schizandrin C: from Schizandra chinensis Baill & Fructus schisandrae; protects liver from carbon tetrachloride injury; [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 443027 |
| CHEMBL ID | 437412 |
| CHEBI ID | 10044 |
| SCHEMBL ID | 2406629 |
| MeSH ID | M0098703 |
| Synonym |
|---|
| cycloocta(1,2-f:3,4-f')bis(1,3)benzodioxole 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, (6r,7s,13as)- |
| schizandrin c |
| schisandrin-c |
| CHEMBL437412 , |
| chebi:10044 , |
| AC1L9DW8 , |
| c8754w6b3g , |
| unii-c8754w6b3g |
| AKOS015897177 |
| CS-3664 |
| SCHEMBL2406629 |
| (s)-(-)-schisandrin c |
| cycloocta(1,2-f:3,4-f')bis(1,3)benzodioxole, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, (6r,7s,13as)- |
| (-)-wuweizisu c |
| HY-N0690 |
| surecn2406629 |
| (6r,7s,13as)-5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-cycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole |
| Q27108563 |
| A14756 |
| wuweizisu-c |
| schizandrin-c |
| Class | Description |
|---|---|
| tannin | Any of a group of astringent polyphenolic vegetable principles or compounds, chiefly complex glucosides of catechol and pyrogallol. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID335886 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 500 mol ratio relative to TPA | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. |
| AID1585503 | Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by SYBR Green I dye-based qRT-PCR analysis | 2019 | European journal of medicinal chemistry, Jan-15, Volume: 162 | Small molecules as inhibitors of PCSK9: Current status and future challenges. |
| AID380431 | Antiinflammatory activity against LPS-induced prostaglandin E2 production in mouse macrophages upto 25 ug/ml | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID399882 | Antiviral activity against HIV | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2 | Current developments in the discovery and design of new drug candidates from plant natural product leads. |
| AID380432 | Inhibition of COX2 in mouse macrophages | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID313794 | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. |
| AID721569 | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity. |
| AID313797 | Antiproliferative activity against human T47D cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. |
| AID335887 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 100 mol ratio relative to TPA | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. |
| AID721568 | Cytotoxicity against human U87 cells after 72 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity. |
| AID335885 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 1000 mol ratio relative to TPA | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. |
| AID335888 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 10 mol ratio relative to TPA | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. |
| AID313799 | Antiproliferative activity against human K562 cells after 72 hrs by MTT assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. |
| AID380426 | Cytotoxicity against pig LLC-PK1 cells upto 48 uM | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID313795 | Antiproliferative activity against human SK-HEP1 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. |
| AID721571 | Cytotoxicity against mouse LLC cells after 72 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity. |
| AID1371180 | Substrate activity at CYP3A5 (unknown origin) assessed as enzyme-mediated compound turnover assessed per pmol protein at 10 uM | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5. |
| AID404000 | Antiviral activity against HIV | 1998 | Journal of natural products, Nov, Volume: 61, Issue:11 | Antiviral activity of lignans. |
| AID380427 | Cytotoxicity against human SK-MEL cells upto 48 uM | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID380425 | Cytotoxicity against african green monkey Vero cells upto 48 uM | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID380423 | Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID1168387 | Inhibition of P-gp-mediated doxorubicin efflux in human HL60/MDR cells assessed as intracellular doxorubicin accumulation at 25 uM preincubated for 15 mins measured after 60 mins by flow cytometry | 2014 | Journal of natural products, Oct-24, Volume: 77, Issue:10 | Identification of key structural characteristics of Schisandra chinensis lignans involved in P-glycoprotein inhibition. |
| AID380428 | Cytotoxicity against human KB cells upto 48 uM | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID313800 | Antiproliferative activity against human A549 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. |
| AID721570 | Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Jan, Volume: 59 | Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity. |
| AID313796 | Antiproliferative activity against human SNU638 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. |
| AID335889 | Cytotoxicity against human Raji cells at 1000 mol ratio by trypan blue staining method | 2002 | Journal of natural products, Sep, Volume: 65, Issue:9 | Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. |
| AID1371179 | Substrate activity at CYP3A4 (unknown origin) assessed as enzyme-mediated compound turnover assessed per pmol protein at 10 uM | 2017 | Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9 | A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5. |
| AID380429 | Cytotoxicity against human BT549 cells upto 48 uM | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID313798 | Antiproliferative activity against human HCT15 cells after 72 hrs by SRB assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2 | Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. |
| AID380424 | Cytotoxicity against human HL60 cells by XTT assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| AID380430 | Cytotoxicity against human SKOV3 cells upto 48 uM | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 9 (13.04) | 18.7374 |
| 1990's | 7 (10.14) | 18.2507 |
| 2000's | 14 (20.29) | 29.6817 |
| 2010's | 30 (43.48) | 24.3611 |
| 2020's | 9 (13.04) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (8.57%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 64 (91.43%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Article | Year |
|---|---|
| Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells. Phytotherapy research : PTR, Volume: 25, Issue: 3 | 2011 |
| Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. Journal of neuroscience research, May-01, Volume: 76, Issue: 3 | 2004 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication. Journal of ethnopharmacology, Jul-15, Volume: 311 | 2023 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties. Phytomedicine : international journal of phytotherapy and phytopharmacology, Volume: 106 | 2022 |
| Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe. Journal of ethnopharmacology, May-26, Volume: 166 | 2015 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus. Drug metabolism and disposition: the biological fate of chemicals, Volume: 42, Issue: 1 | 2014 |
| Solubilization of biphenyl dimethyl dicarboxylate by cosolvency. Drug development and industrial pharmacy, Volume: 25, Issue: 11 | 1999 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |
| Article | Year |
|---|---|
| Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chemico-biological interactions, Apr-25, Volume: 231 | 2015 |
| Solubilization of biphenyl dimethyl dicarboxylate by cosolvency. Drug development and industrial pharmacy, Volume: 25, Issue: 11 | 1999 |
| Methylenedioxy group and cyclooctadiene ring as structural determinants of schisandrin in protecting against myocardial ischemia-reperfusion injury in rats. Biochemical pharmacology, Jan-01, Volume: 57, Issue: 1 | 1999 |
| [information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | |