contraceptive drug

A chemical substance that prevents or reduces the probability of conception.

ChEBI ID: 49323

Members (13)

Member	Definition	Class
curcumin	A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	curcumin
desogestrel		desogestrel
drospirenone		drospirenone
ethynodiol diacetate		ethynodiol diacetate
etonogestrel		etonogestrel
levonorgestrel		levonorgestrel
medroxyprogesterone	A 3-oxo Delta(4)-steroid that is pregn-4-ene-3,20-dione substituted by an alpha-hydroxy group at position 17 and a methyl group at position 6.	medroxyprogesterone
megestrol	A 3-oxo Delta(4)-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17.	megestrol
megestrol acetate	A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.	megestrol acetate
mifepristone		mifepristone
nonoxynol-9	A tergitol polymer consisting of nonylbenzene with a nine-membered poly(ethylene glycol) moiety attached at position 4.	tergitol NP-9
norgestimate		norgestimate
ulipristal acetate	A 20-oxo steroid obtained by acetylation of the 17-hydroxy group of (11beta,17alpha)-17-acetyl-11-[4-(dimethylamino)phenyl]-3-oxoestra-4,9-dien-17-ol (ulipristal). A selective progesterone receptor modulator, which is employed as an emergency contraceptive.	ulipristal acetate

Research

Studies (33,686)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	4,527 (13.44)	18.7374
1990's	4,349 (12.91)	18.2507
2000's	6,436 (19.11)	29.6817
2010's	12,526 (37.18)	24.3611
2020's	5,848 (17.36)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	4,014 (10.80%)	5.53%
Reviews	3,842 (10.34%)	6.00%
Case Studies	1,255 (3.38%)	4.05%
Observational	175 (0.47%)	0.25%
Other	27,879 (75.01%)	84.16%

Protein Targets (298)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	26.9680	1	2
15-lipoxygenase, partial	Homo sapiens (human)	Potency	14.2191	1	2
acetylcholinesterase	Homo sapiens (human)	Potency	63.6740	3	4
activating transcription factor 6	Homo sapiens (human)	Potency	32.7131	2	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	25.6357	1	3
Alpha-synuclein	Homo sapiens (human)	Potency	18.8541	1	2
Androgen receptor	Homo sapiens (human)	Potency	0.0050	1	1
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	10.6025	1	2
AR protein	Homo sapiens (human)	Potency	7.1014	12	143
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	31.5724	3	6
ATAD5 protein, partial	Homo sapiens (human)	Potency	20.1348	4	5
Ataxin-2	Homo sapiens (human)	Potency	33.2809	2	9
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	0.0060	1	1
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	35.5876	2	11
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	23.2809	1	1
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	26.2000	1	2
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	27.4727	1	1
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	26.3648	1	3
caspase-3	Homo sapiens (human)	Potency	27.4727	1	1
Caspase-7	Homo sapiens (human)	Potency	12.5893	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	30.8186	3	21
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	39.8107	2	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	35.4813	1	2
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	53.3769	2	4
Chain A, Breast cancer type 1 susceptibility protein	Homo sapiens (human)	Potency	5.0119	1	3
Chain A, Cruzipain	Trypanosoma cruzi	Potency	28.2641	1	4
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	18.8954	1	3
Chain A, HADH2 protein	Homo sapiens (human)	Potency	17.8020	2	2
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	47.6408	1	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	17.7407	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	22.0130	1	4
Chain B, HADH2 protein	Homo sapiens (human)	Potency	17.8020	2	2
chromobox protein homolog 1	Homo sapiens (human)	Potency	49.5275	2	4
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	11.6440	1	8
cytochrome P450 2D6	Homo sapiens (human)	Potency	14.9582	1	5
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	20.0203	2	6
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	6.2432	2	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	15.4643	1	11
D(1A) dopamine receptor	Homo sapiens (human)	Potency	2.3108	1	1
D(1A) dopamine receptor	Sus scrofa (pig)	Potency	11.6681	1	1
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	Potency	2.5119	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	22.3872	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	27.2454	2	3
DNA polymerase beta	Homo sapiens (human)	Potency	71.8210	1	3
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	41.3958	1	5
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	57.9023	1	2
