The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Reference |
|---|
| "Features of fatigue are analyzed theoretically as perceptual phenomena as related to alcohol and accidents." | ( Carlson, D; Ladan, CJ; Nelson, TM, 1979) |
| "Muscular fatigue is manifested by a decline in force- or power-generating capacity and may be prominent in both submaximal and maximal contractions." | ( McKenna, MJ, 1992) |
| "Metabolic fatigue is a characteristic muscle response to intense exercise that has outstripped the rate of ATP replacement." | ( Layzer, RB, 1990) |
| "Muscle fatigue is accompanied by a series of biochemical correlations as substrate depletion, lactate accumulation, shifts of pH, increase of phosphate (Pi), arise of free radicals or disturbances of ionic balances." | ( Caffier, G; Kössler, F; Lange, F, 1990) |
| "Because dyspnea and fatigue are prime symptoms and sources of clinical distress, the index helps reflect the quality of life in patients with congestive heart failure." | ( Feinstein, AR; Fisher, MB; Pigeon, JG, 1989) |
| "Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment." | ( Cohen, RA; Fisher, M, 1989) |
| "Fatigue is a frequent complaint from patients suffering from the hyperventilation syndrome." | ( Folgering, H; Snik, A, 1988) |
| "Muscle fatigue is thus considered to be due to an insufficient rate of ADP rephosphorylation resulting in a block in the activation process or in the excitation/contraction coupling." | ( Sahlin, K, 1986) |
| "Although fatigue is a well-known phenomenon and the phrase "exercised until exhaustion" is commonly understood, there is no unequivocal agreement on the fundamental nature of the fatigue process." | ( Banister, EW; Mutch, BJ, 1983) |
| "Fatigue is a complication of MS." | ( Coyle, PK; Cross, AH; Doscher, C; Grimson, R; Halper, J; Jandorf, L; Johnson, B; Krupp, LB; Miller, A; Morgante, L, 1995) |
| "Although fatigue is a common debilitating complaint in multiple sclerosis (MS), its relationship to the cardiopulmonary exercise response has yet to be defined." | ( Mashman, J; Vaz Fragoso, CA; Wirz, D, 1995) |
| "Central fatigue is largely unexplored, but there is increasing evidence that increased brain serotonin (5-HT) can lead to central (mental) fatigue, thereby causing a deterioration in sport and exercise performance." | ( Davis, JM, 1995) |
| "Fatigue is a common complaint in patients with liver disease; however, the etiology of fatigue is poorly understood and no therapeutic options are available to treat it." | ( Maric, M; Swain, MG, 1997) |
| "Fatigue is the most commonly reported symptom among cancer patients and can significantly affect their daily lives." | ( Cella, D, 1997) |
| "Fatigue is a common symptom in patients with multiple sclerosis." | ( Hohlfeld, R; Zimmermann, C, 1999) |
| "Fatigue is a frequent and often severe symptom in multiple sclerosis." | ( Bastianello, S; Ciccarelli, O; Comi, G; Faroni, J; Filippi, M; Gasperini, C; Giugni, E; Mainero, C; Pozzilli, C; Rovaris, M, 1999) |
| "Central fatigue is implicated in clinical conditions such as chronic fatigue syndrome and post-operative fatigue." | ( Castell, LM; Newsholme, EA; Phoenix, J; Yamamoto, T, 1999) |
| "Fatigue is an important but under-recognised side-effect of hormone therapy." | ( A'Hern, R; Hardy, J; Huddart, R; Richards, M; Stone, P, 2000) |
| "Fatigue is a commonly encountered symptom of human immunodeficiency virus (HIV) disease, associated with significant psychological and functional morbidity and poor quality of life." | ( Breitbart, W; Funesti-Esch, J; Kaim, M; Rosenfeld, B, 2001) |
| "HIV-related fatigue is easy to overlook because it is attributed to be a normal part of HIV disease and begins slowly, worsening over time." | ( Capaldini, L, 1998) |
| "Fatigue is a common complaint of patients with cancer or other physical or mental disorders." | ( Aprile, G; Belvedere, O; Grossi, F; Guglielmi, A; Puglisi, F; Ramello, M; Sobrero, A, 2001) |
| "Because persistent fatigue is the most common complaint of patients following hysterectomy, the use of epoetin alfa should be considered to preoperatively correct anemia in this patient population." | ( Bachmann, GA, 2001) |
| "Fatigue is a common complaint in patients affected by multiple sclerosis." | ( Waubant, E, 2001) |
| "Fatigue is a common complaint of patients with cholestatic liver disease." | ( Burak, KW; Le, T; Swain, MG, 2002) |
| "Fatigue is among the most common, yet least understood, symptoms of multiple sclerosis (MS) [1." | ( Christodoulou, C; Krupp, LB, 2001) |
| "Although fatigue is a common symptom among cancer patients, it is also a common experience in the general, healthy population." | ( Cella, D; Chang, CH; Lai, JS; Peterman, A; Slavin, M, 2002) |
| "Thus, although fatigue is a symptom most anyone can relate to, the fatigue of cancer patients, particularly those who are anemic, is decidedly worse." | ( Cella, D; Chang, CH; Lai, JS; Peterman, A; Slavin, M, 2002) |
| "Fatigue is a common phenomenon in patients with SLE." | ( Husby, G; Jacobsen, EA; Koldingsnes, W; Mellgren, SI; Omdal, R, 2002) |
| "Fatigue is a well-recognized complaint with major impact on daily life in primary Sjögren's syndrome (PSS) and systemic lupus erythematosus (SLE)." | ( Bijlsma, JW; Derksen, RH; Garssen, A; Geenen, R; Godaert, GL; Hartkamp, A; Kruize, AA, 2002) |
| "Although fatigue is a commonly reported symptom in cancer patients its etiology is still poorly understood." | ( Fleischhacker, WW; Greil, R; Hejna, M; Holzner, B; Huber, H; Kemmler, G; Kopp, M; Krajnik, G; Raderer, M; Sperner-Unterweger, B; Zeimet, A; Zöchbauer, S, 2002) |
| "Fatigue is often related to cancer, and that related to its treatment is the most commonly reported side effect of cancer treatment." | ( Andrews, PL; Hickok, JT; Matteson, S; Morrow, GR; Roscoe, JA, 2002) |
| "Fatigue is the most common symptom of anemia, being reported by 80-100% of patients undergoing chemotherapy." | ( Kuhn, JG, 2002) |
| "Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC)." | ( Benzaken, S; Ferrua, B; Gelsi, E; Giudicelli, J; Hastier, P; Hébuterne, X; Laffont, C; Longo, F; Montoya, ML; Piche, T; Rampal, P; Schneider, SM; Tran, A, 2002) |
| "Fatigue is present in CHC patients and is more pronounced in females." | ( Benzaken, S; Ferrua, B; Gelsi, E; Giudicelli, J; Hastier, P; Hébuterne, X; Laffont, C; Longo, F; Montoya, ML; Piche, T; Rampal, P; Schneider, SM; Tran, A, 2002) |
| "Fatigue is a common complaint of patients seen in primary care." | ( Corwin, EJ; Klein, LC; Rickelman, K, 2002) |
| "Fatigue is common after major surgery and delays recovery." | ( Hall, GM; Salmon, P, 2002) |
| "Fatigue is common after major surgery and delays recovery." | ( Hall, GM; Salmon, P, 2002) |
| "Fatigue is an indispensable sense for ordering rest." | ( Evengård, B; Hagberg, G; Iwase, M; Kanakura, Y; Kitani, T; Kuratsune, H; Långström, B; Lindh, G; Machii, T; Matsumura, K; Onoe, H; Takahashi, M; Watanabe, Y; Yamaguti, K, 2002) |
| "Results showed that fatigue is a common health problem but seldom on the agenda in general practice." | ( Bensing, J; Meeuwesen, L; van den Brink-Muinen, A, 2002) |
| "Fatigue is one of the most significant symptoms." | ( Beckers, EA; Essink-Bot, ML; Hop, WC; Jansen, AJ; Schipperus, MR; Van Rhenen, DJ, 2003) |
| "Fatigue is a common complaint in patients with liver disease." | ( Luca, S; Malaguarnera, M; Neri, S; Pennisi, G; Pistone, G; Saraceno, B, 2003) |
| "Fatigue is one of the most common and disabling symptoms of people with Multiple Sclerosis (MS)." | ( D'Amico, R; Giuliani, G; Pucci, E; Solari, A; Taus, C, 2003) |
| "Fatigue is an important feature in IBD in remission, adversely affecting the quality of life." | ( Minderhoud, IM; Oldenburg, B; van Berge Henegouwen, GP; van Dam, PS, 2003) |
