Page last updated: 2024-08-05 11:12:50
1,3-benzoxazoles
Compounds based on a fused 1,3-oxazole and benzene bicyclic ring skeleton.
ChEBI ID: 51548
Members (10)
| Member | Definition | Role |
|---|---|---|
| 2-(2-amino-4H-[1,3,5]triazino[2,1-b][1,3]benzoxazol-4-yl)propanedioic acid diethyl ester | 2-(2-amino-4H-[1,3,5]triazino[2,1-b][1,3]benzoxazol-4-yl)propanedioic acid diethyl ester | |
| 2-(2'-hydroxyphenyl)benzoxazole | A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole substituted by a 2-hydroxyphenyl group at position 2. | 2-(1,3-benzoxazol-2-yl)phenol |
| 3,3'-diethyloxacarbocyanine | The cationic form of a C3 cyanine dye having 3-ethyl-1,3-benzoxazol-2(3H)-yl units at each end. | C3-oxacyanine cation |
| benoxaprofen | A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals. | benoxaprofen |
| benzoxazoles | A benzoxazole in which the benzene ring is fused to a 1,3-oxazole ring across positions 4 and 5. | 1,3-benzoxazole |
| chlorzoxazone | A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm. | chlorzoxazone |
| flunoxaprofen | A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects. | flunoxaprofen |
| phosalone | A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide. | phosalone |
| suvorexant | An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia. | suvorexant |
| tafamidis | A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis. | tafamidis |
Research
Studies (3,616)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 650 (17.98) | 18.7374 |
| 1990's | 356 (9.85) | 18.2507 |
| 2000's | 713 (19.72) | 29.6817 |
| 2010's | 1,411 (39.02) | 24.3611 |
| 2020's | 486 (13.44) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 258 (6.28%) | 5.53% |
| Reviews | 234 (5.69%) | 6.00% |
| Case Studies | 115 (2.80%) | 4.05% |
| Observational | 16 (0.39%) | 0.25% |
| Other | 3,486 (84.84%) | 84.16% |