An agent that promotes the excretion of urine through its effects on kidney function.
| Member | Definition | Class |
|---|
| acetazolamide | | acetazolamide |
| amiloride | A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. | amiloride |
| amiloride hydrochloride | A hydrate that is the dihydrate of amiloride hydrochloride. | amiloride hydrochloride dihydrate |
| amiloride hydrochloride, anhydrous | A hydrochloride obtained by combining amiloride with one molar equivalent of hydrochloric acid. | amiloride hydrochloride |
| bendroflumethiazide | A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group. | bendroflumethiazide |
| benzothiazide | 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema. | benzthiazide |
| bumetanide | A member of the class of benzoic acids that is 4-phenoxybenzoic acid in which the hydrogens ortho to the phenoxy group are substituted by butylamino and sulfamoyl groups. Bumetanide is a diuretic, and is used for treatment of oedema associated with congestive heart failure, hepatic and renal disease. | bumetanide |
| caffeine | A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee. | caffeine |
| chlormerodrin | Urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. | chlormerodrin |
| chlorothiazide | 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. | chlorothiazide |
| cleistanthin | A member of the class of cleistanthins that is the 4-O-3,4-di-O-methyl-beta-D-xylopyranoside of 1,3-dihydronaphtho[2,3-c]furan-4-ol which is substituted by an oxo group at position 1, methoxy groups at positions 6 and 7, and a 1,3-benzodioxol-5-yl group at position 9. It is one of the toxic principles in Cleistanthus collinus. | cleistanthin A |
| cleistanthin b | A member of the class of cleistanthins that is cleistanthin A in which the 3,4-di-O-methyl-D-xylopyranosyl group is replaced by a beta-D-glucopyranosyl group. | cleistanthin B |
| cyclothiazide | 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema. | cyclothiazide |
| diazoxide | A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies. | diazoxide |
| ethoxzolamide | A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic. | ethoxzolamide |
| hydrochlorothiazide | A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure. | hydrochlorothiazide |
| hydroflumethiazide | A benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. | hydroflumethiazide |
| indapamide | A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine. | indapamide |
| metolazone | A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics. | metolazone |
| potassium citrate | The anhydrous form of the tripotassium salt of citric acid. | potassium citrate (anhydrous) |
| quinethazone | A member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension. | quinethazone |
| solasodine | An oxaspiro compound and steroid alkaloid sapogenin with formula C27H43NO2 found in the Solanum (nightshade) family. It is used as a precursor in the synthesis of complex steroidal compounds such as contraceptive pills. | solasodine |
| spironolactone | A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. | spironolactone |
| triamterene | Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema. | triamterene |
| trichlormethiazide | A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. | trichlormethiazide |
| trimethoprim | An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge. | trimethoprim |
| u 69593 | A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine. | U69593 |
| u-50488 | A monocarboxylic acid amide obtained by formal condensation between the carboxy group of 3,4-dichlorophenylacetic acid and the secondary amino group of (1R,2R)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine | U50488 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 17.3220 | 1 | 16 |
| 67.9K protein | Vaccinia virus | Potency | 13.9800 | 2 | 10 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 34.6989 | 2 | 15 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 26.0533 | 1 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 36.4705 | 2 | 8 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.4013 | 1 | 28 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 30.7525 | 5 | 18 |
| AR protein | Homo sapiens (human) | Potency | 24.7485 | 12 | 75 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.6368 | 2 | 12 |
| arylsulfatase A | Homo sapiens (human) | Potency | 5.0824 | 1 | 6 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.5063 | 3 | 9 |
| Ataxin-2 | Homo sapiens (human) | Potency | 28.8427 | 2 | 5 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 16.3180 | 2 | 7 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 48.7606 | 2 | 7 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 4.7755 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 191.3687 | 2 | 13 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 68.9736 | 1 | 2 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 16.9893 | 1 | 3 |
