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1,3-benzoxazoles

Compounds based on a fused 1,3-oxazole and benzene bicyclic ring skeleton.

ChEBI ID: 51548

Members (10)

MemberDefinitionRole
2-(2-amino-4H-[1,3,5]triazino[2,1-b][1,3]benzoxazol-4-yl)propanedioic acid diethyl ester2-(2-amino-4H-[1,3,5]triazino[2,1-b][1,3]benzoxazol-4-yl)propanedioic acid diethyl ester
2-(2'-hydroxyphenyl)benzoxazoleA member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole substituted by a 2-hydroxyphenyl group at position 2.2-(1,3-benzoxazol-2-yl)phenol
3,3'-diethyloxacarbocyanineThe cationic form of a C3 cyanine dye having 3-ethyl-1,3-benzoxazol-2(3H)-yl units at each end.C3-oxacyanine cation
benoxaprofenA monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.benoxaprofen
benzoxazolesA benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5.1,3-benzoxazole
chlorzoxazoneA member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm.chlorzoxazone
flunoxaprofenA monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.flunoxaprofen
phosaloneA member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide.phosalone
suvorexantAn aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia.suvorexant
tafamidisA member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.tafamidis

Research

Studies (3,616)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990650 (17.98)18.7374
1990's356 (9.85)18.2507
2000's713 (19.72)29.6817
2010's1,411 (39.02)24.3611
2020's486 (13.44)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials258 (6.28%)5.53%
Reviews234 (5.69%)6.00%
Case Studies115 (2.80%)4.05%
Observational16 (0.39%)0.25%
Other3,486 (84.84%)84.16%