Complex IV Deficiency

A disease that results from a congenital defect in ELECTRON TRANSPORT COMPLEX IV. Defects in ELECTRON TRANSPORT COMPLEX IV can be caused by mutations in the SURF1, SCO2, COX10, or SCO1 genes. ELECTRON TRANSPORT COMPLEX IV deficiency caused by mutation in SURF1 manifests itself as LEIGH DISEASE; that caused by mutation in SCO2 as fatal infantile cardioencephalomyopathy; that caused by mutation in COX10 as tubulopathy and leukodystrophy; and that caused by mutation in SCO1 as early-onset hepatic failure and neurologic disorder. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#220110, May 17, 2001)

Synonym
Deficiency, Cytochrome-c Oxidase
Mitochondrial Complex IV Deficiency
Complex IV Deficiency
Cox Deficiency
Cytochrome C Oxidase Deficiency
Cytochrome Oxidase Deficiency
Cytochrome-c Oxidase Deficiency

Excerpt	Reference
"Cox deficiency is associated with hematopoietic diseases such as tubulopathy and leukodystrophy, but whether and how cox17 functions in hematopoiesis are still unknown."	( Chen, M; Li, L; Liu, JX; Liu, W; Liu, X; Tai, P, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	30 (17.96)	23.3326
1990's	74 (44.31)	12.5806
2000's	36 (21.56)	18.1394
2010's	22 (13.17)	28.8240
2020's	5 (2.99)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	3	0
carnitine	low	15	0
malic acid	low	1	0
lactic acid	low	22	0
dimethylglycine	medium	1	1
glycine	low	1	0
hydrogen carbonate	low	1	0
pyruvic acid	low	18	0
sarcosine	medium	1	1
succinic acid	low	4	0
thiamine	medium	3	1
thymine	low	1	0
carbonyl cyanide m-chlorophenyl hydrazone	low	1	0
valproic acid	low	5	0
gemfibrozil	low	1	0
hydrochlorothiazide	low	1	0
indomethacin	low	1	0
thymidine	low	1	0
prednisone	low	1	0
alanine	low	1	0
uridine	low	1	0
galactose	low	1	0
tyrosine	low	1	0
cysteamine	low	1	0
methylene blue	low	1	0
leucine	low	1	0
phenylalanine	low	1	0
histidine	low	3	0
threonine	low	1	0
isoleucine	low	1	0
dichloroacetic acid	low	3	0
rotenone	low	1	0
thiamine pyrophosphate	medium	1	1
cyclopentane	low	1	0
nitroblue tetrazolium	low	1	0
methylphenazonium methosulfate	low	1	0
aminoimidazole carboxamide	low	2	0
malondialdehyde	low	1	0
myristic acid	low	1	0
ethylmalonic acid	low	4	0
acetylcysteine	low	2	0
methionine sulfoximine	low	1	0
buthionine sulfoximine	low	1	0
gold	low	1	0
zalcitabine	low	1	0
phytanic acid	low	2	0
4-methoxyamphetamine	low	1	0
glutamic acid	low	3	0
azides	low	1	0
zidovudine	low	7	0
bezafibrate	low	4	0
enoximone	low	1	0
adefovir	low	1	0
acridine orange	low	1	0
aica ribonucleotide	low	2	0
bilobalide	low	1	0
coenzyme a	low	2	0
homocysteine	low	1	0
deoxyglucose	low	1	0
copper bis(histidinate)	low	2	0
biotin	low	1	0
organophosphonates	low	1	0
glycogen	low	1	0
resveratrol	low	2	0
cerivastatin	low	1	0
riboflavin	medium	4	1
sodium bicarbonate	low	1	0
isomethyleugenol	low	1	0
stilbenes	low	2	0
flunarizine	low	1	0
valinomycin	low	1	0
cystine	low	1	0
2,4-dinitrophenylhydrazine	low	1	0
vitamin k semiquinone radical	low	1	0
coenzyme q10	low	5	0
cysteine	low	2	0
phosphorus	low	1	0
2-(4-(dimethylamino)styryl)-1-methylpyridinium	low	1	0
antimycin a	low	1	0
phosphocreatine	low	1	0
nad	low	3	0
cytochrome c-t	medium	3	1
glucagon	low	1	0
anticodon	low	2	0
ubiquinone	low	9	0
heme	low	7	0
ascorbic acid	low	1	0
antimycin	low	1	0
oligomycins	low	1	0
flavin mononucleotide	medium	1	1
guanine	low	2	0
eye	low	1	0
leptin	low	1	0