dopamine D1 receptor	Homo sapiens (human)	Potency	0.0103	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	18.9217	12	105
Estrogen receptor	Homo sapiens (human)	Potency	1.0000	1	1
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	18.2297	3	12
Estrogen receptor beta	Homo sapiens (human)	Potency	1.0000	1	1
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	28.8655	10	72
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	14.4085	1	6
EWS/FLI fusion protein	Homo sapiens (human)	Potency	0.2828	4	4
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	43.0588	4	12
flap endonuclease 1	Homo sapiens (human)	Potency	60.4566	1	2
Fumarate hydratase	Homo sapiens (human)	Potency	18.5772	1	2
G	Vesicular stomatitis virus	Potency	11.6440	1	8
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
GALC protein	Homo sapiens (human)	Potency	20.2593	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	20.0203	1	3
geminin	Homo sapiens (human)	Potency	13.9274	2	12
GLI family zinc finger 3	Homo sapiens (human)	Potency	16.7425	3	26
glp-1 receptor, partial	Homo sapiens (human)	Potency	11.2202	1	1
GLS protein	Homo sapiens (human)	Potency	19.0919	2	2
glucocerebrosidase	Homo sapiens (human)	Potency	32.4648	1	2
Glucocorticoid receptor	Homo sapiens (human)	Potency	0.0008	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	14.0513	4	31
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	47.7867	1	6
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	35.4813	1	1
Guanine nucleotide-binding protein G	Homo sapiens (human)	Potency	35.4813	1	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	18.8677	1	2
heat shock protein beta-1	Homo sapiens (human)	Potency	22.5518	2	5
hemoglobin subunit beta	Homo sapiens (human)	Potency	39.8107	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	7.9433	1	4
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	87.2960	2	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	14.1254	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	11.6440	1	8
huntingtin isoform 2	Homo sapiens (human)	Potency	19.5147	1	2
hypothetical protein, conserved	Trypanosoma brucei	Potency	19.8384	2	3
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	40.3801	2	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	4.7774	2	6
IDH1	Homo sapiens (human)	Potency	16.3601	1	1
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	25.6651	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	11.6440	1	16
Integrin alpha-IIb	Homo sapiens (human)	Potency	39.8107	1	1
Integrin beta-3	Homo sapiens (human)	Potency	39.8107	1	1
Interferon beta	Homo sapiens (human)	Potency	15.5937	3	15
interleukin 8	Homo sapiens (human)	Potency	84.1267	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	9.6832	1	7
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	0.0794	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	27.3234	3	3
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	39.5068	1	1
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	11.9173	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	5.3362	1	3
Mineralocorticoid receptor	Homo sapiens (human)	Potency	1.0000	1	1
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	34.3521	1	3
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	39.8107	1	2
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	5.0122	1	4
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	14.1254	1	1
Nrf2	Homo sapiens (human)	Potency	22.3872	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	19.8540	4	25
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	13.4001	1	3
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	Potency	50.1187	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	17.7508	1	6
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	33.4915	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	22.7309	2	14
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	11.3660	1	5
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	51.8232	3	16
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	75.0594	1	2
Parkin	Homo sapiens (human)	Potency	36.2530	1	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	19.9526	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	20.6627	2	7
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	18.9196	5	22
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	20.9097	5	17
phosphopantetheinyl transferase	Bacillus subtilis	Potency	62.3990	1	3
PINK1	Homo sapiens (human)	Potency	36.2530	1	2
plasminogen precursor	Mus musculus (house mouse)	Potency	6.4468	1	2
polyprotein	Zika virus	Potency	18.5772	1	2
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	19.9526	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	7.9433	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	13.0840	1	3
