A drug used to treat asthma.
| Member | Definition | Class |
|---|
| acetosyringone | A member of the class of acetophenones that is 1-phenylethanone substituted by a hydroxy group at position 4 and methoxy groups at positions 3 and 5. | acetosyringone |
| arformoterol | An N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have R configuration. The active enantiomer of formoterol, it is administered by inhalation (generally as the tartrate salt) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema). | arformoterol |
| azelastine | A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position. | azelastine |
| azelastine hydrochloride | The hydrochloride salt of azelastine. | azelastine hydrochloride |
| bambuterol | A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol |
| bambuterol hydrochloride | The hydrochloride salt of bambuterol. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | bambuterol hydrochloride |
| beclomethasone | A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively. | beclomethasone |
| beclomethasone dipropionate | A steroid ester comprising beclomethasone having propionyl groups at the 17- and 21-positions. | beclomethasone dipropionate |
| bitolterol | The di-4-toluate ester of (+-)-N-tert-butylnoradrenaline (colterol). A pro-drug for colterol, a beta2-adrenergic receptor agonist, bitolterol is used as its methanesulfonate salt for relief of bronchospasm in conditions such as asthma, chronic bronchitis and emphysema. | bitolterol |
| cinalukast | 2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in the human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma. | cinalukast |
| colterol | A member of the class of ethanolamines that is catechol in which the hydrogen at position 4 is replaced by a 2-(tert-butylamino)-1-hydroxyethyl group. | colterol |
| cromolyn | A dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer. | cromoglycic acid |
| cromolyn sodium | An organic sodium salt that is the disodium salt of cromoglycic acid. | disodium cromoglycate |
| cyclosporine | A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. | cyclosporin A |
| doxofylline | An oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. | doxofylline |
| enprofylline | Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. | enprofylline |
| flunisolide | | flunisolide |
| fluticasone | A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis. | fluticasone |
| fluticasone furoate | A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a 2-furoyl substituent at position 17. Used in combination with vilanterol trifenate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. | fluticasone furoate |
| fluticasone propionate | A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity. | fluticasone propionate |
| ketotifen | An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect. | ketotifen |
| ketotifen fumarate | An organoammonium salt consisting of equimolar amounts of ketotifen(1+) and fumarate(1-) ions. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is a non-bronchodilator anti-asthmatic drug. | ketotifen fumarate |
| ly 171883 | A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity. | tomelukast |
| methylprednisolone suleptanate | An organic sodium salt that is the monosodium salt of methylprednisolone 21-suleptanic acid ester. It is a prodrug of methylprednisolone developed by Pharmacia Corp for the treatment of asthma. | methylprednisolone suleptanate |
| montelukast | | montelukast |
| nedocromil | | nedocromil |
| pseudoephedrine | A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group. | pseudoephedrine |
| roflumilast | A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease. | roflumilast |
| rp 73401 | A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine. | piclamilast |
| skullcapflavone ii | A tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6' and hydroxy groups at positons 5 and 2' respectively. | scullcapflavone II |
| terbutaline | A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group. | terbutaline |
| theophylline | A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. | theophylline |
| tranilast | An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group. | tranilast |
| zardaverine | A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4. | zardaverine |
| zileuton | A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. | zileuton |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 17.5141 | 1 | 6 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 20.1044 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 6.3625 | 2 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 20.8213 | 4 | 5 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 4.7609 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.5154 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 24.0030 | 3 | 3 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 10.4041 | 12 | 71 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 16.4026 | 2 | 11 |
| arylsulfatase A | Homo sapiens (human) | Potency | 18.2509 | 1 | 5 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 5.6080 | 4 | 6 |
| Ataxin-2 | Homo sapiens (human) | Potency | 5.7128 | 2 | 5 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 14.6183 | 3 | 8 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 6.1352 | 2 | 6 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 9.5283 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 8.3908 | 1 | 2 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 10.3225 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.1033 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 59.2490 | 1 | 4 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 28.1366 | 2 | 9 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 14.7114 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 30.0909 | 1 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 4.7088 | 2 | 5 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 9.2467 | 2 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 18.9031 | 2 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.3342 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 32.1885 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 9.2467 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 66.8893 | 2 | 6 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.2691 | 1 | 6 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.8972 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 20.8620 | 1 | 9 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 9.6595 | 1 | 8 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 7.1767 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 8.0504 | 2 | 12 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 8.8700 | 2 | 13 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 9.6412 | 1 | 10 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.2282 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 58.0650 | 1 | 4 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 12.0581 | 11 | 53 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 26.0500 | 2 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 19.2470 | 9 | 36 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.4747 | 1 | 11 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 14.8562 | 4 | 15 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 17.6366 | 2 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 20.8620 | 1 | 9 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 8.0504 | 1 | 6 |
| geminin | Homo sapiens (human) | Potency | 6.8345 | 2 | 20 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 8.6436 | 2 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 9.1547 | 3 | 8 |
| GLS protein | Homo sapiens (human) | Potency | 18.5344 | 2 | 6 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 7.3647 | 4 | 23 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 32.3357 | 1 | 4 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 9.9430 | 1 | 4 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 2.0749 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9224 | 2 | 12 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 53.8306 | 2 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 17.4882 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 20.8620 | 1 | 9 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 12.7687 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 4.0352 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 12.8848 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 15.9888 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 20.8620 | 1 | 18 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 7.8506 | 1 | 4 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 17.5594 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 17.5594 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 17.3296 | 2 | 14 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.5390 | 2 | 12 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 3.4486 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 14.3917 | 4 | 10 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 7.9454 | 3 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 3.0680 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 22.6072 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 18.8217 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 5.6234 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 5.6234 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 28.1838 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 4.7394 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 1.5179 | 1 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 23.7751 | 3 | 12 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 3.8189 | 2 | 6 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 35.0650 | 1 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 42.1632 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.7381 | 2 | 11 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 7.9924 | 1 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 18.1237 | 3 | 20 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 13.9480 | 1 | 2 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 13.0816 | 2 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.3648 | 1 | 5 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 52.9804 | 1 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 11.0417 | 5 | 20 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 19.3058 | 4 | 13 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 48.0224 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 6.2685 | 1 | 6 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 5.1209 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 14.9477 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 10.1377 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 24.8728 | 3 | 18 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 3.5481 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 7.1555 | 3 | 8 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 11.2947 | 2 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 13.9480 | 2 | 4 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 13.5346 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.0084 | 2 | 13 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.3611 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 18.1836 | 1 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 21.2982 | 3 | 23 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19.5705 | 3 | 22 |
| RGS12 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 16.8944 | 2 | 7 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 16.8944 | 2 | 7 |
| snurportin-1 | Homo sapiens (human) | Potency | 15.9888 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 25.3072 | 1 | 5 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 13.1255 | 1 | 8 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 27.5916 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.6030 | 2 | 26 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 61.9285 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 23.1675 | 3 | 6 |
| Thrombopoietin | Homo sapiens (human) | Potency | 6.5812 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.9961 | 3 | 18 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 11.2716 | 7 | 15 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 10.6840 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 20.1815 | 1 | 4 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 6.2685 | 1 | 6 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 6.2685 | 1 | 6 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 81.3916 | 2 | 8 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 16.0938 | 2 | 6 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 15.2946 | 4 | 9 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 25.4890 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 32.3357 | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 27.4278 | 5 | 5 |
| 3',5'-cyclic-AMP phosphodiesterase | Sus scrofa (pig) | IC50 | 0.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 2.5370 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 86.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 1.4500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 2.5370 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.4500 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0310 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0124 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 3.1510 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.0154 | 3 | 4 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.2616 | 3 | 3 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.1600 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0840 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 1.1410 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.5300 | 1 | 1 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | Ki | 8.3000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 25.0000 | 4 | 4 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | IC50 | 55.0000 | 1 | 1 |
| Adenosine receptor A1 | Bos taurus (cattle) | IC50 | 1,006,650,005.0433 | 3 | 3 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 9.0520 | 2 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 19.0000 | 2 | 2 |
| Adenosine receptor A1 | Bos taurus (cattle) | Ki | 4.1143 | 7 | 7 |
| Adenosine receptor A1 | Cavia porcellus (domestic guinea pig) | Ki | 21.3333 | 6 | 6 |
| Adenosine receptor A1 | Gallus gallus (chicken) | Ki | 6.0000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 10.2759 | 18 | 20 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 15.8823 | 31 | 40 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 6.5035 | 2 | 2 |
| Adenosine receptor A2a | Cavia porcellus (domestic guinea pig) | Ki | 14.0000 | 2 | 2 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 17.7950 | 27 | 32 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 31.0789 | 24 | 37 |
| Adenosine receptor A2b | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 16.8692 | 20 | 26 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 34.2190 | 18 | 29 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.4340 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 58.6156 | 21 | 23 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 47.3650 | 8 | 10 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.6890 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.6670 | 1 | 1 |
| Alkaline phosphatase, germ cell type | Homo sapiens (human) | IC50 | 12,840.0000 | 2 | 2 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | IC50 | 52.5000 | 2 | 2 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | Ki | 82.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.8870 | 2 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0501 | 3 | 3 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1476 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.8870 | 2 | 2 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0501 | 3 | 3 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2450 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 3.7270 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 9.3400 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 1.8320 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 3.0530 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.1450 | 1 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.7100 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.3240 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 5.2790 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.7670 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 5.9400 | 1 | 2 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | IC50 | 0.5800 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 106.0702 | 2 | 9 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 3.9534 | 43 | 44 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 2.7500 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 1.7183 | 6 | 6 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 3.5750 | 2 | 2 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0010 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 3.4880 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 2.3980 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 3.2000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 0.5910 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 289.3004 | 8 | 28 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 641.2500 | 1 | 4 |
| Bile salt export pump | Homo sapiens (human) | Ki | 9.5000 | 1 | 1 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | Ki | 0.3000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 24.6546 | 3 | 3 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Calcineurin subunit B type 1 | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Homo sapiens (human) | IC50 | 320.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Bos taurus (cattle) | IC50 | 285.3333 | 6 | 6 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Bos taurus (cattle) | IC50 | 242.4000 | 5 | 5 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | IC50 | 94.4426 | 2 | 31 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Homo sapiens (human) | IC50 | 320.0000 | 1 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Homo sapiens (human) | IC50 | 86.9241 | 1 | 30 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 74.1441 | 29 | 31 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | Ki | 75.7152 | 7 | 7 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Rattus norvegicus (Norway rat) | Ki | 265.0130 | 2 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 53.0603 | 55 | 89 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | Ki | 66.2509 | 8 | 8 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Rattus norvegicus (Norway rat) | Ki | 265.0130 | 2 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | IC50 | 68.3029 | 26 | 28 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | Ki | 75.7152 | 7 | 7 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Rattus norvegicus (Norway rat) | Ki | 265.0130 | 2 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 55.0745 | 45 | 84 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | Ki | 75.7152 | 7 | 7 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Rattus norvegicus (Norway rat) | Ki | 265.0130 | 2 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 7B | Homo sapiens (human) | IC50 | 86.9241 | 1 | 30 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 85.0808 | 5 | 12 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | Ki | 11.2700 | 3 | 3 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 5.9800 | 2 | 2 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 85.8448 | 3 | 34 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 | 80.2947 | 8 | 10 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 | 89.1575 | 7 | 36 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 79.9624 | 3 | 34 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 0.0763 | 1 | 36 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 0.0616 | 1 | 26 |
| Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 0.0783 | 1 | 10 |
| Chain A, Phosphodiesterase 4D | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| Chain A, Pyridoxal Kinase | Homo sapiens (human) | Ki | 50.0000 | 1 | 2 |
| Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 0.0783 | 1 | 5 |
| Chitotriosidase-1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 2 |
| Cholinesterase | Equus caballus (horse) | IC50 | 0.1193 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 0.0033 | 4 | 4 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | IC50 | 0.0852 | 5 | 5 |
| Cysteinyl leukotriene receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0034 | 1 | 2 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | Ki | 0.3006 | 2 | 2 |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | IC50 | 5.2100 | 2 | 2 |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 117.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 0.7000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 38.8000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 34.3333 | 3 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0501 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 3.7340 | 4 | 5 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 4.8480 | 3 | 5 |
| Cytochrome P450 3A43 | Homo sapiens (human) | IC50 | 2.0600 | 1 | 1 |
| Cytochrome P450 3A43 | Homo sapiens (human) | Ki | 7.6000 | 1 | 2 |
| Cytochrome P450 3A5 | Homo sapiens (human) | IC50 | 2.0600 | 1 | 1 |
| Cytochrome P450 3A5 | Homo sapiens (human) | Ki | 7.6000 | 1 | 2 |
| Cytochrome P450 3A7 | Homo sapiens (human) | IC50 | 2.0600 | 1 | 1 |
| Cytochrome P450 3A7 | Homo sapiens (human) | Ki | 7.6000 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.8720 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.4360 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 4.8550 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 1.6490 | 1 | 2 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0006 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 4.7950 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 1.6900 | 1 | 1 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Homo sapiens (human) | IC50 | 86.9241 | 1 | 30 |
| dual specificity protein phosphatase 6 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Endochitinase B1 | Aspergillus fumigatus | IC50 | 1,000.0000 | 1 | 2 |
| Endothelin-1 receptor | Sus scrofa (pig) | IC50 | 0.0010 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 3.1970 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 7.5000 | 1 | 2 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 7.5000 | 1 | 2 |
| fMet-Leu-Phe receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | Ki | 2.3400 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.0018 | 7 | 9 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0026 | 2 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.0022 | 2 | 3 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 5.2000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | Ki | 0.8000 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0068 | 1 | 2 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 1 | 2 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0068 | 1 | 2 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 1 | 2 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0068 | 1 | 2 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 1 | 2 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0068 | 1 | 2 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.0031 | 1 | 2 |
| Hematopoietic prostaglandin D synthase | Homo sapiens (human) | IC50 | 11.6000 | 2 | 2 |
| hepatocyte nuclear factor 4-alpha isoform 2 | Homo sapiens (human) | IC50 | 39.8410 | 2 | 2 |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Homo sapiens (human) | IC50 | 82.0825 | 2 | 33 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0011 | 3 | 3 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0008 | 5 | 5 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 4.1290 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 4.0600 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 0.1514 | 3 | 3 |
| Ileal sodium/bile acid cotransporter | Homo sapiens (human) | Ki | 24.0000 | 1 | 1 |
| Interleukin-2 | Mus musculus (house mouse) | IC50 | 0.0050 | 1 | 1 |
| Intestinal-type alkaline phosphatase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Leukotriene C4 synthase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 0.1575 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 0.8560 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 3.5082 | 10 | 10 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 116.5000 | 1 | 8 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 5.1555 | 2 | 3 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 1.1030 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.8380 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.2980 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 4.4175 | 1 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.9360 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.0090 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.1410 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.3740 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.2690 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 25.0000 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase A | Homo sapiens (human) | IC50 | 0.0252 | 12 | 12 |
| Peptidyl-prolyl cis-trans isomerase A | Homo sapiens (human) | Ki | 0.0645 | 8 | 8 |
| Peptidyl-prolyl cis-trans isomerase B | Homo sapiens (human) | IC50 | 0.0088 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase D | Homo sapiens (human) | IC50 | 0.0036 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase D | Homo sapiens (human) | Ki | 0.0129 | 4 | 4 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP1B | Homo sapiens (human) | Ki | 0.0060 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase FKBP4 | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| Peptidylglycine alpha-amidating monooxygenase | Rattus norvegicus (Norway rat) | Ki | 0.0060 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 27.7990 | 2 | 2 |
| perilipin-5 | Homo sapiens (human) | IC50 | 24.3245 | 4 | 4 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | IC50 | 2,904.0000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Mus musculus (house mouse) | IC50 | 0.5700 | 1 | 1 |
| Phosphodiesterase | Bos taurus (cattle) | IC50 | 250.3333 | 6 | 6 |
| Phosphodiesterase | Bos taurus (cattle) | Ki | 77.0000 | 1 | 1 |
| Phosphodiesterase | Trypanosoma brucei | Ki | 3.1623 | 1 | 1 |
| Phospholipase A-2-activating protein | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 18.9000 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 5.8341 | 76 | 77 |
| Polyunsaturated fatty acid 5-lipoxygenase | Mus musculus (house mouse) | IC50 | 0.1900 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 6.0465 | 19 | 19 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 0.1000 | 4 | 4 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 0.0210 | 1 | 2 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 27.0000 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 150.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 44.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 68.0000 | 3 | 3 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 44.0000 | 1 | 1 |
| Renin | Homo sapiens (human) | Ki | 2.3250 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 52.9100 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 100.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 0.4550 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 62.0000 | 1 | 1 |
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 0.1830 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 7.9000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 2.6010 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.0670 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.6890 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.6670 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.5002 | 2 | 2 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 0.9500 | 5 | 5 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 0.4845 | 4 | 4 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 1.2000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 36.0000 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 3.9805 | 1 | 2 |
| Substance-K receptor | Homo sapiens (human) | Ki | 1.3270 | 1 | 2 |
| Thromboxane-A synthase | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 1.5250 | 1 | 1 |
| Thyroid hormone receptor beta | Rattus norvegicus (Norway rat) | Ki | 14.0000 | 1 | 1 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 14.9000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | IC50 | 125.9465 | 1 | 2 |
| Transient receptor potential cation channel subfamily V member 2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Transthyretin | Homo sapiens (human) | Ki | 0.0026 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
| Tumor necrosis factor ligand superfamily member 11 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 4.7020 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
| UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | Ki | 6.5400 | 1 | 1 |