Compounds > vialinin a
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vialinin a

Description

vialinin A: free radical scavenger from an edible mushroom in China; structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID11563133
CHEMBL ID2012938
MeSH IDM0496101

Synonyms (15)

Synonym
858134-23-3
vialinin a
CHEMBL2012938
bdbm50437693
1,1'-(4,4'',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
4,4'',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl ester benzeneacetic acid
NOJUKCRPSUMHQQ-UHFFFAOYSA-N
gtpl8669
[3,4-dihydroxy-2,5-bis(4-hydroxyphenyl)-6-(2-phenylacetyl)oxyphenyl] 2-phenylacetate
AKOS024458452
DTXSID00468621
Q27089142
terrestrin a
HY-103435
CS-0027883

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Ubiquitin carboxyl-terminal hydrolase isozyme L1Homo sapiens (human)IC5022.3000AID761505
Ubiquitin carboxyl-terminal hydrolase 5Homo sapiens (human)IC505.9000AID761509
Ubiquitin carboxyl-terminal hydrolase 5Homo sapiens (human)Ki8.2500AID761507; AID761509
Ubiquitin carboxyl-terminal hydrolase 4Homo sapiens (human)IC501.5000AID761508
Sentrin-specific protease 1Homo sapiens (human)IC501.7650AID1637028; AID1637029
Sentrin-specific protease 1Homo sapiens (human)Ki1.0000AID1637030; AID1637031

Bioassays (29)

Assay IDTitleYearJournalArticle
AID761496Inhibition of cathepsin B (unknown origin) at 6.3 uM after 20 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761508Inhibition of human USP4 using Ub-AMC as substrate after 60 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID654111Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA2012Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7
ISSN: 1464-3405		Design and synthesis of a vialinin A analog with a potent inhibitory activity of TNF-α production and its transformation into a couple of bioprobes.
AID1126481Inhibition of DNP-BSA-stimulated TNF-alpha production in rat RBL2H3 cells preincubated for 15 mins followed by DNP-BSA addition measured after 3 hrs by ELISA2014Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8
ISSN: 1464-3391		Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production.
AID761515Competitive binding affinity to human USP5 C335A mutant by SDS-PAGE analysis in presence of biotin-DMT2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID1637032Inhibition of SENP1 in human KU812 cells preincubated for 20 mins followed by addition of HA-SUMO1-VS as substrate measured after 2 hrs by immunoblot analysis2016Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
ISSN: 1464-3405		Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
AID654112Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry2012Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7
ISSN: 1464-3405		Design and synthesis of a vialinin A analog with a potent inhibitory activity of TNF-α production and its transformation into a couple of bioprobes.
AID1637027Inhibition of TNF-alpha production in mouse bone marrow-derived mast cells measured after 15 mins by ELISA2016Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
ISSN: 1464-3405		Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
AID761504Inhibition of human USP2 using Ub-AMC as substrate at 1 to 30 uM after 60 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID1637030Binding affinity to recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli2016Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
ISSN: 1464-3405		Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
AID761509Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate after 60 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761503Inhibition of human USP8 using Ub-AMC as substrate at 1 to 30 uM after 60 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID1637031Binding affinity to full-length recombinant human 6His-tagged SENP1 expressed in Escherichia coli BL21 (DE3)2016Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
ISSN: 1464-3405		Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
AID761513Competitive binding affinity to human USP5 C335A/H818A mutant by SDS-PAGE analysis in presence of biotin-DMT2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761512Inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using K48-linked tetraubiquitin as substrate assessed as substrate hydrolysis at 10 uM after 15 mins by SDS-PAGE analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761497Inhibition of calpain1/2 (unknown origin) using Suc-LLVY-AMC as substrate at 6.3 uM after 20 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761507Competitive inhibition of wild type human USP5 expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761520Inhibition of TNF-alpha production in rat RBL2H3 cells after 16 hrs by ELISA2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID1851299Inhibition of TNF-alpha production in rat RBL-2H3 cells2022Bioorganic & medicinal chemistry, 09-15, Volume: 70ISSN: 1464-3391Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora.
AID1637026Inhibition of TNF-alpha production in antigen-stimulated rat RBL2H3 cells measured after 15 mins by ELISA2016Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
ISSN: 1464-3405		Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
AID1637028Inhibition of recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli preincubated for 15 mins followed by addition of SUMO1-AMC as substrate measured after 1 hr by fluorescence analysis2016Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
ISSN: 1464-3405		Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
AID1637029Inhibition of full-length recombinant human 6His-tagged SENP1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins followed by addition of SUMO1-AMC as substrate measured after 1 hr by fluorescence analysis2016Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17
ISSN: 1464-3405		Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
AID1851302Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs2022Bioorganic & medicinal chemistry, 09-15, Volume: 70ISSN: 1464-3391Anti-inflammatory and anticancer p-terphenyl derivatives from fungi of the genus Thelephora.
AID761505Inhibition of human UCH-L1 using Ub-AMC as substrate after 60 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761506Inhibition of human UCH-L3 using Ub-AMC as substrate at 1 to 30 uM after 60 mins by fluorometric analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID1126480Inhibition of TNF-alpha production in rat RBL2H3 cells2014Bioorganic & medicinal chemistry, Apr-15, Volume: 22, Issue:8
ISSN: 1464-3391		Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production.
AID761516Competitive binding affinity to human recombinant USP5 after 1 hr by SDS-PAGE analysis in presence of biotin-DMT2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761514Competitive binding affinity to human USP5 H818A mutant by SDS-PAGE analysis in presence of biotin-DMT2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.
AID761519Binding affinity to USP5 in rat RBL2H3 cell extracts at 10 to 40 uM by SDS-PAGE analysis2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Vialinin A is a ubiquitin-specific peptidase inhibitor.