| caspase-3 | Homo sapiens (human) | Potency | 68.9736 | 1 | 2 |
| Caspase-7 | Homo sapiens (human) | Potency | 12.8127 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 23.5620 | 3 | 14 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 15.4668 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 21.9296 | 1 | 22 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 28.3616 | 2 | 6 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 44.6903 | 3 | 9 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 30.2062 | 2 | 8 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 18.9119 | 2 | 23 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 17.2166 | 2 | 13 |
| Chain A, PAPAIN | Carica papaya (papaya) | Potency | 22.3872 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.8114 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 33.6662 | 1 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 18.9119 | 2 | 23 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 66.8793 | 2 | 12 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 16.2511 | 1 | 5 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 17.1531 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 17.7968 | 1 | 5 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 9.1450 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 19.8774 | 2 | 23 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 16.1399 | 1 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 19.8866 | 1 | 8 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 3.9061 | 1 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 8.7947 | 1 | 3 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0231 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 46.0920 | 2 | 4 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.3690 | 11 | 52 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 28.0049 | 3 | 12 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 30.4374 | 10 | 45 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.9766 | 1 | 18 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 22.4543 | 4 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.4303 | 5 | 21 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 17.1531 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| GALC protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 19.5737 | 1 | 12 |
| geminin | Homo sapiens (human) | Potency | 5.3990 | 3 | 17 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 25.8532 | 3 | 19 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.2318 | 2 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 23.6424 | 2 | 5 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 22.2059 | 1 | 9 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 26.8572 | 5 | 25 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 37.6269 | 1 | 5 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 7.8566 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 35.3476 | 2 | 6 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 16.2511 | 1 | 15 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 30.5456 | 1 | 4 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 35.1981 | 2 | 8 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 65.3776 | 1 | 4 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 76.0613 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 17.1531 | 1 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 31.5875 | 2 | 7 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 10.1976 | 3 | 11 |
| IDH1 | Homo sapiens (human) | Potency | 11.2209 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 38.5710 | 2 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 17.1531 | 1 | 10 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 8.7580 | 2 | 4 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 17.1531 | 1 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 72.2601 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.7277 | 2 | 19 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 8.9958 | 1 | 5 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.2909 | 3 | 7 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 30.4219 | 4 | 11 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 0.0251 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 13.9661 | 2 | 9 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 155.0909 | 1 | 5 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 33.9972 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 33.9972 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 4.6454 | 2 | 8 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.3129 | 1 | 2 |
