Page last updated: 2024-08-05 15:33:04

EC 1.2.3.1 (aldehyde oxidase) inhibitor

An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1).

ChEBI ID: 62872

Members (2)

MemberDefinitionClass
isovanillinA member of the class of benzaldehydes that is 4-methoxybenzaldehyde substituted by a hydroxy group at position 3. It is an inhibitor of aldehyde oxidase.isovanillin
tamoxifentamoxifen

Research

Studies (19,584)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19902,505 (12.79)18.7374
1990's4,323 (22.07)18.2507
2000's5,896 (30.11)29.6817
2010's5,492 (28.04)24.3611
2020's1,368 (6.99)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,227 (10.77%)5.53%
Reviews2,768 (13.39%)6.00%
Case Studies1,253 (6.06%)4.05%
Observational61 (0.29%)0.25%
Other14,369 (69.49%)84.16%

Protein Targets (215)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency8.912511
acetylcholinesteraseHomo sapiens (human)Potency62.959424
activating transcription factor 6Homo sapiens (human)Potency44.053724
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency17.782811
Alpha-synucleinHomo sapiens (human)Potency18.356411
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency35.481311
AR proteinHomo sapiens (human)Potency40.6516610
arylsulfatase AHomo sapiens (human)Potency5.358211
Ataxin-2Homo sapiens (human)Potency48.340523
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency61.317212
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency35.481311
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency44.301612
caspase-3Cricetulus griseus (Chinese hamster)Potency39.483912
caspase-3Homo sapiens (human)Potency44.301612
Caspase-7Cricetulus griseus (Chinese hamster)Potency39.483912
Cellular tumor antigen p53Homo sapiens (human)Potency53.896425
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency31.622822
Chain A, Beta-lactamaseEscherichia coli K-12Potency5.011911
Chain A, Ferritin light chainEquus caballus (horse)Potency25.285512
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency44.668411
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency8.912511
chromobox protein homolog 1Homo sapiens (human)Potency58.430723
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency31.622811
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency31.622822
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency6.025012
D(1A) dopamine receptorHomo sapiens (human)Potency6.020022
D(1A) dopamine receptorSus scrofa (pig)Potency14.689211
DNA polymerase III, partialBacillus subtilisPotency29.934911
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.48451020
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency54.291834
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency33.0717915
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency14.814914
farnesoid X nuclear receptorHomo sapiens (human)Potency49.592433
Fumarate hydrataseHomo sapiens (human)Potency35.481311
GABA theta subunitRattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency31.622811
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency31.622811
gemininHomo sapiens (human)Potency7.147422
GLI family zinc finger 3Homo sapiens (human)Potency20.840824
GLS proteinHomo sapiens (human)Potency35.481311
glucocerebrosidaseHomo sapiens (human)Potency24.702812
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency27.981436
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency4.430212
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.118711
heat shock protein beta-1Homo sapiens (human)Potency54.941022
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency6.309614
Histone H2A.xCricetulus griseus (Chinese hamster)Potency46.087624
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency45.907924
IDH1Homo sapiens (human)Potency16.360111
importin subunit beta-1 isoform 1Homo sapiens (human)Potency50.118711
Integrin alpha-IIbHomo sapiens (human)Potency31.622811
Integrin beta-3Homo sapiens (human)Potency31.622811
Interferon betaHomo sapiens (human)Potency30.088313
lethal factor (plasmid)Bacillus anthracis str. A2012Potency31.622811
M-phase phosphoprotein 8Homo sapiens (human)Potency21.192311
Microtubule-associated protein tauHomo sapiens (human)Potency18.854112
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency58.047911
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency35.618423
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency26.706324
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency23.735822
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency68.694334
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency58.932134
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency54.941022
phosphopantetheinyl transferaseBacillus subtilisPotency51.020424
polyproteinZika virusPotency35.481311
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency6.309612
PPM1D proteinHomo sapiens (human)Potency30.088312
pregnane X nuclear receptorHomo sapiens (human)Potency12.021412
progesterone receptorHomo sapiens (human)Potency68.910434
RAR-related orphan receptor gammaMus musculus (house mouse)Potency29.361824
ras-related protein Rab-9AHomo sapiens (human)Potency91.999711
regulator of G-protein signaling 4Homo sapiens (human)Potency11.018012
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency50.191036
retinoid X nuclear receptor alphaHomo sapiens (human)Potency38.609723
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency18.498244
SMAD family member 2Homo sapiens (human)Potency59.353635
SMAD family member 3Homo sapiens (human)Potency59.353635
snurportin-1Homo sapiens (human)Potency50.118711
TDP1 proteinHomo sapiens (human)Potency24.204924
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency12.125935
thyroid stimulating hormone receptorHomo sapiens (human)Potency64.087524
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency27.318524
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency11.220211
USP1 protein, partialHomo sapiens (human)Potency59.664912
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency20.518824
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency61.644822
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency46.485213
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency4.430212

