Bone Cysts

Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.

Synonym
Ganglion, Intra-Osseous
Ganglia, Intraosseous
Ganglia, Intra-Osseous
Intraosseous Ganglion
Subchondral Cysts
Intra-Osseous Ganglion
Intra-Osseous Ganglia
Bone Cysts
Solitary Cysts

Excerpt	Reference
"Aneurysmal bone cysts are a rare finding in the facial bones and jaws."	( Carmichael, F; Malcolm, AJ; Ord, RA, 1989)
"Unicameral bone cysts are not seen commonly in the calcaneus."	( Davidson, RS; Dormans, JP; Glaser, DL; Stanton, RP, 1999)
"Solitary calcaneal bone cysts are uncommon."	( Buckley, RE; Csizy, M; Fennell, C, 2001)
"Subchondral bone cysts are fairly common in horses."	( Auer, JA; Derungs, S; Fuerst, A; Schense, J; von Rechenberg, B; Watson, J, 2007)
"Simple bone cysts are common benign lesions in growing children that predispose them to fracture and are sometimes painful."	( Donaldson, S; Marley, L; Wright, JG; Yandow, S, 2008)
"Juvenile bone cysts are benign lytic lesions posing a threat to bone compactness in childhood."	( Gál, P; Jochymek, J; Ondrus, S; Plánka, L; Skvaril, J; Straka, M, 2009)
"Unicameral bone cysts are benign lesions that usually spontaneously regress with skeletal maturity; however, the high risk of pathologic fractures often justifies treatment that could reinforce a weakened bone cortex."	( Cevolani, L; Di Bella, C; Donati, D; Dozza, B; Frisoni, T, 2010)
"Solitary bone cysts are benign, fluid-filled, expansive lesions in children."	( Iwamoto, Y; Matsuda, S; Sakamoto, A; Yoshida, T, 2010)
"Simple bone cysts are common benign lytic bone lesions in children."	( Chen, H; Du, M; Li, W; Xu, R, 2016)
"Bone cysts are very rare and if they appear in bone they usually appear in the distal phalanges of the fingers."	( Agani, Z; Hamiti, V; Kryeziu, K; Loxha, MP; Loxha, S; Rexhepi, A; Salihu, S, 2016)

Excerpt	Reference
"Bone cysts have also been described as a rare complication of afibrinogenaemia."	( Brons, PP; de Rooy, JW; Schreuder, HW; van Meegeren, ME, 2014)

Excerpt	Reference
"The treatment of bone cysts by topical injection of methylprednisolone acetate was initiated at the end of 1973, and the late results are reported in this paper."	( Bartolozzi, P; Marchetti, PG; Scaglietti, O, 1979)
"In a retrospective study, 21 simple bone cysts (SBC) treated by curettage (with or without bone grafting) are compared to 20 SBC treated by intralesional injections of methylprednisolone."	( Burssens, A; Fabry, G; Mylle, J, 1992)
"A series of 7 cases of aneurysmal bone cysts (ABC), all but 1 located in the pelvic bones, which were treated by transcatheter embolization is presented."	( Kónya, A; Szendröi, M, 1992)
"Eleven children with simple bone cysts in the proximal humerus metaphysis were treated with intracavity infiltration of methylprednisolone acetate."	( Pedersen, NW; Rud, B; Thomsen, PB, 1991)
"Treatment of aneurysmal bone cysts of the small bones of the hand requires either thorough exteriorization, curettage, and bone grafting or excision and bone grafting."	( Amadio, PC; Beabout, JW; Frassica, FJ; Wold, LE, 1988)
"Treating bone cysts by injection with MPA is simple and effective."	( Campos, OP, 1982)
"The treatment of children's essential bone cysts, is controversial."	( Finidori, G; Journeau, P; Morel, G; Padovani, JP; Rigault, P; Touzet, P, 1995)
"Benign bone cysts often require treatment in order to prevent pathological fracture."	( Adamsbaum, C; Dubousset, J; Kalifa, G; Seringe, R, 1993)
"In 23 patients, simple bone cysts were treated by curettage followed by packing the cavity with cubes of high-porosity hydroxyapatite (HA)."	( Ibaraki, K; Inoue, O; Shimabukuro, H; Shingaki, Y, 1993)
"Unicameral and aneurysmal bone cysts are benign lesions, but they often require treatment to prevent pathologic fractures."	( Adamsbaum, C; Leclet, H, 1998)
"A total of 69 children with unicameral bone cysts were treated either by (i) open curettage and bone grafting, (ii) steroid injection or (iii) cannulated screw insertion."	( Brecelj, J; Suhodolcan, L, 2007)
"The study included 20 juvenile bone cysts patients aged 10-17, treated with tricalcium phosphate during 2004-2007 in the KDCHOT."	( Gál, P; Ondrus, S; Plánka, L; Skvaril, J; Starý, D, 2008)
"Unicameral bone cysts are benign lesions that usually spontaneously regress with skeletal maturity; however, the high risk of pathologic fractures often justifies treatment that could reinforce a weakened bone cortex."	( Cevolani, L; Di Bella, C; Donati, D; Dozza, B; Frisoni, T, 2010)
"The operative treatment of bone cysts after total ankle replacements (TAR) is not well described."	( DeOrio, JK; Easley, M; Green, C; Gross, CE; Huh, J; Nunley, JA; Shah, S, 2016)
"Grafting bone cysts without revision of TAR was in general an effective and safe means for treating patients with peri-prosthetic bone cysts."	( DeOrio, JK; Easley, M; Green, C; Gross, CE; Huh, J; Nunley, JA; Shah, S, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	236 (51.08)	23.3326
1990's	78 (16.88)	12.5806
2000's	74 (16.02)	18.1394
2010's	66 (14.29)	28.8240
2020's	8 (1.73)	9.53

