agnuside profile

agnuside: isolated from Vitex peduncularis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

agnuside : A benzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with the primary hydroxy group of aucubin. It is an iridoid glycoside found in several Vitex plants including Vitex agnus-castus. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Vitex	genus	A genus of trees in the Lamiaceae family containing assorted flavonoids with possible analgesic and antineoplastic properties. The fruit of these trees is used in herbal preparations.[MeSH]	Lamiaceae	The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID Source	ID
PubMed CID	442416
CHEMBL ID	483223
CHEBI ID	2515
SCHEMBL ID	382107
MeSH ID	M0421990

Synonyms (36)

Synonym
ACON1_000039
MEGXP0_000767
agnuside
11027-63-7
C09765
NCGC00168851-01
BRD-K25132901-001-01-5
[(1s,4ar,5s,7as)-5-hydroxy-1-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-7-yl]methyl 4-hydroxybenzoate
CHEMBL483223
jb24q0ot9g ,
(-)-buddlejoside a
buddlejoside a
unii-jb24q0ot9g
agnoside
AKOS015896848
.beta.-d-glucopyranoside, (1s,4ar,5s,7as)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(((4-hydroxybenzoyl)oxy)methyl)cyclopenta(c)pyran-1-yl
.beta.-d-glucopyranoside, 1,4a,5,7a-tetrahydro-5-hydroxy-7-(((4-hydroxybenzoyl)oxy)methyl)cyclopenta(c)pyran-1-yl, (1.alpha.,4a.alpha.,5.alpha.,7a.alpha.)-
agnuside [usp-rs]
SCHEMBL382107
CHEBI:2515 ,
[(1s,4ar,5s,7as)-1-(beta-d-glucopyranosyloxy)-5-hydroxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-7-yl]methyl 4-hydroxybenzoate
DTXSID10149191 ,
[(1s,4ar,5s,7as)-5-hydroxy-1-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1h,4ah,5h,7ah-cyclopenta[c]pyran-7-yl]methyl 4-hydroxybenzoate
agnusid
mfcd00210471
NCGC00168851-03
((1s,4ar,5s,7as)-5-hydroxy-1-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-7-yl)methyl 4-hydroxybenzoate
Q16826128
CS-0022789
HY-N2518
AS-79164
beta-d-glucopyranoside, (1s,4ar,5s,7as)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(((4-hydroxybenzoyl)oxy)methyl)cyclopenta(c)pyran-1-yl
agnuside (usp-rs)
dtxcid9071682
((1s,4ar,5s,7as)-1-(beta-d-glucopyranosyloxy)-5-hydroxy-1,4a,5,7a-tetrahydrocyclopenta(c)pyran-7-yl)methyl 4-hydroxybenzoate
beta-d-glucopyranoside, 1,4a,5,7a-tetrahydro-5-hydroxy-7-(((4-hydroxybenzoyl)oxy)methyl)cyclopenta(c)pyran-1-yl, (1alpha,4aalpha,5alpha,7aalpha)-

Excerpt	Reference	Relevance
" The mean absolute bioavailability (%F) of AGN was∼0."	( Plasma pharmacokinetics, bioavailability and tissue distribution of agnuside following peroral and intravenous administration in mice using liquid chromatography tandem mass spectrometry. Bhateria, M; Bhatta, RS; Puttrevu, SK; Ramakrishna, R; Singh, R, 2016)	0.67
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
anti-inflammatory agent	Any compound that has anti-inflammatory effects.
pro-angiogenic agent	Any compound that promotes the growth of new blood vessels from pre-existing vessels.
cyclooxygenase 2 inhibitor	A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
terpene glycoside	A terpenoid in which one or more hydroxy functions are glycosylated.
iridoid monoterpenoid	One of a class of monoterpenoids biosynthesized from isoprene and often intermediates in the biosynthesis of alkaloids. Iridoids usually consist of a cyclopentane ring fused to a six-membered oxygen heterocycle; cleavage of a bond in the cyclopentane ring gives rise to the subclass known as secoiridoids.
benzoate ester	Esters of benzoic acid or substituted benzoic acids.
phenols	Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
beta-D-glucoside	Any D-glucoside in which the anomeric centre has beta-configuration.
cyclopentapyran
monosaccharide derivative	A carbohydrate derivative that is formally obtained from a monosaccharide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (24)

Assay ID	Title	Year	Journal	Article
AID1585168	Effect on cell morphology in HUVEC at 1 to 2500 ng/ml after 24 to 96 hrs by DAPI staining-based spectrofluorometric analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID467895	Antiviral activity against HCV expressing E1E2 glycoprotein with Vpr-deficient HIV vector assessed as inhibition of viral entry in human Huh7 cells at 20 ug/ml after 72 hrs by luciferase reporter gene assay in presence of beta-glucosidase enzyme for 0.5 h	2009	Journal of natural products, Dec, Volume: 72, Issue:12	Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.
AID1251041	Inhibition of COX2 (unknown origin) assessed as PGH2 production at 100 uM by measuring PGH2alpha level by enzyme immunoassay	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID1251036	Inhibition of COX1 (unknown origin) assessed as PGH2 production at 10 uM by measuring PGH2alpha level by enzyme immunoassay	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID1585172	Pro-angiogenic activity in HUVEC assessed as increase in tubular network formation at 0.1 ng/ml preincubated for 30 mins followed by ZM 323881 HCl addition and measured after 22 hrs by phase-contrast image analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID1585165	Pro-angiogenic activity in HUVEC assessed as increase in cell proliferation at 2500 ng/ml after 96 hrs by DAPI staining-based spectrofluorometric analysis relative to control	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID467896	Antiviral activity against HCV expressing E1E2 glycoprotein with Vpr-deficient HIV vector assessed as inhibition of viral entry in human Huh7 cells at 20 ug/ml after 72 hrs by luciferase reporter gene assay in presence of beta-glucosidase enzyme for 4 hrs	2009	Journal of natural products, Dec, Volume: 72, Issue:12	Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.
AID333729	Inhibition of 5-lipoxygenase activity at 1000 uM by ferric-xylenol orange peroxide assay relative to control	2004	Journal of natural products, Dec, Volume: 67, Issue:12	New acylated iridoid glucosides from Vitex altissima.
AID1585173	Antimigratory activity in HUVEC assessed as wound closure at 100 ng/ml after 24 hrs by phase-contrast microscopic analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID1585167	Pro-angiogenic activity in HUVEC assessed as increase in cell proliferation after 96 hrs by DAPI staining-based spectrofluorometric analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID1585171	Pro-angiogenic activity in HUVEC assessed as increase in tubular network formation at 0.1 ng/ml after 22 hrs by phase-contrast image analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID1251038	Inhibition of COX1 (unknown origin) assessed as PGH2 production at 100 uM by measuring PGH2alpha level by enzyme immunoassay	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID1585169	Pro-angiogenic activity in HUVEC assessed as increase in meshes formation after 22 hrs by phase-contrast image analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID1585166	Pro-angiogenic activity in HUVEC assessed as increase in cell proliferation at 2500 ng/ml after 24 to 72 hrs by DAPI staining-based spectrofluorometric analysis relative to control	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID1585170	Pro-angiogenic activity in HUVEC assessed as increase in meshes formation at 0.1 to 10 ng/ml after 22 hrs by phase-contrast image analysis	2018	European journal of medicinal chemistry, Dec-05, Volume: 160	Identification and characterization of agnuside, a natural proangiogenic small molecule.
AID1251039	Inhibition of COX2 (unknown origin) assessed as PGH2 production at 10 uM by measuring PGH2alpha level by enzyme immunoassay	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID1251040	Inhibition of COX2 (unknown origin) assessed as PGH2 production at 35 uM by measuring PGH2alpha level by enzyme immunoassay	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID467894	Antiviral activity against HCV expressing E1E2 glycoprotein with Vpr-deficient HIV vector assessed as inhibition of viral entry in human Huh7 cells at 20 ug/ml measured after 72 hrs by luciferase reporter gene assay	2009	Journal of natural products, Dec, Volume: 72, Issue:12	Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.
AID1251037	Inhibition of COX1 (unknown origin) assessed as PGH2 production at 35 uM by measuring PGH2alpha level by enzyme immunoassay	2015	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20	In vitro COX-1 and COX-2 enzyme inhibitory activities of iridoids from Penstemon barbatus, Castilleja tenuiflora, Cresentia alata and Vitex mollis.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (25.00)	29.6817
2010's	9 (56.25)	24.3611
2020's	3 (18.75)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
histamine [no description available]	2.07	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.11	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
masoprocol nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)	2.02	1	catechols; lignan; tetrol	antioxidant; ferroptosis inhibitor; geroprotector; plant metabolite
butylated hydroxyanisole [no description available]	2.02	1
butylated hydroxytoluene 2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.	2.02	1	phenols	antioxidant; ferroptosis inhibitor; food additive; geroprotector
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	3.79	10	D-glucopyranose	epitope; mouse metabolite
cornin iridoid cornin iridoid: structure	2.05	1	terpene glycoside
loganin [no description available]	2.48	2	beta-D-glucoside; cyclopentapyran; enoate ester; iridoid monoterpenoid; methyl ester; monosaccharide derivative; secondary alcohol	anti-inflammatory agent; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; EC 3.4.23.46 (memapsin 2) inhibitor; neuroprotective agent; plant metabolite
loganic acid loganic acid: structure. loganic acid : A cyclopentapyran that is 1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid substituted at positions 1, 6 and 7 by beta-D-glucosyloxy, hydroxy and methyl groups respectively	2.48	2	alpha,beta-unsaturated monocarboxylic acid; cyclopentapyran; glucoside	plant metabolite
aucubin [no description available]	2.48	2	organic molecular entity	metabolite
catalpol [no description available]	2.11	1	organic molecular entity	metabolite
geniposide [no description available]	2.05	1	terpene glycoside
6-o-veratroyl catalpol [no description available]	2.11	1
genipin [no description available]	2.05	1	iridoid monoterpenoid	anti-inflammatory agent; antioxidant; apoptosis inhibitor; cross-linking reagent; hepatotoxic agent; uncoupling protein inhibitor
geniposidic acid [no description available]	2.11	1	terpene glycoside
iridoids Iridoids: A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES).	2.01	1
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	7.57	2
diclofenac sodium Diclofenac Sodium: The sodium form of DICLOFENAC. It is used for its analgesic and anti-inflammatory properties.. diclofenac sodium : The sodium salt of diclofenac.	2.02	1	organic sodium salt
luteolin [no description available]	2.03	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
leukotriene b4 Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990). leukotriene B4 : A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.	2.07	1	dihydroxy monocarboxylic acid; hydroxy polyunsaturated fatty acid; leukotriene; long-chain fatty acid	human metabolite; mouse metabolite; plant metabolite; vasoconstrictor agent
harpagoside harpagoside: glycoside of a cyclopenta[c]pyran from root of S. African plant Harpagophytum procumbens DC; structure in Negwer, 5th ed, #5281, 7th ed #9921; Harpagophytum extract WS 1531 is plant extract containing harpagoside; Antidiabetic Agent	2.05	1	terpene glycoside
casticin casticin: from fruit of Vitex rotundifolia; structure in second source. casticin : A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii.	3	4	dihydroxyflavone; tetramethoxyflavone	apoptosis inducer; plant metabolite
negundoside negundoside: an antioxidant irridiod glycoside from leaves of Vitex negundo; structure in first source	2.77	3
Shanzhiside methyl ester [no description available]	2.05	1	glycoside; iridoid monoterpenoid
lamalbid lamalbid: from Pedicula dicora	2.05	1

Condition	Relationship Strength	Studies
Anasarca [description not available]	2.44	2
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.44	2
Angiogenesis, Pathologic [description not available]	2.17	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.72	2
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1
Asthma, Bronchial [description not available]	2.41	1
Cirrhosis [description not available]	2.41	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	7.41	1
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	7.41	1
Adjuvant Arthritis [description not available]	2.07	1
Premenstrual Tension A term used to describe the psychological aspects of PREMENSTRUAL SYNDROME, such as the indescribable tension, depression, hostility, and increased seizure activity in women with seizure disorder.	2.03	1
Premenstrual Syndrome A combination of distressing physical, psychologic, or behavioral changes that occur during the luteal phase of the menstrual cycle. Symptoms of PMS are diverse (such as pain, water-retention, anxiety, cravings, and depression) and they diminish markedly 2 or 3 days after the initiation of menses.	2.03	1

agnuside

Description

Cross-References

Synonyms (36)

Research Excerpts

Bioavailability

Roles (4)

Drug Classes (7)

Bioassays (24)

Research

Studies (16)

Market Indicators

Research Demand Index: 31.75

Study Types

agnuside

Description

Related Flora

Cross-References

Synonyms (36)

Research Excerpts

Bioavailability

Roles (4)

Drug Classes (7)

Bioassays (24)

Research

Studies (16)

Market Indicators

Research Demand Index: 31.75

Study Types

Related Drugs (25)

Related Conditions (13)