A small protein-like chain designed to mimic a peptide.
ChEBI ID: 63175
| Member | Definition | Class |
|---|---|---|
| b 581 | A dipeptide obtained from the tetrapeptide Cys-Val-Phe-Met by reduction of the amide carbonyl groups of the Cys and Val residues. | B 581 |
| icatibant | A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acute attacks of hereditary angioedema in adult patients. | icatibant |
| l 685458 | A peptide and carboxamide that is L-leucyl-L-phenylalaninamide, L-Leu-L-Phe-NH2, which has been acylated on the N-terminus by a Phe-Phe hydroxyethylene dipeptide isotere, 2R-benzyl-5S-tert-butoxycarbonylamino-4R-hydroxy-6-phenylhexanoic acid. Compounds based on the structure of L-685,458 are potent inhibitors of gamma-secretase, which mediates the final catalytic step that generates the amyloid beta-peptide (Abeta), which assembles into the neurotoxic aggregates in the brains of sufferers of Alzheimer's disease. | L-685,458 |
| n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide | A synthetic tripeptide consisting of N-(tert-butylcarbamoyl)-3-methyl-L-valyl, a cyclopropyl-fused prolyl and 3-amino-4-cyclobutyl-2-oxobutanamide residues joined in sequence. Used for treatment of chronic hepatitis C virus genotype 1 infection. | boceprevir |
| ro 42-5892 | An L-histidine derivative that is L-histidine in which one of the amino hydrogens is replaced by a (2S)-2-[(2-methylpropane-2-sulfonyl)methyl]-3-phenylpropanoyl group and the carboxy group is replaced by a [(2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]amino group. It is a renin inhibitor which was under development for the treatment of hypertension (now discontinued). | remikiren |
| telaprevir | An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used for treatment of chronic hepatitis C virus genotype 1 infection. | telaprevir |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 64 (5.57) | 18.2507 |
| 2000's | 152 (13.24) | 29.6817 |
| 2010's | 896 (78.05) | 24.3611 |
| 2020's | 36 (3.14) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 155 (12.64%) | 5.53% |
| Reviews | 236 (19.25%) | 6.00% |
| Case Studies | 91 (7.42%) | 4.05% |
| Observational | 31 (2.53%) | 0.25% |
| Other | 713 (58.16%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 4.7957 | 1 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 13.1373 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 21.4509 | 2 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 11.2322 | 2 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 13.1373 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.1192 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 28.1838 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 24.8115 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 22.1969 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 1 | 1 |
| B2 bradykinin receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0025 | 2 | 3 |
| B2 bradykinin receptor | Homo sapiens (human) | IC50 | 0.0019 | 4 | 4 |
| B2 bradykinin receptor | Homo sapiens (human) | Ki | 0.0001 | 4 | 4 |
| B2 bradykinin receptor | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Beta-secretase 2 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | IC50 | 3.2820 | 3 | 5 |
| Cathepsin F | Homo sapiens (human) | IC50 | 5.5500 | 1 | 2 |
| Cathepsin K | Homo sapiens (human) | IC50 | 0.3350 | 1 | 2 |
| Cathepsin L2 | Homo sapiens (human) | IC50 | 0.7125 | 1 | 2 |
| Cathepsin S | Homo sapiens (human) | IC50 | 50.1050 | 2 | 4 |
| Chymase | Homo sapiens (human) | IC50 | 0.0290 | 1 | 2 |
| Chymotrypsin-like elastase family member 1 | Homo sapiens (human) | IC50 | 5.0150 | 1 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 6.1000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0820 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 6.1000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0820 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | Ki | 0.0001 | 1 | 1 |
| Gamma-secretase subunit APH-1A | Homo sapiens (human) | IC50 | 0.0782 | 7 | 7 |
| Gamma-secretase subunit APH-1B | Homo sapiens (human) | IC50 | 0.0782 | 7 | 7 |
| Gamma-secretase subunit PEN-2 | Homo sapiens (human) | IC50 | 0.1059 | 8 | 8 |
| Genome polyprotein | Hepatitis C virus (isolate H77) | Ki | 0.0140 | 2 | 2 |
| Genome polyprotein | Ki | 0.0140 | 2 | 2 | |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 23.9467 | 3 | 6 |
| Nicastrin | Homo sapiens (human) | IC50 | 0.0782 | 7 | 7 |
| Non-structural protein 4A | Ki | 0.0140 | 1 | 1 | |
| NS3 protease | IC50 | 0.9757 | 7 | 7 | |
| NS3 protease | Ki | 0.0039 | 1 | 1 | |
| NS3 protease | Hepatitis C virus subtype 1b | Ki | 3.0910 | 2 | 2 |
| Plasminogen | Homo sapiens (human) | IC50 | 54.3500 | 1 | 2 |
| Presenilin-1 | Homo sapiens (human) | IC50 | 0.0782 | 7 | 7 |
| Presenilin-2 | Homo sapiens (human) | IC50 | 0.0782 | 7 | 7 |
| Procathepsin L | Homo sapiens (human) | IC50 | 2.1300 | 1 | 2 |
| Protein farnesyltransferase subunit beta | Bos taurus (cattle) | IC50 | 0.0210 | 1 | 1 |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Bos taurus (cattle) | IC50 | 0.0210 | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | IC50 | 1.0000 | 1 | 2 |
| Renin | Homo sapiens (human) | IC50 | 0.0000 | 1 | 2 |
| Renin | Homo sapiens (human) | Ki | 0.0007 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 8.2277 | 12 | 17 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 8.6257 | 3 | 7 |
| Squalene synthase | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| Squalene synthase | Bos taurus (cattle) | IC50 | 0.0210 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| B2 bradykinin receptor | Homo sapiens (human) | Kd | 0.0003 | 1 | 1 |
| Renin | Homo sapiens (human) | Kd | 0.0001 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 5.6550 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 1.3100 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | Km | 52.2600 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | Km | 43.5500 | 1 | 1 |
| Cathepsin S | Homo sapiens (human) | IC90 | 100.0000 | 1 | 2 |
| Gamma-secretase subunit PEN-2 | Homo sapiens (human) | ED50 | 0.0250 | 2 | 2 |
| Neutrophil elastase | Homo sapiens (human) | IC90 | 100.0000 | 1 | 2 |
| NS3 protease | Km | 262.6667 | 3 | 3 | |
| Plasminogen | Homo sapiens (human) | IC90 | 105.0000 | 1 | 2 |
| Prothrombin | Homo sapiens (human) | IC90 | 1.2000 | 1 | 2 |