Drug	Relationship Strength	Studies	Trials
dinitrochlorobenzene	low	1	0
methane	low	1	0
salicylic acid	low	2	0
lactic acid	medium	3	1
glycerol	low	2	0
methanol	low	3	0
nitrates	low	1	0
nitrites	low	1	0
thiamine	low	1	0
uric acid	low	3	0
urea	low	1	0
aminopropionitrile	low	1	0
phenytoin	low	1	0
oxyquinoline	low	1	0
albendazole	low	2	0
diatrizoic acid	low	5	0
aspirin	low	1	0
bromisovalum	low	1	0
celecoxib	low	1	0
pentetic acid	low	4	0
etidronate	low	1	0
fluorouracil	low	1	0
gentamicin	low	1	0
guaifenesin	low	3	0
haloperidol	low	1	0
halothane	low	1	0
lidocaine	low	1	0
isoniazid	low	1	0
2-propanol	low	1	0
khellin	low	1	0
phenylbutazone	low	1	0
phloretin	low	1	0
risedronic acid	low	1	0
succinylcholine	low	1	0
prednisolone	low	6	0
hydroxyproline	low	4	0
prednisolone acetate	low	1	0
methylprednisolone acetate	medium	36	5
penicillin g	low	1	0
lysine	low	1	0
aminopyrine	low	1	0
ampicillin	low	1	0
vinyl chloride	low	1	0
triamcinolone acetonide	low	2	0
methylmethacrylate	medium	1	1
methylprednisolone	medium	69	6
acrylonitrile	medium	3	1
framycetin	low	2	0
diatrizoate meglumine	low	1	0
betamethasone	low	3	0
limestone	medium	3	1
chenodeoxycholic acid	low	1	0
bucrylate	low	1	0
durapatite	low	11	0
streptomycin	low	1	0
enbucrilate	low	1	0
technetium	low	9	0
titanium	low	7	0
gadolinium	low	7	0
barium sulfate	low	1	0
calcium phosphate, dibasic, anhydrous	low	1	0
calcium phosphate, monobasic, anhydrous	low	1	0
tricalcium phosphate	medium	28	4
calcium sulfate	low	16	0
calcium pyrophosphate	low	3	0
trolamine salicylate	medium	25	1
triamcinolone	low	2	0
alkenes	low	1	0
glutamic acid	low	1	0
adenosine diphosphate ribose	low	1	0
propiconazole	low	27	0
fluorodeoxyglucose f18	low	2	0
zoledronic acid	low	1	0
fibrinogen	low	8	0
yttrium radioisotopes	low	1	0
n(6)-carboxymethyllysine	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	medium	1	1
an-69	medium	3	1
calcium pyrophosphate	low	1	0
cortisone	low	5	0
glycogen	low	2	0
fibrin	low	3	0
glucosamine	low	2	0
inositol 3-phosphate	low	1	0
dipyrone	low	1	0
bromochloroacetic acid	low	9	0
pyrophosphate	low	3	0
indium oxine	low	1	0
alpha-chymotrypsin	low	2	0
bilirubin	low	1	0
dinoprostone	low	1	0
dinoprost	low	1	0
calcitriol	low	1	0
vitamin d 2	low	1	0
6-ketoprostaglandin f1 alpha	low	1	0
phenylephrine hydrochloride	low	5	0
aluminum	low	2	0
strontium	low	2	0
indium	low	1	0
gallium	low	1	0
sulfur	low	1	0
phosphorus	low	5	0
strontium radioisotopes	low	3	0
technetium tc 99m pyrophosphate	low	2	0
gadolinium dtpa	low	6	0
chlorhexidine	low	1	0
technetium tc 99m diphosphonate	medium	1	1
aluminum oxide	low	1	0
aminopyrine, dexamethasone, phenylbutazone, thiamine, vitamin b12 drug combination	low	1	0
dihydrotachysterol	low	1	0
acid phosphatase	low	6	0
jaw	low	7	0
cellulose	medium	6	3
ro13-9904	low	1	0
sodium ethylxanthate	low	2	0
chiniofon	low	1	0
ascorbic acid	low	2	0
tetracycline	low	3	0
oxytetracycline, anhydrous	low	1	0
nebacetin	low	1	0
transforming growth factor beta	low	2	0
hyaluronoglucosaminidase	low	1	0
vitamin b 12	low	1	0
technetium tc 99m medronate	medium	7	1
muramidase	low	1	0
chondroitin sulfates	low	2	0
cyclic gmp	low	1	0
allopurinol	low	2	0
acetylcellulose	low	1	0

