Page last updated: 2024-08-05 11:19:14
hydroxypiperidine
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ChEBI ID: 48590
Members (11)
| Member | Definition | Role |
|---|---|---|
| 3-epi-fagomine | A member of the class of hydroxypiperidines that is piperidine carrying a hydroxymethyl substituent at position 2 as well as two hydroxy substituents at positions 3 and 4 (the 2R,3R,4S-diastereomer). | 3-epi-fagomine |
| 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one | A member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol. | rohitukine |
| alvocidib | A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. | alvocidib |
| deoxyfuconojirimycin | A hydroxypiperidine in which the three hydroxy substituents are located at positions 3, 4 and 5 together with an additional methyl substituent at position 2. | deoxyfuconojirimycin |
| haloperidol | A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. | haloperidol |
| mor-14 | A hydroxypiperidine that is duvoglustat in which the amino hydrogen is replaced by a methyl group. It is an inhibitor of alpha-glucosidase, an agonist of the glucose sensor SGLT3 and exhibits anti-HIV activity. | N-methyl-1-deoxynojirimycin |
| n-nonyl-1-deoxynojirimycin | A hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. | N-nonyldeoxynojirimycin |
| nadifloxacin | nadifloxacin | |
| nojirimycin | nojirimycin | |
| periciazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic. | periciazine |
| tempol | A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties. | 4-hydroxy-TEMPO |
Research
Studies (19,835)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 7,755 (39.10) | 18.7374 |
| 1990's | 4,221 (21.28) | 18.2507 |
| 2000's | 3,889 (19.61) | 29.6817 |
| 2010's | 3,077 (15.51) | 24.3611 |
| 2020's | 893 (4.50) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,833 (8.62%) | 5.53% |
| Reviews | 881 (4.14%) | 6.00% |
| Case Studies | 1,706 (8.02%) | 4.05% |
| Observational | 28 (0.13%) | 0.25% |
| Other | 16,828 (79.09%) | 84.16% |