| "Fatigue is an indispensable biosignal for maintaining life." | ( Watanabe, Y, 2003) |
| "Fatigue is a common symptom of older cancer patients treated with antineoplastic medical treatment." | ( Balducci, L; Jacobsen, PB; Respini, D; Thors, C; Tralongo, P, 2003) |
| "Fatigue is a common and distressing symptom for patients with multiple sclerosis (MS)." | ( Arnold, DL; De Stefano, N; Francis, SJ; Lapierre, Y; Narayanan, S; Santos, AC; Tartaglia, MC, 2004) |
| "Fatigue is the commonest symptom in primary biliary cirrhosis (PBC), affecting individuals at all stages of disease." | ( Allsop, JM; Bassendine, M; Forton, DM; Goldblatt, J; Hajnal, JV; Hamilton, G; Jones, DE; Oatridge, A; Patel, N; Prince, M; Taylor-Robinson, SD; Thomas, HC, 2004) |
| "Fatigue is a symptom of liver disease." | ( Bergasa, NV; Bir, K; Mehlman, J, 2004) |
| "Fatigue is a major symptom of anemia and is a primary complaint in patients with cancer." | ( Bokemeyer, C; Foubert, J, 2004) |
| "Fatigue is the most common symptom of MS and is associated with a reduced quality of life." | ( Zifko, UA, 2004) |
| "Fatigue is often reported after long duration flights." | ( Batéjat, D; Beaumont, M; Charbuy, H; Coste, O; Touitou, Y; Van Beers, P, 2004) |
| "Fatigue is a major clinical problem in many patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC)." | ( Hansen, BE; ter Borg, PC; van Buuren, HR; van den Broek, WW; van Os, E, 2004) |
| "Fatigue is a symptom that is frequently found in chronic pain patients with low back pain and/or neck pain." | ( Cole, B; Cutler, RB; Fishbain, DA; Lewis, J; Rosomoff, HL; Steele-Rosomoff, R, 2004) |
| "Chronic fatigue is the more frequent symptom identified in the course of hereditary haemochromatosis." | ( Durieu, I; Durupt, S; François, S; Morel, Y; Nové-Josserand, R; Rousset, H; Vital Durand, D, 2004) |
| "Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS) patients." | ( Montalbán, X; Téllez, N, 2004) |
| "Fatigue is a common toxicity associated with weekly docetaxel; other adverse effects that are seen in a minority of patients include hyperlacrimation, nail toxicity, and alopecia." | ( Hainsworth, JD, 2004) |
| "Fatigue is common and can be profound in patients with chronic liver diseases, such as primary biliary cirrhosis (PBC) and chronic hepatitis C." | ( Jones, EA, 2004) |
| "Fatigue is widespread among human immunodeficiency virus-positive (HIV+) patients, yet few studies have assessed effective treatments." | ( Ferrando, SJ; McElhiney, MC; Rabkin, JG; Rabkin, R, 2004) |
| "Fatigue is a common and disabling symptom in patients with multiple sclerosis (MS)." | ( Flachenecker, P; Gottschalk, M; Holsboer, F; Kümpfel, T; Trenkwalder, C; Uhr, M; Weber, F, 2005) |
| "Fatigue is an important component of QOL." | ( Angermund, R; Lutz, H; Reinhardt, U; Tulusan, A, 2005) |
| "Fatigue is assessed with the Functional Assessment of Cancer Therapy (FACT)-Fatigue subscale score." | ( Berndt, E; Glaspy, J; Kallich, J; Lee, H; McDermott, A; Xu, X, 2005) |
| "Reducing fatigue is associated with gains in productive time, reductions in caregiver burden and enhanced ability to perform activities." | ( Berndt, E; Glaspy, J; Kallich, J; Lee, H; McDermott, A; Xu, X, 2005) |
| "Fatigue is common in primary biliary cirrhosis (PBC)." | ( Burak, KW; Girlan, L; Heathcote, EJ; Heslegrave, RJ; Huet, PM; Swain, M; Theal, JJ; Tomlinson, GA; Toosi, MN, 2005) |
| "Fatigue is common in this population and BFI correlates with more extensive measurements." | ( Bhatia, S; Einhorn, LH; Hanna, A; Hanna, N; Juliar, BE; Monahan, P; Shafqat, A; Sledge, GW, 2005) |
| "Anemia and fatigue are frequent in lung cancer patients." | ( Méric, JB; Morère, JF, 2005) |
| "Fatigue is among the most commonly reported symptoms of patients with cancer, with prevalence exceeding 60% in many studies." | ( Hickok, JT; Morrow, GR; Mustian, K; Roscoe, JA; Shelke, AR, 2005) |
| "Fatigue is one of the most common and disturbing residual symptoms of depression." | ( Marin, H; Menza, MA, 2005) |
| "Chronic fatigue is considered a complex symptom for which currently there is no curative treatment available." | ( Dhanasekaran, M; Manyam, BV; Tharakan, B, 2005) |
| "Fatigue is the commonest symptom described by patients in most populations with the autoimmune liver disease primary biliary cirrhosis (PBC), and appears to be unrelated to liver disease severity." | ( Bhala, N; Burt, J; Goldblatt, J; Jones, DE; Newton, JL; Prince, M, 2006) |
| "Fatigue is a major complaint in patients with immune mediated polyneuropathies." | ( Garssen, MP; Jacobs, BC; Merkies, IS; Schmitz, PI; van der Meché, FG; van Doorn, PA, 2006) |
| "Fatigue is a multidimensional symptom that is described in terms of perceived energy, mental capacity, and psychological status: it can impair daily functioning and lead to negative effects on quality of life." | ( Astara, G; Deiana, L; Dessì, M; Gramignano, G; Lamonica, G; Lusso, MR; Macciò, A; Madeddu, C; Mantovani, G; Massa, E; Serpe, R; Spiga, C, 2006) |
| "Fatigue is the most commonly encountered symptom in patients with liver disease, and it has a significant impact on their quality of life." | ( Swain, MG, 2006) |
| "Profound fatigue is a clinically significant complication of chronic liver disease." | ( Jones, EA, 2006) |
| "Chronic fatigue is a complex and little understood symptom for which there is no safe and effective pharmacotherapy." | ( Brown-Borg, HM; Dhanasekaran, M; Manyam, BV; Tharakan, B, 2006) |
| "Fatigue is common in patients with chronic heart failure (CHF) and has great impact on functional ability and daily activity." | ( Ekman, I; Falk, K; Gaston-Johansson, F; Swedberg, K, 2006) |
| "Fatigue is a common symptom of depression, especially the bipolar type." | ( Nasr, S; Steiner, K; Wendt, B, 2006) |
| "Fatigue is one of the most limiting symptoms in multiple sclerosis (MS) and the mechanisms underlying its origin are poorly understood." | ( Brieva, L; Comabella, M; Julià, E; Montalban, X; Nos, C; Río, J; Téllez, N; Tintoré, M, 2006) |
| "Fatigue is common in cancer patients treated with chemotherapy, and it has detrimental effects on their quality of life." | ( Cella, D, 2006) |
| "Fatigue is a common problem following cancer treatment and our previous studies suggest that a chronic inflammatory process might contribute to cancer-related fatigue." | ( Aziz, N; Bower, JE; Cole, SW; Ganz, PA; Irwin, MR; Olmstead, R, 2007) |
| "Fatigue is a common symptom in primary biliary cirrhosis (PBC)." | ( Donlinger, JJ; Gossard, AA; Jorgensen, RA; Keach, JC; Lindor, KD; Petz, JC; Talwalkar, JA, 2006) |
| "Central fatigue is the term used to describe when muscle contractions become limited by the ability of the central nervous system to recruit motor neurones." | ( Dalsgaard, MK; Quistorff, B; Secher, NH, 2006) |
| "Fatigue is one of the most common and disabling symptoms of people with Multiple Sclerosis (MS)." | ( Branãs, P; D'Amico, R; Giuliani, G; Pucci, E; Solari, A; Taus, C, 2007) |
| "Fatigue is a debilitating symptom which frequently impairs the quality of life of patients with primary biliary cirrhosis (PBC)." | ( Jones, DE; Newton, JL, 2007) |
| "Fatigue is a common complaint among adolescents, especially in girls, and is associated with high rates of school absenteeism." | ( Coffeng, LE; Heijnen, CJ; Kavelaars, A; Ter Wolbeek, M; van Doornen, LJ, 2007) |
| "Fatigue is associated with circulating leptin levels independently from age, sex, fat mass and body mass index in irritable bowel syndrome." | ( Barjoan, EM; Caroli-Bosc, FX; Cherick, F; Gelsi, E; Hébuterne, X; Huet, PM; Piche, T; Tran, A, 2007) |
| "Pain and fatigue are important features in FSHD." | ( Bleijenberg, G; Hendriks, JC; Kalkman, JS; Lindeman, E; Padberg, GW; van der Kooi, EL; van Engelen, BG, 2007) |