Protein Targets (837)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 1A	0	3	1	5
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	2	1	3
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	10	0	0	10
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	5	0	0	5
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	8	0	0	8
RAR-related orphan receptor gamma	19	0	0	19
USP1 protein, partial	8	0	0	8
NFKB1 protein, partial	3	0	0	3
Microtubule-associated protein tau	9	0	0	9
Thrombopoietin	1	0	0	1
AR protein	21	0	0	21
regulator of G-protein signaling 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	19	0	0	19
retinoic acid nuclear receptor alpha variant 1	20	0	0	20
retinoid X nuclear receptor alpha	14	0	0	14
farnesoid X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	27	0	0	27
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
Bloom syndrome protein isoform 1	6	0	0	6
D(1A) dopamine receptor	3	0	0	3
thyroid hormone receptor beta isoform a	12	0	0	12
thyroid hormone receptor beta isoform 2	15	0	0	15
heat shock protein beta-1	9	0	0	9
flap endonuclease 1	5	0	0	5
geminin	17	0	0	17
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	9	0	0	9
muscarinic acetylcholine receptor M1	2	0	0	2
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	3	0	5
Histone deacetylase 4	0	3	0	3
Guanine nucleotide-binding protein G	5	0	0	5
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	8	0	0	8
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	9	0	0	9
Telomerase reverse transcriptase	0	1	0	1
Amyloid-beta precursor protein	0	3	1	4
Reverse transcriptase/RNaseH	0	3	3	10
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Phosphoribosyl pyrophosphate synthase-associated protein 2	0	1	0	2
Adenylate kinase isoenzyme 1	0	0	0	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Adenosine deaminase	0	1	0	2
Capsid protein	0	0	1	1
Solute carrier family 22 member 6	0	2	0	4
Solute carrier family 22 member 8	0	1	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
estrogen-related nuclear receptor alpha	21	0	0	21
pregnane X nuclear receptor	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	15	0	15
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	8	2	1	11
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	6	0	0	6
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	6	0	0	6
Fructose-1,6-bisphosphatase 1	0	1	0	2
Bifunctional purine biosynthesis protein ATIC	0	1	0	2
Histidine triad nucleotide-binding protein 1	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Carbonic anhydrase 1	0	6	0	12
Carbonic anhydrase 2	0	7	0	13
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	2	10
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
chromobox protein homolog 1	13	0	0	13
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Guanine deaminase	0	1	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
vitamin D3 receptor isoform VDRA	7	0	0	7
cytochrome P450 3A4 isoform 1	9	0	0	9
caspase-1 isoform alpha precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit delta	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-2	9	0	0	9
GABA theta subunit	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	9	0	0	9
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	12	0	0	12
thioredoxin glutathione reductase	4	0	0	4
IDH1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	16	0	0	16
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	7	0	0	7
Polyphenol oxidase 2	0	2	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	2	1	3
Spike glycoprotein	9	0	0	9
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	1	1	3
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Carbonic anhydrase 4	0	5	0	8
Carbonic anhydrase	0	3	0	6
Carbonic anhydrase 15	0	3	0	6
Luciferase	10	0	0	10
thioredoxin reductase	7	0	0	7
G	8	0	0	8
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	10	0	0	10
Glutamate receptor ionotropic, NMDA 2D	0	1	1	2
Glutamate receptor ionotropic, NMDA 3B	0	1	1	2
Bile salt export pump	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	1	3
Interferon beta	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Fatty acid-binding protein, liver	0	3	0	3
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	0	1	2
Glutamate receptor ionotropic, NMDA 1	0	1	1	2
Peroxisome proliferator-activated receptor alpha	1	0	3	4
Glutamate receptor ionotropic, NMDA 2A	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	1	1	2
Glutamate receptor ionotropic, NMDA 2C	0	1	1	2
Glutamate receptor ionotropic, NMDA 3A	0	1	1	2
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
EWS/FLI fusion protein	5	0	0	5
Chain A, PAPAIN	1	0	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Ferritin light chain	4	0	0	4
Chain A, Cruzipain	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
thyroid stimulating hormone receptor	5	0	0	5
estrogen receptor 2 (ER beta)	10	0	0	10
progesterone receptor	9	0	0	9
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	4	0	0	4
histone deacetylase 9 isoform 3	5	0	0	5
nuclear receptor ROR-gamma isoform 1	7	0	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Cellular tumor antigen p53	12	0	0	12
Histamine H2 receptor	8	0	0	8
Inositol monophosphatase 1	5	0	0	5
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Insulin receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	4	1	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
glp-1 receptor, partial	5	0	0	5
ATAD5 protein, partial	7	0	0	7
GLS protein	4	0	0	4
cytochrome P450 2D6	6	0	0	6
thyroid stimulating hormone receptor	6	0	0	6
serine-protein kinase ATM isoform a	2	0	0	2
peripheral myelin protein 22 isoform 1	5	0	0	5
cytochrome P450 2C9 precursor	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
serine/threonine-protein kinase PLK1	3	0	0	3
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	7	0	0	7
neuropeptide S receptor isoform A	4	0	0	4
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	7	0	7
