Page last updated: 2024-09-27

Eisenmenger Complex

A condition associated with VENTRICULAR SEPTAL DEFECT and other congenital heart defects that allow the mixing of pulmonary and systemic circulation, increase blood flow into the lung, and subsequent responses to low oxygen in blood. This complex is characterized by progressive PULMONARY HYPERTENSION; HYPERTROPHY of the RIGHT VENTRICLE; CYANOSIS; and ERYTHROCYTOSIS.

Synonyms(1)

Synonym
Eisenmenger Complex

Research

Studies (215)

TimeframeStudies, This Condition (%)All Conditions %
pre-199036 (16.74)23.3326
1990's23 (10.70)12.5806
2000's68 (31.63)18.1394
2010's81 (37.67)28.8240
2020's7 (3.26)9.53
DrugIndicatedRelationship StrengthStudiesTrials
carbon monoxide0low10
choline0low10
n(g),n(g')-dimethyl-l-arginine0low10
creatine0low10
hydrogen0low10
uric acid0low10
normetanephrine0low10
3,4-methylenedioxyamphetamine0low10
albuterol0low10
amiodarone0low20
aspirin0low10
azathioprine0low10
bunazosin0low10
bupivacaine0low20
fenfluramine0low10
fentanyl0low40
furosemide0low20
2-propanol0low10
isoproterenol0low10
ketamine0low20
metoprolol0low20
milrinone0low10
nifedipine0medium52
nitroglycerin0low10
papaverine0low10
propofol0low40
sevoflurane0low10
ticlopidine0low10
tolazoline0low30
carbachol0low10
prednisone0low10
metaraminol0low20
aspartic acid0low10
phenylephrine0low30
methylene blue0low10
tryptophan0low10
arginine0low20
methylprednisolone0low10
thiophenes0medium41
quinazolines0low10
isoxazoles0medium41
pyrazines0low10
citrulline0medium11
n-pentyl nitrite0low10
vancomycin0low10
aminorex0low10
streptomycin0low10
platinum0low10
technetium0low30
gadolinium0low40
xenon0low10
trolamine salicylate0low10
4-methoxyamphetamine0low30
transferrin0low10
dobutamine0low20
sufentanil0low10
atracurium0low10
clopidogrel0low10
remifentanil0low30
fluorodeoxyglucose f180low10
fibrinogen0low10
n,n-dimethylarginine0low10
naproxen0low10
citrulline malate0medium11
tbc-112510medium41
glycogen0low10
oxytocin0low20
zithromax0low10
etomidate0low20
digoxin0low10
bilirubin0low10
dinoprostone0low10
vitamin k semiquinone radical0low10
morphine0low20
iloprost0medium62
thallium0low10
urobilin0low10
ferrous fumarate0low10
aminorex fumarate0low10
beraprost0medium11
u 628400low20
lu 2080750low40
phosphocreatine0low10
selexipag0low10
macitentan0medium31
endothelin-10medium31
technetium tc 99m sestamibi0low10
cardiovascular agents0low20
piperidines0low30
vasoactive intestinal peptide0low10
natriuretic peptide, brain0medium133
ascorbic acid0low20
warfarin0low30
transforming growth factor beta0low10
cyclosporine0low10
cyclic gmp0low20
sildenafil citrate0medium348
eye0low10

Protein Targets (926)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma150015
GLI family zinc finger 3200020
AR protein230023
aldehyde dehydrogenase 1 family, member A1160016
retinoic acid nuclear receptor alpha variant 1240024
retinoid X nuclear receptor alpha120012
estrogen nuclear receptor alpha290029
peroxisome proliferator-activated receptor delta9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
activating transcription factor 6110011
v-jun sarcoma virus 17 oncogene homolog (avian)110011
Histone H2A.x7007
thyroid hormone receptor beta isoform a5005
heat shock protein beta-19009
nuclear factor erythroid 2-related factor 2 isoform 1160016
lamin isoform A-delta10200020
Voltage-dependent calcium channel gamma-2 subunit7007
Glutamate receptor 27007
5-hydroxytryptamine receptor 2C0224
5-hydroxytryptamine receptor 2A0426
5-hydroxytryptamine receptor 1A0235
Sodium-dependent noradrenaline transporter 0819
Sodium-dependent dopamine transporter0011
5-hydroxytryptamine receptor 1B0123
5-hydroxytryptamine receptor 1D0123
5-hydroxytryptamine receptor 1F0123
5-hydroxytryptamine receptor 2B0224
5-hydroxytryptamine receptor 60022
Sodium-dependent serotonin transporter08210
Sodium-dependent serotonin transporter0426
5-hydroxytryptamine receptor 7 0022
5-hydroxytryptamine receptor 5A0022
5-hydroxytryptamine receptor 5B0022
5-hydroxytryptamine receptor 3A0022
Sodium-dependent dopamine transporter 0606
5-hydroxytryptamine receptor 4 0022
5-hydroxytryptamine receptor 3B0022
ATAD5 protein, partial7007
GLS protein120012
Microtubule-associated protein tau9009
Smad34004
thyroid stimulating hormone receptor150015
nuclear receptor subfamily 1, group I, member 3120012
progesterone receptor130013
EWS/FLI fusion protein140014
estrogen-related nuclear receptor alpha250025
peroxisome proliferator activated receptor gamma140014
aryl hydrocarbon receptor100010
chromobox protein homolog 1150015
thyroid hormone receptor beta isoform 2160016
peripheral myelin protein 22130013
cytochrome P450 3A4 isoform 1100010
Gamma-aminobutyric acid receptor subunit pi102214
ATP-binding cassette sub-family C member 3019019
Multidrug resistance-associated protein 4019021
Solute carrier family 22 member 60404
Carbonic anhydrase 120306
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0909
Bile salt export pump032032
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 106010
Carbonic anhydrase 206010
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20102
Prostaglandin G/H synthase 10303
Carbonic anhydrase 30305
Cytochrome P450 3A407210
Cytochrome P450 2D60303
Cytochrome P450 2C9 0707
Polyunsaturated fatty acid lipoxygenase ALOX150505
Gamma-aminobutyric acid receptor subunit beta-1102214
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta102214
Gamma-aminobutyric acid receptor subunit gamma-2102214
UDP-glucuronosyltransferase 1-60102
Gamma-aminobutyric acid receptor subunit alpha-5102214
Gamma-aminobutyric acid receptor subunit alpha-3102214
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0102
Carbonic anhydrase 40306
Prostaglandin G/H synthase 10606
Carbonic anhydrase 60306
Gamma-aminobutyric acid receptor subunit gamma-1102214
Gamma-aminobutyric acid receptor subunit alpha-2102214
Gamma-aminobutyric acid receptor subunit alpha-4102214
Gamma-aminobutyric acid receptor subunit gamma-3102214
Gamma-aminobutyric acid receptor subunit alpha-6102214
Carbonic anhydrase 5A, mitochondrial0306
Prostaglandin G/H synthase 20304
Carbonic anhydrase 70306
Nuclear receptor ROR-gamma7119
Cytochrome P450 2J20606
Gamma-aminobutyric acid receptor subunit alpha-1103215
Gamma-aminobutyric acid receptor subunit beta-3102214
Gamma-aminobutyric acid receptor subunit beta-2102214
Carbonic anhydrase 90306
GABA theta subunit102214
Canalicular multispecific organic anion transporter 1016016
Carbonic anhydrase 150203
Carbonic anhydrase 130205
Gamma-aminobutyric acid receptor subunit epsilon102214
Carbonic anhydrase 140306
Carbonic anhydrase 5B, mitochondrial0306
toxin B0001
glp-1 receptor, partial9009
thioredoxin reductase150015
regulator of G-protein signaling 46006
NPYLR7B0033
arylsulfatase A7007
euchromatic histone-lysine N-methyltransferase 2240024
thyroid stimulating hormone receptor130013
flap endonuclease 17007
Beta-2 adrenergic receptor08615
Beta-1 adrenergic receptor08513
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0202
Beta-3 adrenergic receptor0347
Delta-type opioid receptor0528
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
Beta-2 adrenergic receptor 0125
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Beta-2 adrenergic receptor0258
ATP-dependent phosphofructokinase100010
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
acetylcholinesterase9009
phosphopantetheinyl transferase120012
SMAD family member 27007
Fumarate hydratase7007
USP1 protein, partial6006
NFKB1 protein, partial6006
PPM1D protein8008
SMAD family member 37007
TDP1 protein170017
Thrombopoietin3003
caspase 7, apoptosis-related cysteine protease3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)8008
estrogen receptor 2 (ER beta)8008
glucocorticoid receptor [Homo sapiens]190019
farnesoid X nuclear receptor100010
pregnane X nuclear receptor190019
G160016
cytochrome P450 2D6130013
polyprotein7007
caspase-33003
cytochrome P450 2D6 isoform 15005
cellular tumor antigen p53 isoform a4004
cytochrome P450 2C9 precursor3003
D(1A) dopamine receptor5005
potassium voltage-gated channel subfamily H member 2 isoform d5005
huntingtin isoform 23003
mitogen-activated protein kinase 17007
serine/threonine-protein kinase mTOR isoform 13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 16006
geminin210021
survival motor neuron protein isoform d5005
muscarinic acetylcholine receptor M1100010
lethal factor (plasmid)8008
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Solute carrier organic anion transporter family member 1A40203
Voltage-dependent L-type calcium channel subunit alpha-1F0303
5-hydroxytryptamine receptor 40606
Lysine-specific demethylase PHF20101
Interferon beta200020
HLA class I histocompatibility antigen, B alpha chain 160016
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p53130013
Integrin beta-33104
Tyrosine-protein kinase Fyn0202
ATP-dependent translocase ABCB10404
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20428
Muscarinic acetylcholine receptor M40428
ATP-dependent translocase ABCB1010114
Integrin alpha-IIb3104
Muscarinic acetylcholine receptor M50428
Alpha-2A adrenergic receptor0628
Adenosine receptor A30404
Cytochrome P450 2C80303
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10428
D(2) dopamine receptor0404
Androgen receptor0404
Alpha-1B adrenergic receptor010111
Lethal factor0101
Alpha-2B adrenergic receptor0718
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M30428
ATP-dependent translocase ABCB10404
Substance-K receptor0202
D(1A) dopamine receptor0303
D(4) dopamine receptor0404
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Histamine H2 receptor0202
Endothelin-1 receptor0909
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0606
Lysine-specific demethylase 5A0101
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor06310
D(3) dopamine receptor0606
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0404
Squalene synthase0101
Delta-type opioid receptor0618
Kappa-type opioid receptor0618
5-hydroxytryptamine receptor 2B0404
C-C chemokine receptor type 20404
Melanocortin receptor 30202
Alpha-1A adrenergic receptor010111
Histamine H2 receptor3014
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60202
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein120012
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Potassium voltage-gated channel subfamily H member 20909
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0607
Sodium channel protein type 5 subunit alpha0505
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0303
Lysine-specific demethylase 7A0101
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 1160016
Sodium channel protein type 2 subunit alpha0202
Ataxin-28008
Sigma non-opioid intracellular receptor 109110
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0202
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0202
Sodium channel protein type 10 subunit alpha0202
cytochrome P450 2C9, partial160016
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE150015
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
alpha-galactosidase2002
cytochrome P450 2C19 precursor7007
DNA polymerase iota isoform a (long)100010
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0203
Nitric oxide synthase, brain 0203
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase7007
cytochrome P450 family 3 subfamily A polypeptide 4200020
vitamin D (1,25- dihydroxyvitamin D3) receptor120012
IDH1100010
nuclear factor erythroid 2-related factor 2 isoform 25005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0102
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Ferritin light chain6006
Bloom syndrome protein isoform 19009
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0102
Glutamate receptor ionotropic, NMDA 1 0315
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0315
Glutamate receptor ionotropic, NMDA 2B0315
Glutamate receptor ionotropic, NMDA 2C0315
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0315
Glutamate receptor ionotropic, NMDA 3B0315
Carbonic anhydrase 40001
Glutamate receptor ionotropic, NMDA 3A0315
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, 2-oxoglutarate Oxygenase7007
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 85005
hypothetical protein, conserved3003
glucocerebrosidase1001
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase kappa isoform 14004
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0303
Fatty acid-binding protein, liver0101
Myeloperoxidase0202
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10202
Adenosine receptor A2a0303
Substance-P receptor0202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10112
Amine oxidase [flavin-containing] A 0011
Small conductance calcium-activated potassium channel protein 30112
P531001
peripheral myelin protein 22 isoform 13003
hemoglobin subunit beta1001
M-phase phosphoprotein 83003
muscleblind-like protein 1 isoform 14004
ATPase family AAA domain-containing protein 56006
Protein-arginine deiminase type-40404
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, Cruzipain4004
