An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
| Member | Definition | Class |
|---|
| (3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone | A organic heterotricyclic compound that is 5-methyl-3-(morpholin-4-ylmethyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indole substituted at position 6 by a 1-naphthylcarbonyl group. | WIN 55212-2 |
| (R)-ketamine | The R- (less active) enantiomer of ketamine. | (R)-ketamine |
| 1,3,7,9-tetramethyluric acid | An oxopurine that is uric acid in which the hydrogens at positions 1,3,7 and 9 are replaced by methyl groups. It is a purine alkaloid that is found in Chinese tea known as kucha (Camellia assamica var. kucha) and exhibits anti-inflammatory and analgesic properties. | 1,3,7,9-tetramethyluric acid |
| acetanilide | A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group. | N-phenylacetamide |
| adenosine | A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta-N(9)-glycosidic bond. | adenosine |
| amantadine | A member of the class of adamantanes that is used as an antiviral and antiparkinson drug. | amantadine |
| ampiroxicam | A benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. | ampiroxicam |
| benzoylmesaconine | A diterpene alkaloid with formula C31H43NO10 that is isolated from several Aconitum species. | benzoylmesaconine |
| benzydamine | A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties. | benzydamine |
| betulin | A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents. | betulin |
| butalbital | A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. Frequently combined with other medicines, such as aspirin, paracetamol and codeine, it is used for treatment of pain and headache. | butalbital |
| carbamazepine | A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. | carbamazepine |
| cimetidine | A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. | cimetidine |
| cubebin | A lignan that consists of tetrahydrofuran-2-ol substituted by two 1,3-benzodioxol-5-ylmethyl groups at positions 3 and 4 respectively (the 2S,3R,4R stereoisomer). It is isolated from the leaves of Piper nigrum and exhibits analgesic, anti-inflammatory, antimicrobial and trypanocidal activities. | (-)-cubebin |
| decursinol | An organic heterotricyclic compound that is 7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one substituted by a beta-hydroxy group at position 7 and two methyl groups at position 8. It is isolated from the roots of Angelica gigas and has been found to possess significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7). | decursinol |
| dexmedetomidine | | dexmedetomidine |
| diazooxonorleucine | A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. | 6-diazo-5-oxo-L-norleucine zwitterion; 6-diazo-5-oxo-L-norleucine |
| ecgonine methyl ester | The O-debenzoyl analogue of cocaine. | ecgonine methyl ester |
| enkephalin, leucine | A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties. | Leu-enkephalin zwitterion; Leu-enkephalin |
| enkephalin, methionine | A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-methionine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide with antitumor, analgesic, and immune-boosting properties. | Met-enkephalin zwitterion; Met-enkephalin |
| esketamine | The S- (more active) enantiomer of ketamine. | esketamine |
| indomethacin | A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. | indometacin |
| jwh-133 | A dibenzopyran that is Delta(9)-tetrahydrocannabinol which is lacking the hydroxy group and in which the pentyl group at position 3 has been replaced by a 1,1-dimethylbutyl group. A potent and highly selective CB2 receptor agonist. | JWH-133 |
| ketamine | A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group. | ketamine |
| ketorolac | A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure. | 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; ketorolac |
| ketorolac tromethamine | An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. | ketorolac tromethamine |
| magnesium sulfate | A magnesium salt having sulfate as the counterion. | magnesium sulfate |
| meclofenamate sodium anhydrous | A hydrate that is the monohydrate of the sodium salt of meclofenamic acid. It is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis. | sodium meclofenamate monohydrate |
| meclofenamic acid | An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis. | meclofenamic acid |
| mefenamic acid | An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. | mefenamic acid |
| mitoxantrone | A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8. | mitoxantrone |
| mobic | A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis. | meloxicam |
| nefazodone | | nefazodone |
| nitrous oxide | A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream. | dinitrogen oxide |
| nortriptyline | An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. | nortriptyline |
| oxaprozin | A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis. | oxaprozin |
| patuletin | A trimethoxyflavone that is quercetagetin methylated at position 6. | patuletin |
| picrinine | A natural product with formula C20H22N2O3 that is the member of the akuammiline family of alkaloids, first isolated in 1965 from the leaves of Alstonia scholaris. | picrinine |
| piroxicam | A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling. | piroxicam |
| propionylcarnitine | An O-acylcarnitine compound having propanoyl as the acyl substituent. | O-propanoylcarnitine |
| resiniferatoxin | A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). | resiniferatoxin |
| rofecoxib | A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. | rofecoxib |
| sch772984 | A member of the class of indazoles that is 1H-indazole substituted by pyridin-4-yl and {[(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidin-3-yl]carbonyl}amino groups at positions 3 and 5, respectively. It is a potent inhibitor of mitogen-activated protein kinases ERK1 and ERK2 (IC50 = 4 and 1 nM, respectively) that exhibits anti-cancer properties. | SCH772984 |
| sulindac | A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions. | sulindac |
| ta 0910 | An oligopeptide comprising of (4S)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid, L-histidine and L-prolinamide joined in sequence by peptide linkages. It is a thyrotropin-releasing hormone (TRH) analog. Its tetrahydrate form is approved in Japan for the treatment of spinal muscular atrophy. | taltirelin |
| u-50488 | A monocarboxylic acid amide obtained by formal condensation between the carboxy group of 3,4-dichlorophenylacetic acid and the secondary amino group of (1R,2R)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine | U50488 |
| venlafaxine | A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group. | venlafaxine |