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)IC500.012011
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)Ki0.005011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC5012.160011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki6.949011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC5012.160011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)Ki6.949011
5-hydroxytryptamine receptor 2AHomo sapiens (human)IC504.801011
5-hydroxytryptamine receptor 2AHomo sapiens (human)Ki1.372011
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC502.084011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki1.326011
5-hydroxytryptamine receptor 2CHomo sapiens (human)IC500.460011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki0.241011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)IC500.460011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)Ki0.241011
5-hydroxytryptamine receptor 6Homo sapiens (human)IC502.679011
5-hydroxytryptamine receptor 6Homo sapiens (human)Ki1.142522
7-dehydrocholesterol reductaseHomo sapiens (human)IC500.012011
Adenosine receptor A1Homo sapiens (human)IC5023.767011
Adenosine receptor A1Homo sapiens (human)Ki13.864011
Adenosine receptor A2aHomo sapiens (human)IC507.099011
Adenosine receptor A2aHomo sapiens (human)Ki3.985011
Adenosine receptor A3Homo sapiens (human)IC503.701011
Adenosine receptor A3Homo sapiens (human)Ki2.092011
Aldehyde oxidaseHomo sapiens (human)IC5015.000011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC501.472011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki1.459011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC503.701011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki2.092011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC503.701011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki2.092011
Alpha-1D adrenergic receptorHomo sapiens (human)IC504.982011
Alpha-1D adrenergic receptorHomo sapiens (human)Ki2.449011
Alpha-2A adrenergic receptorHomo sapiens (human)IC501.935011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.726011
Alpha-2B adrenergic receptorHomo sapiens (human)IC503.518011
Alpha-2B adrenergic receptorHomo sapiens (human)Ki1.606011
Androgen receptorRattus norvegicus (Norway rat)IC5017.342322
Androgen receptorRattus norvegicus (Norway rat)Ki15.108011
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)IC500.967011
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)Ki0.792211
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
ATP-dependent translocase ABCB1Homo sapiens (human)IC5019.725044
ATP-dependent translocase ABCB1Homo sapiens (human)Ki0.100011
B2 bradykinin receptorHomo sapiens (human)IC5020.356011
B2 bradykinin receptorHomo sapiens (human)Ki12.048011
Beta-1 adrenergic receptorHomo sapiens (human)IC5017.289011
Beta-1 adrenergic receptorHomo sapiens (human)Ki9.984011
Beta-3 adrenergic receptorHomo sapiens (human)IC507.703011
Beta-3 adrenergic receptorHomo sapiens (human)Ki5.778011
Bile salt export pumpHomo sapiens (human)IC5063.340055
C-8 sterol isomeraseSaccharomyces cerevisiae S288CKi1.500011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Chain A, CES1 proteinHomo sapiens (human)Ki15.200011
Cytochrome P450 2B6Homo sapiens (human)Ki0.900011
Cytochrome P450 3A4Homo sapiens (human)Ki0.200011
D(1A) dopamine receptorHomo sapiens (human)IC508.502011
D(1A) dopamine receptorHomo sapiens (human)Ki4.251011
D(2) dopamine receptorHomo sapiens (human)IC5013.885011