Protein Targets (1,013)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
RAR-related orphan receptor gamma	26	0	0	26
GLI family zinc finger 3	32	0	0	32
AR protein	39	0	0	39
aldehyde dehydrogenase 1 family, member A1	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	29	0	0	29
retinoid X nuclear receptor alpha	21	0	0	21
estrogen nuclear receptor alpha	41	0	0	41
peroxisome proliferator-activated receptor delta	18	0	0	18
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	20	0	0	20
activating transcription factor 6	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
Histone H2A.x	11	0	0	11
thyroid hormone receptor beta isoform a	11	0	0	11
heat shock protein beta-1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
lamin isoform A-delta10	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Glutamate receptor 2	16	2	1	19
Solute carrier organic anion transporter family member 2A1	0	1	0	4
thyroid stimulating hormone receptor	13	0	0	13
thyroid hormone receptor beta isoform 2	21	0	0	21
Cellular tumor antigen p53	21	0	0	21
TDP1 protein	25	0	0	25
Transient receptor potential cation channel subfamily M member 2	0	0	1	1
Chain A, Beta-lactamase	9	0	0	9
Luciferase	11	0	0	11
glp-1 receptor, partial	11	0	0	11
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	4	0	0	4
caspase 7, apoptosis-related cysteine protease	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
progesterone receptor	18	0	0	18
glucocorticoid receptor [Homo sapiens]	27	0	0	27
estrogen-related nuclear receptor alpha	29	0	0	29
farnesoid X nuclear receptor	15	0	0	15
pregnane X nuclear receptor	21	0	0	21
polyprotein	4	0	0	4
67.9K protein	7	0	0	7
peroxisome proliferator activated receptor gamma	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	21	0	0	21
caspase-3	8	0	0	8
IDH1	17	0	0	17
euchromatic histone-lysine N-methyltransferase 2	28	0	0	28
aryl hydrocarbon receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
cellular tumor antigen p53 isoform a	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
chromobox protein homolog 1	19	0	0	19
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
transcriptional regulator ERG isoform 3	7	0	0	7
histone deacetylase 9 isoform 3	2	0	0	2
mitogen-activated protein kinase 1	8	0	0	8
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	29	0	0	29
Vif	0	0	0	1
peripheral myelin protein 22	12	0	0	12
survival motor neuron protein isoform d	8	0	0	8
muscleblind-like protein 1 isoform 1	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
neuropeptide S receptor isoform A	2	0	0	2
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	19
Bile salt export pump	0	27	0	27
Interferon beta	12	0	0	12
Integrin beta-3	3	1	1	5
Integrin alpha-IIb	3	1	1	5
Methionine aminopeptidase	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Inositol monophosphatase 1	3	0	0	3
Canalicular multispecific organic anion transporter 1	0	17	0	17
ATPase family AAA domain-containing protein 5	13	0	0	13
Ataxin-2	13	0	0	13
interleukin 8	6	0	0	6
estrogen receptor 2 (ER beta)	12	0	0	12
Bloom syndrome protein isoform 1	7	0	0	7
ras-related protein Rab-9A	1	0	0	1
Polyphenol oxidase 2	0	4	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	0	1	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	9	0	0	9
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	2
Lysyl oxidase homolog 2	0	1	0	1
arylsulfatase A	7	0	0	7
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
thioredoxin reductase	17	0	0	17
15-lipoxygenase, partial	5	0	0	5
GLS protein	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
G	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Nicotinate phosphoribosyltransferase	0	4	0	4
Inositol hexakisphosphate kinase 1	7	0	0	7
cytochrome P450 2C9, partial	7	0	0	7
ORF73	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Cruzipain	6	0	0	6
Beta-lactamase	0	0	0	2
acid sphingomyelinase	3	0	0	3
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
DNA polymerase beta	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	9	0	0	9
DNA polymerase kappa isoform 1	8	0	0	8
Carbonic anhydrase 1	0	14	0	15
Carbonic anhydrase 2	0	14	0	15
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	10	0	0	10
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	10	0	0	10
thioredoxin glutathione reductase	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	7	0	0	7
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	2	6
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	8	0	0	8
cytochrome P450 2D6	10	0	0	10
glucocerebrosidase	4	0	0	4
Rac1 protein	0	0	2	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
