Roles > detergent
Page last updated: 2024-08-05 14:51:53

detergent

A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions.

ChEBI ID: 27780

Members (8)

MemberDefinitionClass
cetrimonium bromideThe organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide.cetyltrimethylammonium bromide
cholesteryl succinateA dicarboxylic acid monoester resulting from the formal condensation of the hydroxy group of cholesterol with one of the carboxy groups of succinic acid. A detergent that is often used to replace cholesterol in protein crystallography, biochemical studies of proteins, and pharmacology.cholesteryl hemisuccinate
dodecyl-beta-d-maltosideA glycoside resulting from attachment of a dodecyl group to the reducing-end anomeric centre of a beta-maltose molecule.dodecyl beta-D-maltoside
dodecyldimethylamine oxideA tertiary amine oxide resulting from the formal oxidation of the amino group of dodecyldimethylamine.dodecyldimethylamine N-oxide
dodecylphosphocholineA phosphocholine that is the monododecyl ester of phosphocholinedodecylphosphocholine
glycerolA triol with a structure of propane substituted at positions 1, 2 and 3 by hydroxy groups.glycerol
sodium dodecyl sulfateAn organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.sodium dodecyl sulfate
zwittergent 3-12An ammonium betaine in which the ammonium nitrogen is substituted by dodecyl, 3-sulfatopropyl and two methyl groups.lauryl sulfobetaine

Research

Studies (39,855)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199015,993 (40.13)18.7374
1990's5,517 (13.84)18.2507
2000's7,325 (18.38)29.6817
2010's8,491 (21.30)24.3611
2020's2,529 (6.35)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,239 (2.95%)5.53%
Reviews1,031 (2.45%)6.00%
Case Studies373 (0.89%)4.05%
Observational22 (0.05%)0.25%
Other39,362 (93.66%)84.16%

Protein Targets (91)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency11.220211
15-lipoxygenase, partialHomo sapiens (human)Potency39.810711
67.9K proteinVaccinia virusPotency10.610122
acetylcholinesteraseHomo sapiens (human)Potency56.563934
activating transcription factor 6Homo sapiens (human)Potency44.689213
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency28.183811
alpha-galactosidaseHomo sapiens (human)Potency39.810711
AR proteinHomo sapiens (human)Potency28.44981128
Ataxin-2Homo sapiens (human)Potency3.757811
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency3.757811
Cellular tumor antigen p53Homo sapiens (human)Potency39.608029
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency12.589311
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency39.810711
Chain A, CruzipainTrypanosoma cruziPotency32.184113
Chain A, Ferritin light chainEquus caballus (horse)Potency50.118711
cytochrome P450 2C9, partialHomo sapiens (human)Potency26.837011
cytochrome P450 2D6Homo sapiens (human)Potency0.859812
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency16.809612
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency15.811913
estrogen nuclear receptor alphaHomo sapiens (human)Potency31.60401124
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency71.379333
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency23.2445619
farnesoid X nuclear receptorHomo sapiens (human)Potency44.184757
Fumarate hydrataseHomo sapiens (human)Potency35.481311
GVesicular stomatitis virusPotency26.837011
GALC proteinHomo sapiens (human)Potency0.631011
gemininHomo sapiens (human)Potency5.395123
GLI family zinc finger 3Homo sapiens (human)Potency17.091838
GLS proteinHomo sapiens (human)Potency28.183811
glucocerebrosidaseHomo sapiens (human)Potency31.622811
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency34.2556511
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency45.490012
heat shock protein beta-1Homo sapiens (human)Potency47.790323
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency35.481311
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency44.668411
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency26.837011
huntingtin isoform 2Homo sapiens (human)Potency31.622811
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency35.334726
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency26.837012
Integrin alpha-IIbHomo sapiens (human)Potency12.589311
Integrin beta-3Homo sapiens (human)Potency12.589311
Interferon betaHomo sapiens (human)Potency28.255222
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency0.306013
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.100011
LuciferasePhotinus pyralis (common eastern firefly)Potency69.891923
Microtubule-associated protein tauHomo sapiens (human)Potency19.091922
mitogen-activated protein kinase 1Homo sapiens (human)Potency34.002923
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency54.8164413
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency50.118711
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency55.485624
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency14.140622
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency71.379333
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency16.593722
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency45.533245
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency44.668411
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency48.9059511
phosphopantetheinyl transferaseBacillus subtilisPotency44.668411
polyproteinZika virusPotency35.481311
pregnane X nuclear receptorHomo sapiens (human)Potency59.656523
pregnane X receptorRattus norvegicus (Norway rat)Potency50.118712
progesterone receptorHomo sapiens (human)Potency54.403923
RAR-related orphan receptor gammaMus musculus (house mouse)Potency13.919526
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency43.432238
retinoid X nuclear receptor alphaHomo sapiens (human)Potency37.5834412
SMAD family member 2Homo sapiens (human)Potency28.265024
SMAD family member 3Homo sapiens (human)Potency28.265024
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency10.217512
survival motor neuron protein isoform dHomo sapiens (human)Potency12.589311
TDP1 proteinHomo sapiens (human)Potency0.803424
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency22.0494212
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency27.424025
thyroid stimulating hormone receptorHomo sapiens (human)Potency40.160657
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency28.844022
USP1 protein, partialHomo sapiens (human)Potency44.480913
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency45.815626
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency30.464248
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency59.487313
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency45.490012

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
10 kDa chaperonin Escherichia coliIC509.250022
10 kDa heat shock protein, mitochondrialHomo sapiens (human)IC507.400011
60 kDa chaperoninEscherichia coli K-12IC50210.000011
60 kDa chaperonin Escherichia coliIC509.250022
60 kDa heat shock protein, mitochondrialHomo sapiens (human)IC507.400011
Bifunctional epoxide hydrolase 2Homo sapiens (human)IC50135.500033
Dynamin-1Homo sapiens (human)IC504.370011
Lanosterol synthaseHomo sapiens (human)IC504.230022
Thiosulfate sulfurtransferaseHomo sapiens (human)IC50100.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, Synaptobrevin homolog YKT6Rattus norvegicus (Norway rat)Kd60.000011
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4EHomo sapiens (human)Kd110,000.000011