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hydroxypiperidine

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ChEBI ID: 48590

Members (11)

MemberDefinitionRole
3-epi-fagomineA member of the class of hydroxypiperidines that is piperidine carrying a hydroxymethyl substituent at position 2 as well as two hydroxy substituents at positions 3 and 4 (the 2R,3R,4S-diastereomer).3-epi-fagomine
5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-oneA member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol.rohitukine
alvocidibA synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.alvocidib
deoxyfuconojirimycinA hydroxypiperidine in which the three hydroxy substituents are located at positions 3, 4 and 5 together with an additional methyl substituent at position 2.deoxyfuconojirimycin
haloperidolA compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.haloperidol
mor-14A hydroxypiperidine that is duvoglustat in which the amino hydrogen is replaced by a methyl group. It is an inhibitor of alpha-glucosidase, an agonist of the glucose sensor SGLT3 and exhibits anti-HIV activity.N-methyl-1-deoxynojirimycin
n-nonyl-1-deoxynojirimycinA hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group.N-nonyldeoxynojirimycin
nadifloxacinnadifloxacin
nojirimycinnojirimycin
periciazineA member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.periciazine
tempolA member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.4-hydroxy-TEMPO

Research

Studies (19,835)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19907,755 (39.10)18.7374
1990's4,221 (21.28)18.2507
2000's3,889 (19.61)29.6817
2010's3,077 (15.51)24.3611
2020's893 (4.50)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials1,833 (8.62%)5.53%
Reviews881 (4.14%)6.00%
Case Studies1,706 (8.02%)4.05%
Observational28 (0.13%)0.25%
Other16,828 (79.09%)84.16%