Page last updated: 2024-08-05 15:31:44
contraceptive drug
A chemical substance that prevents or reduces the probability of conception.
ChEBI ID: 49323
Members (13)
| Member | Definition | Class |
|---|---|---|
| curcumin | A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. | curcumin |
| desogestrel | desogestrel | |
| drospirenone | drospirenone | |
| ethynodiol diacetate | ethynodiol diacetate | |
| etonogestrel | etonogestrel | |
| levonorgestrel | levonorgestrel | |
| medroxyprogesterone | A 3-oxo Delta(4)-steroid that is pregn-4-ene-3,20-dione substituted by an alpha-hydroxy group at position 17 and a methyl group at position 6. | medroxyprogesterone |
| megestrol | A 3-oxo Delta(4)-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17. | megestrol |
| megestrol acetate | A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer. | megestrol acetate |
| mifepristone | mifepristone | |
| nonoxynol-9 | A tergitol polymer consisting of nonylbenzene with a nine-membered poly(ethylene glycol) moiety attached at position 4. | tergitol NP-9 |
| norgestimate | norgestimate | |
| ulipristal acetate | A 20-oxo steroid obtained by acetylation of the 17-hydroxy group of (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-ol (ulipristal). A selective progesterone receptor modulator, which is employed as an emergency contraceptive. | ulipristal acetate |
Research
Studies (33,686)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,527 (13.44) | 18.7374 |
| 1990's | 4,349 (12.91) | 18.2507 |
| 2000's | 6,436 (19.11) | 29.6817 |
| 2010's | 12,526 (37.18) | 24.3611 |
| 2020's | 5,848 (17.36) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4,014 (10.80%) | 5.53% |
| Reviews | 3,842 (10.34%) | 6.00% |
| Case Studies | 1,255 (3.38%) | 4.05% |
| Observational | 175 (0.47%) | 0.25% |
| Other | 27,879 (75.01%) | 84.16% |
Protein Targets (298)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 26.9680 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 63.6740 | 3 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 32.7131 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.6357 | 1 | 3 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 18.8541 | 1 | 2 |
| Androgen receptor | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 10.6025 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 7.1014 | 12 | 143 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 31.5724 | 3 | 6 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.1348 | 4 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 33.2809 | 2 | 9 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0060 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 35.5876 | 2 | 11 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 26.2000 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 27.4727 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 26.3648 | 1 | 3 |
| caspase-3 | Homo sapiens (human) | Potency | 27.4727 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 30.8186 | 3 | 21 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 53.3769 | 2 | 4 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 5.0119 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 28.2641 | 1 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 18.8954 | 1 | 3 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 17.8020 | 2 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 47.6408 | 1 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.7407 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 22.0130 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 17.8020 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 49.5275 | 2 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 11.6440 | 1 | 8 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 14.9582 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 20.0203 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.2432 | 2 | 9 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 15.4643 | 1 | 11 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.3108 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 11.6681 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 27.2454 | 2 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 71.8210 | 1 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 41.3958 | 1 | 5 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 57.9023 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0103 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.9217 | 12 | 105 |
| Estrogen receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 18.2297 | 3 | 12 |
| Estrogen receptor beta | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 28.8655 | 10 | 72 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 14.4085 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.2828 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 43.0588 | 4 | 12 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 60.4566 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 18.5772 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 11.6440 | 1 | 8 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| GALC protein | Homo sapiens (human) | Potency | 20.2593 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 20.0203 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 13.9274 | 2 | 12 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.7425 | 3 | 26 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 19.0919 | 2 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | Potency | 0.0008 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 14.0513 | 4 | 31 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 47.7867 | 1 | 6 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 18.8677 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 22.5518 | 2 | 5 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9433 | 1 | 4 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 87.2960 | 2 | 7 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 11.6440 | 1 | 8 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 19.5147 | 1 | 2 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 19.8384 | 2 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 40.3801 | 2 | 5 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 4.7774 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 11.6440 | 1 | 16 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 15.5937 | 3 | 15 |
| interleukin 8 | Homo sapiens (human) | Potency | 84.1267 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.6832 | 1 | 7 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.0794 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.3234 | 3 | 3 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 39.5068 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 11.9173 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 5.3362 | 1 | 3 |
| Mineralocorticoid receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 34.3521 | 1 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.0122 | 1 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 14.1254 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.8540 | 4 | 25 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 13.4001 | 1 | 3 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 17.7508 | 1 | 6 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.7309 | 2 | 14 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 11.3660 | 1 | 5 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 51.8232 | 3 | 16 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 75.0594 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 36.2530 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 20.6627 | 2 | 7 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.9196 | 5 | 22 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.9097 | 5 | 17 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 62.3990 | 1 | 3 |
| PINK1 | Homo sapiens (human) | Potency | 36.2530 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 6.4468 | 1 | 2 |
| polyprotein | Zika virus | Potency | 18.5772 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.9433 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 13.0840 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 20.8212 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 23.9159 | 3 | 19 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 43.6880 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 14.3159 | 3 | 24 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 26.3139 | 2 | 22 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.0030 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 26.2294 | 3 | 27 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.6594 | 4 | 20 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 17.4745 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 25.0063 | 2 | 13 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 25.0063 | 2 | 13 |
