cyperin: a phytotoxin; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 182142 |
| CHEMBL ID | 487020 |
| CHEBI ID | 4041 |
| MeSH ID | M0524723 |
| Synonym |
|---|
| ACON1_001039 |
| MEGXM0_000353 |
| ACON0_001000 |
| C09923 , |
| 33716-82-4 |
| cyperine |
| NCGC00169734-01 |
| BRD-K96563692-001-01-8 |
| 2-(3-hydroxy-5-methylphenoxy)-5-methoxy-3-methylphenol |
| chebi:4041 , |
| CHEMBL487020 |
| cyperin |
| phenol, 2-(3-hydroxy-5-methylphenoxy)-5-methoxy-3-methyl- |
| cy[erom |
| 2-(3-hydroxy-5-methylphenoxy)-5-methoxy-3-methylphenol, 9ci |
| ll-v125a |
| antibiotic ll-v125a |
| 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenylether |
| Q27106294 |
| 3,5'-dimethyl-5-methoxy-(2,3'-oxybisphenol) |
| DTXSID10955330 |
| cyperine; 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether; ll-v-125-a|or ll-vi-25a |
| BS-1515 |
| bdbm50601434 |
| AKOS040735056 |
Cyperin is a natural diphenyl ether phytotoxin produced by several fungal plant pathogens.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Cyperin is a natural diphenyl ether phytotoxin produced by several fungal plant pathogens. " | ( A pathogenic fungi diphenyl ether phytotoxin targets plant enoyl (acyl carrier protein) reductase. Dayan, FE; Ferreira, D; Khan, IA; McInroy, JA; Pan, Z; Wang, YH, 2008) | 1.79 |
| Class | Description |
|---|---|
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 (µMol) | 17.0000 | 0.0005 | 3.4984 | 9.7600 | AID1894481 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1894481 | Inhibition of human recombinant PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by microplate reader based analysis | 2021 | Journal of natural products, 03-26, Volume: 84, Issue:3 | Freshwater Fungi as a Source of Chemical Diversity: A Review. |
| AID334299 | Antifungal activity against Sordaria fimicola NRRL 6460 assessed as hyphal morphological changes | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5 | Interference Competition Among Natural Fungal Competitors: an Antifungal Metabolite from the Coprophilous Fungus Preussia fleischhakii. |
| AID689840 | Antibacterial activity against methicillin-resistant Staphylococcus aureus up to 30 uM after 24 hrs | 2012 | Journal of natural products, Oct-26, Volume: 75, Issue:10 | Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. |
| AID334300 | Antifungal activity against sAscobolus furfuraceus NRRL 6459 assessed as hyphal morphological changes | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5 | Interference Competition Among Natural Fungal Competitors: an Antifungal Metabolite from the Coprophilous Fungus Preussia fleischhakii. |
| AID334301 | Toxicity in brine shrimp | 1988 | Journal of natural products, Sep, Volume: 51, Issue:5 | Interference Competition Among Natural Fungal Competitors: an Antifungal Metabolite from the Coprophilous Fungus Preussia fleischhakii. |
| AID689842 | Antifungal activity against Aspergillus fumigatus up to 30 uM after 48 hrs | 2012 | Journal of natural products, Oct-26, Volume: 75, Issue:10 | Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. |
| AID689841 | Antibacterial activity against Klebsiella pneumoniae up to 30 uM after 24 hrs | 2012 | Journal of natural products, Oct-26, Volume: 75, Issue:10 | Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. |
| AID689839 | Antioxidant activity assessed as DPPH free radical scavenging activity up to 30 uM after 30 mins | 2012 | Journal of natural products, Oct-26, Volume: 75, Issue:10 | Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (30.94) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||