vitamin D3 receptor isoform VDRA8008
caspase-1 isoform alpha precursor1001
Caspase-71001
Inositol monophosphatase 14004
Solute carrier organic anion transporter family member 1B30304
Solute carrier organic anion transporter family member 1B10304
Nuclear receptor subfamily 1 group I member 20044
Endothelin receptor type B0314
Endothelin receptor type B0516
Endothelin-1 receptor0325
Endothelin receptor type B0011
Deoxyhypusine synthase0101
Sodium/bile acid cotransporter0303
Endothelin-1 receptor0101
Alpha-1D adrenergic receptor0314
Alpha-1A adrenergic receptor0224
Alpha-1B adrenergic receptor0224
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20123
Potassium channel subfamily K member 90101
Chain A, Beta-lactamase8008
GALC protein3003
thyrotropin-releasing hormone receptor2002
Neuronal acetylcholine receptor subunit alpha-30202
Muscarinic acetylcholine receptor M10316
Muscarinic acetylcholine receptor M30315
Muscarinic acetylcholine receptor M40304
Muscarinic acetylcholine receptor M50304
Neuronal acetylcholine receptor subunit alpha-40202
Muscarinic acetylcholine receptor M20304
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20202
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Muscarinic acetylcholine receptor M10112
Neuronal acetylcholine receptor subunit alpha-50202
Delta-type opioid receptor0305
Neuronal acetylcholine receptor subunit alpha-60202
Neuronal acetylcholine receptor subunit alpha-90202
Neuronal acetylcholine receptor subunit alpha-70202
Sigma non-opioid intracellular receptor 10415
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100202
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
streptokinase A precursor0022
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60202
30S ribosomal protein S70202
50S ribosomal protein L150202
50S ribosomal protein L100202
50S ribosomal protein L110202
50S ribosomal protein L7/L120202
50S ribosomal protein L190202
50S ribosomal protein L10202
50S ribosomal protein L200202
50S ribosomal protein L270202
50S ribosomal protein L280202
50S ribosomal protein L290202
50S ribosomal protein L310202
50S ribosomal protein L31 type B0202
50S ribosomal protein L320202
50S ribosomal protein L330202
50S ribosomal protein L340202
50S ribosomal protein L350202
50S ribosomal protein L360202
30S ribosomal protein S100202
30S ribosomal protein S110202
30S ribosomal protein S120202
30S ribosomal protein S130202
30S ribosomal protein S160202
30S ribosomal protein S180202
30S ribosomal protein S190202
30S ribosomal protein S200202
30S ribosomal protein S20202
30S ribosomal protein S30202
30S ribosomal protein S40202
30S ribosomal protein S50202
30S ribosomal protein S80202
30S ribosomal protein S90202
50S ribosomal protein L130202
50S ribosomal protein L140202
50S ribosomal protein L160202
50S ribosomal protein L230202
30S ribosomal protein S150202
50S ribosomal protein L170202
50S ribosomal protein L210202
50S ribosomal protein L300202
50S ribosomal protein L60202
30S ribosomal protein S140202
30S ribosomal protein S170202
30S ribosomal protein S10202
50S ribosomal protein L180202
50S ribosomal protein L20202
50S ribosomal protein L30202
50S ribosomal protein L240202
50S ribosomal protein L40202
50S ribosomal protein L220202
50S ribosomal protein L50202
30S ribosomal protein S210202
50S ribosomal protein L250202
50S ribosomal protein L36 20202
Methionine--tRNA ligase, mitochondrial0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20002
Solute carrier family 22 member 1 0507
Solute carrier family 22 member 20101
Acetylcholinesterase0202
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Solute carrier family 22 member 10102
High affinity choline transporter 10101
Solute carrier family 22 member 20102
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10203
General amino-acid permease GAP10001
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
72 kDa type IV collagenase0101
Stromelysin-10202
Matrix metalloproteinase-90101
Macrophage metalloelastase0101
nonstructural protein 13003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
Cytochrome P450 2B60303
Liver carboxylesterase 10001
Cytochrome P450 2C190404
Rap guanine nucleotide exchange factor 41001
P2Y purinoceptor 120101
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10101
Phosphodiesterase 0303
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0606