| "Fatigue is a major problem in multiple sclerosis (MS), and its association with MRI features is debated." | ( Alfano, B; Bellacosa, A; Bonavita, S; Bonavita, V; Bresciamorra, V; Brunetti, A; Cammarata, E; Coniglio, G; Di Costanzo, A; Dinacci, D; Lavorgna, L; Livrea, P; Messina, C; Orefice, G; Paciello, M; Paolillo, A; Patti, F; Prinster, A; Quarantelli, M; Quattrone, A; Reggio, A; Salemi, G; Salvatore, M; Savettieri, G; Servillo, G; Simone, I; Tedeschi, G; Valentino, P, 2007) |
| "Fatigue is a common nonmotor symptom in idiopathic Parkinson disease (IPD) that can prominently affect everyday function." | ( Jog, MS; Mendonça, DA; Menezes, K, 2007) |
| "Fatigue is recognized as one of the most disabling and common symptoms of MS." | ( Hum, S; Lapierre, Y, 2007) |
| "Fatigue is common in celiac disease." | ( Bucci, C; Calvani, M; Ciacci, C; Iannoni, E; Iovino, P; Margarucci, S; Peluso, G; Rispo, A; Siniscalchi, M; Tortora, R; Zingone, F, 2007) |
| "Fatigue is one of the most common symptoms found in both community and medical care settings." | ( Han, C; Lee, C; Lim, HK; Masand, PS; Pae, CU; Patkar, AA; Steffens, DC, 2007) |
| "Fatigue is a common and highly distressing symptom of cancer associated with reduced quality of life and considerable psychological and functional morbidity." | ( Alici-Evcimen, Y; Breitbart, W, 2007) |
| "The course of fatigue is significantly related to the type of chemotherapy." | ( Abu-Saad, HH; Courtens, AM; de Jong, N; Kester, AD; Schouten, HC, 2007) |
| "Cancer-related fatigue is a very frequent problem in cancer, interfering with many patients' life activities." | ( Corvasce, C; Di Bisceglie, M; Mattioli, V; Montanaro, R; Romito, F, 2008) |
| "Fatigue is a common complaint in patients with sarcoidosis." | ( Baughman, RP; Harman, S; Lower, EE, 2008) |
| "Fatigue is one of the most common non-specific symptoms associated with several disease states including liver diseases." | ( Ahboucha, S; Baker, GB; Butterworth, RF; Hassoun, Z; Pomier-Layrargues, G; Vincent, C, 2008) |
| "Fatigue is a common symptom among cancer patients, influencing their quality of life." | ( Brix, C; Füller, J; Röhrig, B; Schleussner, C; Strauss, B, 2009) |
| "Depression and fatigue are frequent side effects of interferon-alpha (IFN-alpha) treatment, and there is compelling evidence that the inflammatory response system (including interleukin-6, IL-6) and the serotonergic system is important in the pathophysiology of such symptoms." | ( Aitchison, KJ; Alexander, N; Binder, EB; Bull, SJ; Cassidy, E; Cleare, AJ; Cubells, JF; Hotopf, M; Huezo-Diaz, P; Maddock, C; Miller, AH; Miyazaki, C; Norris, S; Pariante, CM; Ranjith, G, 2009) |
| "Fatigue is a common symptom in dialysis patients." | ( Desbordes, E; Ficheux, M; Henri, P; Joly, F; Lobbedez, T; Ryckelynck, JP, 2008) |
| "Cancer-related fatigue is an important clinical problem." | ( Hotopf, M; Minton, O; Richardson, A; Sharpe, M; Stone, P, 2008) |
| "Fatigue is a common complaint in Parkinson disease (PD)." | ( Comella, CL; Fahn, S; Friedman, JH; Marek, K; Oakes, D; Schifitto, G; Shulman, L, 2008) |
| "Fatigue is a frequent symptom in early, untreated, non-depressed patients with Parkinson disease (PD), affecting over 1/3 of the patients in this cohort at baseline and 50% by week 42." | ( Comella, CL; Fahn, S; Friedman, JH; Marek, K; Oakes, D; Schifitto, G; Shulman, L, 2008) |
| "Fatigue is very common in patients with cancer." | ( Auret, KA; Bremner, AP; Bulsara, M; Schug, SA, 2009) |
| "Perceived pain and fatigue is apparent after continuous typing, though no change in average typing speed is observed." | ( Chang, FH; Hwang, YH; Liang, HW, 2008) |
| "Fatigue is a common chronic problem for older cancer patients and may represent a major cause of functional dependence." | ( Balducci, L; Extermann, M; Foa, P; Jacobsen, PB; Luciani, A; Marussi, D; Overcash, JA, 2008) |
| "Fatigue is a highly distressing symptom of cancer associated with significant psychological morbidity and reduced quality of life." | ( Alici, Y; Breitbart, W, 2008) |
| "This fatigue is not necessarily correlated with greater central or peripheral fatigue in patients, and some patients experience severe fatigue without any demonstrable somatic disease." | ( Campbell, KP; Chamberlain, JS; Crawford, RW; Faulkner, JA; Iyengar, NK; Kobayashi, YM; Moore, SA; Parikh, SV; Rader, EP; Thedens, DR; Weiss, RM, 2008) |
| "Fatigue is a common complication of adjuvant chemotherapy and compromises the quality of life of breast cancer survivors." | ( Bardwell, WA; Blair, S; Mortimer, JE; Podbelewicz-Schuller, Y, 2008) |
| "Apathy and fatigue are frequent in PD and show significant correlation with the severity of the disease." | ( Celik, M; Forta, H; Kenangil, G; Orken, DN; Ur, E, 2009) |
| "Cancer-related fatigue is the most prevalent and distressing symptom experienced by patients with advanced cancer." | ( Booden, D; Dhillan, R; Fife, K; Forbes, K; Spathis, A; Vrotsou, K, 2009) |
| "Fatigue is one of the most common and debilitating complaints of HIV-positive individuals, potentially leading to important functional limitations." | ( Barroso, J; Hammill, BG; Harmon, JL; Leserman, J; Pence, BW; Salahuddin, N, 2009) |
| "Fatigue is a nearly universal adverse effect of cancer and its treatment that is unrelated to physical exertion, is not relieved by sleep or rest, and negatively affects quality of life." | ( Bird, HM; Cooper, MR; Steinberg, M, 2009) |
| "Fatigue is a common symptom that lowers the quality of life of patients with cancer, affecting between 60% and 90% of patients." | ( Baum, L; Blackhall, L; Farace, E; Petroni, G; Shu, J, 2009) |
| "Fatigue is a common debilitating symptom in patients with primary biliary cirrhosis (PBC)." | ( Ahboucha, S; Baker, GB; Butterworth, RF; Gamrani, H; Lalonde, R; Power, C, 2009) |
| "Fatigue is recognized as the most serious complication of chemotherapy for the majority of patients." | ( Cornes, P; Doyle, S; Lloyd, A; van Hanswijck de Jonge, P, 2008) |
| "Fatigue is the most frequent symptom experienced by children/adolescents with cancer." | ( Gregurich, M; Hockenberry, MJ; Hooke, MC; McCarthy, K, 2009) |
| "Management of fatigue is cause-specific when conditions known to cause fatigue can be identified and treated." | ( , 2003) |
| "Fatigue is the most common and often the most bothersome complaint of individuals who are treated for cancer." | ( Block, I; Gold, MA; Johnson, RL; Markwell, S; Zupancic, M, 2010) |
| "(3) Arthralgia and fatigue are the most common symptoms among patients with HH." | ( Dever, JB; Kowdley, KV; Mallory, JE; Mallory, MA; Wallace, D, 2010) |
| "Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS) and has a significant, often underestimated, impact on patients' quality of life." | ( Allain, H; Edan, G; Flet, L; Guillard, O; Javaudin, L; Leray, E; Polard, E, 2010) |
| "Fatigue is frequent in cancer patients undergoing chemotherapy." | ( Adamsen, L; Andersen, C; Burmølle, SH; Madsen, KR; Midtgaard, J; Nielsen, B; Rørth, M; Stage, M, 2011) |
| "Fatigue is reported to occur in up to 92% of patients with multiple sclerosis (MS) and has been described as the most debilitating of all MS symptoms by 28% to 40% of MS patients." | ( Nathwani, S; Rowell, G; Spiwak, R; Tejani, AM; Wasdell, M, 2010) |
| "Fatigue is a common and potentially debilitating symptom of neuromuscular disease (NMD)." | ( Carter, GT; Lou, JS; Weiss, MD, 2010) |
| "Fatigue is a symptom with a relevant impact on the daily lives of cancer patients and is gaining importance as an outcome measure." | ( Baró, E; Carulla, J; Cassinello, J; Colomer, R; Gascón, P; Gasquet, JA; Mata, JG; Rodríguez, CA; Valentín, V, 2011) |