| xylazine | A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties. | xylazine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 11.9014 | 1 | 3 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 23.9341 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 7.0922 | 2 | 5 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 18.1355 | 2 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 14.4381 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 11.7172 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 33.5278 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 15.8669 | 1 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 10.0000 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 20.3251 | 11 | 53 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.6354 | 2 | 10 |
| arylsulfatase A | Homo sapiens (human) | Potency | 10.8767 | 1 | 10 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.8728 | 4 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 20.0442 | 2 | 6 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.6404 | 1 | 6 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 27.8857 | 2 | 3 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 30.9336 | 1 | 2 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 16.5545 | 1 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 1.9379 | 3 | 8 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 76.5882 | 1 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 21.3290 | 2 | 6 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 14.5971 | 2 | 11 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.7236 | 1 | 10 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 20.3866 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 20.0819 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.3424 | 1 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 11.2202 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 40.6347 | 1 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 49.5091 | 2 | 12 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 25.1574 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 9.9819 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 47.8073 | 2 | 9 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 7.6341 | 1 | 8 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 14.4386 | 1 | 9 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 16.4319 | 1 | 10 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 11.2175 | 1 | 7 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 15.1402 | 1 | 12 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 11.4221 | 2 | 32 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 17.0002 | 2 | 10 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 25.6584 | 1 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 7.9899 | 3 | 3 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 20.8868 | 1 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 15.2172 | 1 | 3 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 11.0869 | 2 | 2 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 1.5003 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 25.7698 | 2 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 11.2008 | 2 | 6 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 4.3133 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.7322 | 9 | 53 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 23.2289 | 2 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 37.3620 | 7 | 18 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.2167 | 1 | 22 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 21.0002 | 4 | 28 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 15.8864 | 2 | 6 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 3.7261 | 3 | 6 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 12.8723 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 16.4319 | 1 | 10 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 11.4221 | 1 | 16 |
| geminin | Homo sapiens (human) | Potency | 11.2376 | 2 | 17 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 18.4163 | 2 | 7 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 20.3158 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 17.7645 | 2 | 10 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 20.2208 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 11.8161 | 4 | 19 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 35.4235 | 1 | 6 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 15.1652 | 1 | 2 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 15.7615 | 2 | 6 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 23.4106 | 1 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 14.1065 | 2 | 37 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 31.6009 | 1 | 5 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 6.3030 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 51.4955 | 2 | 4 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 16.4319 | 1 | 10 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 13.0333 | 2 | 3 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 39.8107 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 17.1284 | 1 | 5 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 8.6827 | 2 | 16 |
| IDH1 | Homo sapiens (human) | Potency | 18.6021 | 1 | 5 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 16.4319 | 1 | 20 |
| inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 6.7474 | 3 | 7 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 11.6173 | 1 | 5 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 11.6173 | 1 | 5 |
| Interferon beta | Homo sapiens (human) | Potency | 12.8545 | 2 | 13 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.4978 | 1 | 14 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 5.0119 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.3004 | 3 | 16 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 10.4937 | 1 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.9280 | 1 | 4 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 5.4904 | 2 | 6 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 9.8395 | 2 | 12 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 15.0815 | 3 | 5 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 8.7169 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 1.6079 | 2 | 6 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 5.4593 | 1 | 3 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 60.5598 | 1 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 44.2159 | 3 | 13 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.3117 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 34.5596 | 1 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 9.4392 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 21.3294 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 33.7924 | 3 | 16 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 22.0164 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 16.1619 | 2 | 5 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.1642 | 2 | 10 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 20.9697 | 5 | 17 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.2987 | 4 | 14 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 21.3313 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 37.6535 | 1 | 6 |