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0606
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
PAX80001
STAT3, partial0101
67.9K protein2002
NPC intracellular cholesterol transporter 1 precursor1001
tumor necrosis factor2002
ras-related protein Rab-9A3003
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 1A40001
prostaglandin E2 receptor EP2 subtype1001
Solute carrier organic anion transporter family member 1A50001
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0235
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0314
Prostaglandin E2 receptor EP2 subtype0235
Prostacyclin receptor0549
Solute carrier organic anion transporter family member 2A10103
Solute carrier family 22 member 60103
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 80102
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
dopamine D1 receptor2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Tyrosine-protein kinase Lck0101
POU domain, class 2, transcription factor 10002
Carbonic anhydrase 130101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit beta0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Gamma-aminobutyric acid receptor subunit alpha-10224
Cytochrome P450 11B1, mitochondrial0101
Gamma-aminobutyric acid receptor subunit gamma-20224
Cytochrome P450 11B2, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-20022
Gamma-aminobutyric acid receptor subunit beta-20123
Transporter0202
Luciferase5005
Amine oxidase [flavin-containing] A0202
Amine oxidase [flavin-containing] B0101
Mu-type opioid receptor07212
Kappa-type opioid receptor0416
Histamine H1 receptor0101
Kappa-type opioid receptor0404
Mu-type opioid receptor0316
Mu-type opioid receptor0404
Albumin0224
Glucose-6-phosphate 1-dehydrogenase0101
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
6-phosphogluconate dehydrogenase, decarboxylating0101
Holo-[acyl-carrier-protein] synthase0101
Multidrug and toxin extrusion protein 10202
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Prostacyclin receptor0123
Prostaglandin D2 receptor0033
Beta-1 adrenergic receptor 0023
beta-2 adrenergic receptor2002
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0427
Beta-2 adrenergic receptor0011
Alpha-2B adrenergic receptor0516
Alpha-2C adrenergic receptor0516
Alpha-2A adrenergic receptor0516
Alpha-1D adrenergic receptor0617
Beta-adrenergic receptor kinase 10011
Beta-3 adrenergic receptor0011
Beta-3 adrenergic receptor0112
Vasopressin V1a receptor0112
Beta-1 adrenergic receptor0213
Beta-2 adrenergic receptor0101
Taste receptor type 2 member 380011
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310011
Taste receptor type 2 member 450011
Taste receptor type 2 member 460011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600011
Oxytocin receptor0112
Taste receptor type 2 member 420011
Taste receptor type 2 member 160011
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 100011
Taste receptor type 2 member 90011
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40011
Taste receptor type 2 member 30011
Taste receptor type 2 member 10011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0202
Glutamate receptor ionotropic, NMDA 3B0101
Rap guanine nucleotide exchange factor 32002
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
Potassium voltage-gated channel subfamily A member 50202
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Potassium voltage-gated channel subfamily E member 10202
Potassium voltage-gated channel subfamily KQT member 10202
Potassium voltage-gated channel subfamily D member 30101
Macrophage migration inhibitory factor0202
Chain E, Fibrin beta chain0101
Chain A, JmjC domain-containing histone demethylation protein 3A3003
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
TSHR protein1001
Apoptotic peptidase activating factor 10101
isocitrate dehydrogenase 1, partial1001
luciferase1001
bromodomain adjacent to zinc finger domain 2B4004
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
caspase-9 isoform alpha precursor0101
histone deacetylase 9 isoform 31001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
DNA polymerase eta isoform 11001
Vpr2002
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A1001
Glutathione reductase0101
Glutathione reductase, mitochondrial0304
Glycoprotein hormones alpha chain1001
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Cruzipain0101