| "Cancer-related fatigue is a debilitating symptom affecting psychosocial functioning and quality of life in 70% to 100% of cancer patients during and after treatment." | ( Esparaz, BT; Heckler, C; Hemstad, A; Hopkins, JO; Janelsins, M; Jean-Pierre, P; Mohile, S; Morrow, GR; Peppone, L; Roscoe, JA, 2010) |
| "Fatigue is one of the most common symptoms experienced by patients with cancer." | ( Ali, A; Atherton, PJ; Barton, D; Dakhil, SR; Duane, SF; Griffin, PC; Johnson, DB; Loprinzi, CL; Moraska, AR; Silberstein, PT; Sloan, JA; Sood, A; Suh, JJ, 2010) |
| "A common symptom of fatigue is a feeling of tiredness or weariness because of overexertion, such as that associated with intense or prolonged physical exercise." | ( Keyser, RE, 2010) |
| "Fatigue is a frequent reason for seeking medical attention." | ( Chrousos, G; Kaltsas, G; Vgontzas, A, 2010) |
| "Fatigue is a common side effect of medications." | ( Byrne, M; Zlott, DA, 2010) |
| "Fatigue is a highly prevalent and clinically significant symptom of advanced prostate cancer." | ( Arauz, G; Breitbart, W; Morris, M; Nelson, C; O'Shea, N; Rosenfeld, B; Roth, AJ; Scher, H; Slovin, S, 2010) |
| "Fatigue is highly prevalent in the general population and is one of the most common side effects of cancer treatment." | ( Arevalo, JM; Bower, JE; Cole, SW; Ganz, PA; Irwin, MR, 2011) |
| "Fatigue is a highly prevalent and distressing symptom associated with significant psychological and functional morbidity and decreased quality of life among patients with cancer." | ( Alici, Y; Breitbart, W, 2010) |
| "Disabling fatigue is a symptom in a number of neurological diseases, including multiple sclerosis, stroke and Parkinson's disease." | ( Bose, SK; Brooks, DJ; Chaudhuri, KR; Metta, V; Pavese, N, 2010) |
| "Fatigue is a complex phenomenon that can be evoked by peripheral and central factors." | ( Meeusen, R; Roelands, B, 2010) |
| "Fatigue is estimated by EMG mean frequency and conduction velocity assessments as well as by maximum voluntary contraction (MVC) force measurements." | ( Cardinale, M; Mischi, M; Rabotti, C, 2010) |
| "Fatigue is among the most common symptoms reported by HIV-infected individuals." | ( Clifford, D; Deng, L; Ernst, T; Evans, SR; Schifitto, G; Yeh, TM; Zhong, J, 2011) |
| "Depression and fatigue are among the most common symptoms of multiple sclerosis (MS)." | ( Gold, SM; Heesen, C; Krieger, T; Krüger, S; Otte, C; Schulz, KH; Ziegler, KJ, 2011) |
| "Fatigue is frequently reported in hepatic encephalopathy (HE) and may be related to hyperammonemia." | ( Bella, R; Galvano, F; Giordano, M; Li Volti, G; Malaguarnera, M; Pennisi, G; Rampello, L; Vacante, M, 2011) |
| "Fatigue is a common but often overlooked symptom after stroke." | ( Aass, HC; Amthor, KF; Lund-Sørensen, N; Ormstad, H; Sandvik, L, 2011) |
| "Fatigue is an important determinant of altered quality of life in patients affected by chronic hepatitis C or the irritable bowel syndrome (IBS)." | ( Anty, R; Bekri, S; Cherikh, F; Dainese, R; DeGalleani, L; Gelsi, E; Marjoux, S; Piche, T; Tran, A, 2011) |
| "Fatigue is a notable clinical problem in cancer survivors, and understanding its pathophysiology is important." | ( Fagundes, CP; Gouin, JP; Hwang, BS; Kiecolt-Glaser, JK; Malarkey, WB; Murray, DM; Shapiro, CL; Sollers, JJ; Thayer, JF, 2011) |
| "Fatigue is prevalent among patients with hepatitis C virus (HCV) and with HIV/AIDS but there are no established fatigue treatments for either condition or their combination." | ( McElhiney, MC; Rabkin, JG; Rabkin, R, 2011) |
| "Fatigue is a major issue for our patients with RA and must be included in the routine assessment of patients." | ( Amine, B; Hajjaj-Hassouni, N; Ibn Yacoub, Y; Laatiris, A; Wafki, F; Znat, F, 2012) |
| "Fatigue is one of the most disabling symptoms associated with fibromyalgia that greatly impacts quality of life." | ( Ahl, J; Arnold, LM; Gaynor, PJ; Wang, F; Wohlreich, MM, 2011) |
| "Important levels of fatigue are common in knee and hip OA patients." | ( Arts-Sanders, MA; Defoort, KC; den Broeder, AA; Fransen, J; Snijders, GF; Stukstette, MJ; van den Ende, CH; van den Hoogen, FH; van Riel, PL, 2011) |
| "Fatigue is a chief complaint in cancer patients, and warrants effective treatment." | ( Acer, J; Bruyere, RL; Coulter, I; Distefan, J; Garcia, R; Ives, J; Jain, S; Jonas, W; Mills, PJ; Pavlik, D; Roesch, SC, 2012) |
| "Fatigue is common among patients with cirrhosis and associated with impaired quality of life." | ( Andersson, B; Bengtsson, M; Björnsson, E; Castedal, M; Henfridsson, P; Hugosson, I; Josefsson, A; Kalaitzakis, E, 2012) |
| "Fatigue is considered by cancer patients as the most important secondary effect regarding the impact on their quality of life and, consequently, is expected to compromise the protocol and the efficacy of the treatment." | ( Joly, F, 2011) |
| "Fatigue is a major determinant for quality of life for patients undergoing chronic hemodialysis (HD) treatment." | ( Karakan, S; Ozdemir, FN; Sezer, S, 2011) |
| "Fatigue is a frequent problem during and after cancer treatment." | ( Chang-Claude, J; Flesch-Janys, D; Heinz, J; Schmidt, ME; Steindorf, K; Vrieling, A, 2012) |
| "Fatigue is highly prevalent in populations with advanced illness and is often associated with depressed mood." | ( Brazeau, DA; Brazeau, GA; Donnelly, JP; Drake, J; Kerr, CW; Milch, RA; Skretny, JA, 2012) |
| "Excess fatigue is a pathological state of continuing accumulation of fatigue, which may cause the deterioration of body health, occurrence of diseases, and even lead to death." | ( Dai, W; Gao, P; Jia, Z; Lu, X; Wei, C; Wu, Y; Xu, G; Zhang, F, 2011) |
| "Fatigue is reported to occur in up to 92% of patients with multiple sclerosis (MS) and has been described as the most debilitating of all MS symptoms by 28% to 40% of MS patients." | ( Nathwani, S; Rowell, G; Spiwak, R; Tejani, AM; Wasdell, M, 2012) |
| "Fatigue is seen in many medical conditions." | ( Cherian, D; Paladugu, S; Parkman, HP; Pathikonda, M, 2012) |
| "Fatigue is an important significant symptom in patients with gastroparesis with a high prevalence and severity." | ( Cherian, D; Paladugu, S; Parkman, HP; Pathikonda, M, 2012) |
| "Fatigue is a common symptom in individuals with multiple sclerosis (MS)." | ( Capello, E; Krueger, F; Mancardi, G; Pardini, M; Uccelli, A, 2013) |
| "Fatigue is the most frequent and often debilitating symptom of chronic hepatitis C." | ( Evon, DM; Hoofnagle, JH; Jiang, Z; Sarkar, S; Wahed, AS, 2012) |
| "Fatigue is common in patients with chronic hepatitis C but is poorly associated with biochemical parameters." | ( Evon, DM; Hoofnagle, JH; Jiang, Z; Sarkar, S; Wahed, AS, 2012) |
| "Fatigue is a common and distressing symptom of MS which is unrelated to its clinical form, stage of development, the degree of disability, or the lesion load on magnetic resonance imaging." | ( Bibani, RH; Bradshaw, CM; Constantinescu, CS; Langley, RW; Niepel, G; Szabadi, E; Vilisaar, J, 2013) |
| "Fatigue is one of the most common symptoms reported by cancer survivors, and fatigue worsens when patients are engaged in muscle exertion, which results in early motor task failure." | ( Davis, MP; Hou, J; Kisiel-Sajewicz, K; Seyidova-Khoshknabi, D; Siemionow, V; Walsh, D; Wyant, A; Yue, GH, 2012) |
| "Although fatigue is not synonymous with impaired quality of life, most studies of sarcoidosis identify fatigue as a major cause of impaired quality of life." | ( Baughman, RP; Lower, EE; Malhotra, A; Surdulescu, V, 2013) |
| "Fatigue is the most common and debilitating symptom in multiple sclerosis (MS) and is believed to be distinctly different from fatigue seen in other chronic conditions." | ( Constantinescu, CS; Gran, B; Induruwa, I, 2012) |
| "Fatigue is a major problem in systemic lupus erythematosus (SLE), but the physiological substrate of this fatigue is largely unclear." | ( Bijl, M; Bijlsma, JW; Bossema, ER; Derksen, RH; Geenen, R; Godaert, GL; Hartkamp, A; Overman, CL, 2012) |
