Any environmental contaminant that is resistant to environmental degradation through photolytic, biological or chemical processes. Such substances can have significant impact on health and the environment, as they persist in the environment, bioaccumulate in animal tissue and so biomagnify in food chains.
| Member | Definition | Class |
|---|
| 4-bromophenol | A bromophenol containing only hydroxy and bromo substituents that are para to one another. | 4-bromophenol |
| chlordan | | chlordane |
| chlordecone | An organochlorine compound with insecticidal activity. | chlordecone |
| ddt | A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide. | DDT |
| dichlorodiphenyl dichloroethylene | A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2. | DDE |
| endosulfan | A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10. | endosulfan |
| heptachlor | A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domestic situations. | heptachlor |
| hexachlorobenzene | A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants. | hexachlorobenzene |
| mirex | | mirex |
| pentachlorobenzene | A member of the class of pentachlorobenzenes that is benzene in which five of the hydrogens are replaced by chlorines. Now classed as a persistent organic pollutant under the Stockholm Convention. | pentachlorobenzene |
| perfluoro-n-nonanoic acid | A fluoroalkanoic acid that is nonanoic acid in which all of the hydrogens in the alkyl chain are replaced by fluorines. | perfluorononanoic acid |
| perfluorooctane sulfonic acid | A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines. | perfluorooctane-1-sulfonic acid |
| perfluorooctanesulfonamide | A perfluorinated compound that is perfluorooctane in which one of the terminal fluorines has been replace by a sulfamoyl group. | perfluorooctanesulfonamide |
| pyrene | An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system. | pyrene |
| triclosan | An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes. | triclosan |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.2172 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 20.6978 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 11.2202 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 53.5826 | 3 | 5 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 51.7838 | 2 | 26 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 26.6514 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 39.4070 | 11 | 96 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 60.7062 | 3 | 6 |
| Ataxin-2 | Homo sapiens (human) | Potency | 34.0452 | 1 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 34.0452 | 1 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 63.2034 | 1 | 7 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 68.5735 | 1 | 9 |
| caspase-3 | Homo sapiens (human) | Potency | 63.2034 | 1 | 7 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 68.5735 | 1 | 9 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 60.1040 | 3 | 39 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 21.1656 | 2 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 5.0119 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 26.5047 | 1 | 3 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 25.4565 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 63.3425 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.3627 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 8.3702 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.7836 | 2 | 18 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 17.4386 | 2 | 6 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 38.9940 | 1 | 14 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 81.5478 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 16.8336 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 42.4630 | 12 | 115 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 50.1887 | 3 | 31 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 42.1435 | 10 | 96 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 26.6514 | 1 | 2 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 42.8630 | 5 | 45 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 2.3627 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| GALC protein | Homo sapiens (human) | Potency | 1.4987 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.7836 | 1 | 9 |
| geminin | Homo sapiens (human) | Potency | 17.4086 | 2 | 5 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 31.6316 | 3 | 31 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 16.3253 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 43.3398 | 5 | 50 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 47.1320 | 1 | 8 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 48.8482 | 2 | 30 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 92.6148 | 2 | 26 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.3627 | 1 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 47.4126 | 2 | 28 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 60.1518 | 1 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 19.7347 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.3627 | 1 | 8 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 11.7995 | 2 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 58.7285 | 1 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.5506 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 16.8962 | 1 | 9 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 53.5076 | 2 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 14.4542 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 42.7435 | 4 | 50 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 48.9032 | 1 | 4 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 52.3181 | 2 | 25 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 28.1921 | 1 | 8 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 27.0050 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 29.7634 | 3 | 33 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 67.7406 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 10.1815 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 42.2732 | 5 | 31 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 40.3199 | 1 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 44.8757 | 5 | 26 |
| PINK1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| polyprotein | Zika virus | Potency | 63.0957 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 23.2804 | 1 | 10 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.9307 | 2 | 27 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 60.7097 | 1 | 6 |
| progesterone receptor | Homo sapiens (human) | Potency | 39.5683 | 2 | 27 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 37.8226 | 2 | 32 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 46.1447 | 3 | 44 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 30.4616 | 4 | 35 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 55.9438 | 2 | 10 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 55.9438 | 2 | 10 |
| Smad3 | Homo sapiens (human) | Potency | 16.8158 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 10.0000 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.7682 | 2 | 12 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 100.0000 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 32.7643 | 3 | 43 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 45.3794 | 4 | 13 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 23.7093 | 6 | 54 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 32.4377 | 2 | 8 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 33.4622 | 2 | 30 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 48.5540 | 5 | 20 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 47.1320 | 1 | 8 |
| Vpr | Human immunodeficiency virus 1 | Potency | 56.2341 | 1 | 1 |