Roles > antispasmodic drug
Page last updated: 2024-08-05 15:18:14

antispasmodic drug

A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.

ChEBI ID: 53784

Members (20)

MemberDefinitionClass
alverineA tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel syndrome.alverine
alverine citrateThe citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome.alverine citrate
darifenacin2-[(3S)-1-Ethylpyrrolidin-3-yl]-2,2-diphenylacetamide in which one of the hydrogens at the 2-position of the ethyl group is substituted by a 2,3-dihydro-1-benzofuran-5-yl group. It is a selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, and is used as the hydrobromide salt in the management of urinary incontinence.darifenacin
dicyclomineThe ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.dicyclomine
dicyclomine hydrochlorideThe hydrochloride salt of dicyclomine. An anticholinergic, it is used to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.dicyclomine hydrochloride
flavoxateA carboxylic ester resulting from the formal condensation of 3-methylflavone-8-carboxylic acid with 2-(1-piperidinyl)ethanol.flavoxate
flavoxate hydrochlorideThe hydrochloride salt of flavoxate.flavoxate hydrochloride
glycycoumarinA member of the class of coumarins that is coumarin substituted by a hydroxy group at position 7, a methoxy group at position 5, a prenyl group at position 6 and a 2,4-dihydroxyphenyl group at position 3. Isolated from Glycyrrhiza uralensis, it exhibits antispasmodic activity.glycycoumarin
mentholA p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer.(-)-menthol
meperidineA piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.pethidine
meperidine hydrochlorideThe hydrochloride salt of pethidine. An analgesic used for the treatment of postoperative and labour pain.pethidine hydrochloride
nimetazepamA nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia.nimetazepam
nitrazepamA 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).nitrazepam
oxybutyninA racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.4-(diethylamino)but-2-yn-1-ol; oxybutynin
papaverineA benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.papaverine
pirenzepinepirenzepine
propyromazineAn organic bromide salt of propyromazine. It is a muscarinic antagonist which has antispasmodic potential.propyromazine bromide
tiquizium bromideA organic bromide salt of tiquizium. It is an antispasmodic drug used for the treatment of convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis.tiquizium bromide
tolterodinetolterodine
tridihexethyltridihexethyl

Research

Studies (17,950)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19908,586 (47.83)18.7374
1990's3,576 (19.92)18.2507
2000's2,943 (16.40)29.6817
2010's2,315 (12.90)24.3611
2020's530 (2.95)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,995 (15.01%)5.53%
Reviews1,170 (5.86%)6.00%
Case Studies1,279 (6.41%)4.05%
Observational66 (0.33%)0.25%
Other14,446 (72.39%)84.16%