muscarinic acetylcholine receptor M1	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	3	0	3
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	6
Adenosine receptor A1	0	4	0	4
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	8	1	10
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	10	3	0	13
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
pregnane X receptor	7	0	0	7
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	12	1	18
Glycine receptor subunit alpha-1	0	12	0	12
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
phosphopantetheinyl transferase	8	0	0	8
USP1 protein, partial	13	0	0	13
Microtubule-associated protein tau	9	0	0	9
vitamin D3 receptor isoform VDRA	6	0	0	6
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
GALC protein	5	0	0	5
thyroid stimulating hormone receptor	10	0	0	10
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	4	0	0	4
nuclear receptor ROR-gamma isoform 1	9	0	0	9
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	3	0	4
Cytochrome P450 3A4	0	6	1	9
Androgen receptor	0	3	0	3
Cytochrome P450 2D6	0	3	0	3
Vitamin D3 receptor	0	2	3	7
Cytochrome P450 2C9	0	8	0	9
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	3	0	3
Kappa-type opioid receptor	0	1	1	3
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
SMAD family member 2	9	0	0	9
SMAD family member 3	9	0	0	9
Smad3	6	0	0	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	4	0	0	4
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
caspase-3	4	0	0	4
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	1	0	11
Prostaglandin E synthase	0	1	0	1
Histone deacetylase 3	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Carbonic anhydrase 12	0	4	0	4
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 3	0	3	0	3
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Beta-3 adrenergic receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	10	1	0	11
Alpha-1B adrenergic receptor	0	5	0	5
Calpain-2 catalytic subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	10	1	0	11
Gamma-aminobutyric acid receptor subunit gamma-2	10	1	0	11
5-hydroxytryptamine receptor 1A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-3	10	1	0	11
D(1A) dopamine receptor	0	4	0	5
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	5	0	5
Carbonic anhydrase 6	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-2	10	1	0	11
Sodium-dependent noradrenaline transporter	0	4	0	4
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	10	1	0	11
Gamma-aminobutyric acid receptor subunit gamma-3	10	1	0	11
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	10	1	0	11
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	1	1	2
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	4	0	4
Alpha-1A adrenergic receptor	0	5	0	5
Carbonic anhydrase 7	0	3	0	3
Carbonic anhydrase	0	1	0	1
Histone deacetylase 4	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	10	1	0	11
Gamma-aminobutyric acid receptor subunit beta-2	10	1	0	11
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Histone deacetylase 1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Carbonic anhydrase 9	0	5	0	5
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	2	0	2
Cyclooxygenase-2	0	2	0	2
Histone deacetylase 7	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
GABA theta subunit	10	1	0	11
Histone deacetylase 2	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Carbonic anhydrase 15	0	5	0	5
Histone deacetylase 8	0	1	1	2
P2Y purinoceptor 12	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	10	1	0	11
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Carbonic anhydrase 14	0	4	0	4
Histone deacetylase 5	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-2C adrenergic receptor	0	2	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Guanine nucleotide-binding protein G	3	0	0	3
Ileal sodium/bile acid cotransporter	0	1	0	1
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
PAX8	0	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
PINK1	1	0	0	1
Parkin	2	0	0	2
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	5	0	0	5
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	5	0	0	5
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
huntingtin isoform 2	2	0	0	2
importin subunit beta-1 isoform 1	5	0	0	5
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	9	0	0	9
protein AF-9 isoform a	0	0	0	1
snurportin-1	5	0	0	5
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	3	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	5	0	6
72 kDa type IV collagenase	0	4	0	4
Matrix metalloproteinase-9	0	2	0	2
