbonic anhydrase 4 | Homo sapiens (human) | IC50 | 0.0659 | 5 | 10 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | Ki | 45,111,104.5091 | 30 | 135 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 15.4423 | 95 | 239 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | IC50 | 8.1323 | 4 | 4 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 14.0267 | 56 | 196 |
| Carbonic anhydrase 5A, mitochondrial | Mus musculus (house mouse) | Ki | 3.0219 | 2 | 29 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | IC50 | 0.2300 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 14.3868 | 45 | 184 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 10.2602 | 3 | 8 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 19.7528 | 46 | 181 |
| Carbonic anhydrase 7 | Homo sapiens (human) | IC50 | 1.1737 | 6 | 6 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 10.4878 | 89 | 244 |
| Carbonic anhydrase 7 | Mus musculus (house mouse) | Ki | 0.0160 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 0.5851 | 71 | 78 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 4.4500 | 330 | 744 |
| Carbonic anhydrase-related protein 11 | Homo sapiens (human) | Ki | 0.0057 | 1 | 1 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 0.1351 | 1 | 7 |
| Cathepsin B | Bos taurus (cattle) | IC50 | 0.0200 | 1 | 1 |
| Chain A, Carbonic anhydrase | Coccomyxa sp. PA | Ki | 1.0000 | 1 | 1 |
| Chain A, Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 0.0160 | 1 | 1 |
| Chain A, Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.0066 | 1 | 30 |
| Chain A, CARBONIC ANHYDRASE II | Homo sapiens (human) | Ki | 0.0013 | 1 | 6 |
| Chain A, CARBONIC ANHYDRASE IV | Mus musculus (house mouse) | IC50 | 0.0453 | 1 | 1 |
| Chain A, Class Iii Chitinase Chia1 | Aspergillus fumigatus A1163 | IC50 | 164.0000 | 1 | 1 |
| Chain A, Endochitinase | Saccharomyces cerevisiae (brewer's yeast) | Ki | 21.0000 | 1 | 3 |
| Chain B, Carbonic anhydrase | Coccomyxa sp. PA | Ki | 1.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 138.7900 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | Ki | 0.2500 | 1 | 1 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Mus musculus (house mouse) | Ki | 0.0100 | 1 | 1 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 0.0070 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 0.0295 | 3 | 11 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 0.0155 | 2 | 4 |
| Cytochrome P450 2B6 | Homo sapiens (human) | Ki | 0.0398 | 2 | 4 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0577 | 5 | 9 |
| Cytochrome P450 2C8 | Homo sapiens (human) | Ki | 0.0354 | 4 | 8 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 0.0237 | 4 | 11 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0541 | 5 | 9 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0371 | 8 | 20 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Ki | 0.0120 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 1 | 1 |
| Delta carbonic anhydrase | Conticribra weissflogii | Ki | 0.1928 | 1 | 7 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 8.7022 | 2 | 14 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0365 | 2 | 9 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 0.0070 | 1 | 1 |
| Endochitinase | Saccharomyces cerevisiae S288C | Ki | 21.0000 | 1 | 1 |
| Endochitinase A1 | Aspergillus fumigatus | IC50 | 164.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 1 | 1 |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | Ki | 0.1288 | 1 | 4 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.2500 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0917 | 3 | 9 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 12.1555 | 4 | 10 |
| Multidrug resistance-associated protein 1 | Rattus norvegicus (Norway rat) | Ki | 0.0161 | 3 | 4 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 0.0330 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 0.0025 | 1 | 1 |
| Prolyl endopeptidase | Rattus norvegicus (Norway rat) | Ki | 0.2393 | 1 | 3 |
| Renin | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
| Renin | Macaca mulatta (Rhesus monkey) | IC50 | 8.2000 | 1 | 1 |
| Renin | Homo sapiens (human) | Ki | 3.3000 | 1 | 1 |
| Serum paraoxonase/arylesterase 1 | Homo sapiens (human) | Ki | 743.0000 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.2500 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 2 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.1310 | 2 | 2 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 1,100.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2A1 | Homo sapiens (human) | Ki | 5.0745 | 1 | 2 |
| Squalene synthase | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 2 | 2 |
| Steryl-sulfatase | Homo sapiens (human) | IC50 | 5.0125 | 1 | 2 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 0.7090 | 1 | 2 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 0.0070 | 1 | 1 |