Protein Targets (240)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency25.118911
15-lipoxygenase, partialHomo sapiens (human)Potency39.810711
acetylcholinesteraseHomo sapiens (human)Potency35.382224
activating transcription factor 6Homo sapiens (human)Potency54.941011
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency14.333512
AR proteinHomo sapiens (human)Potency13.2507813
aryl hydrocarbon receptorHomo sapiens (human)Potency61.939611
ATAD5 protein, partialHomo sapiens (human)Potency5.394022
Ataxin-2Homo sapiens (human)Potency25.200822
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency10.923522
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency13.372222
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency23.934111
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency13.091811
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency67.833412
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency51.494412
caspase-3Cricetulus griseus (Chinese hamster)Potency29.849311
caspase-3Homo sapiens (human)Potency51.494412
Caspase-7Cricetulus griseus (Chinese hamster)Potency29.849311
Cellular tumor antigen p53Homo sapiens (human)Potency3.965014
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency16.432314
Chain A, Beta-lactamaseEscherichia coli K-12Potency79.432811
Chain A, HADH2 proteinHomo sapiens (human)Potency25.118911
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency22.387211
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.050111
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency0.020011
Chain B, HADH2 proteinHomo sapiens (human)Potency25.118911
chromobox protein homolog 1Homo sapiens (human)Potency50.742323
CREB-binding proteinHomo sapiens (human)Potency5.690448
cytochrome P450 2C19 precursorHomo sapiens (human)Potency6.331013
cytochrome P450 2C9 precursorHomo sapiens (human)Potency20.114413
cytochrome P450 2C9, partialHomo sapiens (human)Potency18.902413
cytochrome P450 2D6Homo sapiens (human)Potency2.528716
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency12.653718
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency4.5071212
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency8.893229
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency8.017514
D(1A) dopamine receptorHomo sapiens (human)Potency6.890534
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency12.589312
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
DNA polymerase kappa isoform 1Homo sapiens (human)Potency4.104012
dopamine D1 receptorHomo sapiens (human)Potency3.662611
estrogen nuclear receptor alphaHomo sapiens (human)Potency13.433848
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency29.8410813
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency32.397617
EWS/FLI fusion proteinHomo sapiens (human)Potency21.638944
flap endonuclease 1Homo sapiens (human)Potency8.436811
Fumarate hydrataseHomo sapiens (human)Potency35.197312
GVesicular stomatitis virusPotency18.902413
GABA theta subunitRattus norvegicus (Norway rat)Potency4.507216
GALC proteinHomo sapiens (human)Potency0.070811
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency4.507216
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency4.507216
gemininHomo sapiens (human)Potency8.875925
GLI family zinc finger 3Homo sapiens (human)Potency23.349329
glp-1 receptor, partialHomo sapiens (human)Potency7.289633
GLS proteinHomo sapiens (human)Potency16.933423
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency1.387835
glucokinase regulatory proteinHomo sapiens (human)Potency0.707911
hexokinase-4 isoform 1Homo sapiens (human)Potency0.707911
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency18.0103217
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810712
Histone H2A.xCricetulus griseus (Chinese hamster)Potency49.194011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency18.902413
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency6.256024
IDH1Homo sapiens (human)Potency29.092911
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency18.902416
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency9.932814
Interferon betaHomo sapiens (human)Potency11.280137
lamin isoform A-delta10Homo sapiens (human)Potency10.235518
lethal factor (plasmid)Bacillus anthracis str. A2012Potency12.589311
M-phase phosphoprotein 8Homo sapiens (human)Potency44.668411
Microtubule-associated protein tauHomo sapiens (human)Potency5.011911
mitogen-activated protein kinase 1Homo sapiens (human)Potency17.385123
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency1.395526
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency46.011012
neuropeptide S receptor isoform AHomo sapiens (human)Potency25.118911
NFKB1 protein, partialHomo sapiens (human)Potency10.000022
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency26.601111
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency23.914512
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency11.599824
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency23.710111
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency89.125111
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency12.558313
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency60.119811
phosphopantetheinyl transferaseBacillus subtilisPotency2.818411
polyproteinZika virusPotency35.197312
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency7.079511
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency15.643214
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency3.166415
PPM1D proteinHomo sapiens (human)Potency0.415412
pregnane X nuclear receptorHomo sapiens (human)Potency13.467927
RAR-related orphan receptor gammaMus musculus (house mouse)Potency3.898212
ras-related protein Rab-9AHomo sapiens (human)Potency91.999711
regulator of G-protein signaling 4Homo sapiens (human)Potency1.337111
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency40.313338
retinoid X nuclear receptor alphaHomo sapiens (human)Potency14.069713
shiga toxin 1 B subunitEscherichia coli O157:H7Potency0.317711
shiga toxin 1 variant A subunitEscherichia coli O157:H7Potency0.317711
SMAD family member 2Homo sapiens (human)Potency19.162323
SMAD family member 3Homo sapiens (human)Potency19.162323
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency20.490716
survival motor neuron protein isoform dHomo sapiens (human)Potency7.943311
TDP1 proteinHomo sapiens (human)Potency21.2639219
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.335922
ThrombopoietinHomo sapiens (human)Potency11.294724
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency20.407329
thyroid stimulating hormone receptorHomo sapiens (human)Potency17.7928411
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency13.450411
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency12.589312
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency22.112729

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)IC502.635022
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)IC501.700011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC500.038011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki0.047911
5-hydroxytryptamine receptor 2AHomo sapiens (human)IC500.240011
5-hydroxytryptamine receptor 2AHomo sapiens (human)Ki0.069011
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC501.046512
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki0.666012
5-hydroxytryptamine receptor 2CHomo sapiens (human)IC500.468011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki0.245011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)IC500.468011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)Ki0.245011
5-hydroxytryptamine receptor 6Homo sapiens (human)IC503.065011
5-hydroxytryptamine receptor 6Homo sapiens (human)Ki1.423011
AcetylcholinesteraseHomo sapiens (human)IC5024.330011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC502.595111
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki2.573711
Amyloid-beta precursor proteinHomo sapiens (human)Ki0.005911
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)IC5022.348912
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)Ki18.310012
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000013
Beta-1 adrenergic receptorHomo sapiens (human)IC500.316211
Beta-1 adrenergic receptorHomo sapiens (human)Ki0.180011
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)Ki0.015911
Beta-2 adrenergic receptorHomo sapiens (human)Ki0.038422
Bile salt export pumpHomo sapiens (human)IC50166.8240410
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)IC5015.300022
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)IC5015.300022
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)IC5015.300022
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)IC500.07001213
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Rattus norvegicus (Norway rat)IC500.036044
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Rattus norvegicus (Norway rat)Ki0.237713
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)IC501.600011
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)IC5013.200022
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000013
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC5014.766733
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)IC505.557655
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)Ki0.248024
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)IC501.030011
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)Ki0.282524
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)IC5016.900022
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ARattus norvegicus (Norway rat)IC500.076011
Cytochrome P450 2C19Homo sapiens (human)IC500.681012
D(2) dopamine receptorHomo sapiens (human)IC5025.118911
D(3) dopamine receptorHomo sapiens (human)IC500.819412
D(3) dopamine receptorHomo sapiens (human)Ki0.278312
Delta-type opioid receptorHomo sapiens (human)IC5016.833333
Delta-type opioid receptorMus musculus (house mouse)IC5020.250022
fMet-Leu-Phe receptorHomo sapiens (human)IC5066.700011
Gamma-aminobutyric acid receptor subunit alpha-1Bos taurus (cattle)IC500.038012
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit alpha-2Bos taurus (cattle)IC500.038012
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit alpha-3Bos taurus (cattle)IC500.038012
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit alpha-4Bos taurus (cattle)IC500.038012
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit beta-1Bos taurus (cattle)IC500.038012
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit gamma-2Bos taurus (cattle)IC500.038012
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)IC50100,000.000011
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)IC50100,000.000011
hepatocyte nuclear factor 4-alpha isoform 2Homo sapiens (human)IC5039.841011
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)IC5025.000011
Histamine H2 receptorHomo sapiens (human)IC501.625011
Histamine H2 receptorHomo sapiens (human)Ki1.598011
Kappa-type opioid receptorHomo sapiens (human)IC5014.290033
Kappa-type opioid receptorMus musculus (house mouse)IC5020.250022
Lethal(3)malignant brain tumor-like protein 1Homo sapiens (human)IC50100.000011
Lethal(3)malignant brain tumor-like protein 3Homo sapiens (human)IC5054.000011
Lethal(3)malignant brain tumor-like protein 4Homo sapiens (human)IC50100.000011
Lysine-specific demethylase 4CHomo sapiens (human)IC50200.000011
Lysine-specific demethylase 4CHomo sapiens (human)Ki200.000011
MBT domain-containing protein 1Homo sapiens (human)IC50100.000011
Mu-type opioid receptorCavia porcellus (domestic guinea pig)IC500.500011
Mu-type opioid receptorHomo sapiens (human)IC5013.605033
Mu-type opioid receptorMus musculus (house mouse)IC5020.250022
Mu-type opioid receptorHomo sapiens (human)Ki0.920022
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki0.000811
Multidrug resistance-associated protein 4Homo sapiens (human)IC5096.376713
Muscarinic acetylcholine receptorCavia porcellus (domestic guinea pig)Ki0.065722
Muscarinic acetylcholine receptor DM1Drosophila melanogaster (fruit fly)Ki0.410022
Muscarinic acetylcholine receptor M1Homo sapiens (human)IC500.02591516
Muscarinic acetylcholine receptor M1Mus musculus (house mouse)IC500.750013
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)IC500.61343344
Muscarinic acetylcholine receptor M1Homo sapiens (human)Ki0.03761920
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Ki0.044656
Muscarinic acetylcholine receptor M2Homo sapiens (human)IC500.362834
Muscarinic acetylcholine receptor M2Mus musculus (house mouse)IC500.510036
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)IC500.62813545
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki0.11961114
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)Ki2.425768
Muscarinic acetylcholine receptor M3Homo sapiens (human)IC500.320923
Muscarinic acetylcholine receptor M3Mus musculus (house mouse)IC500.750013
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)IC500.62223444
Muscarinic acetylcholine receptor M3Homo sapiens (human)Ki0.67241316
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)Ki0.078946
Muscarinic acetylcholine receptor M4Homo sapiens (human)IC500.391256
Muscarinic acetylcholine receptor M4Mus musculus (house mouse)IC500.750013
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)IC500.62273343
Muscarinic acetylcholine receptor M4Homo sapiens (human)Ki0.083178
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)Ki0.146234
Muscarinic acetylcholine receptor M5Homo sapiens (human)IC500.115423
Muscarinic acetylcholine receptor M5Mus musculus (house mouse)IC500.750013
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)IC500.62273343
Muscarinic acetylcholine receptor M5Homo sapiens (human)Ki0.089378
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)Ki0.110012
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)IC5022.348912
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)Ki18.310012
perilipin-1Homo sapiens (human)IC502.261011
perilipin-5Homo sapiens (human)IC502.635022
Phosphodiesterase Sus scrofa (pig)IC500.620011
Potassium voltage-gated channel subfamily D member 3Homo sapiens (human)IC5012.589222
Potassium voltage-gated channel subfamily E member 1Homo sapiens (human)IC5049.692722
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC5017.0194912
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)Ki18.310012
Potassium voltage-gated channel subfamily KQT member 1Homo sapiens (human)IC5049.692722
Serine hydroxymethyltransferase, mitochondrialHomo sapiens (human)IC502.691511
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC500.014512
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki0.006112
Sodium channel protein type 5 subunit alphaHomo sapiens (human)IC5013.172433
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki17.800022
Sodium-dependent dopamine transporter Homo sapiens (human)IC500.085511
Sodium-dependent dopamine transporter Homo sapiens (human)Ki0.067911
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC502.595111
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki2.573711
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)Ki0.412733
Solute carrier family 22 member 1 Homo sapiens (human)IC5022.250011
Translocator proteinHomo sapiens (human)IC50100,000.000011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50183.900011
Vascular endothelial growth factor receptor 1 Homo sapiens (human)IC5024.330011
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC5024.330011
Vascular endothelial growth factor receptor 3Homo sapiens (human)IC5024.330011
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC50805.004422

