A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.
| Member | Definition | Class |
|---|
| alverine | A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel syndrome. | alverine |
| alverine citrate | The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome. | alverine citrate |
| darifenacin | 2-[(3S)-1-Ethylpyrrolidin-3-yl]-2,2-diphenylacetamide in which one of the hydrogens at the 2-position of the ethyl group is substituted by a 2,3-dihydro-1-benzofuran-5-yl group. It is a selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, and is used as the hydrobromide salt in the management of urinary incontinence. | darifenacin |
| dicyclomine | The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome. | dicyclomine |
| dicyclomine hydrochloride | The hydrochloride salt of dicyclomine. An anticholinergic, it is used to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome. | dicyclomine hydrochloride |
| flavoxate | A carboxylic ester resulting from the formal condensation of 3-methylflavone-8-carboxylic acid with 2-(1-piperidinyl)ethanol. | flavoxate |
| flavoxate hydrochloride | The hydrochloride salt of flavoxate. | flavoxate hydrochloride |
| glycycoumarin | A member of the class of coumarins that is coumarin substituted by a hydroxy group at position 7, a methoxy group at position 5, a prenyl group at position 6 and a 2,4-dihydroxyphenyl group at position 3. Isolated from Glycyrrhiza uralensis, it exhibits antispasmodic activity. | glycycoumarin |
| menthol | A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer. | (-)-menthol |
| meperidine | A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain. | pethidine |
| meperidine hydrochloride | The hydrochloride salt of pethidine. An analgesic used for the treatment of postoperative and labour pain. | pethidine hydrochloride |
| nimetazepam | A nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia. | nimetazepam |
| nitrazepam | A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome). | nitrazepam |
| oxybutynin | A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder. | 4-(diethylamino)but-2-yn-1-ol; oxybutynin |
| papaverine | A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum. | papaverine |
| pirenzepine | | pirenzepine |
| propyromazine | An organic bromide salt of propyromazine. It is a muscarinic antagonist which has antispasmodic potential. | propyromazine bromide |
| tiquizium bromide | A organic bromide salt of tiquizium. It is an antispasmodic drug used for the treatment of convulsion and hypermobility in gastritis, gastric ulcer, duodenal ulcer, enteritis, irritable bowel syndrome, gallbladder disease, biliary tract disease and urolithiasis. | tiquizium bromide |
| tolterodine | | tolterodine |
| tridihexethyl | | tridihexethyl |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.3822 | 2 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.3335 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 13.2507 | 8 | 13 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 61.9396 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 5.3940 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 25.2008 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 10.9235 | 2 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 13.3722 | 2 | 2 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 13.0918 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 51.4944 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 29.8493 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 51.4944 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 29.8493 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 3.9650 | 1 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 16.4323 | 1 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 79.4328 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0501 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0200 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 50.7423 | 2 | 3 |
| CREB-binding protein | Homo sapiens (human) | Potency | 5.6904 | 4 | 8 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 6.3310 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 20.1144 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 18.9024 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 2.5287 | 1 | 6 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.6537 | 1 | 8 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 4.5071 | 2 | 12 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 8.8932 | 2 | 9 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 8.0175 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 6.8905 | 3 | 4 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 4.1040 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.4338 | 4 | 8 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.8410 | 8 | 13 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 32.3976 | 1 | 7 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 21.6389 | 4 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.1973 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 18.9024 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| GALC protein | Homo sapiens (human) | Potency | 0.0708 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 4.5072 | 1 | 6 |
| geminin | Homo sapiens (human) | Potency | 8.8759 | 2 | 5 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 23.3493 | 2 | 9 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.2896 | 3 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 16.9334 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 1.3878 | 3 | 5 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 18.0103 | 2 | 17 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 49.1940 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 18.9024 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 6.2560 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 18.9024 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 9.9328 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 11.2801 | 3 | 7 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 10.2355 | 1 | 8 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.5893 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 17.3851 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.3955 | 2 | 6 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 46.0110 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.6011 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 23.9145 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.5998 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 12.5583 | 1 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 60.1198 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 2.8184 | 1 | 1 |
| polyprotein | Zika virus | Potency | 35.1973 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 15.6432 | 1 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 3.1664 | 1 | 5 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.4154 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 13.4679 | 2 | 7 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 3.8982 | 1 | 2 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 91.9997 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.3371 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 40.3133 | 3 | 8 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 14.0697 | 1 | 3 |
| shiga toxin 1 B subunit | Escherichia coli O157:H7 | Potency | 0.3177 | 1 | 1 |
| shiga toxin 1 variant A subunit | Escherichia coli O157:H7 | Potency | 0.3177 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 19.1623 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 19.1623 | 2 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 20.4907 | 1 | 6 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 21.2639 | 2 | 19 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.3359 | 2 | 2 |
| Thrombopoietin | Homo sapiens (human) | Potency | 11.2947 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 20.4073 | 2 | 9 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 17.7928 | 4 | 11 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 22.1127 | 2 | 9 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 2.6350 | 2 | 2 |