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Potassium channel subfamily K member 2	0	0	1	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Aldo-keto reductase family 1 member B1	0	5	0	5
Sodium channel protein type 3 subunit alpha	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Cytochrome P450 2C9	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	2	6
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Cytochrome P450 2J2	0	3	0	3
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	2	1	3
DNA polymerase kappa isoform 1	3	0	0	3
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
interleukin 8	2	0	0	2
Smad3	2	0	0	2
aryl hydrocarbon receptor	6	0	0	6
Transthyretin	0	0	2	2
Cytochrome P450 2C8	0	1	0	1
Cannabinoid receptor 2	0	0	1	1
Guanylate cyclase soluble subunit alpha-1	0	0	1	1
Guanylate cyclase soluble subunit beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1B3	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	2	9
Glutamate receptor ionotropic, NMDA 2B	0	4	2	9
Glutamate receptor ionotropic, NMDA 2C	0	4	2	9
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	4	2	9
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	4	2	9
Alpha-ketoglutarate-dependent dioxygenase FTO	0	3	0	3
Glutamate receptor ionotropic, NMDA 3A	0	4	2	9
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	6	0	7
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	2	0	5
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	2	0	5
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 6	0	3	0	6
Adenosine receptor A1	0	1	0	4
Adenosine receptor A2a	0	1	0	4
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
Carbonic anhydrase 7	0	2	0	5
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 9	0	3	0	6
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	3	0	6
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
Hsf1 protein	0	0	1	1
Carbonic anhydrase	0	1	0	1
Albumin	0	2	3	5
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
67.9K protein	2	0	0	2
glucocerebrosidase	1	0	0	1
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	8	0	0	8
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	1	5
Procathepsin L	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	3
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Chain A, Beta-lactamase	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Methyl-accepting chemotaxis protein NahY	0	0	2	2
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
Fumarate hydratase	2	0	0	2
PPM1D protein	2	0	0	2
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
caspase 7, apoptosis-related cysteine protease	3	0	0	3
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
polyprotein	2	0	0	2
luciferase	1	0	0	1
caspase-3	3	0	0	3
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	2	0	0	2
DNA polymerase beta	3	0	0	3
mitogen-activated protein kinase 1	3	0	0	3
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
Vpr	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	2	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Cruzipain	0	1	0	1
Alpha-synuclein	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	2	2
phosphoglycerate kinase	1	0	0	1
acid sphingomyelinase	1	0	0	1
Toll-like receptor 2	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Dynamin-1	0	1	0	1
G-protein coupled receptor 84	0	1	1	2
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
ClpP	1	0	0	1
P53	1	0	0	1
pyruvate kinase	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
glucokinase regulatory protein	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	1	2
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Tyrosine-protein kinase ABL1	0	1	0	2
Myc proto-oncogene protein	0	1	0	2
Estrogen receptor	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Cholinesterase	0	1	0	1
Cathepsin D	0	1	0	1
Luciferin 4-monooxygenase	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
DNA polymerase alpha catalytic subunit	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Leukotriene A-4 hydrolase	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	3	0	3
Aromatase	0	2	0	2
Ornithine decarboxylase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Protein kinase C alpha type	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Estrogen receptor	0	0	1	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Endothelin receptor type B	1	0	0	1
Acetylcholinesterase	0	1	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Endothelin-1 receptor	1	0	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Cannabinoid receptor 1	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Alpha-glucosidase MAL12	0	1	0	1
Cholinesterase	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
Cytochrome P450 1B1	0	2	0	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	3
Tubulin beta-2B chain	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Prenyltransferase homolog	0	0	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
large T antigen	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
nonstructural protein 1	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Lysine-specific demethylase 4E	0	1	0	1
Delta-aminolevulinic acid dehydratase	0	1	0	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 13 member 3	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	4	0	7
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	3
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	2	0	4
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	1	0	3
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Protein cereblon	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
GALC protein	1	0	0	1
Deoxycytidine kinase	0	1	0	1
C-X-C chemokine receptor type 4	0	0	1	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protease	0	1	1	2
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(7)

Research Excerpts

Overview

Research

Studies (167)

Protein Targets (837)

Complex IV Deficiency

Synonyms(7)

Research Excerpts

Overview

Research

Studies (167)

Drugs Studied (108)

Protein Targets (837)