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Beta-1 adrenergic receptorHomo sapiens (human)EC500.039811
Beta-1 adrenergic receptorRattus norvegicus (Norway rat)EC502.310011
Beta-2 adrenergic receptorHomo sapiens (human)EC500.004944
D(2) dopamine receptorHomo sapiens (human)EC5010.000011
Mu-type opioid receptorHomo sapiens (human)EC509.400011
Muscarinic acetylcholine receptorCavia porcellus (domestic guinea pig)Kd0.049813
Muscarinic acetylcholine receptor M1Homo sapiens (human)Kd0.020011
Muscarinic acetylcholine receptor M2Homo sapiens (human)Kd0.023813
Muscarinic acetylcholine receptor M3Homo sapiens (human)EC500.029333
Transient receptor potential cation channel subfamily A member 1Homo sapiens (human)EC5096.000011
Transient receptor potential cation channel subfamily M member 8Homo sapiens (human)EC5010.100011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)IC200.650011
Liver carboxylesterase 1Homo sapiens (human)Km1,900.000011
Muscarinic acetylcholine receptor M1Homo sapiens (human)KA0.011011
Muscarinic acetylcholine receptor M1Homo sapiens (human)Kb0.010011
Muscarinic acetylcholine receptor M2Homo sapiens (human)Kb0.098014
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