| "Fatigue is one of the most common presenting symptoms of chronic hepatitis C virus (HCV) infection." | ( Ali-Eldin, FA; El-Gindy, EM; Meguid, MA, 2012) |
| "Fatigue is highly prevalent in Egyptian patients with chronic HCV infection." | ( Ali-Eldin, FA; El-Gindy, EM; Meguid, MA, 2012) |
| "Fatigue is one of the most commonly reported side effects during treatment for breast cancer and can persist following treatment completion." | ( Campbell, KL; Garland, SJ; Klika, RJ; McKenzie, DC; Neil, SE, 2013) |
| "Iron deficiency and fatigue are common problems in adolescent females." | ( Berlan, ED; Bourgeois, T; Fischer, AN; Klima, J; O'Brien, SH; Wang, W, 2013) |
| "Fatigue is a common symptom in patients with multiple sclerosis (MS)." | ( Bahrami Taghanaki, HR; Foroughipour, M; Khazaei, M; Saeidi, M; Sasannezhad, P; Shoeibi, A, 2013) |
| "Fatigue is a common, debilitating side-effect of prostate cancer and its treatment." | ( Cleeland, C; de Bono, JS; Fizazi, K; Gagnon, DD; Hao, Y; Haqq, CM; Kheoh, T; Mainwaring, P; Molina, A; North, S; Rothman, M; Scher, HI; Sternberg, CN, 2013) |
| "Fatigue is a common symptom of Parkinson's disease (PD), often considered by patients as one of the most disabling PD symptoms with significant impact on quality of life." | ( Stocchi, F, 2014) |
| "It is known that fatigue is one of the most disabling symptoms in numerous neurological populations, including stroke, multiple sclerosis, Parkinson’s disease, and traumatic brain injury." | ( DeLuca, J; Dobryakova, E; Genova, HM; Wylie, GR, 2013) |
| "Fatigue is a common symptom of patients with chronic kidney disease, but seldom investigated after transplantation." | ( Bleijenberg, G; Bloot, L; Goedendorp, MM; Hoitsma, AJ; Knoop, H, 2013) |
| "Asthenia (or fatigue) is one of the most common symptoms in palliative patients." | ( Palacio, P; Royo, P; Saralegui, A, 2013) |
| "Fatigue is a chronic symptom for people with multiple sclerosis (PwMS)." | ( Barker, K; Collett, J; Dawes, H; Duda, J; Izadi, H; Meaney, A; Sackley, C; Wade, D, 2014) |
| "Fatigue is synonymous with a wide spectrum of familiar physiological conditions, from pathology and general health, to sport and physical exercise." | ( Chang, Q; Gao, C; Huang, C; Huang, T; Ju, X; Miao, X; Zhu, L; Zuo, X, 2013) |
| "Fatigue is the most common symptom related to cytotoxic chemotherapeutic treatment of cancer." | ( Marks, DL; Weymann, KB; Wood, LJ; Zhu, X, 2014) |
| "Fatigue is a frequent symptom of patients with sarcoidosis." | ( Bosse-Henck, A; Brähler, E; Fleischer, M; Hinz, A; Wirtz, H, 2014) |
| "Fatigue is a complex and cumulative condition of patients treated for advanced RCC, and it considerably affects patient's quality of life." | ( A, M; H J, H; L, M; M, K; N, M; P J, G; S, B, 2014) |
| "Fatigue is a debilitating and pervasive complication of cancer and cancer care." | ( Fey, EG; Lyng, GD; Sonis, ST; Zombeck, JA, 2013) |
| "Fatigue is an important symptom to patients with advanced chronic kidney disease (CKD)." | ( Dew, MA; Jhamb, M; Liang, K; Shah, N; Steel, JL; Unruh, M; Yabes, J, 2013) |
| "Although fatigue is a common non-motor symptom in patients affected by Parkinson's disease (PD), its association with motor and other non-motor symptoms is still largely unclear." | ( Bassareo, PP; Cannas, A; Corona, A; Marrosu, F; Mulas, CS; Perra, S; Solla, P, 2014) |
| "Fatigue is the most common symptom associated with cancer and cancer treatment." | ( Arnaldi, G; Cascinu, S; Conti, A; De Giorgi, U; Iacovelli, R; Massari, F; Procopio, G; Rizzo, M; Santoni, M; Tortora, G; Trementino, L, 2015) |
| "Although fatigue is a ubiquitous finding, sleep disturbance and headache are each commonly reported without the other." | ( Baillie, JK; Bates, MG; Collier, DJ; Cosens, S; Freeman, T; Hall, DP; Hope-Jones, D; Hume, DA; Jackson, S; MacCormick, IJ; Phythian-Adams, AT; Rzechorzek, NM; Thompson, AA, 2014) |
| "Fatigue is a common, often debilitating, side effect of cancer chemotherapy." | ( Carr, AC; Cook, J; Vissers, MC, 2014) |
| "Fatigue is a frequently experienced complaint in patients with adrenal insufficiency (AI) and may be influenced by cortisol levels." | ( Bleijenberg, G; Giebels, V; Hermus, A; Kroese, JM; Repping-Wuts, H; Stikkelbroeck, N, 2014) |
| "While fatigue is the most commonly reported symptom of chemotherapy, there are currently no effective treatments for chemotherapy-induced fatigue (CIF)." | ( Davis, JM; Mahoney, SE; McClellan, JL; Murphy, EA; Pena, MM, 2014) |
| "Fatigue is a debilitating symptom of chronic illness that is deleteriously affected by perceived stress, a process particularly relevant to inflammatory disease." | ( Hirsch, JK; Sirois, FM, 2016) |
| "Although fatigue is a common symptom in heart failure (HF), little is known about its association with prognosis." | ( Böhm, M; Cleland, JG; Gullestad, L; Jhund, PS; Kjekshus, J; Lewsey, JD; Macdonald, MR; McMurray, JJ; Perez-Moreno, AC; Petrie, MC; van Veldhuisen, DJ; Wikstrand, J, 2014) |
| "In HF, greater fatigue is associated with worse clinical outcomes." | ( Böhm, M; Cleland, JG; Gullestad, L; Jhund, PS; Kjekshus, J; Lewsey, JD; Macdonald, MR; McMurray, JJ; Perez-Moreno, AC; Petrie, MC; van Veldhuisen, DJ; Wikstrand, J, 2014) |
| "Fatigue is associated with low serum testosterone level in non-OSA patients." | ( Bercea, RM; Bjorvatn, B; Cojocaru, C; Mihaescu, T, 2015) |
| "Unexplained fatigue is often left untreated or treated with antidepressants." | ( Balck, K; Breymann, C; Favrat, B; Gasche, C; Hedenus, M; Keller, T; Mezzacasa, A, 2014) |
| "Fatigue is a distressing symptom occurring in more than 60% of patients with cancer." | ( Bahadori, R; Bates, N; Benepal, T; Blackhall, F; Dutton, S; Fife, K; O'Brien, M; Spathis, A; Stone, P; Wee, B; Wharton, R, 2014) |
| "Fatigue is among the most distressing symptoms across the breast cancer continuum." | ( Chang-Claude, J; Flesch-Janys, D; Heinz, J; Schmidt, ME; Seibold, P; Steindorf, K; Vrieling, A, 2015) |
| "Fatigue is a core symptom in fibromyalgia that can negatively affect a patient's quality of life." | ( Mease, PJ; Palmer, RH; Wang, Y, 2014) |
| "Fatigue is a common, disabling symptom of multiple sclerosis (MS), but little is known about fatigue in patients with clinically isolated syndrome (CIS), often the presenting symptom of MS." | ( Hintzen, RQ; Jafari, N; Runia, TF; Siepman, DA, 2015) |
| "Fatigue is a common symptom of chronic hepatitis C virus (HCV) infection and a frequent side-effect of peginterferon/ribavirin (PR) therapy for HCV." | ( Beumont, M; Cerri, K; Evon, DM; Fu, M; Gilles, L; Peeters, M; Rosa, K; Scott, J; Zeuzem, S, 2014) |
| "Fatigue is a common symptom after stroke." | ( Careddu, P; Catalano, ML; Costantini, A; Notarangelo, C; Pala, MI, 2014) |
| "Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment." | ( Clark, YY; McCarthy, DO; Szalacha, LA; Wold, LE, 2015) |
| "Fatigue is a common problem among multiple myeloma (MM) patients." | ( Andreu-Vieyra, C; Berenson, JR; Charu, V; Chen, CS; Nassir, Y; Sanani, S; Schlutz, M; Shamasunder, HK; Swift, RA; Vescio, R; Woliver, TB; Yellin, O, 2015) |
| "Driver fatigue is one of the biggest health and safety concerns within the road transport sector." | ( Chia, SE; Lim, SM, 2015) |
| "Fatigue is common in life-limiting cancer." | ( Carmont, SA; Currow, DC; Good, P; Hardy, JR; Mitchell, GK; Nikles, CJ; Schluter, PJ; Senior, HE, 2015) |
| "Because fatigue is known to persist among persons with SCI, interventions to reduce fatigue seem necessary." | ( Bergen, MP; Bongers-Janssen, HM; Nooijen, CF; Stam, HJ; van den Berg-Emons, HJ; Vogels, S, 2015) |
| "Fatigue is caused in part by oxidative stress." | ( Hayashi, J; Ono, Y; Shibata, H; Takemoto, D; Tomimori, N; Yasutake, Y, 2015) |