| 3',5'-cyclic-AMP phosphodiesterase | Sus scrofa (pig) | IC50 | 1.7000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0380 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0479 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.2400 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0690 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.0465 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.6660 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.4680 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.2450 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.4680 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.2450 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 3.0650 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 1.4230 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 24.3300 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.5951 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.5737 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Ki | 0.0059 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 22.3489 | 1 | 2 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 18.3100 | 1 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 0.3162 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.1800 | 1 | 1 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0159 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 0.0384 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 166.8240 | 4 | 10 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Homo sapiens (human) | IC50 | 15.3000 | 2 | 2 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | IC50 | 15.3000 | 2 | 2 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Homo sapiens (human) | IC50 | 15.3000 | 2 | 2 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Homo sapiens (human) | IC50 | 0.0700 | 12 | 13 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Rattus norvegicus (Norway rat) | IC50 | 0.0360 | 4 | 4 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Rattus norvegicus (Norway rat) | Ki | 0.2377 | 1 | 3 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 13.2000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 14.7667 | 3 | 3 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 | 5.5576 | 5 | 5 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | Ki | 0.2480 | 2 | 4 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 | 1.0300 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | Ki | 0.2825 | 2 | 4 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 16.9000 | 2 | 2 |
| Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Rattus norvegicus (Norway rat) | IC50 | 0.0760 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.6810 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 25.1189 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.8194 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.2783 | 1 | 2 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 16.8333 | 3 | 3 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 20.2500 | 2 | 2 |
| fMet-Leu-Phe receptor | Homo sapiens (human) | IC50 | 66.7000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| hepatocyte nuclear factor 4-alpha isoform 2 | Homo sapiens (human) | IC50 | 39.8410 | 1 | 1 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.6250 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 1.5980 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 14.2900 | 3 | 3 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 20.2500 | 2 | 2 |
| Lethal(3)malignant brain tumor-like protein 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 3 | Homo sapiens (human) | IC50 | 54.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lysine-specific demethylase 4C | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Lysine-specific demethylase 4C | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| MBT domain-containing protein 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.5000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 13.6050 | 3 | 3 |
| Mu-type opioid receptor | Mus musculus (house mouse) | IC50 | 20.2500 | 2 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.9200 | 2 | 2 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 96.3767 | 1 | 3 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0657 | 2 | 2 |
| Muscarinic acetylcholine receptor DM1 | Drosophila melanogaster (fruit fly) | Ki | 0.4100 | 2 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.0259 | 15 | 16 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.6134 | 33 | 44 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0376 | 19 | 20 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0446 | 5 | 6 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.3628 | 3 | 4 |
| Muscarinic acetylcholine receptor M2 | Mus musculus (house mouse) | IC50 | 0.5100 | 3 | 6 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.6281 | 35 | 45 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.1196 | 11 | 14 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 2.4257 | 6 | 8 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.3209 | 2 | 3 |
| Muscarinic acetylcholine receptor M3 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.6222 | 34 | 44 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.6724 | 13 | 16 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0789 | 4 | 6 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.3912 | 5 | 6 |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.6227 | 33 | 43 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0831 | 7 | 8 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.1462 | 3 | 4 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.1154 | 2 | 3 |
| Muscarinic acetylcholine receptor M5 | Mus musculus (house mouse) | IC50 | 0.7500 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.6227 | 33 | 43 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0893 | 7 | 8 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 2 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 22.3489 | 1 | 2 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 18.3100 | 1 | 2 |
| perilipin-1 | Homo sapiens (human) | IC50 | 2.2610 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 2.6350 | 2 | 2 |
| Phosphodiesterase | Sus scrofa (pig) | IC50 | 0.6200 | 1 | 1 |
| Potassium voltage-gated channel subfamily D member 3 | Homo sapiens (human) | IC50 | 12.5892 | 2 | 2 |
| Potassium voltage-gated channel subfamily E member 1 | Homo sapiens (human) | IC50 | 49.6927 | 2 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 17.0194 | 9 | 12 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 18.3100 | 1 | 2 |
| Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens (human) | IC50 | 49.6927 | 2 | 2 |
| Serine hydroxymethyltransferase, mitochondrial | Homo sapiens (human) | IC50 | 2.6915 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.0145 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0061 | 1 | 2 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 13.1724 | 3 | 3 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 17.8000 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.0855 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.0679 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.5951 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.5737 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.4127 | 3 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 22.2500 | 1 | 1 |
| Translocator protein | Homo sapiens (human) | IC50 | 100,000.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 183.9000 | 1 | 1 |
| Vascular endothelial growth factor receptor 1 | Homo sapiens (human) | IC50 | 24.3300 | 1 | 1 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 24.3300 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 24.3300 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 805.0044 | 2 | 2 |