Compounds > duroquinone
Page last updated: 2024-09-23

duroquinone

Description

tetramethyl-1,4-benzoquinone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

duroquinone : A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which all four hydrogens are substituted by methyl groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID68238
CHEMBL ID151604
CHEBI ID42023
SCHEMBL ID58325
MeSH IDM0105705

Synonyms (56)

Synonym
x0q8791r69 ,
unii-x0q8791r69
STL356801
tetramethylquinone
2,5,6-tetramethyl-p-benzoquinone
tetramethyl-1,4-benzoquinone
2,5,6-tetramethylbenzoquinone
nsc-2068
2,5,6-tetramethyl-1,4-benzoquinone
tetramethyl-p-benzoquinone
duroquinone
nsc2068
2,4-dione, 2,3,5,6-tetramethyl-
p-benzoquinone,3,5,6-tetramethyl-
527-17-3
nsc 2068
einecs 208-409-8
tetramethyl-p-quinone
p-benzoquinone, tetramethyl-, semiquinone
p-benzoquinone, tetramethyl-
ccris 2989
ai3-61045
2,3,5,6-tetramethyl-1,4-benzoquinone
p-benzoquinone, 2,3,5,6-tetramethyl-
2,5-cyclohexadiene-1,4-dione, 2,3,5,6-tetramethyl-
2,3,5,6-tetramethylbenzo-1,4-quinone
inchi=1/c10h12o2/c1-5-6(2)10(12)8(4)7(3)9(5)11/h1-4h
duroquinone, 97%
2,3,5,6-tetramethylcyclohexa-2,5-diene-1,4-dione
CHEBI:42023 ,
2,3,5,6-tetramethylbenzoquinone
2,3,5,6-tetramethyl-p-benzoquinone
DB01927
2,3,5,6-tetramethyl-[1,4]benzoquinone
CHEMBL151604
HMS1667I20
T0672
AKOS004903738
FT-0625631
2,3,5,6-tetramethyl-2,5-cyclohexadiene-1,4-dione
duroquinone [mi]
tetramethylbenzoquinone
SCHEMBL58325
tetramethyl benzoquinone
2,3,5,6-tetramethylbenzo-1,4-quinone #
AC-27924
DTXSID50200659
mfcd00001604
duroquinone, standard for quantitative nmr, tracecert(r)
AS-67719
tetramethylcyclohexa-2,5-diene-1,4-dione
Q2423089
D70252
SY051484
CS-0153601
1,4-diodo-2,3,5,6-tetramethylbenzene

Drug Classes (1)

ClassDescription
1,4-benzoquinonesAny member of the class of benzoquinones that is 1,4-benzoquinone or its C-substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1083211Bactericidal activity against Erwinia amylovora 295/93 assessed as growth inhibition in King's B full medium measured at pH 7.2 after overnight incubation by suspension culture assay2012Journal of agricultural and food chemistry, Dec-12, Volume: 60, Issue:49
Potent and specific bactericidal effect of juglone (5-hydroxy-1,4-naphthoquinone) on the fire blight pathogen Erwinia amylovora.
AID19832Partition coefficient (logP)1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
In vivo activity and hydrophobicity of cytostatic aziridinyl quinones.
AID224600Efficiency at pBR322 DNA interstand cross-linking at 10 uM1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Cross-linking and sequence specific alkylation of DNA BY aziridinylquinones. 1. Quinone methides.
AID19838Partition coefficient (logP)1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
In vivo activity and hydrophobicity of cytostatic aziridinyl quinones.
AID224601Efficiency at pBR322 DNA interstand cross-linking at 100 uM1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Cross-linking and sequence specific alkylation of DNA BY aziridinylquinones. 1. Quinone methides.
AID19426HPLC capacity factor (logK)1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
In vivo activity and hydrophobicity of cytostatic aziridinyl quinones.
AID96156In vitro cytotoxicity against Human Chronic Leukemia K562 cells1996Journal of medicinal chemistry, Jan-19, Volume: 39, Issue:2
Cross-linking and sequence specific alkylation of DNA BY aziridinylquinones. 1. Quinone methides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (79)