PPM1D protein	Homo sapiens (human)	Potency	20.8212	1	2
pregnane X nuclear receptor	Homo sapiens (human)	Potency	23.9159	3	19
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	43.6880	1	2
progesterone receptor	Homo sapiens (human)	Potency	14.3159	3	24
pyruvate kinase PKM isoform a	Homo sapiens (human)	Potency	28.1838	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	26.3139	2	22
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	15.0030	1	1
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	26.2294	3	27
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	18.6594	4	20
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	17.4745	2	2
SMAD family member 2	Homo sapiens (human)	Potency	25.0063	2	13
SMAD family member 3	Homo sapiens (human)	Potency	25.0063	2	13
Smad3	Homo sapiens (human)	Potency	28.9342	1	2
snurportin-1	Homo sapiens (human)	Potency	25.6651	2	2
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	39.8107	1	3
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	8.7071	1	3
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	35.4813	1	1
TDP1 protein	Homo sapiens (human)	Potency	19.3488	2	30
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	39.8107	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	24.9600	2	3
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	21.0389	3	35
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	52.1315	3	3
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	22.1798	6	11
thyrotropin-releasing hormone receptor	Homo sapiens (human)	Potency	27.7247	1	1
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	8.3701	1	2
tumor susceptibility gene 101 protein	Homo sapiens (human)	Potency	19.9526	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	2.5119	1	1
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	6.4468	1	2
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	6.4468	1	2
USP1 protein, partial	Homo sapiens (human)	Potency	35.6271	2	8
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	18.5034	2	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	27.0588	5	15
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	50.4512	1	2
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	47.7867	1	6

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	Homo sapiens (human)	IC50	9.6995	2	2
10 kDa chaperonin	Escherichia coli	IC50	3.0000	2	2
10 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	8.3000	1	1
17-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens (human)	IC50	1.7300	1	1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	0.0014	1	1
60 kDa chaperonin	Escherichia coli K-12	IC50	250.0000	1	1
60 kDa chaperonin	Escherichia coli	IC50	3.0000	2	2
60 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	8.3000	1	1
Acetylcholinesterase	Electrophorus electricus (electric eel)	IC50	132.1300	2	2
Acetylcholinesterase	Homo sapiens (human)	IC50	5.0000	1	1
alkaline phosphatase, germ cell type preproprotein	Homo sapiens (human)	IC50	100.0000	1	1
alkaline phosphatase, intestinal	Homo sapiens (human)	IC50	100.0000	1	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	Homo sapiens (human)	IC50	100.0000	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	5.4000	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	5.4000	1	1
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	5.4000	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	IC50	26.4600	1	1
Alpha-2B adrenergic receptor	Homo sapiens (human)	Ki	12.0820	1	1
Alpha-synuclein	Homo sapiens (human)	IC50	81.0100	2	2
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	3.6975	4	4
Amine oxidase [flavin-containing] A	Homo sapiens (human)	Ki	0.7100	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	2.5733	3	3
Amine oxidase [flavin-containing] B	Homo sapiens (human)	Ki	21.5000	1	1
Aminopeptidase N	Homo sapiens (human)	IC50	15.5000	1	1
Aminopeptidase N	Sus scrofa (pig)	IC50	15.5000	1	1
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	9.8541	30	30
Androgen receptor	Homo sapiens (human)	IC50	0.2988	18	21
Androgen receptor	Rattus norvegicus (Norway rat)	IC50	0.8188	1	4
Androgen receptor	Homo sapiens (human)	Ki	0.0087	6	6
Androgen receptor	Rattus norvegicus (Norway rat)	Ki	0.5459	1	4
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	4
Beta lactamase (plasmid)	Pseudomonas aeruginosa	IC50	7.7510	1	1
Beta-secretase 1	Homo sapiens (human)	IC50	343.0000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	40.2033	3	6
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	1.6300	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	3
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens (human)	IC50	2.3600	1	1
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens (human)	Ki	0.1010	1	1