| Nrf2 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 30.9971 | 4 | 27 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 5.1304 | 2 | 4 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 42.2395 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 31.2956 | 2 | 8 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 18.7744 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 39.4130 | 3 | 15 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 32.5733 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 22.5012 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 22.2934 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 55.9921 | 1 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.9495 | 5 | 17 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.6392 | 5 | 18 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 74.9307 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.2450 | 1 | 2 |
| polyprotein | Zika virus | Potency | 35.4813 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 17.7142 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 35.3801 | 2 | 16 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 34.4117 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 23.9054 | 3 | 7 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 39.8107 | 1 | 1 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.8489 | 2 | 2 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 32.4648 | 2 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 24.5859 | 2 | 17 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 11.7129 | 1 | 6 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 32.4611 | 3 | 28 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 20.9662 | 4 | 20 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.4930 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 23.8114 | 2 | 7 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 23.8114 | 2 | 7 |
| Smad3 | Homo sapiens (human) | Potency | 16.6410 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 38.5710 | 2 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 14.5121 | 1 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 2.2963 | 1 | 7 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 26.1277 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.9955 | 2 | 25 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 35.1530 | 4 | 26 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 36.7168 | 3 | 19 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 13.3166 | 3 | 12 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.6770 | 4 | 24 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 0.0658 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 19.6511 | 1 | 3 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.2450 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.2450 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 354.8130 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 41.4051 | 2 | 6 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 29.3522 | 5 | 19 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 37.6269 | 1 | 5 |
| Vpr | Human immunodeficiency virus 1 | Potency | 3.1623 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 15.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0082 | 4 | 6 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 86.8167 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0094 | 3 | 5 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0433 | 5 | 7 |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | IC50 | 56.9000 | 1 | 4 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 7.2500 | 1 | 1 |
| Acid-sensing ion channel 1 | Rattus norvegicus (Norway rat) | IC50 | 30.2000 | 1 | 1 |
| Acid-sensing ion channel 3 | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| Acidic mammalian chitinase | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Acyl-CoA desaturase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0035 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 113.5000 | 2 | 2 |
| Adenosine receptor A1 | Cavia porcellus (domestic guinea pig) | Ki | 100.0000 | 5 | 5 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 35.4333 | 15 | 15 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 34.4611 | 33 | 36 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 20.4720 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 63.0000 | 1 | 5 |
| Adenosine receptor A2a | Cavia porcellus (domestic guinea pig) | Ki | 50.0000 | 3 | 3 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 19.0635 | 24 | 24 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 146.2774 | 28 | 33 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | IC50 | 63.0000 | 1 | 5 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 26.7211 | 19 | 19 |