| Smad3 | Homo sapiens (human) | Potency | 28.9342 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 8.7071 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.3488 | 2 | 30 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 24.9600 | 2 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.0389 | 3 | 35 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 52.1315 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.1798 | 6 | 11 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 27.7247 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 8.3701 | 1 | 2 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 6.4468 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 6.4468 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.6271 | 2 | 8 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 18.5034 | 2 | 7 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 27.0588 | 5 | 15 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 50.4512 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 47.7867 | 1 | 6 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 9.6995 | 2 | 2 |
| 10 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 1.7300 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 132.1300 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 26.4600 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 12.0820 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 81.0100 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 3.6975 | 4 | 4 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 2.5733 | 3 | 3 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 21.5000 | 1 | 1 |
| Aminopeptidase N | Homo sapiens (human) | IC50 | 15.5000 | 1 | 1 |
| Aminopeptidase N | Sus scrofa (pig) | IC50 | 15.5000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 9.8541 | 30 | 30 |
| Androgen receptor | Homo sapiens (human) | IC50 | 0.2988 | 18 | 21 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8188 | 1 | 4 |
| Androgen receptor | Homo sapiens (human) | Ki | 0.0087 | 6 | 6 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.5459 | 1 | 4 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 7.7510 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 343.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 40.2033 | 3 | 6 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 1.6300 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 2.3600 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 0.1010 | 1 | 1 |
| Chain A, PROGESTERONE RECEPTOR | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 300.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| CREB-binding protein | Homo sapiens (human) | IC50 | 25.0000 | 4 | 4 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 7.7500 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 1.5000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 7.4500 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 9.5000 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 4.7000 | 2 | 2 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 1.0700 | 2 | 2 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 6.6102 | 8 | 8 |
| Estrogen receptor | Homo sapiens (human) | Ki | 6.7385 | 4 | 4 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 3.5140 | 4 | 4 |
| Estrogen receptor beta | Homo sapiens (human) | Ki | 4.5420 | 3 | 3 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 0.2496 | 51 | 53 |
| Glucocorticoid receptor | Mus musculus (house mouse) | IC50 | 0.0022 | 1 | 1 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.7740 | 6 | 9 |
| Glucocorticoid receptor | Sus scrofa (pig) | IC50 | 0.0153 | 2 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 0.0144 | 21 | 23 |
| Glucocorticoid receptor | Canis lupus familiaris (dog) | IC50 | 0.0264 | 2 | 2 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 69.0000 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0134 | 1 | 3 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0061 | 1 | 3 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0134 | 1 | 3 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0061 | 1 | 3 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0134 | 1 | 3 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0061 | 1 | 3 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0134 | 1 | 3 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.0061 | 1 | 3 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 17.9500 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 0.0660 | 1 | 1 |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Histone acetyltransferase p300 | Homo sapiens (human) | IC50 | 21.9167 | 6 | 6 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 50.7900 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 97.6700 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 64.9800 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| hypothetical protein SA1422 | Staphylococcus aureus subsp. aureus N315 | IC50 | 42.9000 | 2 | 2 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 18.7000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 20.0960 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 8.0380 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 9.6000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 54.8750 | 4 | 4 |
| Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 2.5337 | 10 | 13 |
| Mineralocorticoid receptor | Homo sapiens (human) | Ki | 3.8303 | 3 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 83.0610 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 2.4570 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.9970 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 109.2250 | 1 | 4 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 24.2000 | 1 | 1 |
| Neuronal proto-oncogene tyrosine-protein kinase Src | Mus musculus (house mouse) | IC50 | 2.2000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 9.1670 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 10.2320 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 11.1000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 0.5550 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 0.1318 | 43 | 46 |
| Progesterone receptor | Homo sapiens (human) | Ki | 0.0045 | 13 | 13 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 1.8000 | 3 | 3 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 0.0078 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 42.5568 | 2 | 3 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 63.8350 | 1 | 2 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 31.7500 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 31.7500 | 1 | 2 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 3.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Rattus norvegicus (Norway rat) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | Ki | 8.6000 | 1 | 1 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 26.2800 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 11.0470 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 3.4674 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 1.9200 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 3.7154 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 2.8700 | 1 | 1 |
| Sortase A | Streptococcus mutans | IC50 | 10.2000 | 1 | 1 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Norway rat) | IC50 | 0.0016 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0015 | 2 | 2 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| Thyroid hormone receptor alpha | Homo sapiens (human) | Ki | 1.2500 | 1 | 1 |
| Thyroid hormone receptor beta | Homo sapiens (human) | Ki | 2.2500 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 0.0067 | 2 | 2 |
| toll-like receptor 9 | Homo sapiens (human) | IC50 | 8.3620 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 19.7000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 21.3570 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | EC50 | 0.0092 | 2 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC50 | 0.0158 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Kd | 3.5000 | 4 | 4 |
| Androgen receptor | Homo sapiens (human) | EC50 | 0.0113 | 3 | 3 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Kd | 20.0000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC50 | 0.7292 | 6 | 6 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0025 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kd | 0.0150 | 1 | 1 |
| Lymphocyte antigen 96 | Homo sapiens (human) | Kd | 379.0000 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | EC50 | 21.0000 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | EC50 | 2.0205 | 5 | 5 |
| Progesterone receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0158 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.0000 | 1 | 1 |
| Sex hormone-binding globulin | Homo sapiens (human) | Kd | 0.1285 | 1 | 2 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | Kd | 64.3000 | 1 | 1 |
| Tegument protein VP16 | Human alphaherpesvirus 1 strain 17 | EC50 | 0.0007 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | DC50 | 0.7550 | 2 | 2 |
| bioA | Mycobacterium tuberculosis UT205 | AC50 | 11.0100 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | AbsAC35_uM | 40.2500 | 1 | 1 |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | Activity | 0.2700 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kapp | 32.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kif | 0.0020 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | DC50 | 200.0000 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | Kif | 0.0100 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | Activity | 0.0013 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | Kif | 0.0118 | 1 | 1 |