Page last updated: 2024-08-05 15:42:28
retinoic acid receptor agonist
An agonist that selectively binds to and activates a retinoic acid receptor.
ChEBI ID: 67198
Members (2)
| Member | Definition | Class |
|---|---|---|
| 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid | A retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR). | arotinoid acid |
| tretinoin | A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. | all-trans-retinoic acid |
Research
Studies (22,873)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,540 (15.48) | 18.7374 |
| 1990's | 6,557 (28.67) | 18.2507 |
| 2000's | 6,068 (26.53) | 29.6817 |
| 2010's | 5,295 (23.15) | 24.3611 |
| 2020's | 1,413 (6.18) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,085 (4.55%) | 5.53% |
| Reviews | 1,990 (8.35%) | 6.00% |
| Case Studies | 1,373 (5.76%) | 4.05% |
| Observational | 15 (0.06%) | 0.25% |
| Other | 19,365 (81.27%) | 84.16% |
Protein Targets (169)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 58.2993 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 34.1072 | 1 | 5 |
| AR protein | Homo sapiens (human) | Potency | 12.4064 | 7 | 15 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 39.1150 | 2 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 28.0346 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 27.4122 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 17.2824 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 31.1448 | 2 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 19.9166 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 68.5199 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 68.5199 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 53.6913 | 3 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 26.2000 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 21.7600 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 25.5154 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 8.9125 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 29.3884 | 1 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 36.4261 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 25.0594 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 5.9622 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 0.0126 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 19.4971 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 34.6543 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 10.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 6.9950 | 11 | 31 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 28.2453 | 2 | 7 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 15.0343 | 10 | 28 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 32.3891 | 1 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 25.8292 | 4 | 10 |
| G | Vesicular stomatitis virus | Potency | 27.5404 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 18.1721 | 3 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.0323 | 3 | 7 |
| GLS protein | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 52.1422 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.1646 | 1 | 4 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 52.1194 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 49.6428 | 2 | 6 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 56.0456 | 2 | 4 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 0.2512 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 27.5404 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 14.5376 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 30.3001 | 2 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 45.1176 | 3 | 6 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 10.4220 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 28.1274 | 2 | 6 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0891 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.0795 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 8.1995 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 39.7580 | 4 | 9 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 3.2643 | 1 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 7.7679 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 24.0778 | 3 | 9 |
| Parkin | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.1994 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 13.8468 | 4 | 10 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 28.5795 | 4 | 7 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 79.4328 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 47.4704 | 2 | 6 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 37.6188 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 11.8832 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 3.9743 | 2 | 6 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 11.0429 | 3 | 10 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 0.4762 | 3 | 11 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 0.5212 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.2088 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 13.2084 | 2 | 7 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 35.4813 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 27.6719 | 4 | 10 |
| Thrombopoietin | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.6776 | 3 | 8 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 49.2287 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 24.7291 | 4 | 5 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 26.3190 | 1 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 18.4927 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 45.9866 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 47.3936 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.1646 | 1 | 4 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 13.8500 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0005 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.3580 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.2280 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 13.8500 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 5.2750 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.9820 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2750 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0004 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.7458 | 2 | 4 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2750 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.7458 | 2 | 4 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 3 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.1800 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 71.5000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cellular retinoic acid-binding protein 1 | Gallus gallus (chicken) | IC50 | 0.5233 | 3 | 3 |
| Chain A, Nuclear Receptor ROR-beta | Rattus norvegicus (Norway rat) | Ki | 0.2800 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 301.3000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 2 | Mus musculus (house mouse) | IC50 | 28.7000 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 0.5760 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Nuclear receptor ROR-alpha | Homo sapiens (human) | IC50 | 0.1995 | 1 | 1 |
| Nuclear receptor ROR-beta | Homo sapiens (human) | IC50 | 12.6224 | 2 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | IC50 | 0.1995 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | IC50 | 0.8200 | 1 | 1 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Ki | 0.8200 | 1 | 1 |
| Retinoic acid receptor alpha | Homo sapiens (human) | IC50 | 1.8105 | 4 | 5 |
| Retinoic acid receptor alpha | Mus musculus (house mouse) | IC50 | 0.0057 | 3 | 3 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Ki | 0.0568 | 3 | 4 |
| Retinoic acid receptor beta | Homo sapiens (human) | IC50 | 0.6040 | 4 | 5 |
| Retinoic acid receptor beta | Mus musculus (house mouse) | IC50 | 0.0050 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | Ki | 0.0084 | 3 | 4 |
| Retinoic acid receptor gamma | Mus musculus (house mouse) | IC50 | 0.0040 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | IC50 | 0.0113 | 3 | 4 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Ki | 0.0054 | 4 | 5 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | IC50 | 1.0000 | 1 | 2 |
| Retinoic acid receptor RXR-alpha | Mus musculus (house mouse) | IC50 | 18.0000 | 3 | 3 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | Ki | 0.2268 | 3 | 3 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 2 |
| Retinoic acid receptor RXR-beta | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | Ki | 0.3118 | 3 | 3 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | IC50 | 0.6750 | 1 | 2 |
| Retinoic acid receptor RXR-gamma | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | Ki | 0.1365 | 3 | 3 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 91.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cellular retinoic acid-binding protein 1 | Mus musculus (house mouse) | Kd | 0.0004 | 2 | 2 |
| Cellular retinoic acid-binding protein 2 | Mus musculus (house mouse) | Kd | 0.0020 | 2 | 2 |
| Chain A, Retinoic acid receptor beta | Homo sapiens (human) | Kd | 0.0020 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | EC50 | 0.0005 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | EC50 | 0.0006 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | EC50 | 0.0012 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | EC50 | 0.0002 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | EC50 | 0.0015 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | EC50 | 13.5000 | 1 | 2 |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Kd | 0.8000 | 1 | 1 |
| Retinoic acid receptor alpha | Homo sapiens (human) | EC50 | 0.1432 | 19 | 22 |
| Retinoic acid receptor alpha | Mus musculus (house mouse) | EC50 | 0.0082 | 3 | 3 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Kd | 0.0102 | 10 | 12 |
| Retinoic acid receptor alpha | Mus musculus (house mouse) | Kd | 0.0150 | 1 | 1 |
| Retinoic acid receptor beta | Homo sapiens (human) | EC50 | 0.0303 | 19 | 22 |
| Retinoic acid receptor beta | Mus musculus (house mouse) | EC50 | 0.0012 | 3 | 3 |
| Retinoic acid receptor beta | Homo sapiens (human) | Kd | 0.0086 | 11 | 13 |
| Retinoic acid receptor beta | Mus musculus (house mouse) | Kd | 0.0130 | 1 | 1 |
| Retinoic acid receptor gamma | Mus musculus (house mouse) | EC50 | 0.0004 | 2 | 2 |
| Retinoic acid receptor gamma | Mus musculus (house mouse) | Kd | 0.0180 | 1 | 1 |
| Retinoic acid receptor gamma | Homo sapiens (human) | EC50 | 0.0113 | 16 | 19 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Kd | 0.0114 | 12 | 15 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 | 1.4913 | 7 | 10 |
| Retinoic acid receptor RXR-alpha | Mus musculus (house mouse) | EC50 | 2.0000 | 1 | 1 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | Kd | 0.0681 | 6 | 8 |
| Retinoic acid receptor RXR-alpha | Mus musculus (house mouse) | Kd | 1.0000 | 1 | 1 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | EC50 | 2.8397 | 4 | 5 |
| Retinoic acid receptor RXR-beta | Mus musculus (house mouse) | EC50 | 1.2110 | 1 | 1 |
| Retinoic acid receptor RXR-beta | Homo sapiens (human) | Kd | 0.0000 | 1 | 1 |
| Retinoic acid receptor RXR-beta | Mus musculus (house mouse) | Kd | 0.6530 | 2 | 2 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | EC50 | 2.6854 | 4 | 5 |
| Retinoic acid receptor RXR-gamma | Mus musculus (house mouse) | EC50 | 0.4835 | 2 | 2 |
| Retinoic acid receptor RXR-gamma | Homo sapiens (human) | Kd | 0.1530 | 2 | 2 |
| Retinoic acid receptor RXR-gamma | Mus musculus (house mouse) | Kd | 0.3500 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cellular retinoic acid-binding protein 1 | Gallus gallus (chicken) | ID50 | 0.9000 | 2 | 2 |
| Ornithine decarboxylase | Mus musculus (house mouse) | ID50 | 0.0001 | 1 | 1 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | ID50 | 0.0000 | 1 | 2 |
| Retinoic acid receptor alpha | Homo sapiens (human) | AC50 | 0.2000 | 1 | 1 |
| Retinoic acid receptor alpha | Homo sapiens (human) | EC30 | 0.0010 | 2 | 2 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Relative EC30 | 0.0022 | 2 | 2 |
| Retinoic acid receptor alpha | Homo sapiens (human) | Relative IC50 | 0.0009 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | AC50 | 0.0220 | 1 | 1 |
| Retinoic acid receptor beta | Homo sapiens (human) | EC30 | 0.0008 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | Relative EC30 | 0.0016 | 2 | 2 |
| Retinoic acid receptor beta | Homo sapiens (human) | Relative IC50 | 0.0007 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | AC50 | 0.0260 | 1 | 1 |
| Retinoic acid receptor gamma | Homo sapiens (human) | EC30 | 0.0002 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Relative EC30 | 0.0006 | 2 | 2 |
| Retinoic acid receptor gamma | Homo sapiens (human) | Relative IC50 | 0.0007 | 2 | 2 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | AC50 | 1.0000 | 1 | 1 |