Page last updated: 2024-12-06
n-hydroxyacetaminophen
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
N-hydroxyacetaminophen: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 45750 |
CHEMBL ID | 107641 |
SCHEMBL ID | 874035 |
MeSH ID | M0068098 |
Synonyms (13)
Synonym |
---|
ccris 9182 |
brn 2833948 |
acetamide, n-hydroxy-n-(4-hydroxyphenyl)- |
n-hydroxyparacetamol |
n,4'-dihydroxyacetanilide |
n-hydroxyacetaminophen |
n-hydroxy-n-(4-hydroxyphenyl)acetamide |
CHEMBL107641 |
AKOS006278702 |
63975-21-3 |
SCHEMBL874035 |
DTXSID00213810 |
n-hydroxy-paracetamol |
Research Excerpts
Toxicity
Excerpt | Reference | Relevance |
---|---|---|
" In contrast, no toxic effects of pHAA (less than or equal to 20 mM) could be demonstrated." | ( Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol. Dahlin, DC; Dybing, E; Holme, JA; Nelson, SD, 1984) | 0.27 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (53)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID24935 | Percent total excretion of N-methoxyacetaminophen sulfate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24936 | Percent total excretion of acetaminophen | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID1146393 | Aqueous stability of the compound in 100 mM Na2HPO4 buffer assessed as half life at 2 mM at pH 6.6 at 37 degC by ferric chloride assay | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. |
AID24012 | The compound was tested for half life in presence of N-acetyl cysteine as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID22481 | Percent dose excreted in 0-48 hours administered ip to male rat | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24019 | The compound was tested for half life in presence of cysteine as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID1146398 | Aqueous stability of the compound in 100 mM NaOH buffer at 2 mM at pH 12.7 at 37 degC by ferric chloride assay | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. |
AID24020 | The compound was tested for half life in presence of dithionite as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID24026 | The compound was tested for half life in presence of phenol as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID13267 | Percent total excretion of acetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID1146396 | Aqueous stability of the compound in 100 mM Na2HPO4 buffer assessed as half life at 2 mM at pH 8.0 at 37 degC by ferric chloride assay | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. |
AID24027 | The compound was tested for half life in presence of pyrogallol as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID13111 | Percent total excretion of acetaminophen | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24937 | Percent total excretion of acetaminophen cysteine conjugate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24940 | Percent total excretion of acetaminophen-mercapturic acid | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24013 | The compound was tested for half life in presence of acetaminophen as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID22480 | Percent dose excreted in 0-48 hours administered ip to male mouse | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24934 | Percent total excretion of N-methoxyacetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24931 | Percent total excretion of 3-(thiomethyl)acetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID31113 | The compound tested for toxicity in liver against male rat after intraperitoneal administration of 2.0 mmol/kg | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24938 | Percent total excretion of acetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID30992 | The compound tested for toxicity in kidney against male mouse after intraperitoneal administration of 2.0 mmol/kg | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID1146392 | Aqueous stability of the compound in 100 mM HCl buffer assessed as half life at 2 mM at pH 1.5 at 37 degC by ferric chloride assay | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. |
AID24029 | The compound was tested for half life in presence of thiosulphate as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID24939 | Percent total excretion of acetaminophen sulfate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24932 | Percent total excretion of 3-(thiomethyl)acetaminophen sulfate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID31112 | The compound tested for toxicity in liver against male rat after intraperitoneal administration of 1.0 mmol/kg | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID31111 | The compound tested for toxicity in liver against male mouse after intraperitoneal administration of 2.0 mmol/kg | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24028 | The compound was tested for half life in presence of salicylate as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID13106 | Percent total excretion of 3-(thiomethyl)acetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24023 | The compound was tested for half life in presence of lysine as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID24025 | The compound was tested for half life in presence of p-Nitrosophenol as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID30993 | The compound tested for toxicity in kidney against male rat after intraperitoneal administration of 1.0 mmol/kg | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID13110 | Percent total excretion of N-methoxyacetaminophen sulfate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24015 | The compound was tested for half life in presence of aspirin as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID30994 | The compound tested for toxicity in kidney against male rat after intraperitoneal administration of 2.0 mmol/kg; Positive | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24017 | The compound was tested for half life in presence of cystamine as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID1146394 | Aqueous stability of the compound in 100 mM Na2HPO4 buffer assessed as half life at 2 mM at pH 7.0 at 37 degC by ferric chloride assay | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. |
AID24933 | Percent total excretion of 3-methoxyacetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24022 | The compound was tested for half life in presence of glycine as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID1146395 | Aqueous stability of the compound in 100 mM Na2HPO4 buffer assessed as half life at 2 mM at pH 7.2 at 37 degC by ferric chloride assay | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. |
AID13266 | Percent total excretion of acetaminophen cysteine conjugate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID13107 | Percent total excretion of 3-(thiomethyl)acetaminophen sulfate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID13108 | Percent total excretion of 3-methoxyacetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24021 | The compound was tested for half life in presence of ethanol as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID13269 | Percent total excretion of acetaminophen-mercapturic acid | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID11520 | Percent dose excreted in 0-48 hours administered ip to male rat | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID13109 | Percent total excretion of N-methoxyacetaminophen glucuronide | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
AID24014 | The compound was tested for half life in presence of ascorbic acid as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID24018 | The compound was tested for half life in presence of cysteamine as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID24016 | The compound was tested for half life in presence of control | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID24024 | The compound was tested for half life in presence of methionine as additive (20 mM) | 1980 | Journal of medicinal chemistry, Mar, Volume: 23, Issue:3 | Mechanism of decomposition of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen. |
AID13268 | Percent total excretion of acetaminophen sulfate | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8 | N-hydroxyacetaminophen: a postulated toxic metabolite of acetaminophen. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (14)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 13 (92.86) | 18.7374 |
1990's | 1 (7.14) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.56
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.56) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 1 (7.14%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 13 (92.86%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |