Any ionophore capable of transportation of potassium ions across membranes.
ChEBI ID: 88227
| Member | Definition | Class |
|---|---|---|
| bafilomycin a1 | The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus. | bafilomycin A1 |
| nigericin | A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. | nigericin |
| salinomycin | Salinomycin | |
| valinomycin | A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains. | valinomycin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,030 (39.12) | 18.7374 |
| 1990's | 1,105 (21.30) | 18.2507 |
| 2000's | 743 (14.32) | 29.6817 |
| 2010's | 1,042 (20.08) | 24.3611 |
| 2020's | 269 (5.18) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 34 (0.60%) | 5.53% |
| Reviews | 107 (1.88%) | 6.00% |
| Case Studies | 11 (0.19%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5,549 (97.33%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 1.0800 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 3.4533 | 3 | 3 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| P2X purinoceptor 3 | Homo sapiens (human) | IC50 | 0.7550 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 0.2400 | 1 | 1 |
| V-type proton ATPase subunit S1 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Vacuolar proton pump subunit B | Gallus gallus (chicken) | IC50 | 0.0300 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 1.0000 | 1 | 1 |