Page last updated: 2024-09-27

Heavy Metal Poisoning, Nervous System

Conditions associated with damage or dysfunction of the nervous system caused by exposure to heavy metals, which may cause a variety of central, peripheral, or autonomic nervous system injuries.

Synonyms(2)

Synonym
Heavy Metal Poisoning, Nervous System
Poisoning, Heavy Metals, Nervous System

Research

Studies (48)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's19 (39.58)18.1394
2010's27 (56.25)28.8240
2020's2 (4.17)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
dihydrolipoic acid0low10
thioctic acid0low20
nickel0low10
sulfuric acid0low10
dimercaprol0low10
fluorouracil0low10
histidine0low10
acetylcysteine0low10
manganese0low50
mercury0low50
platinum0low40
cadmium0low60
chromium0low10
vanadium0low10
nickel chloride0low10
copper sulfate0low10
thallium sulfate0low10
mercuric oxide0low10
glutamic acid0low10
cobalt0low20
copper bis(histidinate)0low10
biotin0low10
leuprolide0low10
curcumin0low10
ferric ferrocyanide0low10
succimer0medium21
cobaltous chloride0low10
lead0low60
trimethyltin0low10
aluminum0low40
thallium0low50
triethyltin0low10
arsenic0low30
lewisite0low10
alpha-synuclein0low10
cytochrome c-t0low10
thimerosal0low10
ascorbic acid0low10
levoleucovorin0low10
folic acid0low10

Protein Targets (445)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
acetylcholinesterase6006
dopamine D1 receptor1001
15-lipoxygenase, partial3003
pregnane X receptor4004
phosphopantetheinyl transferase4004
RAR-related orphan receptor gamma7007
USP1 protein, partial4004
NFKB1 protein, partial1001
Microtubule-associated protein tau4004
Thrombopoietin2002
AR protein9009
regulator of G-protein signaling 43003
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha6006
farnesoid X nuclear receptor4004
estrogen nuclear receptor alpha100010
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 27007
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor1001
thyroid hormone receptor beta isoform a4004
thyroid hormone receptor beta isoform 26006
heat shock protein beta-13003
flap endonuclease 15005
geminin6006
peripheral myelin protein 224004
survival motor neuron protein isoform d3003
muscarinic acetylcholine receptor M11001
Histone deacetylase 30202
Solute carrier family 22 member 60101
Histone deacetylase 40202
Guanine nucleotide-binding protein G2002
Histone deacetylase 10303
Histone deacetylase 70202
Histone deacetylase 20303
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Ataxin-25005
Histone deacetylase 80303
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
ATP-dependent phosphofructokinase4004
Chain A, Hyaluronidase, phage associated0101
GLI family zinc finger 35005
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 43003
estrogen-related nuclear receptor alpha5005
IDH14004
chromobox protein homolog 13003
nuclear factor erythroid 2-related factor 2 isoform 25005
nuclear factor erythroid 2-related factor 2 isoform 15005
lethal(3)malignant brain tumor-like protein 1 isoform I2002
lethal factor (plasmid)2002
lamin isoform A-delta105005
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Alpha-2B adrenergic receptor0011
Spike glycoprotein1001
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
apical membrane antigen 1, AMA13003
nonstructural protein 10101
green fluorescent protein, partial0101
vitamin D3 receptor isoform VDRA3003
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
Carbonic anhydrase 10205
Carbonic anhydrase 20205
Carbonic anhydrase 40203
Carbonic anhydrase0203
Carbonic anhydrase 150102
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, Ferritin light chain2002
Chain A, Cruzipain2002
Luciferase3003
interleukin 82002
Nrf22002
thioredoxin reductase4004
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 23003
ATAD5 protein, partial3003
GLS protein3003
SMAD family member 33003
TDP1 protein5005
alkaline phosphatase, intestinal0101
Smad32002
caspase 7, apoptosis-related cysteine protease1001
aldehyde dehydrogenase 1 family, member A15005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
PINK11001
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor3003
EWS/FLI fusion protein1002
pregnane X nuclear receptor4004
glucocerebrosidase3003
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
toll-like receptor 90202
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
caspase-31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
TPA: protein transporter TIM100101
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor2002
activating transcription factor 63003
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x3003
lysosomal alpha-glucosidase preproprotein2002
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
hemoglobin subunit beta2002
cellular tumor antigen p53 isoform a2002
polyunsaturated fatty acid lipoxygenase ALOX122002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
perilipin-50101
intestinal alkaline phosphatase precursor0101
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 31001
huntingtin isoform 23003
importin subunit beta-1 isoform 12002
pyruvate kinase PKM isoform a1001
DNA polymerase beta3003
mitogen-activated protein kinase 12002
nuclear factor NF-kappa-B p105 subunit isoform 12002
snurportin-12002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 12002
DNA polymerase iota isoform a (long)2002
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 13003
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 12002
cytochrome P450 3A4 isoform 13003
muscleblind-like protein 1 isoform 12002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
alkaline phosphatase, germ cell type preproprotein0101
caspase-1 isoform alpha precursor1001
hypothetical protein SA14220101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi3003
Prostaglandin E synthase0101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Acetylcholinesterase0101
Lysine-specific histone demethylase 1A0101
Voltage-dependent calcium channel gamma-2 subunit3003
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Cellular tumor antigen p536006
Amyloid-beta precursor protein1103
Integrin beta-32013
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Prostaglandin G/H synthase 10101
Cholinesterase0202
Heme oxygenase 1 0101
Integrin alpha-IIb2013
Glutathione S-transferase P0101
Polyunsaturated fatty acid 5-lipoxygenase0101
60 kDa chaperonin0101
Replicase polyprotein 1ab0213
Replicase polyprotein 1ab0314
Microtubule-associated protein tau0102
60 kDa heat shock protein, mitochondrial0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0101
Aminopeptidase N0101
Aminopeptidase N0101
Gamma-aminobutyric acid receptor subunit beta-13003
Alpha-1B adrenergic receptor0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Glutamate receptor 24217
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Amine oxidase [flavin-containing] A0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Acetylcholinesterase0202
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Heme oxygenase 20101
Alpha-1D adrenergic receptor0101
Amine oxidase [flavin-containing] B0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50101
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Prostaglandin G/H synthase 20101
17-beta-hydroxysteroid dehydrogenase type 20101
Alpha-synuclein3115
Alpha-1A adrenergic receptor0101
Histamine H2 receptor2002
Glycogen synthase kinase-3 beta0101
Nuclear receptor ROR-gamma2002
Caspase-71001
Beta-secretase 10101
10 kDa heat shock protein, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Cholinesterase0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
TAR DNA-binding protein 433003
Serine/threonine-protein kinase PAK 10101
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0011
Nuclear factor erythroid 2-related factor 20011
Thiosulfate sulfurtransferase0101
Thioredoxin reductase 1, cytoplasmic0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Thioredoxin reductase 30101
Sortase A0101
GABA theta subunit3003
CREB-binding protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 54004
Gamma-aminobutyric acid receptor subunit epsilon3003
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Lymphocyte antigen 960011
Beta lactamase (plasmid)0202
Aldo-keto reductase family 1 member B10303
G2002
cytochrome P450 2D62002
Nuclear receptor subfamily 1 group I member 20011
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Uracil Phosphoribosyltransferase0101
endonuclease IV1001
glp-1 receptor, partial4004
Skn7p0001
nonstructural protein 11001
67.9K protein2002
peripheral myelin protein 22 isoform 11001
serine/threonine-protein kinase mTOR isoform 11001
Vpr1001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40102
Solute carrier family 22 member 80001
Bile salt export pump0202
Epidermal growth factor receptor0101
Thymidylate synthase0202
Aromatase0101
Canalicular multispecific organic anion transporter 10101
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Dihydrofolate reductase0011
acid sphingomyelinase1001
alpha-galactosidase1001
Thymidylate synthase0202
Dihydrofolate reductase0011
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
ATP-citrate synthase 0101
Glutamate receptor 11214
Glutamate receptor 31214
Glutamate receptor 41214
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 0214
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0214
Glutamate receptor ionotropic, NMDA 2B0214
Glutamate receptor ionotropic, NMDA 2C0214
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0214
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0214
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0214
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
histone acetyltransferase KAT2A isoform 13003
Carbonic anhydrase 120001
Plasma kallikrein0001
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Carbonic anhydrase 60102
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90102
Carbonic anhydrase 0001
Carbonic anhydrase0102
Carbonic anhydrase0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Carbonic anhydrase 40001
Carbonic anhydrase 130102
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0102
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
Replicase polyprotein 1ab0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Caspase 6, apoptosis-related cysteine peptidase0001
Fumarate hydratase1001
hypothetical protein, conserved1001
polyprotein1001
caspase recruitment domain family, member 150101
nuclear receptor subfamily 1, group I, member 21001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
histone deacetylase 9 isoform 31001
neurotensin receptor type 10011
receptor-interacting serine/threonine-protein kinase 2 isoform 10101
serine/threonine-protein kinase PLK11001
heat shock protein HSP 90-alpha isoform 20001
heat shock protein 90, putative0001
large T antigen0101
Chain A, Beta-lactamase1001
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
hexokinase0101
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
Vif0101
Tat0101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]