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.79)29.6817
2010's12 (63.16)24.3611
2020's4 (21.05)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
ethylmaleimide
1
maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor		201620168.0low000010
atromentin
2
dihydroxy-1,4-benzoquinones;
polyphenol		antibacterial agent;
anticoagulant;
antineoplastic agent;
apoptosis inducer;
biological pigment;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
fungal metabolite		201620225.0high000011
acetylleucyl-leucyl-norleucinal
1
aldehyde;
tripeptide		cysteine protease inhibitor2013201311.0low000010
tacrolimus
2
macrolide lactambacterial metabolite;
immunosuppressive agent		2012201311.5medium000020
degrasyn
1
2013201311.0low000010
ascorbic acid
1
ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent		202220222.0low000001
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
gamma-aminobutyric acid
1
amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule		2010201014.0low000100
lidocaine
1
benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic		2010201014.0low000100
qx-314
1
monocarboxylic acid amidelocal anaesthetic2010201014.0low000100
dichlorodicyanobenzoquinone
1
2010201014.0low000100
3,4-dimethylphenol
1
phenols2012201212.0medium000010
bicuculline
1
benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin		2010201014.0low000100
bicuculline methiodide
1
2010201014.0low000100
1,1-diphenyl-2-picrylhydrazyl
1
2005200519.0low000100
transforming growth factor beta
1
201920195.0low000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Angiogenesis, Pathologic0
1
201820186.0low000010
Cicatrix0
1
201920195.0low000010
Cicatrization0
1
201920195.0low000010
Cirrhosis, Liver0
1
202120213.0low000001
Hepatitis0
1
202120213.0low000001
Inflammation0
3
200820236.7medium000102
Innate Inflammatory Response0
3
200820236.7medium000102
Kawasaki Disease0
1
202320231.0low000001
Keloid0
1
201920195.0low000010
Leucocythaemia0
1
2012201212.0low000010
Leukemia0
1
2012201212.0low000010
Liver Cirrhosis0
1
202120213.0low000001
Mucocutaneous Lymph Node Syndrome0
1
202320231.0low000001