| Adenosine receptor A2b | Mus musculus (house mouse) | Ki | 23.0000 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 35.3050 | 15 | 20 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 34.9750 | 12 | 12 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 56.6667 | 6 | 6 |
| Albumin | Homo sapiens (human) | Ki | 2,290,870,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 0.7175 | 1 | 4 |
| Amiloride-sensitive sodium channel subunit alpha | Homo sapiens (human) | IC50 | 0.7760 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 26.9545 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 3,700.0000 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | IC50 | 0.3585 | 6 | 6 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.4060 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | Ki | 0.0394 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0513 | 2 | 2 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | Ki | 0.0025 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 9 |
| ATP-binding cassette sub-family C member 8 | Homo sapiens (human) | IC50 | 470.5000 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 23.6000 | 1 | 1 |
| ATP-sensitive inward rectifier potassium channel 11 | Homo sapiens (human) | IC50 | 470.5000 | 4 | 4 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 0.5595 | 9 | 11 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Cryptosporidium parvum | IC50 | 14.0000 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Leishmania major | IC50 | 20.5000 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium berghei ANKA | IC50 | 0.1200 | 5 | 5 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | IC50 | 68.2550 | 2 | 2 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | IC50 | 80.5069 | 46 | 59 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Leishmania major | Ki | 0.1200 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | Ki | 1.8558 | 7 | 7 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 310.9272 | 3 | 25 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 14,000.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 747.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 8 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0390 | 2 | 2 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 0.4334 | 8 | 15 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 5.7200 | 1 | 1 |
| Carbonic anhydrase | Flaveria bidentis | Ki | 0.0270 | 4 | 4 |
| Carbonic anhydrase | Helicobacter pylori 26695 | Ki | 0.0972 | 2 | 4 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 0.3218 | 8 | 10 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 10.7500 | 4 | 5 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ki | 4.6324 | 5 | 7 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.0895 | 1 | 2 |
| Carbonic anhydrase | Anopheles gambiae (African malaria mosquito) | Ki | 0.0813 | 1 | 3 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 0.2208 | 2 | 4 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 0.0180 | 9 | 10 |
| Carbonic anhydrase | Drosophila melanogaster (fruit fly) | Ki | 0.1060 | 1 | 1 |
| Carbonic anhydrase | Mycobacterium tuberculosis H37Rv | Ki | 0.0880 | 6 | 6 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 0.5300 | 5 | 6 |
| Carbonic anhydrase | Pseudomonas aeruginosa PAO1 | Ki | 0.0759 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.0277 | 2 | 4 |
| Carbonic anhydrase | Sulfurihydrogenibium sp. YO3AOP1 | Ki | 0.0070 | 1 | 3 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 952.7289 | 43 | 60 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 69.7808 | 481 | 861 |
| Carbonic anhydrase 12 | Homo sapiens (human) | IC50 | 0.3178 | 7 | 7 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 132.2617 | 244 | 436 |
| Carbonic anhydrase 13 | Homo sapiens (human) | IC50 | 0.2300 | 2 | 2 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | IC50 | 0.7700 | 2 | 2 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 0.2419 | 21 | 57 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 20.2009 | 19 | 158 |
| Carbonic anhydrase 14 | Homo sapiens (human) | IC50 | 0.1830 | 4 | 4 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 15.3565 | 50 | 209 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 0.0665 | 9 | 13 |
| Carbonic anhydrase 2 | Bos taurus (cattle) | IC50 | 0.7000 | 3 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 3,084,237,772.7582 | 95 | 118 |
| Carbonic anhydrase 2 | Bos taurus (cattle) | Ki | 0.1370 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 67.0225 | 502 | 885 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 0.0180 | 1 | 2 |