| polyprotein | Zika virus | Potency | 12.8723 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 13.2098 | 1 | 5 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.9300 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 38.4429 | 3 | 10 |
| progesterone receptor | Homo sapiens (human) | Potency | 14.4953 | 3 | 8 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 28.1838 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.8489 | 2 | 3 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 19.9526 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 27.2693 | 2 | 18 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 36.9360 | 1 | 6 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 9.8072 | 1 | 6 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 34.4037 | 3 | 15 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 22.3094 | 4 | 15 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 16.7133 | 4 | 9 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 34.1726 | 3 | 3 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 33.6698 | 2 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 16.4077 | 2 | 15 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 16.4077 | 2 | 15 |
| Smad3 | Homo sapiens (human) | Potency | 6.5992 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 16.3743 | 1 | 9 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 5.7636 | 1 | 5 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 21.7371 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.8842 | 2 | 23 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 20.6017 | 4 | 11 |
| Thrombopoietin | Homo sapiens (human) | Potency | 6.3072 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 34.5256 | 3 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 31.5626 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 17.8999 | 3 | 17 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 34.4993 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 15.0852 | 2 | 4 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.1811 | 2 | 8 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 34.7503 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 14.5108 | 5 | 17 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 53.2130 | 1 | 10 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 35.4235 | 1 | 6 |
| Vpr | Human immunodeficiency virus 1 | Potency | 6.0558 | 1 | 2 |
| WRN | Homo sapiens (human) | Potency | 4.9369 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3',5'-cyclic-AMP phosphodiesterase | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.0190 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.5600 | 2 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 1.0190 | 2 | 2 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.0680 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0510 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0104 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.1360 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0860 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 1.7890 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.9369 | 1 | 2 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 1.7890 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.9369 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.5540 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.2355 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| 5'-nucleotidase | Homo sapiens (human) | IC50 | 22.6600 | 2 | 2 |
| 5'-nucleotidase | Mus musculus (house mouse) | IC50 | 50.3200 | 1 | 1 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | Ki | 37.3000 | 1 | 3 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 10.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 14.5185 | 2 | 2 |
| Adenosine kinase | Toxoplasma gondii | Ki | 8.9000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 0.0023 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 164.0000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 0.8128 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.1523 | 5 | 6 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 164.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 0.2900 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 0.0240 | 3 | 3 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 2 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.0011 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.2900 | 1 | 1 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 0.1000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 89,500.0000 | 2 | 2 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Ki | 33,860.0000 | 3 | 3 |
| Albumin | Homo sapiens (human) | Ki | 83,456,100,000.0000 | 1 | 3 |
| Aldehyde oxidase | Homo sapiens (human) | Ki | 155.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 3.4310 | 2 | 3 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 28.5633 | 3 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.5670 | 1 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.6433 | 2 | 5 |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | IC50 | 2.1450 | 2 | 2 |
| Aldo-keto reductase family 1 member C1 | Homo sapiens (human) | IC50 | 48.1386 | 5 | 7 |
| Aldo-keto reductase family 1 member C1 | Homo sapiens (human) | Ki | 0.8100 | 1 | 1 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 36.8688 | 6 | 8 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | Ki | 0.2200 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 2.3902 | 9 | 11 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | Ki | 0.8900 | 3 | 3 |
