Page last updated: 2024-08-05 15:08:21
sympatholytic agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
ChEBI ID: 66991
Members (10)
| Member | Definition | Class |
|---|---|---|
| 1-methyl-d-lysergic acid butanolamide | A synthetic ergot alkaloid, structurally related to the oxytocic agent methylergonovine and to the potent hallucinogen LSD and used prophylactically to reduce the frequency and intensity of severe vascular headaches. | methysergide |
| alprenolol | A secondary alcohol that is propan-2-ol substituted by a 2-allylphenoxy group at position 1 and an isopropylamino group at position 3. It is a beta-adrenergic antagonist used as a antihypertensive, anti-arrhythmia and a sympatholytic agent. | alprenolol |
| atenolol | An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. | atenolol |
| betaxolol | A propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment of glaucoma as well as hypertension, arrhythmias, and coronary heart disease. It is also used to reduce non-fatal cardiac events in patients with heart failure. | betaxolol |
| bisoprolol | bisoprolol | |
| carteolol | carteolol | |
| debrisoquin | debrisoquin | |
| dihydroergotamine | Ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension. | dihydroergotamine |
| guanethidine | A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group. | guanethidine |
| methyldopa | A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring. | alpha-methyl-L-dopa |
Research
Studies (16,786)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 9,591 (57.14) | 18.7374 |
| 1990's | 3,086 (18.38) | 18.2507 |
| 2000's | 2,182 (13.00) | 29.6817 |
| 2010's | 1,525 (9.08) | 24.3611 |
| 2020's | 402 (2.39) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,650 (19.38%) | 5.53% |
| Reviews | 1,138 (6.04%) | 6.00% |
| Case Studies | 1,090 (5.79%) | 4.05% |
| Observational | 39 (0.21%) | 0.25% |
| Other | 12,914 (68.58%) | 84.16% |
Protein Targets (182)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 28.7968 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 37.9330 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 42.1668 | 3 | 5 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 15.2645 | 1 | 3 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 11.2202 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 14.4199 | 4 | 4 |
| arylsulfatase A | Homo sapiens (human) | Potency | 19.0627 | 1 | 4 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.3464 | 1 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 26.8711 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 18.1720 | 4 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 8.2930 | 2 | 3 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 9.9150 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 2.3998 | 2 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 53.8083 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 0.1259 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 3.5501 | 2 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 14.3421 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.4554 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 0.1259 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 20.0493 | 2 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 11.4678 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 40.7784 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.5134 | 2 | 4 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 23.2809 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 1.2673 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 29.7486 | 1 | 4 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 11.6364 | 1 | 5 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0820 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 31.6228 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.6859 | 4 | 5 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 31.6704 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.3209 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 18.6548 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 29.8470 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 33.4020 | 3 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 2.8579 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 43.7130 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 17.5897 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 21.3138 | 1 | 1 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 29.8493 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 11.0344 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 59.2326 | 2 | 3 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 13.4591 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 13.1869 | 1 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 23.2786 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.6852 | 2 | 5 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 30.0450 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 35.4813 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 16.4171 | 2 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 25.5748 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 29.8470 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 8.4120 | 1 | 1 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 2.1331 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 37.6639 | 2 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 0.7943 | 2 | 3 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 9.1812 | 1 | 3 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 23.0014 | 4 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 6.0070 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 6.0070 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 112.2020 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 31.6228 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 28.3604 | 2 | 6 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 22.3872 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 7.9544 | 4 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 29.8765 | 2 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 11.8832 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 48.0224 | 1 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 26.6011 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 29.8493 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.6300 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0028 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.0216 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 3.3726 | 2 | 3 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0080 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0019 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0068 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0043 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0900 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0470 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0900 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0470 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0015 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.0460 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 0.2300 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 0.2300 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.1295 | 2 | 2 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0140 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0010 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0004 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0039 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0018 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0015 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 559.9700 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 1,000.0000 | 2 | 2 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 0.5027 | 12 | 12 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.4323 | 7 | 7 |
| Beta-1 adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0053 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 2.9292 | 5 | 5 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 2.8378 | 6 | 7 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 0.0023 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 638.5870 | 4 | 10 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2D1 | Rattus norvegicus (Norway rat) | IC50 | 529.0000 | 1 | 1 |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | IC50 | 107.0000 | 1 | 1 |
| Cytochrome P450 2D3 | Rattus norvegicus (Norway rat) | IC50 | 1,754.0000 | 1 | 1 |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | IC50 | 747.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 65.6000 | 3 | 3 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 3.9996 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 2.3950 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 1.1970 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.0089 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0053 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0018 | 1 | 1 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0126 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 5.2280 | 1 | 1 |
| estrogen receptor beta isoform 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Fatty acid-binding protein, liver | Rattus norvegicus (Norway rat) | Ki | 717.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 12.6000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.1260 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 107.3600 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 107.3600 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.9120 | 1 | 1 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | IC50 | 151,600.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 49.9000 | 1 | 1 |
| Squalene synthase | Rattus norvegicus (Norway rat) | IC50 | 4.2000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 5.1760 | 1 | 1 |
| Urease | Canavalia ensiformis (jack bean) | IC50 | 64.3600 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 4 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kd | 0.0282 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.2089 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kd | 0.0282 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.2089 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kd | 0.0282 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.2089 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0562 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0562 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0562 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Kd | 6.2729 | 5 | 13 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0644 | 2 | 2 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.0560 | 3 | 4 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Kd | 0.6398 | 2 | 6 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Kd | 6.4426 | 7 | 18 |
| Beta-2 adrenergic receptor | Bos taurus (cattle) | Kd | 186.2100 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Kd | 7.4152 | 3 | 11 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Kd | 0.6398 | 1 | 2 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Kapp | 0.0200 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Kapp | 0.0200 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Kapp | 0.0200 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Kapp | 0.0200 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Kapp | 0.0200 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Kapp | 0.0200 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Kapp | 0.0077 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Kapp | 0.0200 | 1 | 1 |
| Caspase 6, apoptosis-related cysteine peptidase | Homo sapiens (human) | AC50 | 39.2300 | 1 | 1 |
| Nitric oxide synthase, brain | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 1 |
| Nitric oxide synthase, inducible | Homo sapiens (human) | Activity | 0.1000 | 1 | 1 |