| Carbonic anhydrase 2, isoform A | Drosophila melanogaster (fruit fly) | Ki | 0.0780 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | IC50 | 1.9500 | 4 | 4 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 63.5342 | 4 | 20 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 91.8571 | 39 | 183 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | IC50 | 0.0700 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | IC50 | 0.1216 | 3 | 4 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | Ki | 0.1113 | 21 | 53 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 15.3545 | 94 | 271 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | IC50 | 0.1763 | 3 | 3 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 15.1637 | 56 | 215 |
| Carbonic anhydrase 5A, mitochondrial | Mus musculus (house mouse) | Ki | 0.1798 | 2 | 14 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | IC50 | 0.2300 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 15.9194 | 45 | 204 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 7.4740 | 3 | 5 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 20.5091 | 45 | 204 |
| Carbonic anhydrase 7 | Homo sapiens (human) | IC50 | 1.1737 | 6 | 6 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 11.9498 | 89 | 268 |
| Carbonic anhydrase 7 | Mus musculus (house mouse) | Ki | 0.0160 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 0.4513 | 71 | 73 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 100.4545 | 326 | 575 |
| Carbonic anhydrase-related protein 11 | Homo sapiens (human) | Ki | 0.0057 | 1 | 1 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 0.1015 | 1 | 3 |
| Casein kinase I isoform alpha | Homo sapiens (human) | IC50 | 36.8000 | 1 | 1 |
| Casein kinase I isoform delta | Homo sapiens (human) | IC50 | 31.6000 | 1 | 2 |
| Casein kinase I isoform epsilon | Homo sapiens (human) | IC50 | 31.6000 | 1 | 2 |
| Caspase-1 | Homo sapiens (human) | IC50 | 3.6630 | 1 | 1 |
| Cathepsin B | Bos taurus (cattle) | IC50 | 0.0200 | 1 | 1 |
| Cathepsin G | Homo sapiens (human) | IC50 | 7.4130 | 1 | 1 |
| Cationic trypsin | Bos taurus (cattle) | Ki | 345.7667 | 1 | 3 |
| Chain A, Carbonic anhydrase | Coccomyxa sp. PA | Ki | 1.0000 | 1 | 1 |
| Chain A, Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 0.0160 | 1 | 1 |
| Chain A, Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.0032 | 1 | 27 |
| Chain A, Carbonic anhydrase II | Homo sapiens (human) | Ki | 0.0023 | 1 | 3 |
| Chain A, Chitinase | Clonostachys rosea | Ki | 19,700.0000 | 1 | 1 |
| Chain A, Class Iii Chitinase Chia1 | Aspergillus fumigatus A1163 | IC50 | 164.0000 | 1 | 1 |
| Chain A, Dihydrofolate reductase | Bacillus anthracis | IC50 | 77,200.0000 | 1 | 1 |
| Chain A, Dihydrofolate reductase | Homo sapiens (human) | Ki | 0.6050 | 1 | 4 |
| Chain A, dihydrofolate reductase (DHFR) | Bacillus anthracis | IC50 | 77,200.0000 | 1 | 1 |
| Chain A, Endochitinase | Saccharomyces cerevisiae (brewer's yeast) | Ki | 21.0000 | 1 | 3 |
| Chain A, Glycogen Phosphorylase | Oryctolagus cuniculus (rabbit) | Ki | 100.0000 | 1 | 1 |
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 0.0490 | 1 | 2 |
| Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | Homo sapiens (human) | Ki | 5.3000 | 1 | 2 |
| Chain B, Carbonic anhydrase | Coccomyxa sp. PA | Ki | 1.0000 | 1 | 1 |
| Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR | Homo sapiens (human) | Ki | 5.3000 | 1 | 1 |
| Chitotriosidase-1 | Homo sapiens (human) | IC50 | 363.0000 | 1 | 2 |
| Cholinesterase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | Ki | 0.2500 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| Coagulation factor X | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Coagulation factor XI | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Mus musculus (house mouse) | Ki | 0.0100 | 1 | 1 |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | IC50 | 210.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 0.0295 | 3 | 11 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 0.0155 | 2 | 4 |
| Cytochrome P450 2B6 | Homo sapiens (human) | Ki | 0.0398 | 2 | 4 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0665 | 5 | 7 |
| Cytochrome P450 2C8 | Homo sapiens (human) | Ki | 0.0354 | 4 | 8 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 0.0207 | 4 | 9 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0541 | 5 | 9 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0384 | 8 | 16 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Ki | 0.0120 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 1 | 1 |
| Delta carbonic anhydrase | Conticribra weissflogii | Ki | 1.4794 | 1 | 3 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 3.6437 | 4 | 6 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 8.7167 | 2 | 3 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 6.6653 | 14 | 22 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 1.3261 | 7 | 12 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.8856 | 3 | 6 |
| Dihydrofolate reductase | Candida albicans | IC50 | 24.5144 | 5 | 5 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 265.3383 | 32 | 45 |
