A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
| Member | Definition | Class |
|---|
| benzyloxycarbonylleucyl-leucyl-leucine aldehyde | A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative. | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal |
| bortezomib | L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome. | bortezomib |
| carfilzomib | A synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma | carfilzomib |
| delanzomib | A C-terminal boronic acid peptide inhibitor which induces apoptosis in multiple myeloma, hematological and solid tumor cell lines. | delanzomib |
| epoxomicin | A tripeptide consisting of an Ile-Ile-Thr-NH2 sequence N-substituted on the threonamide amidic nitrogen with a (2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl group and with acetyl and methyl groups on the nitrogen of the isoleucine residue distal to the threonamide; a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. | epoxomicin |
| gliotoxin | A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi. | gliotoxin |
| ixazomib | A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma. | ixazomib |
| marizomib | A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers. | salinosporamide A |
| scutellarin | The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein. | scutellarin |
| tmc-95a | A 17-membered macrocyclic lactam that incorporates a phenol and a substituted indole moiety. It includes a R-hydroxy group at position 11 and a (3-methyl-2-oxopentanoyl)amino group at position at position 18 with a S-methyl group. It acts as a proteasome inhibitor and is obtained from Apiospora montagnei Sacc. TC 1093, isolated from a soil sample. | TMC-95A |
| tmc-95b | A 17-membered macrocyclic lactam that incorporates a phenol and a substituted indole moiety. A stereoisomer of TMC-95A, it has a [(3R)-3-methyl-2-oxopentanoyl]amino group at position 18. It acts as a proteasome inhibitor and is isolated from Apiospora montagnei Sacc. TC 1093, isolated from a soil sample. | TMC-95B |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 30.9008 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 0.6125 | 7 | 19 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.0486 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.0503 | 2 | 6 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 0.2386 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 0.0270 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 0.2386 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 0.0270 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.0331 | 2 | 6 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.3342 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 3.1062 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.0232 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.1849 | 9 | 24 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 1.2266 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.0408 | 6 | 13 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.1712 | 4 | 20 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 3.4887 | 2 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 0.4990 | 1 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.0165 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0767 | 3 | 7 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.1138 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 0.2078 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 15.5565 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 0.3606 | 2 | 20 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 0.0387 | 2 | 4 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 0.0447 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 0.0106 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 0.2685 | 3 | 7 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 0.0663 | 3 | 6 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 0.3779 | 3 | 5 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 2.5119 | 1 | 1 |
| polyprotein | Zika virus | Potency | 0.4990 | 1 | 6 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.3913 | 1 | 12 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 0.0230 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 1.2819 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.4441 | 2 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 0.0319 | 3 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 0.1209 | 2 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.8403 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.0080 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 0.0561 | 3 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 1.6279 | 3 | 6 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 21.8959 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.1138 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 26S proteasome complex subunit SEM1 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 1 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 11 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 12 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 13 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 14 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 2 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 3 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 4 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 6 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 7 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome non-ATPase regulatory subunit 8 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome regulatory subunit 10B | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome regulatory subunit 4 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome regulatory subunit 6A | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome regulatory subunit 6B | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome regulatory subunit 7 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 26S proteasome regulatory subunit 8 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 63.4000 | 1 | 1 |