TimeframeStudies, This Drug (%)All Drugs %
pre-199016 (20.25)18.7374
1990's31 (39.24)18.2507
2000's22 (27.85)29.6817
2010's6 (7.59)24.3611
2020's4 (5.06)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other81 (98.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
2,5-dimethyl-4-benzoquinone[no description available]medium30
2-methyl-1,4-benzoquinone[no description available]medium20
2,6-dimethyl-1,4-benzoquinone[no description available]medium20
ethylenimine quinone[no description available]medium201,4-benzoquinones;
aziridines		alkylating agent;
mutagen
carbazilquinone[no description available]medium10organic molecular entity
vitamin k 3[no description available]medium401,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
quinone[no description available]medium601,4-benzoquinonescofactor;
human xenobiotic metabolite;
mouse metabolite
triaziquone[no description available]medium101,4-benzoquinones;
aziridines		alkylating agent;
antineoplastic agent
1,4-naphthoquinone[no description available]medium201,4-naphthoquinones
2-chloro-1,4-naphthoquinone[no description available]medium101,4-naphthoquinones;
organochlorine compound
2-amino-3-chloro-1,4-naphthoquinone[no description available]medium101,4-naphthoquinones
diaziquone[no description available]medium101,4-benzoquinones;
aziridines;
carbamate ester;
enamine		alkylating agent;
antineoplastic agent
2-bromo-1,4-naphthoquinone[no description available]medium10
nsc 30705[no description available]medium10
nsc 224070[no description available]medium101,4-benzoquinones;
aziridines;
enamine;
primary alcohol;
secondary amino compound		alkylating agent;
antineoplastic agent
2-methylamino-1,4-naphthoquinone[no description available]medium10
emodin[no description available]medium10trihydroxyanthraquinoneantineoplastic agent;
laxative;
plant metabolite;
tyrosine kinase inhibitor
juglone[no description available]medium10hydroxy-1,4-naphthoquinonegeroprotector;
herbicide;
reactive oxygen species generator
alizarin[no description available]medium10dihydroxyanthraquinonechromophore;
dye;
plant metabolite
lawsone[no description available]medium10
9,10-anthraquinone[no description available]medium20anthraquinone
naphthazarin[no description available]medium20hydroxy-1,4-naphthoquinoneacaricide;
antibacterial agent;
antineoplastic agent;
apoptosis inducer;
geroprotector;
plant metabolite
rhein[no description available]medium10dihydroxyanthraquinone
plumbagin[no description available]medium10hydroxy-1,4-naphthoquinone;
phenols		anticoagulant;
antineoplastic agent;
immunological adjuvant;
metabolite
aloe emodin[no description available]medium10aromatic primary alcohol;
dihydroxyanthraquinone		antineoplastic agent;
plant metabolite
chrysophanic acid[no description available]medium10dihydroxyanthraquinoneanti-inflammatory agent;
antiviral agent;
plant metabolite
physcione[no description available]medium10dihydroxyanthraquinoneanti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite
streptomycin[no description available]medium10antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
shikonin[no description available]medium10hydroxy-1,4-naphthoquinone
alizarin red s[no description available]medium10organic sodium salt;
organosulfonate salt		histological dye
durene[no description available]medium10tetramethylbenzene
tetramethylpyrazine[no description available]medium10alkaloid;
pyrazines		antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
neuroprotective agent;
platelet aggregation inhibitor;
vasodilator agent
benzene[no description available]medium10aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
pyrazines[no description available]medium10diazine;
pyrazines		Daphnia magna metabolite
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
d-alpha tocopherol[no description available]medium50alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
palladium[no description available]medium10metal allergen;
nickel group element atom;
platinum group metal atom
bromide[no description available]medium10halide anion;
monoatomic bromine
rutin[no description available]medium10disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
glycosides[no description available]medium10
duroquinol[no description available]medium60hydroquinones;
methylbenzene		bacterial xenobiotic metabolite;
volatile oil component
ubiquinone q1[no description available]medium30ubiquinones
dicumarol[no description available]medium20hydroxycoumarinanticoagulant;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
Hsp90 inhibitor;
vitamin K antagonist
ubiquinone[no description available]medium120
coenzyme q10[no description available]medium10ubiquinonesantioxidant;
ferroptosis inhibitor;
human metabolite
hydrogen[no description available]medium10elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
cyclohexane[no description available]medium10cycloalkane;
volatile organic compound		non-polar solvent
isoalloxazine[no description available]medium10benzo[g]pteridine-2,4-dione