D(2) dopamine receptorHomo sapiens (human)Ki4.628011
D(3) dopamine receptorHomo sapiens (human)IC501.072011
D(3) dopamine receptorHomo sapiens (human)Ki0.364011
D(4) dopamine receptorHomo sapiens (human)IC5011.161011
D(4) dopamine receptorHomo sapiens (human)Ki3.913011
Delta-type opioid receptorHomo sapiens (human)IC5013.339011
Delta-type opioid receptorHomo sapiens (human)Ki4.702011
Emopamil-binding protein-likeHomo sapiens (human)Ki0.002811
Epidermal growth factor receptorHomo sapiens (human)IC503.553011
Estrogen receptorHomo sapiens (human)IC501.17964141
Estrogen receptorHomo sapiens (human)Ki0.058644
Estrogen receptor betaHomo sapiens (human)IC501.27902222
Estrogen receptor betaHomo sapiens (human)Ki0.051044
Estrogen-related receptor gammaHomo sapiens (human)IC500.062211
Histamine H2 receptorHomo sapiens (human)IC509.396011
Histamine H2 receptorHomo sapiens (human)Ki9.240011
Kappa-type opioid receptorHomo sapiens (human)IC5015.629011
Kappa-type opioid receptorHomo sapiens (human)Ki6.252011
Melanocortin receptor 3Homo sapiens (human)IC5019.856011
Melanocortin receptor 3Homo sapiens (human)Ki17.329011
Melanocortin receptor 4Homo sapiens (human)IC5030.481011
Melanocortin receptor 4Homo sapiens (human)Ki29.308011
Melanocortin receptor 5Homo sapiens (human)IC5026.529011
Melanocortin receptor 5Homo sapiens (human)Ki24.886011
Mu-type opioid receptorHomo sapiens (human)IC5017.594011
Mu-type opioid receptorHomo sapiens (human)Ki7.142011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Muscarinic acetylcholine receptor M1Homo sapiens (human)IC502.829011
Muscarinic acetylcholine receptor M1Homo sapiens (human)Ki0.681011
Muscarinic acetylcholine receptor M2Homo sapiens (human)IC507.793011
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki2.771011
Muscarinic acetylcholine receptor M3Homo sapiens (human)IC502.974011
Muscarinic acetylcholine receptor M3Homo sapiens (human)Ki0.630011
Muscarinic acetylcholine receptor M4Homo sapiens (human)IC504.817011
Muscarinic acetylcholine receptor M4Homo sapiens (human)Ki0.672011
Muscarinic acetylcholine receptor M5Homo sapiens (human)IC502.585011
Muscarinic acetylcholine receptor M5Homo sapiens (human)Ki1.857011
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)IC500.967011
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)Ki0.792211
Phospholipase D1Homo sapiens (human)IC5020.000011
Phospholipase D1 Rattus norvegicus (Norway rat)IC5020.000011
Platelet-activating factor acetylhydrolaseHomo sapiens (human)IC500.904011
Polyphenol oxidase 2Agaricus bisporusIC50500.000011
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)Ki0.084422
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC501.275922
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)Ki0.792211
Progesterone receptorHomo sapiens (human)IC5050.064422
Prostaglandin G/H synthase 1Homo sapiens (human)IC504.391011
Protein kinase C alpha typeHomo sapiens (human)IC5010.500022
Protein kinase C alpha typeRattus norvegicus (Norway rat)IC5075.000011
Protein kinase C beta typeHomo sapiens (human)IC5010.500022
Protein kinase C beta typeRattus norvegicus (Norway rat)IC5075.000011
Protein kinase C delta typeHomo sapiens (human)IC5010.500022
Protein kinase C delta typeRattus norvegicus (Norway rat)IC5075.000011
Protein kinase C epsilon typeHomo sapiens (human)IC5010.500022
Protein kinase C epsilon typeRattus norvegicus (Norway rat)IC5075.000011
Protein kinase C eta typeHomo sapiens (human)IC5010.500022
