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N-acylurea

A member of the class of ureas that has the general formula R-CO-NH-CO-NH2 or R-CO-NH-CO-NH-CO-R', formally derived by the acylation of one or both of the nitrogens of a urea moiety.

ChEBI ID: 74266

Members (16)

MemberDefinitionRole
5,6-dihydroorotateA pyrimidinemonocarboxylic acid that results from the base-catalysed cyclisation of N(alpha)-carbethoxyasparagine.dihydroorotic acid
apronalideapronal
bromisovalumAn N-acylurea that is urea in which one of the hydrogens is replaced by a 2-bromo-3-methybutanoyl group.2-bromo-N-carbamoyl-3-methylbutanamide
cabergolineAn N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.cabergoline
carbromalcarbromal
fluazuronAn N-acylurea that is urea in which one of the hydrogens has been replaced by a 3,6-difluorobenzoyl group, while a hydrogen attached to the other nitrogen has been replaced by a 4-chloro-3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl group. It is used to control ticks in cattle.fluazuron
fluphenacurlufenuron
hexafluoronAn N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.hexaflumuron
imidaprilA member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure.imidapril
imidaprilatA member of the class of imidazolidines that is imidapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of imidapril used to treat hypertension.imidaprilat
N-[(1-adamantylamino)-oxomethyl]-2-chloroacetamideN-[(1-adamantylamino)-oxomethyl]-2-chloroacetamide
N-[(2-methoxyanilino)-oxomethyl]benzamideN-[(2-methoxyanilino)-oxomethyl]benzamide
N-[(3-chloro-4-fluoroanilino)-oxomethyl]-4-methyl-5-thiadiazolecarboxamideN-[(3-chloro-4-fluoroanilino)-oxomethyl]-4-methyl-5-thiadiazolecarboxamide
N-[anilino(oxo)methyl]-2-methoxy-4-(trifluoromethyl)-3-pyridinecarboxamideN-[anilino(oxo)methyl]-2-methoxy-4-(trifluoromethyl)-3-pyridinecarboxamide
N-carbamoyl-2-[4-oxo-2-[(2-oxo-5H-thiazol-4-yl)hydrazo]-5-thiazolyl]acetamideN-carbamoyl-2-[4-oxo-2-[(2-oxo-5H-thiazol-4-yl)hydrazo]-5-thiazolyl]acetamide
teflubenzuronA N-acylurea that is N-carbamoyl-2,6-difluorobenzamide substituted by a 3,5-dichloro-2,4-difluorophenyl group at the terminal nitrogen atom.teflubenzuron

Research

Studies (1,932)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990164 (8.49)18.7374
1990's297 (15.37)18.2507
2000's645 (33.39)29.6817
2010's639 (33.07)24.3611
2020's187 (9.68)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials284 (13.25%)5.53%
Reviews208 (9.70%)6.00%
Case Studies373 (17.40%)4.05%
Observational11 (0.51%)0.25%
Other1,268 (59.14%)84.16%