Trypanothione reductase	0	1	0	1
Alpha-synuclein	2	1	0	3
Histamine H2 receptor	8	0	0	9
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Spermine oxidase	0	1	0	1
endonuclease IV	4	0	0	4
dopamine D1 receptor	1	0	0	1
regulator of G-protein signaling 4	8	0	0	8
peripheral myelin protein 22 isoform 1	7	0	0	7
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
M-phase phosphoprotein 8	4	0	0	4
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Hsf1 protein	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Vpr	3	0	0	3
Rap guanine nucleotide exchange factor 3	5	0	0	5
Glutathione S-transferase omega-1	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	4
Solute carrier family 22 member 7	0	0	0	3
Solute carrier family 22 member 8	0	4	0	7
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	3
Solute carrier family 22 member 7	0	0	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Thrombopoietin	2	0	0	2
nonstructural protein 1	8	0	0	8
hemoglobin subunit beta	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Solute carrier family 22 member 8	0	1	0	3
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, NMDA 2A	0	3	1	4
Glutamate receptor ionotropic, NMDA 2B	0	3	1	4
Glutamate receptor ionotropic, NMDA 2C	0	3	1	4
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	4
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	4
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	1	4
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
NFKB1 protein, partial	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
D(1A) dopamine receptor	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	2	0	2
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Integrin alpha-4	0	1	0	1
D(2) dopamine receptor	0	2	1	5
5-hydroxytryptamine receptor 2A	0	2	0	2
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Beta-1 adrenergic receptor	0	1	0	1
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
D(4) dopamine receptor	0	2	1	5
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	3	0	3
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	2	1	5
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	4
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	3	0	3
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Albumin	0	2	0	2
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Bile salt export pump	0	3	0	3
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Chymotrypsinogen A	0	2	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Chain A, Bacterial leucyl aminopeptidase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	2	0	3
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Thermolysin	0	2	0	3
Cholinesterase	0	1	0	1
Botulinum neurotoxin type A	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Catechol O-methyltransferase	0	1	0	1
Methionine aminopeptidase 2	0	1	0	1
Methionine aminopeptidase 1	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
microphthalmia-associated transcription factor isoform 9	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
alpha-galactosidase	1	0	0	1
Endolysin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Cannabinoid receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Hth-type Transcriptional Regulator Ttgr	0	0	1	1
Chain A, Hth-type Transcriptional Regulator Ttgr	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
fibroblast growth factor 22 isoform 1 precursor	0	0	0	2
serine/threonine-protein kinase 33 isoform a	0	0	1	1
Monocarboxylate transporter 4	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Transthyretin	0	0	1	1
Estrogen receptor	0	3	0	3
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Sodium/glucose cotransporter 1	0	2	0	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Sodium/glucose cotransporter 2	0	1	0	1
Monocarboxylate transporter 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Sodium/hydrogen exchanger 9B2	0	1	0	1
Solute carrier family 28 member 3	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	2	3
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	4	0	5
Farnesyl pyrophosphate synthase	0	4	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
Farnesyl diphosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
H	0	2	0	2
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
60 kDa chaperonin	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(9)

Research Excerpts

Overview

Context

Treatment

Research

Studies (462)

Protein Targets (1,013)

Bone Cysts

Synonyms(9)

Research Excerpts

Overview

Context

Treatment

Research

Studies (462)

Drugs Studied (157)

Protein Targets (1,013)