tyrosine[no description available]medium20amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
naphthoquinones[no description available]medium60
2,6-dichlorobenzoquinone[no description available]medium101,4-benzoquinones;
organochlorine compound		carcinogenic agent;
poison
plastoquinone[no description available]medium30plastoquinone
chlorophyll a[no description available]medium40chlorophyll;
methyl ester		cofactor
dibromothymoquinone[no description available]medium101,4-benzoquinonescytochrome-b6f complex inhibitor
idebenone[no description available]medium101,4-benzoquinones;
primary alcohol		antioxidant;
ferroptosis inhibitor
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone[no description available]medium201,4-benzoquinonescofactor
nad[no description available]medium50organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
pheophorbide a[no description available]medium10
succinic acid[no description available]medium40alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid		anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
heme[no description available]medium20
dithionite[no description available]medium10sulfur oxide;
sulfur oxoanion
linoleic acid[no description available]medium20octadecadienoic acid;
omega-6 fatty acid		algal metabolite;
Daphnia galeata metabolite;
plant metabolite
gold[no description available]medium10copper group element atom;
elemental gold
imidazole[no description available]medium10imidazole
5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione[no description available]medium10
phenylalanine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
hexacyanoferrate iii[no description available]medium20
tolonium chloride[no description available]medium10
ascorbic acid[no description available]medium20ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
potassium cyanide[no description available]medium10cyanide salt;
one-carbon compound;
potassium salt		EC 1.15.1.1 (superoxide dismutase) inhibitor;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
neurotoxin
cyanides[no description available]medium10pseudohalide anionEC 1.9.3.1 (cytochrome c oxidase) inhibitor
naphthalene[no description available]medium10naphthalenes;
ortho-fused bicyclic arene		apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component
cyclosporine[no description available]medium10
flavin-adenine dinucleotide[no description available]medium20flavin adenine dinucleotide;
vitamin B2		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group
nadp[no description available]medium50
hydroquinone[no description available]medium70benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent
diethylnitrosamine[no description available]medium20nitrosaminecarcinogenic agent;
hepatotoxic agent;
mutagen
diamide[no description available]medium101,1'-azobis(N,N-dimethylformamide)
ditiocarb[no description available]medium20dithiocarbamic acidschelator;
copper chelator
cyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
8-bromocyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
organobromine compound		muscle relaxant;
protein kinase G agonist
acetylcysteine[no description available]medium10acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
6-o-palmitoylascorbic acid[no description available]medium10fatty acid ester
probucol[no description available]medium10dithioketal;
polyphenol		anti-inflammatory drug;
anticholesteremic drug;
antilipemic drug;
antioxidant;
cardiovascular drug
benzophenone[no description available]medium10benzophenonesphotosensitizing agent;
plant metabolite
thioctic acid[no description available]medium20dithiolanes;
heterocyclic fatty acid;
thia fatty acid		fundamental metabolite;
geroprotector
dihydrolipoic acid[no description available]medium20thio-fatty acidantioxidant;
human metabolite;
neuroprotective agent
allopurinol[no description available]medium30nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
xanthine[no description available]medium10xanthineSaccharomyces cerevisiae metabolite
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole[no description available]medium10benzoic acid;
imidazolines;
organic radical		apoptosis inhibitor;
radical scavenger
n-tert-butyl-(2-sulfophenyl)nitrone[no description available]medium10
hydroxyl radical[no description available]medium10oxygen hydride;
oxygen radical;
reactive oxygen species
ferrous sulfate[no description available]medium10iron molecular entity;
metal sulfate		reducing agent
ubiquinone q2[no description available]medium30ubiquinones
vitamin k 1[no description available]medium10phylloquinones;
vitamin K		cofactor;
human metabolite;
plant metabolite
lipoamide[no description available]medium10dithiolanes;
monocarboxylic acid amide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
arsenic[no description available]medium10metalloid atom;
pnictogen		micronutrient
oxophenylarsine[no description available]medium10arsine oxidesantineoplastic agent;