Protein kinase C eta typeRattus norvegicus (Norway rat)IC5075.000011
Protein kinase C gamma typeHomo sapiens (human)IC5010.500022
Protein kinase C gamma typeRattus norvegicus (Norway rat)IC5075.000011
Protein kinase C iota typeHomo sapiens (human)IC5010.500022
Protein kinase C theta typeHomo sapiens (human)IC5010.500022
Protein kinase C theta typeRattus norvegicus (Norway rat)IC5075.000011
Protein kinase C zeta typeHomo sapiens (human)IC5010.500022
Protein kinase C zeta typeRattus norvegicus (Norway rat)IC5075.000011
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)IC502.949011
Serine/threonine-protein kinase D1Homo sapiens (human)IC5010.500022
Serine/threonine-protein kinase D3Homo sapiens (human)IC5010.500022
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)IC5030.573011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC500.021011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki0.021922
Sodium-dependent dopamine transporter Homo sapiens (human)IC501.841011
Sodium-dependent dopamine transporter Homo sapiens (human)Ki1.462011
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC501.472011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki1.459011
Sodium-dependent serotonin transporterHomo sapiens (human)IC502.334011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki1.240011
Steroid hormone receptor ERR1Homo sapiens (human)IC500.200011
Substance-K receptorHomo sapiens (human)IC503.670011
Substance-K receptorHomo sapiens (human)Ki1.223011
Substance-P receptorHomo sapiens (human)IC5015.656011
Substance-P receptorHomo sapiens (human)Ki8.540011
Thromboxane-A synthase Homo sapiens (human)IC500.916011
Transcriptional activator protein LuxRAliivibrio fischeriIC5040.000011
Tyrosine-protein kinase FynHomo sapiens (human)IC501.195011
Tyrosine-protein kinase LckHomo sapiens (human)IC508.033011
ubiquitin-conjugating enzyme E2 NHomo sapiens (human)IC5020.000011
Xanthine dehydrogenase/oxidaseHomo sapiens (human)IC5050.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)Kd0.001011
7-dehydrocholesterol reductaseHomo sapiens (human)Kd0.001011
Angiotensin-converting enzyme 2 Homo sapiens (human)EC5051.495012
ATP-dependent translocase ABCB1Homo sapiens (human)EC5056.500011
Estrogen receptorHomo sapiens (human)EC501.156835
Estrogen receptorRattus norvegicus (Norway rat)EC50150.000012
Estrogen receptor betaHomo sapiens (human)EC500.980835
Estrogen receptor betaRattus norvegicus (Norway rat)EC50150.000012
Lysosomal acid glucosylceramidaseHomo sapiens (human)EC502.500011
Procathepsin LHomo sapiens (human)EC5051.495012
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusEC5051.495012
Replicase polyprotein 1abBetacoronavirus England 1EC5051.495012
Replicase polyprotein 1abHuman coronavirus 229EEC5051.495012
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2EC5051.495012
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusEC5051.495012
Spike glycoproteinBetacoronavirus England 1EC5051.495012
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusEC5051.495012
streptokinase A precursorStreptococcus pyogenes M1 GASEC5078.086022
Transmembrane protease serine 2Homo sapiens (human)EC5051.495012

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Estrogen receptorRattus norvegicus (Norway rat)A500.020011
Estrogen receptorHomo sapiens (human)DC500.091011
Estrogen receptor betaRattus norvegicus (Norway rat)A500.020011
interferon gamma precursorHomo sapiens (human)AC5035.240011
UDP-glucuronosyltransferase 1A4Homo sapiens (human)Km32.000011