A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
ChEBI ID: 59740
| Member | Definition | Class |
|---|---|---|
| ammonium hydroxide | An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms. | ammonia |
| hydroxylamine | The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria. | hydroxylamine |
| sodium ethoxide | An organic monosodium salt that has ethoxide as the counterion. | sodium ethoxide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 10,231 (34.83) | 18.7374 |
| 1990's | 3,690 (12.56) | 18.2507 |
| 2000's | 5,248 (17.87) | 29.6817 |
| 2010's | 7,314 (24.90) | 24.3611 |
| 2020's | 2,892 (9.85) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 580 (1.88%) | 5.53% |
| Reviews | 1,650 (5.34%) | 6.00% |
| Case Studies | 1,050 (3.40%) | 4.05% |
| Observational | 30 (0.10%) | 0.25% |
| Other | 27,577 (89.28%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0120 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 0.0060 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0282 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 49.2215 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.7943 | 1 | 1 |