| "Fatigue is a disturbing symptom of chronic hepatitis C virus (HCV) infection." | ( Escheik, C; Estep, M; Gerber, L; Stepanova, M; Weinstein, A; Younossi, ZM, 2016) |
| "Fatigue is a major burden for breast cancer patients undergoing adjuvant therapy." | ( Habermann, N; Schmidt, ME; Semik, J; Steindorf, K; Ulrich, CM; Wiskemann, J, 2016) |
| "Poststroke fatigue is common and reduces quality of life." | ( Damgaard, B; Overgaard, K; Poulsen, MB; Rasmussen, RS; Zerahn, B, 2015) |
| "Fatigue is a prevalent, distressing side effect of cancer and cancer treatment which commonly coexists with insomnia." | ( Garland, SN; Heckler, CE; Hoefler, J; Kamen, C; Morrow, GR; Peoples, AR; Perlis, ML; Roscoe, JA; Shayne, M, 2016) |
| "Fatigue is a common complaint worldwide and associated with disability and high health service use costs." | ( Alem, A; Dewey, M; Hanlon, C; Medhin, G; Patel, V; Prince, M; Smartt, C, 2016) |
| "Complaints of fatigue are associated strongly with maternal CMD and other psychosocial risk factors in this rural, low-income country setting with a high burden of undernutrition and infectious disease." | ( Alem, A; Dewey, M; Hanlon, C; Medhin, G; Patel, V; Prince, M; Smartt, C, 2016) |
| "Fatigue is a multidimensional condition that is difficult to treat with standard monoaminergic antidepressants." | ( Luckenbaugh, DA; Machado-Vieira, R; Saligan, LN; Slonena, EE; Zarate, CA, 2016) |
| "Fatigue is a common symptom both in diseases status and in healthy subjects." | ( Cho, DY; Kim, KM; Kim, KS; Kim, MJ; Kim, YS; Park, KC; Song, SW; Yang, SW, 2016) |
| "Fatigue is a common and disabling symptom of multiple sclerosis (MS) patients." | ( Azevedo, C; Maghzi, AH; Nourbakhsh, B; Nunan-Saah, J; Pelletier, D; Spain, R; Waubant, E, 2016) |
| "Fatigue is common among glioma patients undergoing radiotherapy (RT) and impacts quality of life (QOL)." | ( Alexander, BM; Arvold, ND; Doherty, L; Drappatz, J; Fadul, CE; Gaffey, SC; Hammond, S; Kesari, S; LaFrankie, D; Lee, EQ; Muzikansky, A; Nayak, L; Norden, AD; Pulverenti, J; Reardon, DA; Rinne, ML; Ruland, SF; Smith, KH; Stefanik, J; Wen, PY; Wong, ET, 2016) |
| "Fatigue is a common and disabling symptom of multiple sclerosis (MS), a classical Th1- and Th17-mediated autoimmune disease." | ( Abreu, JEC; Alvarenga, RMP; Alvarenga-Filho, H; Bento, CAM; Carvalho, SR; Ferreira, TB; Hygino, J; Sacramento, PM; Wing, AC, 2016) |
| "Fatigue is a common and disabling symptom in people with a primary brain tumour (PBT)." | ( Armstrong, T; Bulbeck, H; Cachia, D; Day, J; Katz, LH; Rooney, AG; Tremont, I; Wefel, J; Yust-Katz, S, 2016) |
| "Fatigue is a frequent and distressing symptom in children undergoing leukemia treatment; however, little is known about factors influencing this symptom." | ( Gundy, P; Hockenberry, MJ; Moore, IM; Pasvogel, A; Rodgers, C; Sanborn, C; Taylor, O, 2016) |
| "Stress and fatigue are significantly reduced by the intake of a food supplement with probiotics, magnesium, vitamins, and minerals and this effect is fully maintained one month after discontinuing the food supplement intake." | ( Allaert, FA; Courau, S; Forestier, A, 2016) |
| "Fatigue is one of the most commonly reported complaints in the general population." | ( Ditzen, B; Doerr, JM; Linnemann, A; Nater, UM; Skoluda, N; Strahler, J, 2016) |
| "Three dimensions of fatigue are assessed during follow-up: severity, perceived interference with quality of life, and duration in the past week." | ( Chen, QH; Cheng, HH; Feng, J; Fu, ZC; Lei, Y; Liao, SG; Lin, GS; Luo, HC; Wang, D; Xu, JF; Yin, Q; Zhu, JF, 2016) |
| "Fatigue is a common and distressing symptom that can last for months or years in up to one-third of cancer survivors." | ( Ancoli-Israel, S; Campbell, TS; Carlson, LE; Garland, SN; Johnson, JA; Savard, J; Simpson, JS, 2016) |
| "Fatigue is a common symptom in patients receiving hemodialysis (HD) and is generally associated with anemia." | ( Inaba, M; Koyama, H; Okada, S; Okuno, S; Tsujimoto, Y; Yamada, S; Yamasaki, A; Yoda, K, 2016) |
| "Fatigue is a symptom of many diseases, but it can also manifest as a unique medical condition, such as idiopathic chronic fatigue (ICF)." | ( Adhihetty, PJ; Gundermann, DM; Joseph, AM; Leeuwenburgh, C; Levin, DG; Manini, TM; Sandesara, B; Wawrzyniak, NR, 2016) |
| "Fatigue is a common manifestation of sarcoidosis, often persisting without evidence of disease activity." | ( Atkins, C; Wilson, AM, 2017) |
| "Fatigue is a common symptom in stroke survivors for which there is currently no proven therapy." | ( Attia, J; Bivard, A; Krishnamurthy, V; Levi, CR; Lillicrap, T; Nilsson, M; Parsons, MW, 2016) |
| "Therefore, adrenal fatigue is still a myth." | ( Cadegiani, FA; Kater, CE, 2016) |
| "Fatigue is a common and disabling non-motor symptom in Parkinson's disease associated with a feeling of overwhelming lack of energy." | ( Aminian, K; Cho, SS; Houle, S; Lang, AE; Li, C; Strafella, AP, 2017) |
| "Fatigue is a common and disabling non-motor symptom in Parkinson's disease (PD)." | ( Herlofson, K; Larsen, JP; Ongre, SO; Tysnes, OB, 2017) |
| "Fatigue is a common symptom in PD, also in early, untreated patients." | ( Herlofson, K; Larsen, JP; Ongre, SO; Tysnes, OB, 2017) |
| "Fatigue is the most common toxicity of all grade toxicities with regorafenib, was the second most common toxicity in the CORRECT (regorafenib monotherapy for previously treated metastatic colorectal cancer) study, and is a major reason for early dose modification." | ( Bando, H; Doi, T; Fukuoka, S; Kawazoe, A; Kojima, T; Kuboki, Y; Noguchi, M; Ohtsu, A; Okamoto, W; Shitara, K; Yoshino, T, 2017) |
| "In this domain, fatigue is frequently correlated with the depletion of muscle glycogen." | ( Burnley, M; Jones, AM, 2018) |
| "Fatigue is a common burdensome problem in patients with Parkinson's disease (PD), but its pathophysiological mechanisms are poorly understood." | ( Ding, J; Jiang, SM; Li, JY; Wang, M; Wang, XX; Yuan, YS; Zhang, JJ; Zhang, KZ; Zhang, L; Zhu, L, 2017) |
| "Fatigue is a defining characteristic and one of the most debilitating features of fibromyalgia syndrome (FMS)." | ( Doerr, JM; Fischer, S; Nater, UM; Strahler, J, 2017) |
| "Fatigue is recognised as a common and burdensome symptom among dialysis patients." | ( Almond, M; Chilcot, J; Davenport, A; Day, C; Farrington, K; Friedli, K; Guirguis, A; Wellsted, D, 2017) |
| "Peripheral fatigue is usually described as an impairment located in the muscle and characterized by a metabolic end point, while central fatigue is defined as a failure of the central nervous system to adequately drive the muscle." | ( Meeusen, R; Roelands, B, 2018) |
| "Fatigue is a prevalent and debilitating side effect of docetaxel chemotherapy in metastatic prostate cancer." | ( Bergin, ART; de Souza, P; Hovey, E; Lloyd, A; Marx, G; Parente, P; Rapke, T, 2017) |
| "Fatigue is a disabling non-motor symptom in Parkinson disease (PD)." | ( Bohnen, NI; Chou, KL; Gilman, S, 2017) |
| "Fatigue is reported by 36." | ( Agrawal, N; Cock, HR; Lozsadi, DA; Mula, M; von Oertzen, TJ; Yogarajah, M, 2017) |
| "Fatigue is more likely to be reported by females and seems to be specifically associated with LEV treatment." | ( Agrawal, N; Cock, HR; Lozsadi, DA; Mula, M; von Oertzen, TJ; Yogarajah, M, 2017) |
| "Fatigue is one of the most disabling symptoms in Multiple Sclerosis (MS) patients and is associated with a low quality of life." | ( Debs, R; Delvaux, V; Lubetzki, C; Maillart, E; Masingue, M; Papeix, C; Vidal, JS, 2017) |
| "Fatigue is a common complaint in patients with Parkinson's disease (PD)." | ( Ding, J; Jiang, S; Li, J; Wang, M; Yuan, Y; Zhang, J; Zhang, K; Zhang, L, 2017) |
| "Fatigue is a challenge in ovarian cancer survivorship and greatly impacts quality of life." | ( Bender, D; Cole, SW; Cuneo, MG; Goodheart, M; Lutgendorf, SK; Schrepf, A; Slavich, GM; Sood, AK; Thaker, PH, 2017) |