| Dihydrofolate reductase | Gallus gallus (chicken) | IC50 | 493.3333 | 3 | 3 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 205.3070 | 44 | 62 |
| Dihydrofolate reductase | Lacticaseibacillus casei | IC50 | 0.3492 | 4 | 4 |
| Dihydrofolate reductase | Lactococcus lactis subsp. lactis Il1403 | IC50 | 0.4500 | 1 | 1 |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | IC50 | 88.0000 | 1 | 1 |
| Dihydrofolate reductase | Neisseria gonorrhoeae | IC50 | 0.4500 | 2 | 2 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 267.5895 | 40 | 52 |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | IC50 | 3,261.4521 | 48 | 58 |
| Dihydrofolate reductase | Saccharomyces cerevisiae S288C | IC50 | 12.0000 | 1 | 1 |
| Dihydrofolate reductase | Staphylococcus aureus | IC50 | 982.6437 | 10 | 17 |
| Dihydrofolate reductase | Streptococcus pneumoniae TIGR4 | IC50 | 64.1815 | 2 | 6 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 0.0017 | 8 | 8 |
| Dihydrofolate reductase | Gallus gallus (chicken) | Ki | 104.7130 | 2 | 2 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 11.6282 | 12 | 12 |
| Dihydrofolate reductase | Lacticaseibacillus casei | Ki | 0.1318 | 1 | 1 |
| Dihydrofolate reductase | Mus musculus (house mouse) | Ki | 0.5000 | 1 | 1 |
| Dihydrofolate reductase | Pneumocystis carinii | Ki | 93.4345 | 3 | 3 |
| Dihydrofolate reductase | Staphylococcus aureus | Ki | 0.2115 | 13 | 13 |
| Dihydrofolate reductase | Bacillus anthracis | IC50 | 45.7880 | 5 | 5 |
| Dihydrofolate reductase | Bos taurus (cattle) | IC50 | 6,309.5700 | 1 | 1 |
| Dihydrofolate reductase | Mycobacterium avium | IC50 | 33.5633 | 9 | 9 |
| Dihydrofolate reductase | Pneumocystis jirovecii | IC50 | 0.0920 | 1 | 1 |
| Dihydrofolate reductase | Bacillus anthracis | Ki | 12.7600 | 3 | 3 |
| Dihydrofolate reductase | Salmonella enterica subsp. enterica serovar Typhi | Ki | 0.0083 | 1 | 1 |
| Dihydrofolate reductase type 1 | Escherichia coli | IC50 | 0.2500 | 2 | 2 |
| Dihydrofolate reductase type 1 from Tn4003 | Staphylococcus aureus | IC50 | 109.5308 | 1 | 4 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 2.7000 | 3 | 3 |
| Dipeptidyl peptidase 4 | Rattus norvegicus (Norway rat) | IC50 | 2.7000 | 1 | 1 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Endochitinase | Saccharomyces cerevisiae S288C | Ki | 21.0000 | 1 | 1 |
| Endochitinase A1 | Aspergillus fumigatus | IC50 | 164.0000 | 1 | 1 |
| Endochitinase B1 | Aspergillus fumigatus | IC50 | 363.0000 | 1 | 2 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 12.8510 | 2 | 2 |
| Estrogen receptor | Mus musculus (house mouse) | IC50 | 6.8848 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | Ki | 1.1000 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 46.6667 | 3 | 3 |
| Estrogen receptor beta | Mus musculus (house mouse) | IC50 | 6.8848 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | IC50 | 210.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 4.0745 | 5 | 5 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.4487 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.0540 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Glycogen phosphorylase, liver form | Rattus norvegicus (Norway rat) | IC50 | 648.0000 | 1 | 1 |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | IC50 | 159.1933 | 13 | 15 |
| Glycogen phosphorylase, muscle form | Rattus norvegicus (Norway rat) | IC50 | 182.0000 | 1 | 1 |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | Ki | 0.0330 | 1 | 2 |
| Guanine deaminase | Homo sapiens (human) | Ki | 10.2000 | 1 | 1 |
| Janus kinase 2 (a protein tyrosine kinase) | Homo sapiens (human) | IC50 | 4.6130 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0396 | 3 | 5 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 0.0548 | 17 | 19 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.0027 | 2 | 3 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 4.3587 | 5 | 6 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0274 | 15 | 21 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 0.1470 | 36 | 64 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0081 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 7 | 7 |
| Membrane primary amine oxidase | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Metabotropic glutamate receptor 5 | Rattus norvegicus (Norway rat) | IC50 | 2.7300 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 0.0315 | 13 | 13 |
| Mineralocorticoid receptor | Homo sapiens (human) | Ki | 0.0037 | 2 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 1.1410 | 3 | 4 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 0.1940 | 3 | 4 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 8.7167 | 2 | 3 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.3557 | 12 | 29 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 2.4800 | 8 | 9 |