Chain A, PROGESTERONE RECEPTOR	Homo sapiens (human)	Ki	0.0008	1	1
Cholinesterase	Equus caballus (horse)	IC50	300.0000	1	1
Cholinesterase	Homo sapiens (human)	IC50	5.0000	1	1
Coagulation factor VII	Homo sapiens (human)	IC50	0.0003	1	1
CREB-binding protein	Homo sapiens (human)	IC50	25.0000	4	4
Cysteine protease	Trypanosoma brucei rhodesiense	IC50	7.7500	1	1
Cytochrome P450 2C19	Homo sapiens (human)	IC50	2.0000	1	1
Cytochrome P450 2C8	Homo sapiens (human)	IC50	1.5000	2	2
Cytochrome P450 2C9	Homo sapiens (human)	IC50	7.4500	2	2
Cytochrome P450 3A4	Homo sapiens (human)	IC50	9.5000	2	2
Cytochrome P450 3A4	Homo sapiens (human)	Ki	4.7000	2	2
D-amino-acid oxidase	Sus scrofa (pig)	IC50	1.0700	2	2
Estrogen receptor	Homo sapiens (human)	IC50	6.6102	8	8
Estrogen receptor	Homo sapiens (human)	Ki	6.7385	4	4
Estrogen receptor beta	Homo sapiens (human)	IC50	3.5140	4	4
Estrogen receptor beta	Homo sapiens (human)	Ki	4.5420	3	3
Glucocorticoid receptor	Homo sapiens (human)	IC50	0.2496	51	53
Glucocorticoid receptor	Mus musculus (house mouse)	IC50	0.0022	1	1
Glucocorticoid receptor	Rattus norvegicus (Norway rat)	IC50	0.7740	6	9
Glucocorticoid receptor	Sus scrofa (pig)	IC50	0.0153	2	2
Glucocorticoid receptor	Homo sapiens (human)	Ki	0.0144	21	23
Glucocorticoid receptor	Canis lupus familiaris (dog)	IC50	0.0264	2	2
Glutathione S-transferase P	Homo sapiens (human)	IC50	69.0000	1	1
Glycine receptor subunit alpha-1	Rattus norvegicus (Norway rat)	IC50	0.0134	1	3
Glycine receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Ki	0.0061	1	3
Glycine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	IC50	0.0134	1	3
Glycine receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	0.0061	1	3
Glycine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	0.0134	1	3
Glycine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	0.0061	1	3
Glycine receptor subunit beta	Rattus norvegicus (Norway rat)	IC50	0.0134	1	3
Glycine receptor subunit beta	Rattus norvegicus (Norway rat)	Ki	0.0061	1	3
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	17.9500	1	1
Glycogen synthase kinase-3 beta	Rattus norvegicus (Norway rat)	IC50	0.0660	1	1
Heme oxygenase 1	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
Heme oxygenase 2	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
Histone acetyltransferase p300	Homo sapiens (human)	IC50	21.9167	6	6
Histone deacetylase 1	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 1	Homo sapiens (human)	Ki	50.7900	1	1
Histone deacetylase 11	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 2	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 2	Homo sapiens (human)	Ki	97.6700	1	1
Histone deacetylase 3	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 4	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 5	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 6	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 7	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 8	Homo sapiens (human)	IC50	187.0000	1	1
Histone deacetylase 8	Homo sapiens (human)	Ki	64.9800	1	1
Histone deacetylase 9	Homo sapiens (human)	IC50	187.0000	1	1
hypothetical protein SA1422	Staphylococcus aureus subsp. aureus N315	IC50	42.9000	2	2
intestinal alkaline phosphatase precursor	Mus musculus (house mouse)	IC50	18.7000	1	1
Kappa-type opioid receptor	Homo sapiens (human)	IC50	20.0960	1	1
Kappa-type opioid receptor	Homo sapiens (human)	Ki	8.0380	1	1
Lactoylglutathione lyase	Homo sapiens (human)	Ki	0.0050	1	1
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	9.6000	1	1
Microtubule-associated protein tau	Homo sapiens (human)	IC50	54.8750	4	4
Mineralocorticoid receptor	Homo sapiens (human)	IC50	2.5337	10	13
Mineralocorticoid receptor	Homo sapiens (human)	Ki	3.8303	3	3
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	83.0610	1	1
Mu-type opioid receptor	Homo sapiens (human)	IC50	2.4570	1	1
Mu-type opioid receptor	Homo sapiens (human)	Ki	0.9970	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	109.2250	1	4
NACHT, LRR and PYD domains-containing protein 3	Homo sapiens (human)	IC50	24.2000	1	1
Neuronal proto-oncogene tyrosine-protein kinase Src	Mus musculus (house mouse)	IC50	2.2000	1	1
perilipin-1	Homo sapiens (human)	IC50	9.1670	1	1
perilipin-5	Homo sapiens (human)	IC50	10.2320	1	1
Phospholipase A2	Homo sapiens (human)	IC50	11.1000	1	1
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	187.0000	1	1
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	30.0000	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	IC50	0.5550	1	1
Progesterone receptor	Homo sapiens (human)	IC50	0.1318	43	46
Progesterone receptor	Homo sapiens (human)	Ki	0.0045	13	13
Prostaglandin E synthase	Homo sapiens (human)	IC50	1.8000	3	3
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	0.0078	1	1
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	42.5568	2	3
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	63.8350	1	2
Proteasome subunit beta type-5	Homo sapiens (human)	IC50	10.0000	2	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	31.7500	1	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	31.7500	1	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	3.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	Ki	5.8000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Homo sapiens (human)	IC50	7.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Homo sapiens (human)	Ki	53.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Rattus norvegicus (Norway rat)	Ki	5.8000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	Homo sapiens (human)	IC50	7.0000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	Homo sapiens (human)	Ki	8.6000	1	1
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	IC50	16.0000	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	IC50	26.2800	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	11.0470	1	1
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	IC50	3.4674	1	1
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	Ki	1.9200	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	IC50	3.7154	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	Ki	2.8700	1	1
Sortase A	Streptococcus mutans	IC50	10.2000	1	1
Steroid 17-alpha-hydroxylase/17,20 lyase	Rattus norvegicus (Norway rat)	IC50	0.0016	1	1
Substance-P receptor	Cavia porcellus (domestic guinea pig)	IC50	0.0015	2	2
Thioredoxin reductase 1, cytoplasmic	Homo sapiens (human)	IC50	40.4667	3	3
Thioredoxin reductase 2, mitochondrial	Homo sapiens (human)	IC50	40.4667	3	3
Thioredoxin reductase 3	Homo sapiens (human)	IC50	40.4667	3	3
Thiosulfate sulfurtransferase	Homo sapiens (human)	IC50	56.0000	1	1
Thyroid hormone receptor alpha	Homo sapiens (human)	Ki	1.2500	1	1
Thyroid hormone receptor beta	Homo sapiens (human)	Ki	2.2500	1	1
Tissue factor	Homo sapiens (human)	IC50	0.0067	2	2
toll-like receptor 9	Homo sapiens (human)	IC50	8.3620	1	1
TPA: protein transporter TIM10	Saccharomyces cerevisiae S288C	IC50	19.7000	1	1
Tyrosinase	Homo sapiens (human)	IC50	5.0000	1	1
Tyrosine-protein kinase Fyn	Homo sapiens (human)	IC50	21.3570	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus (Norway rat)	IC50	100.0000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	Rattus norvegicus (Norway rat)	IC50	100.0000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	Rattus norvegicus (Norway rat)	IC50	100.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 4	Homo sapiens (human)	EC50	10.0000	1	1
Adenosine receptor A1	Rattus norvegicus (Norway rat)	EC50	0.0092	2	2
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	EC50	0.0158	1	2
Alpha-synuclein	Homo sapiens (human)	Kd	3.5000	4	4
Androgen receptor	Homo sapiens (human)	EC50	0.0113	3	3
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	Kd	20.0000	1	1
Estrogen receptor	Homo sapiens (human)	EC50	10.0000	1	1
Estrogen receptor beta	Homo sapiens (human)	EC50	10.0000	1	1
Glucocorticoid receptor	Homo sapiens (human)	EC50	0.7292	6	6
Glucocorticoid receptor	Rattus norvegicus (Norway rat)	EC50	0.0025	1	1
Glucocorticoid receptor	Homo sapiens (human)	Kd	0.0150	1	1
Lymphocyte antigen 96	Homo sapiens (human)	Kd	379.0000	1	1
Mineralocorticoid receptor	Homo sapiens (human)	EC50	10.0000	1	1
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)	EC50	21.0000	1	1
Progesterone receptor	Homo sapiens (human)	EC50	2.0205	5	5
Progesterone receptor	Rattus norvegicus (Norway rat)	EC50	0.0158	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	10.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	EC50	10.0000	1	1
Sex hormone-binding globulin	Homo sapiens (human)	Kd	0.1285	1	2
Sodium/bile acid cotransporter	Homo sapiens (human)	Kd	64.3000	1	1
Tegument protein VP16	Human alphaherpesvirus 1 strain 17	EC50	0.0007	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Amyloid-beta precursor protein	Homo sapiens (human)	DC50	0.7550	2	2
bioA	Mycobacterium tuberculosis UT205	AC50	11.0100	1	1
EWS/FLI fusion protein	Homo sapiens (human)	AbsAC35_uM	40.2500	1	1
Glucocorticoid receptor	Rattus norvegicus (Norway rat)	Activity	0.2700	1	1
Glucocorticoid receptor	Homo sapiens (human)	Kapp	32.0000	1	1
Glucocorticoid receptor	Homo sapiens (human)	Kif	0.0020	1	1
Microtubule-associated protein tau	Homo sapiens (human)	DC50	200.0000	1	1
Mineralocorticoid receptor	Homo sapiens (human)	Kif	0.0100	1	1
Progesterone receptor	Homo sapiens (human)	Activity	0.0013	1	1
Progesterone receptor	Homo sapiens (human)	Kif	0.0118	1	1