| "Fatigue is the most frequent and often debilitating symptom for patients with multiple sclerosis (MS)." | ( Kaleağası, H; Sevim, S; Taşdelen, B, 2017) |
| "Fatigue is the most common symptom of MS patients, affecting >80% subjects." | ( Deng, XY; Wang, L; Yang, TT; Yu, G, 2017) |
| "Poststroke fatigue is a debilitating symptom and is poorly understood." | ( Dantzer, R; De Doncker, W; Kuppuswamy, A; Ormstad, H, 2018) |
| "Muscle fatigue is a disturbed homeostatic state characterized by a temporary inability to maintain force output and has lasting effects on the brain in the period immediately after exercise, such as decreased interhemispheric functional connectivity (FC)." | ( Brooks, SJ; Ipser, J; King, M; Rauch, LH; Stein, DJ; van Breda, K, 2018) |
| "Fatigue is the most common symptom of multiple sclerosis (MS)." | ( Nourbakhsh, B; Revirajan, N; Waubant, E, 2018) |
| "Fatigue is frequent among oncologic patients." | ( Cruz, FM; Cubero, DIG; Del Giglio, A; Fonseca, F; Peppone, LJ; Pianowski, LF; Ribas de Alcântara, BB; Schoueri, JHM; Sette, CVM, 2018) |
| "Fatigue is a sensation of unbearable tiredness that frequently accompanies chronic widespread musculoskeletal pain (CWP) and inflammatory joint disease." | ( Freidin, MB; Livshits, G; Menni, C; Potter, T; Wells, HRR; Williams, FMK, 2018) |
| "Fatigue is a frequent and troublesome manifestation of chronic sarcoidosis." | ( Atkins, C; Clark, AB; Fordham, R; Jones, AP; Stockl, A; Wilson, AM, 2017) |
| "Fatigue is a common and serious health problem, and various dietary interventions have previously been employed to ameliorate fatigue." | ( Han, NR; Jeong, H; Jeong, HJ; Kim, HM; Kim, HY; Kim, NR; Lee, WK, 2018) |
| "Depression and fatigue are common among MS patients, even in early disease phases, and the disease course can be negatively affected by stressful events." | ( Al Nimer, F; Brenner, P; Granqvist, M; Jokinen, J; Königsson, J; Piehl, F, 2018) |
| "Fatigue is a significant issue in psoriatic arthritis." | ( Fautrel, B; Gossec, L; Mitrovic, S; Reygaerts, T, 2018) |
| "Persistent fatigue is a common problem (∼20-45% of U." | ( Cameron, MH; Loy, BD; O'Connor, PJ, 2018) |
| "While fatigue is the most common and debilitating side effect of cancer and cancer treatment it is still poorly understood, partly because it is usually characterized by patient-reported outcomes." | ( Dantzer, R; Escalante, C; Gunn, B; Heijnen, CJ; Hess, KR; Lacourt, TE; Manzullo, EF; Vichaya, EG, 2018) |
| "Fatigue is a frequent complaint among healthy population and one of the earliest and most debilitating symptoms in Parkinson's disease (PD)." | ( Benoit, CE; Bouvy, C; Jeanjean, A; Sebti, M; Solopchuk, O; Warlop, T; Zénon, A, 2018) |
| "Fatigue is a common adverse event during treatment with these and other TKIs and a common cause of drug discontinuation or dosage reduction." | ( Colombo, C; De Leo, S; Di Stefano, M; Fugazzola, L; Persani, L; Vannucchi, G, 2019) |
| "Fatigue is a common symptom in many diseases and disorders and can reduce quality of life, yet lacks an adequate pharmacological intervention." | ( Cullen, MJ; Dougherty, JP; Gershengorn, MC; Springer, DA, 2019) |
| "Fatigue is common in children with hemiparesis with perinatal stroke and is associated with motor performance and the presence and excitability of ipsilateral corticospinal projections from the contralesional hemisphere to the more affected hand." | ( Kirton, A; Kuo, HC; Millet, GY; Wrightson, JG; Zewdie, E, 2020) |
| "Fatigue is common in children with hemiparesis with perinatal stroke." | ( Kirton, A; Kuo, HC; Millet, GY; Wrightson, JG; Zewdie, E, 2020) |
| "Fatigue is one problem with driving as it can lead to difficulties with sustaining attention, behavioral lapses, and a tendency to ignore vital information or operations." | ( Chuang, CH; Chuang, WY; Ding, W; King, JT; Liao, LD; Lin, CT; Wang, YK, 2020) |
| "Fatigue is more common with use of palbociclib and abemaciclib, and gastrointestinal effects are more common with abemaciclib use." | ( Cersosimo, RJ, 2019) |
| "Fatigue is one of the most common and disabling chronic symptoms in multiple sclerosis (MS)." | ( Alschuler, KN; Braley, TJ; Ehde, DM; Kratz, AL; Kulkarni, S; Little, R; Pickup, K; von Geldern, G, 2019) |
| "Background Fatigue is a common compliant among patients who undergo coronary artery bypass graft (CABG) surgery." | ( Ardalan, A; Gholami, M; Najafizadeh, H; Pooria, A; Tarrahi, MJ; Teimouri, H, 2019) |
| "Fatigue is a common symptom experienced by people with cancer and other long-term, non-malignant conditions." | ( Dean, A, 2019) |
| "Fatigue is common in multiple sclerosis (MS) patients." | ( Meyer, K; Olbrich, S; Schlingmann, M; Stoppe, M; Then Bergh, F, 2019) |
| "Fatigue is a common symptom in patients visiting the clinic of psychosomatic medicine." | ( Hara, T; Matsubayashi, S; Nakatake, N, 2020) |
| "Fatigue is a common and debilitating symptom in patients with RA." | ( Choy, EH, 2019) |
| "Fatigue is one of the most common non-motor symptoms in Parkinson's disease (PD)." | ( Bang, M; Chang, SK; Han, YM; Hong, JY; Kang, SY; Kim, JS; Lee, SA; Oh, J; Shin, NY; Yoon, U, 2020) |
| "Fatigue is a common adverse event during lenvatinib treatment in patients with hepatocellular carcinoma." | ( Ando, H; Ikejima, K; Ishizuka, K; Kitagawa, R; Kokubu, S; Miyazaki, A; Nagahara, A; Okubo, H; Okubo, S; Saito, H; Shiina, S, 2020) |
| "Cancer-related fatigue is a significant problem and is associated with poor quality of life." | ( Babilonia, MB; Bower, J; Cole, S; Culakova, E; Desta, Z; Han, HS; Heckler, C; Hoogland, AI; Janelsins, M; Jim, HSL; Morrow, G; Peppone, L; Williams, GC, 2020) |
| "Fatigue is a common, debilitating and burdensome symptom experienced by individuals with IBD." | ( Artom, M; Czuber-Dochan, W; Farrell, D; Jelsness-Jørgensen, LP; Norton, C; Savage, E, 2020) |
| "However, general fatigue is frequently observed in patients after introduction of enzalutamide." | ( Domen, T; Ishizuka, O; Kiyokawa, H; Minagawa, T; Nagai, T; Ogawa, T; Suzuki, T; Ueno, M, 2019) |
| "Fatigue is one of the most common symptoms in patients with multiple sclerosis (MS)." | ( Agah, E; Aghamollaii, V; Balali, P; Dehghani, R; Falsafi, Z; Fouladi, Z; Ghaffarpour, M; Harirchian, MH; Mojarrad, M; Mousavi, SV; Pourghaz, B; Tafakhori, A, 2020) |
| "Cancer-related fatigue is a highly prevalent symptom with a strong negative impact on patients' daily life." | ( Groenvold, M; Lund, L; Pedersen, L; Petersen, MA; Sjogren, P, 2020) |
| "Fatigue is highly prevalent in inflammatory arthritis, and people living with the symptom have described it as overwhelming and a challenge to manage." | ( Cramp, F; Dures, E; Hackett, K; Primdahl, J, 2020) |
| "Fatigue is an important yet infrequently evaluated component in patients with rheumatoid arthritis (RA) and may have a major impact on quality of life." | ( Lee, HJ; Ng, CM; Pok, LSL; Raja, J; Sockalingam, S; Tee, YC; Yahya, F, 2020) |
| "Fatigue is the most common symptom of MS and has no effective pharmacotherapy." | ( Balshi, A; Fitzgerald, KC; Kaplin, A; Maher, D; Morris, B; Nourbakhsh, B; Soroosh, A, 2021) |
| "Exercise-induced fatigue is accumulated when lactic acid cannot be timely eliminated after intensive exercise, resulting in sport injuries." | ( Huang, X; Wang, W; Wang, Z; Zhang, X; Zheng, X, 2020) |
| "Fatigue is common in sarcoidosis and OSA could be a relevant, treatable comorbidity." | ( Ballacci, F; Corbo, GM; Iovene, B; Macagno, F; Mari, PV; Martone, F; Pasciuto, G; Richeldi, L; Siciliano, M; Simonetti, J, 2020) |
| "Fatigue is a frequent and disabling symptom of multiple sclerosis (MS) often associated with impaired quality of life (QoL) in patients." | ( de Sèze, J; Delabrousse-Mayoux, JP; Devy, R; Gherib, A; Kabir, M; Planque, E; Vandhuick, O, 2021) |