Alpha-synuclein1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 432002
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
nuclear receptor subfamily 1, group I, member 23003
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor subfamily 1 group I member 20011
Translocator protein0112
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
cGMP-dependent 3',5'-cyclic phosphodiesterase0303
Aurora kinase A0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0303
cGMP-specific 3',5'-cyclic phosphodiesterase0516
3',5'-cyclic-AMP phosphodiesterase 0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Dual specificity protein kinase TTK0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0303
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0303
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0404
cGMP-specific 3',5'-cyclic phosphodiesterase0202
Aurora kinase B0101
Inner centromere protein0101
Phosphodiesterase 0202
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Histidine decarboxylase0011
Proteinase-activated receptor 10112
Kappa-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
Dihydrofolate reductase0303
Polyunsaturated fatty acid 5-lipoxygenase0103
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Caspase-10101
Prostaglandin G/H synthase 2 0102
Aldo-keto reductase family 1 member C30101
Caspase-30101
Caspase-40101
Caspase-50101
Aldo-keto reductase family 1 member C2 0101
Caspase-90101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 1 0102
Atrial natriuretic peptide receptor 10101
pregnane X receptor2002
Parkin1001
polyunsaturated fatty acid lipoxygenase ALOX122002
perilipin-50101
perilipin-10101
atrial natriuretic peptide receptor 2 precursor2002
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Phospholipase A2, membrane associated0001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Thromboxane-A synthase 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Indoleamine 2,3-dioxygenase 10101
Adenosine receptor A2a0101
Adenosine receptor A10202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Leukotriene B4 receptor 10001
Myosin light chain kinase, smooth muscle0101
Transient receptor potential cation channel subfamily A member 10011
Potassium channel subfamily K member 2 0101
Indoleamine 2,3-dioxygenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Leukotriene B4 receptor 20001
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
histone acetyltransferase KAT2A isoform 12002
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
15-lipoxygenase, partial1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Vascular endothelial growth factor receptor 1 0101
Serine hydroxymethyltransferase, mitochondrial0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Disintegrin and metalloproteinase domain-containing protein 172002
CREB-binding protein1001
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0202
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0203
Alpha-1B adrenergic receptor 0011
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0314
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0001
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
cGMP-specific 3',5'-cyclic phosphodiesterase0112
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Cystic fibrosis transmembrane conductance regulator0011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Acetylcholinesterase0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Synaptic vesicular amine transporter0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
Nuclear receptor subfamily 2 group E member 10011
5-hydroxytryptamine receptor 1B0101
Trace amine-associated receptor 10101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Plasma kallikrein0001
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Carbonic anhydrase0001
Tryptophan 2,3-dioxygenase0102
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Carbonic anhydrase 0001
Tryprostatin B synthase0001
Carbonic anhydrase0001
Carbonic anhydrase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Phospholipase A-2-activating protein0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
D-alanyl-D-alanine dipeptidase0101
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
twin arginine protein translocation system - TatA protein0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]