apoptosis inducer;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
tert-butylhydroperoxide[no description available]medium10alkyl hydroperoxideantibacterial agent;
oxidising agent
neuropeptide y[no description available]medium10
3,17-diacetoxyestra-1,3,5(10)-trien-2-carboxylic acid[no description available]medium10
diuron[no description available]medium203-(3,4-substituted-phenyl)-1,1-dimethylurea;
dichlorobenzene		environmental contaminant;
mitochondrial respiratory-chain inhibitor;
photosystem-II inhibitor;
urea herbicide;
xenobiotic
pheophytin a[no description available]medium10
bacteriochlorophylls[no description available]medium10
vitamin k semiquinone radical[no description available]medium80
vasoactive intestinal peptide[no description available]medium10
nicotine[no description available]medium103-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
pyrogallol[no description available]medium10benzenetriol;
phenolic donor		plant metabolite
paraquat[no description available]medium20organic cationgeroprotector;
herbicide
trypan blue[no description available]medium10
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
nitrofurazone[no description available]medium10
n-methylaspartate[no description available]medium10amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
chiniofon[no description available]medium10
2-(n-heptyl)-4-hydroxyquinoline n-oxide[no description available]medium10monohydroxyquinoline
stigmatellin[no description available]medium10aromatic ether;
chromones;
olefinic compound;
phenols		bacterial metabolite;
quinol oxidation site inhibitor
fumaric acid[no description available]medium10butenedioic acidfood acidity regulator;
fundamental metabolite;
geroprotector
fumarates[no description available]medium10butenedioate;
C4-dicarboxylate		human metabolite;
metabolite;
Saccharomyces cerevisiae metabolite
dithionitrobenzoic acid[no description available]medium10nitrobenzoic acid;
organic disulfide		indicator
dithiothreitol tetraacetate[no description available]medium10
dithiothreitol[no description available]medium201,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent
trans-4-coumaric acid[no description available]medium104-coumaric acidfood component;
mouse metabolite;
plant metabolite
2,3-dimethoxy-1,4-naphthoquinone[no description available]medium201,4-naphthoquinones
phenobarbital[no description available]medium10barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
beta-naphthoflavone[no description available]medium10extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound		aryl hydrocarbon receptor agonist
catechol[no description available]medium10catecholsallelochemical;
genotoxin;
plant metabolite
resorcinol[no description available]medium10benzenediol;
phenolic donor;
resorcinols		erythropoietin inhibitor;
sensitiser
dinitrochlorobenzene[no description available]medium10C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser
rotenone[no description available]medium20organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
antimycin a[no description available]medium50amidobenzoic acid
myxothiazol[no description available]medium30
thiazoles[no description available]medium301,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
dicyclohexylcarbodiimide[no description available]medium10carbodiimideATP synthase inhibitor;
cross-linking reagent;
peptide coupling reagent
antimycin[no description available]medium30
phosphorus[no description available]medium10monoatomic phosphorus;
nonmetal atom;
pnictogen		macronutrient
farnesylacetone[no description available]medium10
beta carotene[no description available]medium10carotenoid beta-end derivative;
cyclic carotene		antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A
diphenylamine[no description available]medium10aromatic amine;
bridged diphenyl fungicide;
secondary amino compound		antifungal agrochemical;
antioxidant;
carotogenesis inhibitor;
EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor;
ferroptosis inhibitor;
radical scavenger
carbonyl cyanide p-trifluoromethoxyphenylhydrazone[no description available]medium10aromatic ether;
hydrazone;
nitrile;
organofluorine compound		ATP synthase inhibitor;
geroprotector;
ionophore
dimercaprol[no description available]medium10dithiol;
primary alcohol		chelator
atrazine[no description available]medium10chloro-1,3,5-triazine;
diamino-1,3,5-triazine		environmental contaminant;
herbicide;
xenobiotic
platinum[no description available]medium10elemental platinum;
nickel group element atom;
platinum group metal atom
ditercalinium[no description available]medium10
diadenosine tetraphosphate[no description available]medium10diadenosyl tetraphosphateEscherichia coli metabolite;
mouse metabolite
1,2-naphthoquinone[no description available]medium101,2-naphthoquinonesaryl hydrocarbon receptor agonist;
carcinogenic agent
deferoxamine[no description available]medium10acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
aa 861[no description available]low001,4-benzoquinones;
acetylenic compound;
primary alcohol		EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor
chloranil[no description available]low001,4-benzoquinones;
organochlorine compound		EC 2.7.1.33 (pantothenate kinase) inhibitor;
metabolite
thymoquinone[no description available]low001,4-benzoquinonesadjuvant;
anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
cardioprotective agent;
plant metabolite
2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone[no description available]low001,4-benzoquinones
primin[no description available]low001,4-benzoquinonesallergen;
antifeedant;
antimicrobial agent;
hapten;
metabolite
geldanamycin[no description available]low001,4-benzoquinones;
ansamycin;
carbamate ester;
organic heterobicyclic compound		antimicrobial agent;
antineoplastic agent;
antiviral agent;
cysteine protease inhibitor;
Hsp90 inhibitor
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin[no description available]low001,4-benzoquinones;
ansamycin;
carbamate ester;
secondary amino compound;
tertiary amino compound		Hsp90 inhibitor
herbimycin[no description available]low001,4-benzoquinones;
lactam;
macrocycle		antimicrobial agent;
apoptosis inducer;
herbicide;
Hsp90 inhibitor;
tyrosine kinase inhibitor
tanespimycin[no description available]low001,4-benzoquinones;
ansamycin;
carbamate ester;
organic heterobicyclic compound;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
Hsp90 inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Anoxia, Brain0low10
Anoxia, Cerebral0low10
Anoxic Brain Damage0low10
Anoxic Encephalopathy0low10
Anterior Circulation Transient Ischemic Attack0low10
B16 Melanoma0low10
Benign Neoplasms0low10
Brain Anoxia0low10
Brain Hypoxia0low10
Brain Ischemia0low10
Brain Stem Ischemia, Transient0low10
Brain Stem Transient Ischemic Attack0low10
Brain TIA0low10
Brainstem Ischemia, Transient0low10
Brainstem Transient Ischemic Attack0low10
Burns0low10
Cancer0low10
Carotid Circulation Transient Ischemic Attack0low10
Cell Transformation, Viral0low10
Cerebral Anoxia0low10
Cerebral Hypoxia0low10
Cerebral Ischemia0low10
Cerebral Ischemia, Transient0low10
Chronic Disease0low10
Chronic Illness0low10
Chronic Lung Injury0low20
Chronically Ill0low10
Condition, Preneoplastic0low20
Conditions, Preneoplastic0low20
Crescendo Transient Ischemic Attacks0low10
Encephalitis, Polio0low10
Encephalopathy, Hypoxic0low10
Encephalopathy, Ischemic0low10
Epidemic Acute Poliomyelitis0low10
Experimental Hepatoma0low10
Experimental Hepatomas0low10
Experimental Liver Neoplasms0low10
Experimental Melanoma0low10
Experimental Melanomas0low10
Harding Passey Melanoma0low10
Hepatoma, Experimental0low10
Hepatoma, Morris0low10
Hepatoma, Novikoff0low10
Hepatomas, Experimental0low10
Hyperoxia0low40
Hypoxia, Brain0low10
Hypoxia, Cerebral0low10
Hypoxic Brain Damage0low10
Hypoxic Encephalopathy0low10
Infantile Paralysis0low10
Ischemia, Cerebral0low10
Ischemic Attack, Transient0low10
Ischemic Encephalopathy0low10
Leukemia L 12100low10
Leukemia L12100low10
Liver Neoplasms, Experimental0low10
Lung Injuries0low20
Lung Injury0low20
Malignancy0low10
Malignant Neoplasms0low10
Melanoma, B160low10
Melanoma, Cloudman S910low10
Melanoma, Experimental0low10
Melanoma, Harding-Passey0low10
Melanomas, Experimental0low10
Muscle Contraction0low10
Muscle Relaxation0low30
Neoplasia0low10
Neoplasm0low10
Neoplasms0low10
Neoplasms, Benign0low10
Neoplasms, Experimental Liver0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Posterior Circulation Transient Ischemic Attack0low10
Precancerous Conditions0low20
Preneoplastic Condition0low20
Preneoplastic Conditions0low20
Pulmonary Injury0low20
TIA (Transient Ischemic Attack)0low10
Transformation, Viral Cell0low10
Transient Ischemic Attack0low10
Transient Ischemic Attack, Anterior Circulation0low10
Transient Ischemic Attack, Brain Stem0low10
Transient Ischemic Attack, Brainstem0low10
Transient Ischemic Attack, Carotid Circulation0low10
Transient Ischemic Attack, Posterior Circulation0low10
Transient Ischemic Attack, Vertebrobasilar Circulation0low10
Transient Ischemic Attacks, Crescendo0low10
Tumors0low10
Vertebrobasilar Circulation Transient Ischemic Attack0low10
Viral Cell Transformation0low10

Research Highlights

Safety/Toxicity (4)

ArticleYear
Selective toxicity in putative preneoplastic hepatocytes: a comparison of hydroquinone and duroquinone.
Cancer letters, Volume: 68, Issue: 2-3		1993
The changes of prooxidant and antioxidant enzyme activities in bovine leukemia virus-transformed cells. Their influence on quinone cytotoxicity.
FEBS letters, Jul-12, Volume: 326, Issue: 1-3		1993
Quinone toxicity in hepatocytes: studies on mitochondrial Ca2+ release induced by benzoquinone derivatives.
Archives of biochemistry and biophysics, Volume: 259, Issue: 2		1987
The role of GSH depletion and toxicity in hydroquinone-induced development of enzyme-altered foci.
Carcinogenesis, Volume: 10, Issue: 3		1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]