Roles > calcimimetic
Page last updated: 2024-08-05 15:40:29

calcimimetic

A drug that it mimics the action of calcium on tissues.

ChEBI ID: 48525

Members (2)

MemberDefinitionClass
cinacalcetA secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.cinacalcet
cinacalcet hydrochlorideA hydrochloride derived from equimolar amounts of cinacalcet and hydrogen chloride.cinacalcet hydrochloride

Research

Studies (998)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's312 (31.26)29.6817
2010's557 (55.81)24.3611
2020's129 (12.93)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials155 (14.34%)5.53%
Reviews229 (21.18%)6.00%
Case Studies162 (14.99%)4.05%
Observational36 (3.33%)0.25%
Other499 (46.16%)84.16%

Protein Targets (66)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency17.782811
activating transcription factor 6Homo sapiens (human)Potency26.832522
AR proteinHomo sapiens (human)Potency17.406088
Ataxin-2Homo sapiens (human)Potency29.849311
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency29.287422
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency33.491511
caspase-3Cricetulus griseus (Chinese hamster)Potency33.491511
caspase-3Homo sapiens (human)Potency33.491511
Caspase-7Cricetulus griseus (Chinese hamster)Potency33.491511
Cellular tumor antigen p53Homo sapiens (human)Potency26.836422
cytochrome P450 2C9, partialHomo sapiens (human)Potency27.188712
cytochrome P450 2D6Homo sapiens (human)Potency0.025012
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency0.577612
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency13.333211
estrogen nuclear receptor alphaHomo sapiens (human)Potency28.746099
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency10.590911
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency26.863444
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.258911
EWS/FLI fusion proteinHomo sapiens (human)Potency10.068322
farnesoid X nuclear receptorHomo sapiens (human)Potency33.488911
GVesicular stomatitis virusPotency27.188712
GALC proteinHomo sapiens (human)Potency0.631011
gemininHomo sapiens (human)Potency16.510822
GLI family zinc finger 3Homo sapiens (human)Potency20.608722
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency18.466233
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency29.849311
heat shock protein beta-1Homo sapiens (human)Potency33.488922
Histone H2A.xCricetulus griseus (Chinese hamster)Potency47.818022
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency27.188712
huntingtin isoform 2Homo sapiens (human)Potency15.848911
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency26.832522
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency27.188714
Interferon betaHomo sapiens (human)Potency28.176036
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency27.309422
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency26.327422
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency25.665122
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency7.943311
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency33.491522
ParkinHomo sapiens (human)Potency44.668411
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency14.381811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency29.764833
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency32.323022
phosphopantetheinyl transferaseBacillus subtilisPotency51.480622
PINK1Homo sapiens (human)Potency44.668411
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency11.220211
PPM1D proteinHomo sapiens (human)Potency29.410712
pregnane X nuclear receptorHomo sapiens (human)Potency7.361222
progesterone receptorHomo sapiens (human)Potency33.491511
RAR-related orphan receptor gammaMus musculus (house mouse)Potency29.849322
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency29.849333
retinoid X nuclear receptor alphaHomo sapiens (human)Potency18.176522
SMAD family member 2Homo sapiens (human)Potency19.501822
SMAD family member 3Homo sapiens (human)Potency19.501822
Smad3Homo sapiens (human)Potency35.481311
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.810711
TDP1 proteinHomo sapiens (human)Potency10.416224
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency8.101922
thyroid stimulating hormone receptorHomo sapiens (human)Potency33.491511
USP1 protein, partialHomo sapiens (human)Potency35.481311
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency21.455222
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency26.832511
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency29.849311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Angiotensin-converting enzyme 2 Homo sapiens (human)IC5028.200011
Cytochrome P450 2D6Homo sapiens (human)IC500.100011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Extracellular calcium-sensing receptorHomo sapiens (human)EC500.093333
Glycine receptor subunit alpha-1Homo sapiens (human)EC500.320011