| Acetolactate synthase catalytic subunit, mitochondrial | Saccharomyces cerevisiae S288C | IC50 | 0.2000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 0.0440 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent Clp protease proteolytic subunit | Staphylococcus aureus subsp. aureus NCTC 8325 | IC50 | 5.3000 | 1 | 2 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 7.3000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Calpain-2 catalytic subunit | Homo sapiens (human) | Ki | 0.6530 | 1 | 1 |
| Calpain-9 | Homo sapiens (human) | IC50 | 9.8800 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 104.0000 | 2 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 1.2900 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 5.8700 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 8.4500 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 3.2800 | 1 | 1 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 2.6800 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 1.1600 | 2 | 2 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 4.5700 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 6.5100 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 6.9200 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 6.8300 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 4.3800 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 6.9400 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 3.3800 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | IC50 | 53.6667 | 2 | 3 |
| Cathepsin B | Homo sapiens (human) | Ki | 0.1210 | 2 | 2 |
| Cathepsin G | Homo sapiens (human) | IC50 | 7.1487 | 3 | 5 |
| Cathepsin G | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| Cathepsin K | Homo sapiens (human) | Ki | 0.0014 | 1 | 1 |
| Cathepsin S | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Chain H, Proteasome component PUP1 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 1 |
| Chain I, Proteasome component PUP3 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 1 |
| Chain K, Proteasome component PRE2 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 2 |
| Chain L, Proteasome component C5 | Saccharomyces cerevisiae (brewer's yeast) | Ki | 0.0006 | 1 | 2 |
| Chymase | Homo sapiens (human) | IC50 | 2.3600 | 1 | 2 |
| Chymotrypsinogen A | Bos taurus (cattle) | Ki | 2.4000 | 1 | 1 |
| Chymotrypsinogen B | Homo sapiens (human) | Ki | 0.3200 | 1 | 1 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| E3 ubiquitin-protein ligase RNF31 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.9800 | 1 | 1 |
| Gamma-secretase subunit PEN-2 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Geranylgeranyl transferase type-1 subunit beta | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| Glutathione S-transferase omega-1 | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 0.6200 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 1.1800 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 69.4400 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 0.0720 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 3.4650 | 2 | 2 |
| Histone-lysine N-methyltransferase SUV39H1 | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Lon protease homolog, mitochondrial | Homo sapiens (human) | IC50 | 0.1830 | 1 | 1 |
| Lysosomal protective protein | Homo sapiens (human) | IC50 | 19.6000 | 1 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Mycothiol S-conjugate amidase | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 0.1201 | 1 | 2 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 52.6000 | 3 | 3 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 3.5500 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 92.1000 | 1 | 1 |
| Proteasomal ubiquitin receptor ADRM1 | Homo sapiens (human) | IC50 | 0.4285 | 4 | 5 |
| Proteasome subunit alpha type-1 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit alpha type-2 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit alpha type-3 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit alpha type-4 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit alpha type-5 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit alpha type-7 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit alpha-type 8 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit beta type-1 | Homo sapiens (human) | IC50 | 0.4695 | 33 | 42 |
| Proteasome subunit beta type-1 | Saccharomyces cerevisiae S288C | IC50 | 1.0000 | 1 | 1 |
| Proteasome subunit beta type-1 | Homo sapiens (human) | Ki | 8.4083 | 6 | 6 |
| Proteasome subunit beta type-10 | Homo sapiens (human) | IC50 | 0.5344 | 18 | 23 |
| Proteasome subunit beta type-11 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit beta type-2 | Homo sapiens (human) | IC50 | 1.9136 | 35 | 45 |
| Proteasome subunit beta type-2 | Saccharomyces cerevisiae S288C | IC50 | 1.0000 | 1 | 1 |
| Proteasome subunit beta type-2 | Homo sapiens (human) | Ki | 5.5787 | 6 | 6 |
| Proteasome subunit beta type-3 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit beta type-4 | Homo sapiens (human) | IC50 | 0.5022 | 15 | 17 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 6,838.2971 | 57 | 75 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | Ki | 0.0126 | 8 | 8 |
| Proteasome subunit beta type-6 | Homo sapiens (human) | IC50 | 0.4975 | 16 | 19 |
| Proteasome subunit beta type-7 | Homo sapiens (human) | IC50 | 1.1236 | 16 | 19 |
| Proteasome subunit beta type-8 | Homo sapiens (human) | IC50 | 0.2835 | 24 | 31 |
| Proteasome subunit beta type-8 | Mus musculus (house mouse) | IC50 | 0.0168 | 1 | 1 |
| Proteasome subunit beta type-9 | Homo sapiens (human) | IC50 | 0.5593 | 20 | 25 |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | IC50 | 40.5500 | 2 | 2 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | IC50 | 32.7000 | 3 | 3 |
| Prothrombin | Homo sapiens (human) | Ki | 13.0000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 22.6400 | 1 | 1 |
| RanBP-type and C3HC4-type zinc finger-containing protein 1 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.1874 | 6 | 8 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 6.9500 | 3 | 4 |
| Sharpin | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 25.9000 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 50.6000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 50.6000 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | Ki | 96.6000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A10 | Homo sapiens (human) | Ki | 208.0000 | 1 | 1 |