| "Fatigue is one of the most common adverse events of systemic therapy in patients with metastatic renal cell carcinoma (RCC)." | ( Bondarenko, A; Borisov, P; Tishova, Y; Tsimafeyeu, I; Zakurdaeva, K; Zukov, R, 2021) |
| "Fatigue is a frequently reported and disabling symptom in patients with systemic lupus erythematosus (SLE)." | ( Korsten, P; Piantoni, S, 2021) |
| "Fatigue is the common symptom in patients with multiple sclerosis (MS), yet its pathophysiological mechanism is poorly understood." | ( Al-Iedani, O; Arm, J; Lea, R; Lechner-Scott, J; Ramadan, S; Ribbons, K, 2021) |
| "Fatigue is a common presenting symptom in primary hyperparathyroidism (PHPT)." | ( Chen, H; Fazendin, JM; Lindeman, B; Montgomery, KB, 2021) |
| "Fatigue is a common symptom in patients with multiple sclerosis (MS) with unknown pathophysiology." | ( Al-Iedani, O; Arm, J; Lea, R; Lechner-Scott, J; Oeltzschner, G; Ramadan, S, 2021) |
| "Fatigue is common not only in cancer patients but also after viral and other infections." | ( Kraft, K; Vollbracht, C, 2021) |
| "Fatigue is not well-understood in SSc and reported to be highly distressing." | ( Khanna, D; Krause, D; Murphy, SL; Poole, JL, 2022) |
| "Fatigue is a multifactorial symptom commonly reported by patients with prostate cancer as a result of disease and treatment." | ( Armstrong, AJ; Beer, TM; Bhadauria, H; Freedland, SJ; Ganguli, A; Holmstrom, S; Hussain, M; Ivanescu, C; Ramaswamy, K; Saad, F; Stenzl, A; Sternberg, CN; Tombal, BF; Turnbull, J, 2022) |
| "Fatigue is common in inflammatory bowel disease (IBD)." | ( Bager, P; Dahlerup, JF; Hvas, CL; Rud, CL, 2022) |
| "Fatigue is a complex phenomenon and an important health concern for many people with chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis, primary Sjögren syndrome and systemic lupus erythematosus." | ( Davies, K; Dures, E; Ng, WF, 2021) |
| "Fatigue is a common symptom in patients with insomnia." | ( Atkins, N; Chepke, C; Filippov, G; Jain, R; Kumar, D; Malhotra, M; Moline, M; Perdomo, C; Pinner, K; Rosenberg, R; Yardley, J, 2022) |
| "Fatigue is often reported by colorectal cancer survivors and largely impacts their quality of life." | ( Bours, MJL; Breukink, SO; Janssen-Heijnen, MLG; Kenkhuis, MF; Keulen, ETP; Querido, NR; Ueland, PM; van Duijnhoven, FJB; van Roekel, EH; Vogelaar, FJ; Weijenberg, MP; Wesselink, E, 2022) |
| "Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD), and only limited treatment options are available." | ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "Fatigue is a common and disabling symptom in people with a primary brain tumour (PBT)." | ( Bulbeck, H; Cachia, D; Day, J; Rooney, AG; Tremont Lukats, IW; Wefel, J; Yust-Katz, S, 2022) |
| "Fatigue is independently associated with disease activity assessed using the PGA but not the SLEDAI." | ( Amoura, Z; Arnaud, L; Blaison, G; Bonnotte, B; Chessa, E; Fiehn, C; Korganow, AS; Lorenz, HM; Martin, T; Maurier, F; Mertz, P; Piga, M; Poindron, V; Schwarting, A; Sibilia, J; Voll, RE, 2022) |
| "Cancer-related fatigue is a prevalent, debilitating condition, and preliminary evidence suggests a relationship between higher diet quality and lower fatigue." | ( Jusko, TA; Kleckner, AS; Kleckner, IR; Lin, PJ; Mustian, KM; Peppone, LJ; van Wijngaarden, E, 2022) |
| "Exercise-induced fatigue is a complex physiological phenomenon and is greatly influenced by central mechanisms in brain." | ( Huang, Q; Li, J; Li, P; Shan, F; Xia, Y; Xiong, R; Xu, H; Yang, T; Zhao, Y, 2022) |
| "Fatigue is one of the most prevalent symptoms among pregnant women." | ( Xia, H; Zhu, C; Zhu, X, 2022) |
| "Fatigue is a predominant and distressing symptom in cancer and non-cancer conditions for which there is a paucity of recommendations for pharmacological interventions." | ( Correa-Morales, JE; Cuellar-Valencia, L; Giraldo-Moreno, S; Iriarte-Aristizábal, MF; Mantilla-Manosalva, N; Quintero-Muñoz, E; Rodríguez-Campos, LF, 2023) |
| "Cancer-related fatigue is defined as a distressing persistent subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and that interferes with usual functioning." | ( Chelette, B; Chidomere, CL; Dantzer, R, 2023) |
| "Cancer-related fatigue is defined as a distressing persistent subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and that interferes with usual functioning." | ( Chelette, B; Chidomere, CL; Dantzer, R, 2023) |
| "Cancer-related fatigue is defined as a distressing persistent subjective sense of physical, emotional, and/or cognitive tiredness or exhaustion related to cancer or cancer treatment that is not proportional to recent activity and that interferes with usual functioning." | ( Chelette, B; Chidomere, CL; Dantzer, R, 2023) |
| "Fatigue is common in patients with rheumatoid arthritis (RA)." | ( Fautrel, B; Haladyj, E; Takeuchi, T; van de Laar, MAFJ; Wang, D; Wu, J, 2023) |
| "Fatigue is common in patients with rheumatoid arthritis (RA)." | ( Fautrel, B; Haladyj, E; Takeuchi, T; van de Laar, MAFJ; Wang, D; Wu, J, 2023) |
| "Fatigue is the most commonly reported symptom in people with advanced cancer." | ( Foster, K; Good, P; Hardy, JR; Haywood, A; Khan, S; Rickett, K; Sandford, A, 2023) |
| "Fatigue is associated with reduced cognitive performance and lack of attention and vigilance." | ( Bell, T; Flenady, T; Sahay, A; Sprajcer, M, 2023) |
| "Fatigue is a multidimensional concept that has the capacity to impact nurses' performance when engaged in medication administration." | ( Bell, T; Flenady, T; Sahay, A; Sprajcer, M, 2023) |
| "Fatigue is experienced by more than 65% of individuals with multiple sclerosis (MS)." | ( Kazemi, AH; Khodaie, F; Naser Moghadasi, A; Zhao, B, 2023) |
| "Fatigue is one of the most common symptoms of people with Multiple Sclerosis (MS)." | ( Ghajarzadeh, M; Nourbakhsh, B; Roman, S; Vega, L, 2023) |
| "Muscle cramps and fatigue are common complications in hemodialysis patients and have been associated with reduced patient comfort." | ( Çeliksöz, G; Jabrayilov, J; Kesik, G; Ozdemir, L; Yıldırım, T, 2023) |
| "Edema and fatigue are potentially associated with IM plasma trough concentrations of ≥ 1283 ng/mL in Japanese patients with GISTs." | ( Doki, Y; Eguchi, H; Hayashi, Y; Hirota, S; Koh, M; Kurokawa, Y; Makino, T; Motoori, M; Nakajima, K; Nishida, T; Nishigaki, T; Omori, T; Saito, T; Takahashi, T; Takehara, T; Tanaka, K; Teranishi, R; Yamamoto, K; Yamashita, K, 2023) |
| "General fatigue is a major adverse event after commencing of enzalutamide in CRPC patients; however, its precise impact remains uncertain, especially on the duration of enzalutamide therapy." | ( Iijima, K; Inage, K; Ishizuka, O; Kato, H; Matsuda, H; Minagawa, T; Ogawa, T; Oguchi, T; Oike, H; Yamamoto, T, 2022) |
| "Fatigue is a common symptom in neurological diseases with a complex cause, involving the influence of events occurring in both the central and peripheral nervous systems." | ( Hou, L; Li, K; Liu, R; Wang, J; Xue, Y; Yang, X; Zhao, X, 2023) |
| "Prolonged fatigue is associated with non-pathological causes and lacks an established therapeutic approach." | ( Baldi, A; Buccato, DG; Campiglia, P; Daglia, M; El-Seedi, HR; Khalifa, SAM; Lellis, LF; Minno, AD; Piccinocchi, G; Piccinocchi, R; Riccioni, C; Sacchi, R; Sommella, E; Ullah, H, 2023) |
| "Fatigue is a common symptom in children with inflammatory bowel disease (IBD)." | ( Aliu, A; Bevers, N; Escher, J; Hanssen, A; Maartens, IB; Oudshoorn, A; Pierik, M; Rezazadeh Ardabili, A; Roelant, E; Rosias, P; Stapelbroek, J; Teklenburg-Roord, S; van de Feen, C; Van de Vijver, E; van Rheenen, P; Vande Velde, S; Vreugdenhil, A, 2023) |
| "Fatigue is also thought to increase inter-limb asymmetries, which is speculated to influence injury risk." | ( Blazevich, AJ; Cochrane Wilkie, J; Turner, M; Vial, S, 2023) |