| Mu-type opioid receptor | Mus musculus (house mouse) | Ki | 0.3672 | 6 | 11 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.7871 | 8 | 11 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Rattus norvegicus (Norway rat) | Ki | 0.0161 | 3 | 4 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 9 |
| Muscarinic receptor M1 | Bos taurus (cattle) | IC50 | 6.8848 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 0.0330 | 1 | 2 |
| NH(3)-dependent NAD(+) synthetase | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 1.0000 | 1 | 1 |
| Nociceptin receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.6920 | 1 | 1 |
| Nociceptin receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Palmitoleoyl-protein carboxylesterase NOTUM | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | IC50 | 3,630.0000 | 1 | 1 |
| Phosphodiesterase | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Plasminogen | Homo sapiens (human) | IC50 | 93.9933 | 3 | 3 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 0.0025 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.9180 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 187.4123 | 4 | 4 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 3.3400 | 5 | 5 |
| Progesterone receptor | Homo sapiens (human) | Ki | 0.3997 | 1 | 1 |
| Prolyl endopeptidase | Rattus norvegicus (Norway rat) | Ki | 0.0440 | 1 | 2 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 7,500.0000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | IC50 | 135.0000 | 2 | 2 |
| Pteridine reductase 1 | Leishmania major | Ki | 3.4000 | 1 | 1 |
| Renin | Homo sapiens (human) | IC50 | 8.2000 | 1 | 1 |
| Renin | Macaca mulatta (Rhesus monkey) | IC50 | 8.2000 | 1 | 1 |
| Renin | Homo sapiens (human) | Ki | 9.1500 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 100.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 100.0000 | 1 | 1 |
| Serine-protein kinase ATM | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Serine/threonine-protein kinase ATR | Homo sapiens (human) | IC50 | 1,100.0000 | 1 | 1 |
| serine/threonine-protein kinase D1 isoform 2 | Homo sapiens (human) | IC50 | 6.8848 | 1 | 1 |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 6.6290 | 1 | 1 |
| Serum paraoxonase/arylesterase 1 | Homo sapiens (human) | Ki | 743.0000 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.2500 | 1 | 1 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 6.9200 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.1310 | 2 | 2 |
| Sodium/hydrogen exchanger | Amphiuma tridactylum (three-toed salamander) | IC50 | 98.0000 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Homo sapiens (human) | IC50 | 63.3650 | 2 | 2 |
| Sodium/hydrogen exchanger 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Rattus norvegicus (Norway rat) | Ki | 1.0000 | 2 | 2 |
| Sodium/hydrogen exchanger 2 | Oryctolagus cuniculus (rabbit) | IC50 | 1.0000 | 1 | 1 |
| Sodium/hydrogen exchanger 2 | Oryctolagus cuniculus (rabbit) | Ki | 1.0000 | 2 | 2 |
| Sodium/hydrogen exchanger 3 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Sodium/hydrogen exchanger 3 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 2 | 2 |
| Sodium/hydrogen exchanger 5 | Homo sapiens (human) | IC50 | 21.0000 | 1 | 1 |
| Sodium/hydrogen exchanger 5 | Homo sapiens (human) | Ki | 21.0000 | 2 | 2 |
| Solute carrier family 12 member 2 | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 6.9000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 54.8267 | 2 | 3 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 4.7000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 418.5000 | 1 | 3 |
| Squalene synthase | Rattus norvegicus (Norway rat) | Ki | 0.0090 | 2 | 2 |
| Steryl-sulfatase | Homo sapiens (human) | IC50 | 5.0125 | 1 | 2 |
| Thymidylate synthase | Escherichia coli K-12 | IC50 | 115.6033 | 2 | 6 |
| Thymidylate synthase | Homo sapiens (human) | IC50 | 115.6033 | 2 | 6 |
| Tissue factor | Homo sapiens (human) | IC50 | 740.0000 | 1 | 1 |
| Tissue-type plasminogen activator | Homo sapiens (human) | IC50 | 163.3333 | 3 | 3 |
| Tissue-type plasminogen activator | Homo sapiens (human) | Ki | 345.7667 | 1 | 3 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 0.7090 | 1 | 2 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| tyrosine-protein phosphatase non-receptor type 7 isoform 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 21.2543 | 7 | 7 |
| Urokinase-type plasminogen activator | Mus musculus (house mouse) | IC50 | 2.3000 | 1 | 1 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | Ki | 132.9056 | 6 | 8 |
| Urokinase-type plasminogen activator | Mus musculus (house mouse) | Ki | 2.3130 | 1 | 1 |
| Vitamin K-dependent protein C | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |