A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.
ChEBI ID: 35223
| Member | Definition | Class |
|---|---|---|
| ferric sulfate | A compound of iron and sulfate in which the ratio of iron(3+) to sulfate ions is 3:2. | iron(3+) sulfate |
| greigite | An iron sulfide mineral with formula Fe3S4. | greigite |
| n,n,n',n'-tetramethylethylenediamine | An ethylenediamine derivative in which each nitrogen carries two methyl substituents. It is widely employed both as a ligand for metal ions and as a catalyst in organic polymerisation. | N,N,N',N'-tetramethylethylenediamine |
| palladium chloride | A palladium coordination entity consisting of palladium(II) bound to two chlorine atoms. | palladium(II) chloride |
| piperidine | An azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine. | piperidine |
| platinum tetrachloride | A platinum coordination entity consisting of platinum(II) bound to two chlorine atoms. | platinum dichloride |
| potassium carbonate | A potassium salt that is the dipotassium salt of carbonic acid. | potassium carbonate |
| sulfuric acid | A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom. | sulfuric acid |
| tempo | A member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively. | TEMPO |
| tempol | A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties. | 4-hydroxy-TEMPO |
| triethylenediamine | An organic heterobicylic compound that is piperazine with an ethane-1,2-diyl group forming a bridge between N1 and N4. It is typically used as a catalyst in polymerization reactions. | triethylenediamine |
| zirconium chloride | A zirconium coordination entity comprising four chlorine atoms bound to a central zirconium atom. | zirconium tetrachloride |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 688 (13.24) | 18.7374 |
| 1990's | 495 (9.52) | 18.2507 |
| 2000's | 1,411 (27.15) | 29.6817 |
| 2010's | 2,162 (41.59) | 24.3611 |
| 2020's | 442 (8.50) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 68 (1.24%) | 5.53% |
| Reviews | 112 (2.05%) | 6.00% |
| Case Studies | 73 (1.34%) | 4.05% |
| Observational | 1 (0.02%) | 0.25% |
| Other | 5,209 (95.35%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 51.1870 | 4 | 4 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 46.2223 | 4 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 1.4202 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.3722 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.8904 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 48.3603 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 10.0000 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 27.1950 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 43.9972 | 2 | 5 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 12.2998 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 6.0882 | 1 | 1 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 34.6770 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 48.3603 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 105,850.0000 | 1 | 2 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 497,550.0000 | 1 | 2 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 330.0000 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 910.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 59,222.2222 | 8 | 9 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 267,000.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 197,200.0000 | 9 | 10 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 20,666.6667 | 3 | 3 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 453,333.5600 | 3 | 3 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 340,000.3400 | 2 | 2 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 9,900.0000 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 1,380.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 154,000.0000 | 1 | 1 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 54,000.0000 | 1 | 1 |