| Aldo-keto reductase family 1 member C4 | Homo sapiens (human) | IC50 | 90.8000 | 3 | 5 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0130 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.2730 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0670 | 2 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.3660 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.1388 | 2 | 2 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0013 | 4 | 4 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0470 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0430 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.1015 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0304 | 2 | 2 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0034 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 3.5849 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 2.9370 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 128.2143 | 1 | 14 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 30.8859 | 6 | 7 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 50.0000 | 4 | 4 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0270 | 1 | 1 |
| Beta-lactamase | Escherichia coli K-12 | IC50 | 375.0000 | 2 | 2 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 93.0000 | 3 | 4 |
| Bifunctional epoxide hydrolase 2 | Mus musculus (house mouse) | IC50 | 167.7500 | 2 | 2 |
| Bifunctional epoxide hydrolase 2 | Rattus norvegicus (Norway rat) | IC50 | 181.2500 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 236.6716 | 6 | 38 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 368.3000 | 1 | 3 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 0.9038 | 1 | 1 |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | IC50 | 20.0250 | 1 | 2 |
| Calcium dependent protein kinase | Zea mays | IC50 | 116.0000 | 1 | 1 |
| Calpain-2 catalytic subunit | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 141.5000 | 2 | 12 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 0.0710 | 7 | 7 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 0.2472 | 77 | 84 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | Ki | 0.0186 | 4 | 4 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 114,001.5498 | 8 | 8 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | Ki | 0.0060 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | IC50 | 0.0189 | 6 | 6 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 0.0047 | 79 | 87 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 0.6600 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 4.6420 | 1 | 5 |
| Caspase-3 | Homo sapiens (human) | IC50 | 4.6420 | 1 | 5 |
| Caspase-4 | Homo sapiens (human) | IC50 | 4.6420 | 1 | 5 |
| Caspase-5 | Homo sapiens (human) | IC50 | 4.6420 | 1 | 5 |
| Caspase-9 | Homo sapiens (human) | IC50 | 4.6420 | 1 | 5 |
| Cell division control protein 42 homolog | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Chain A, ADENOSINE RECEPTOR A2A | Homo sapiens (human) | Ki | 0.0309 | 1 | 2 |
| Chain A, membrane-associated prostaglandin E synthase-2 | Macaca fascicularis (crab-eating macaque) | IC50 | 1,000.0000 | 1 | 1 |
| Chain A, Probable serine/threonine-protein kinase pknB | Mycobacterium tuberculosis H37Rv | IC50 | 0.8000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 10.0000 | 1 | 1 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 | 200.0000 | 1 | 1 |
| Cytochrome c oxidase subunit 1 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | IC50 | 0.9250 | 3 | 4 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0020 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | Ki | 49.9000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 5 |
| Cytochrome P450 2D1 | Rattus norvegicus (Norway rat) | IC50 | 204.0000 | 1 | 1 |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | IC50 | 1.9000 | 1 | 1 |
| Cytochrome P450 2D3 | Rattus norvegicus (Norway rat) | IC50 | 14.2000 | 1 | 1 |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | IC50 | 19.3000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 16.8200 | 4 | 5 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 77.0000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 5 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 3,103.0000 | 4 | 5 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 1.0000 | 1 | 3 |
| Cytosolic phospholipase A2 gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.5390 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.2690 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.1790 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0610 | 1 | 1 |
| Dehydrogenase/reductase SDR family member 9 | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 0.0064 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.0139 | 6 | 10 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2816 | 4 | 5 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 2.9277 | 13 | 18 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 1.8591 | 7 | 7 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.8367 | 6 | 6 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 72.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 21.9500 | 2 | 2 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | IC50 | 6.6697 | 3 | 3 |
| Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens (human) | IC50 | 0.0090 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Mus musculus (house mouse) | IC50 | 49.7600 | 1 | 1 |
| Endoplasmin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 55.0965 | 3 | 4 |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | IC50 | 40.0000 | 2 | 2 |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | Ki | 12.0000 | 1 | 1 |
| Equilibrative nucleoside transporter 2 | Homo sapiens (human) | IC50 | 106.0000 | 1 | 1 |
| Equilibrative nucleoside transporter 2 | Homo sapiens (human) | Ki | 106.0000 | 1 | 1 |
| Fatty acid-binding protein, intestinal | Homo sapiens (human) | Ki | 9.1500 | 2 | 2 |
| Fatty acid-binding protein, liver | Rattus norvegicus (Norway rat) | Ki | 32.8088 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 57.9000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | IC50 | 3.1487 | 6 | 6 |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | Ki | 2.2267 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 95.4233 | 11 | 12 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 0.4032 | 17 | 19 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | IC50 | 2.6701 | 4 | 4 |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | Ki | 2.2267 | 5 | 6 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 95.4233 | 11 | 12 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 0.4156 | 16 | 18 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | IC50 | 4.1059 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 110.4080 | 10 | 10 |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | Ki | 2.6360 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.4156 | 16 | 18 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 110.4080 | 10 | 10 |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | Ki | 2.6360 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 0.4294 | 15 | 17 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 110.4080 | 10 | 10 |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | Ki | 2.6360 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 0.4294 | 15 | 17 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 110.4080 | 10 | 10 |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | Ki | 2.6360 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 0.4294 | 15 | 17 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 110.4080 | 10 | 10 |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | Ki | 2.6360 | 4 | 5 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 0.4294 | 15 | 17 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | Ki | 6.1000 | 1 | 1 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | IC50 | 33,597.8571 | 7 | 7 |
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | Ki | 2,500.0000 | 1 | 1 |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | IC50 | 21.8965 | 4 | 5 |
| Heat shock 70 kDa protein 1A | Homo sapiens (human) | IC50 | 560.0000 | 1 | 1 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Ki | 3.0000 | 1 | 1 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 0.3851 | 2 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0000 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0059 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 4.0100 | 2 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.3031 | 8 | 9 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.3020 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 1.2381 | 5 | 7 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Histone-lysine N-methyltransferase, H3 lysine-79 specific | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 0.0820 | 1 | 2 |
| Inosine-5'-monophosphate dehydrogenase 1 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Inosine-5'-monophosphate dehydrogenase 2 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 5.9000 | 2 | 2 |
| Interleukin-8 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0958 | 2 | 2 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 0.0537 | 13 | 14 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.0183 | 4 | 5 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 3.7728 | 6 | 7 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 1.1281 | 14 | 18 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 0.4005 | 27 | 28 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0081 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 5.0003 | 3 | 4 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 56.6800 | 3 | 5 |
| Malate dehydrogenase, cytoplasmic | Homo sapiens (human) | IC50 | 200.0000 | 1 | 2 |
| Matrix protein 2 | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 153.9250 | 4 | 4 |
| Matrix protein 2 | Influenza A virus (A/udorn/1972(H3N2)) | IC50 | 109.8600 | 5 | 5 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 0.2294 | 14 | 14 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 38.6000 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 38.6000 | 1 | 2 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 0.0084 | 6 | 6 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 50.1230 | 2 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 4.7565 | 2 | 2 |
| Mu-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.0308 | 3 | 4 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 5.2816 | 4 | 5 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.4787 | 8 | 15 |
| Mu-type opioid receptor | Danio rerio (zebrafish) | Ki | 1.0005 | 1 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.8614 | 5 | 6 |
| Mu-type opioid receptor | Mus musculus (house mouse) | Ki | 0.5050 | 3 | 4 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.8096 | 9 | 10 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 68.5025 | 5 | 8 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 13.4533 | 3 | 3 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 4.1054 | 6 | 6 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 101.5357 | 1 | 14 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.4154 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.1001 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.2830 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.1004 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.1710 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.3696 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0514 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.0270 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| Myc proto-oncogene protein | Homo sapiens (human) | IC50 | 403.0000 | 1 | 1 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 1.5950 | 2 | 2 |
| Myeloperoxidase | Homo sapiens (human) | Ki | 0.0019 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 25.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0004 | 1 | 3 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 24.3500 | 5 | 5 |
| Nociceptin receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0069 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/California/07/2009(H1N1)) | IC50 | 2.0490 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 3.5849 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 2.9370 | 1 | 1 |
| Nuclear receptor subfamily 4 group A member 2 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Opioid receptor homologue | Danio rerio (zebrafish) | Ki | 0.0730 | 1 | 1 |
| Opioid receptor, delta 1b | Danio rerio (zebrafish) | Ki | 0.1100 | 1 | 2 |
| P2X purinoceptor 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | IC50 | 0.9600 | 1 | 1 |
| P2Y purinoceptor 12 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Pancreatic alpha-amylase | Sus scrofa (pig) | IC50 | 200.0000 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | IC50 | 30.3000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| Phosphoglycerate kinase 1 | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| Phosphoglycerate kinase 2 | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| phospholipase A2, group III | Homo sapiens (human) | IC50 | 121.7940 | 1 | 1 |
| Phospholipase A2, major isoenzyme | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 456.1111 | 8 | 9 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 1.7853 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 206.7905 | 2 | 4 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 2.9370 | 1 | 1 |
| Potassium-transporting ATPase alpha chain 1 | Homo sapiens (human) | IC50 | 50.4100 | 2 | 2 |
| Potassium-transporting ATPase subunit beta | Homo sapiens (human) | IC50 | 50.4100 | 2 | 2 |
| Procathepsin L | Homo sapiens (human) | IC50 | 11.8000 | 1 | 1 |
| Prostaglandin D2 receptor | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 1 |
| Prostaglandin D2 receptor | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin D2 receptor 2 | Homo sapiens (human) | Ki | 4.0250 | 2 | 2 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 60.3000 | 2 | 2 |
| Prostaglandin E2 receptor EP1 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP2 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP3 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP4 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 26.2744 | 79 | 111 |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | IC50 | 3.3407 | 2 | 3 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 36.3008 | 96 | 125 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Ki | 7.9000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 19.1870 | 12 | 16 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 1.4112 | 10 | 11 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 11.7727 | 138 | 177 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 | 0.9627 | 17 | 30 |
| Prostaglandin G/H synthase 2 | Oryctolagus cuniculus (rabbit) | IC50 | 18.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 43.2108 | 42 | 48 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | Ki | 9.8600 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 11.4515 | 8 | 12 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.4466 | 10 | 11 |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | IC50 | 1.1000 | 2 | 2 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase ROS | Homo sapiens (human) | IC50 | 2.9987 | 1 | 1 |
| Purine nucleoside phosphorylase | Homo sapiens (human) | Ki | 2,000.0000 | 1 | 1 |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 14.4600 | 1 | 1 |
| Ras-related C3 botulinum toxin substrate 1 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 801.0176 | 2 | 2 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | IC50 | 82.9000 | 1 | 1 |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | IC50 | 7.7000 | 1 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 50.2500 | 1 | 2 |
| Serine hydroxymethyltransferase, mitochondrial | Homo sapiens (human) | IC50 | 1.9498 | 1 | 1 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Serum paraoxonase/arylesterase 1 | Homo sapiens (human) | Ki | 97.0000 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.4900 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 1,550.0000 | 2 | 2 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Ki | 52.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | Ki | 32.7000 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Mus musculus (house mouse) | IC50 | 170.4120 | 1 | 2 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Mus musculus (house mouse) | IC50 | 389.0225 | 1 | 2 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Mus musculus (house mouse) | IC50 | 269.5765 | 1 | 2 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Mus musculus (house mouse) | IC50 | 250.0945 | 1 | 2 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 4.2500 | 2 | 4 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 8.0956 | 8 | 8 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.7858 | 4 | 4 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 18.6663 | 10 | 12 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.3017 | 6 | 8 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 18.2303 | 10 | 11 |
| Sodium-dependent serotonin transporter | Macaca mulatta (Rhesus monkey) | IC50 | 0.5000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.3955 | 2 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.0773 | 5 | 6 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0385 | 2 | 2 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 | 109.0000 | 1 | 1 |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | Ki | 1.8000 | 1 | 1 |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | Ki | 5.3000 | 1 | 1 |
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | IC50 | 0.5900 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 296.3250 | 4 | 4 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 5.7000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 97.6333 | 3 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 166.0000 | 1 | 1 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | IC50 | 2,000.0000 | 1 | 1 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | Ki | 107.8000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 39.7667 | 3 | 3 |
| Solute carrier family 22 member 2 | Mus musculus (house mouse) | IC50 | 8.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 285.9750 | 4 | 4 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Ki | 57.0000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 103.7000 | 2 | 2 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 60.5000 | 1 | 1 |
| Solute carrier family 22 member 4 | Rattus norvegicus (Norway rat) | IC50 | 1,500.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 171.8333 | 2 | 3 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | Ki | 19.8000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 266.5500 | 3 | 4 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | IC50 | 92.4000 | 1 | 1 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | IC50 | 166.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 315.9575 | 3 | 4 |
| Solute carrier family 22 member 8 | Rattus norvegicus (Norway rat) | Ki | 46.8000 | 1 | 1 |
| Solute carrier family 28 member 3 | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| Solute carrier family 28 member 3 | Homo sapiens (human) | Ki | 2.1000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A3 | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 22.1950 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 20.5500 | 2 | 2 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 140.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 5.7000 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 50.0500 | 2 | 2 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 8.8000 | 1 | 1 |
| Transcription factor SOX-18 | Mus musculus (house mouse) | IC50 | 163.0000 | 2 | 2 |
| Transient receptor potential cation channel subfamily M member 2 | Homo sapiens (human) | IC50 | 124.0000 | 1 | 1 |
| Transporter | Macaca mulatta (Rhesus monkey) | IC50 | 100.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 0.6400 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.7190 | 1 | 1 |
| Tyrosine-protein kinase BTK | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 1.2579 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | IC50 | 28.8000 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 22.5000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 22.5000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 22.5000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 22.5000 | 1 | 1 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |