"Three cases of hepatocellular carcinoma are reported in young men who had been taking androgenic-anabolic steroids." | ( Baird, PJ; Farrell, GC; Joshua, DE; Kronenberg, H; Perkins, KW; Uren, RF, 1975) |
"Primary hepatocellular carcinoma is one of the most common and lethal cancers in the world." | ( Groopman, JD; Kensler, TW; Roebuck, BD, 1992) |
"Hepatocellular carcinoma is not only the leading cause of male cancer death in Taiwan, but also one of the most common cancers in the world." | ( Chi, CW; Liu, TY; Lui, WY; P'eng, FK, 1991) |
"Hepatocellular carcinoma is the most common cause of cancer death in Thai males." | ( Auethaveekiat, V; Cheirsilpa, A; Kangsumrit, N; Leelasethakul, S; Maoleekulpriroj, S; Phanthumjida, P; Thanakaravit, P, 1989) |
"Hepatocellular carcinoma is known to have a doubling time of approximately 41 days." | ( Fishman, EK; Guse, C; Klein, JL; Leibel, SA; Leichner, PK; Order, SE; Stillwagon, GB, 1989) |
"Hepatocellular carcinoma is often an aggressive tumour and, if unresectable, carries a poor prognosis, especially in the presence of jaundice." | ( Blumgart, RL; Krige, JE; Rosen, A; Spence, RA; Temple-Camp, CR; Terblanche, J, 1987) |
"Hepatocellular carcinoma is a rapidly fatal disease in most patients." | ( Friedman, M; Nerenstone, S, 1987) |
"Advanced primary hepatocellular carcinoma is a rapidly fatal neoplasm." | ( Lim, F; Tan, YO, 1986) |
"Primary hepatocellular carcinoma is a very rare disease, especially in association with a pregnancy." | ( Brucker, C; Debus-Thiede, G; Genz, T; Maassen, V; Schweiberer, L; Weiss, M, 1994) |
"Hepatocellular carcinoma is the leading cause of male cancer death in Taiwan." | ( Chang, TJ; Chang, YF; Hsu, ML; Liu, TY; Lui, WY; P'eng, FK; Su, TS; Tsai, TF; Tsay, SH; Wu, CW, 1993) |
"Hepatocellular carcinoma is a refractory cancer for the following two reasons: the tumor characteristics, including formation of tumor thrombus in the portal vein, metastasis within the liver and multicentricity of growth; and liver function disturbance due to cirrhotic change by B- or C-type viral infection." | ( Hatsuno, T; Kokuba, Y; Kurumiya, T; Nobuta, T; Suenaga, M; Sugiura, H; Yamanaka, H, 1995) |
"Hepatocellular carcinoma is the third most common malignancy in Kenyan males occurring with a peak incidence at 40 years of age." | ( Gatei, DG; Mwangi, J, 1993) |
"Hepatocellular carcinoma is different from other solid tumors." | ( Imamura, M; Kanai, F; Kato, N; Niwa, Y; Obi, S; Okudaira, T; Omata, M; Payawal, DA; Shiina, S; Shiratori, Y; Tateishi, R; Teratani, T, 1996) |
"Unresectable hepatocellular carcinoma is related to a poor prognosis." | ( Colleoni, M; Liessi, G; Manente, P; Mastrapasqua, G; Nelli, P; Pancheri, F; Sgarbossa, G; Vicario, G, 1997) |
"The hepatocellular carcinomas are very similar to human well-differentiated hepatocellular carcinoma in histopathological features and on MR images." | ( Fujita, N; Kajiyama, M; Miyasaka, K; Nakakoshi, T; Nakayama, N; Takeichi, N, 1997) |
"Chemotherapy of hepatocellular carcinomas is hampered by the insufficient accumulation of cytostatic drugs within the tumor cells." | ( Beuers, U; Böker, C; Glasa, J; Grützner, U; Hagenbuch, B; Kramer, W; Kullak-Ublick, GA; Meier, PJ; Oswald, M; Paumgartner, G; Stieger, B; Wess, G, 1997) |
"Hepatocellular carcinoma is one of the most malignant tumors in the world." | ( Geisen, FH; Graziadei, I; Kelly, T; Konwalinka, G; Schirmer, M; Vogel, W, 1998) |
"Hepatocellular carcinoma is highly refractory to most chemotherapeutic agents." | ( Chasen, MR; Long, JE; Ruff, P; van Rensburg, CE, 1998) |
"Since the stroma of hepatocellular carcinoma is composed of sinusoid-like structures, cancer cells are readily released from the primary tumor with possible injurious consequences." | ( Funahashi, S; Ishikawa, H; Iso, Y; Kitamura, M; Maeda, T; Matsumata, T; Nozoe, T; Okamoto, M; Suehiro, T; Yo, R, 1998) |
"Hepatocellular carcinoma is one of the most common malignancies world wide." | ( Ahmad, S; Alam, A; Butt, AK; Khan, AA; Naqvi, AB; Shafqat, F; Shah, SW, 1998) |
"Inoperable hepatocellular carcinoma is an incurable malignancy with no accepted standard therapy." | ( Clendennin, N; Johnston, A; Rudy, J; Stuart, K; Tessitore, J, 1999) |
"Hepatocellular carcinoma is relatively rare in the United States, and the patterns of extrahepatic manifestations are diverse." | ( Beech, DJ; Mikesh, C; Simmons, B; UyBarreta, V, 2000) |
"Hepatocellular carcinoma is often diagnosed at a late, inoperable stage for which there are no uniformly efficacious treatment available presently." | ( Chow, PK; Findlay, M; Machin, D; Tan, CK; Wong, C, 2000) |
"Hepatocellular carcinoma is one of the most common cancers in the world." | ( Chau, GY; Chi, CW; Lin, HL; Liu, TY; Lui, WY, 2000) |
"Hepatocellular carcinoma is similar to an adenoma, but typically occurs in a cirrhotic liver and has earlier washout of contrast." | ( Macdonald, GA; Peduto, AJ, 2000) |
"Hepatocellular carcinoma is one of the most lethal malignancies and there is no effective preventive measure in this highly malignant disease to date." | ( Jung, MY; Kang, HJ; Moon, A, 2001) |
"Hepatocellular carcinoma is a common malignancy and a major complication of untreated haemochromatosis." | ( Bridle, KR; Crawford, DH; Powell, LW; Ramm, GA, 2001) |
"Hepatocellular carcinoma is one of the most common tumors worldwide." | ( Adams, MB; Christians, KK; Franco, J; Pitt, HA; Quebbeman, EJ; Quiroz, FA; Rilling, WS; Wallace, JR, 2001) |
"The hepatocellular carcinoma is one of the most widely spread malignant tumors in the world." | ( Di Giacomo, P; Felici, G; Maceratini, R; Truemper, K, 2001) |
"Hepatocellular carcinoma is a lethal disease and methods that develop effective cellular-based immunotherapy are needed." | ( Chen, Y; Dan, Q; Delgado, C; Jadus, MR; Jeffes, EW; Lowell, CA; Morgan, K; Morgan, TR; Sanchez, R; Wepsic, HT, 2001) |
"The incidence of hepatocellular carcinoma is increasing in many countries." | ( Castagnetta, LA; Cervello, M; Dantona, F; Giannitrapani, L; Montalto, G; Terranova, A, 2002) |
"Hepatocellular carcinoma is sometimes associated with p53 dysfunction and decreased p21(WAF1) expression." | ( Alric, L; Dubourdeau, M; Matsuura, Y; Miyamura, T; Pipy, B; Rousseau, D, 2002) |
"Hepatocellular carcinoma is a typical hypervascular tumor." | ( Kim, KR; Kim, KW; Moon, HE, 2002) |
"Hepatocellular carcinoma is a malignant tumor with a poor prognosis, particularly when it is unresectable." | ( Auriault, ML; Boivin, JF; Chayette, C; Cheaib, S; Deplus, R; Macaigne, G, 2002) |
"Hepatocellular carcinoma is likely to accompany liver cirrhosis in which the portal pressure increases with portasystemic shunt." | ( Fukuda, Y; Matsuyama, K; Miyake, H; Tashiro, S; Yogita, S, 2004) |
"Primary hepatocellular carcinoma is one of the most common malignancies worldwide." | ( Alexander, HR; Bartlett, DL; Beresneva, T; Feldman, ED; Helsabeck, C; Libutti, SK; Pingpank, JF; Rodriguez, M; Wu, PC, 2004) |
"Hepatocellular carcinoma is one of the most common malignant diseases worldwide." | ( Antes, G; Galandi, D, 2004) |
"Hepatocellular carcinoma is usually preceded by chronic inflammation." | ( Chang, B; Inoue, M; Nishiguchi, S; Nishikawa, M, 2005) |
"Unresectable hepatocellular carcinoma is extremely difficult to treat." | ( Carr, BI; Geschwind, JF; Goin, JE; Goin, KA; Roberts, CA; Salem, R; Soulen, MC; Thurston, KG; Van Buskirk, M, 2004) |
"Hepatocellular carcinoma is one of the most common malignancies worldwide." | ( Keeffe, EB; Nguyen, MH, 2005) |
"Hepatocellular carcinoma is the eighth most frequent cancer in the world, accounting for approximately 500,000 deaths per year." | ( McKillop, IH; Schrum, LW, 2005) |
"Hepatocellular carcinoma is highly resistant to chemotherapeutic agents, thus the need to discover effective therapeutic molecules to suppress cancer cell growth and to overcome drug resistance is urgent." | ( Alpini, G; Baroni, GS; Benedetti, A; Candelaresi, C; Macarri, G; Marucci, L; Sterpetti, P; Toksoz, D; Ugili, L, 2006) |
"Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis." | ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
"Hepatocellular carcinoma is a major cause of cancer-related deaths." | ( Avila, MA; Berasain, C; Castillo, J; Erroba, E; Lee, DC; Perugorría, MJ; Prieto, J; Santamaría, M, 2006) |
"Hepatocellular carcinoma is a very common malignancy and is chemoresistant to currently available chemotherapeutic agents." | ( Chiang, PC; Guh, JH; Hsu, JL; Li, TK; Lin, CJ; Peng, CY; Wang, SW; Yeh, TC, 2007) |
"The incidence of hepatocellular carcinoma is increasing in the United States and worldwide." | ( Almhanna, K; Kalmadi, S; Kim, R; Pelley, R, 2007) |
"Hepatocellular carcinoma is in 90% of cases associated with cirrhosis and to preserve liver function while destroying the tumor is a main issue in these patients justifying the development of local percutaneous ablative therapies." | ( Beaugrand, M; Seror, O, 2007) |
"Hepatocellular carcinoma is the most common primary tumour of the liver." | ( Achuthan, R; Horgan, KJ; Masannat, YA; McMahon, MJ; Meaney, J; Merchant, W; Munot, K, 2007) |
"Hepatocellular carcinoma is highly chemoresistant to currently available chemotherapeutic agents." | ( Chiang, PC; Guh, JH; Huang, DY; Huang, YC; Kuo, SC; Lee, KH; Pan, SL; Teng, CM; Wang, SW, 2008) |
"Hepatocellular carcinoma is a leading cause of global cancer mortality, with standard chemotherapy being minimally effective in prolonging survival." | ( Chow, PK; Goh, BC; Hor, H; Huynh, H; Kalpana, R; Lee, CK; Lee, HS; Lee, MH; Palanisamy, N; Salto-Tellez, M; Somani, A; Soo, KC; Soong, R; Tan, P; Tan, PH; Toh, HC; Wu, J; Yu, K, 2008) |
"Hepatocellular carcinoma is rare, but increasing in prevalence in the United States." | ( Bekaii-Saab, T; Bloomston, MA; Patel, T; So, BJ, 2008) |
"Hepatocellular carcinoma is one of the most common cancers in the world." | ( Chi, CW; Ko, PH; Liu, TY; Lui, WY; Uen, YH; Yin, PH, 2008) |
"The incidence of hepatocellular carcinoma is increasing in many countries." | ( Elmaghraby, TK; Hafez, EE; Ibrahim, SS; Seufi, AM, 2009) |
"Hepatocellular carcinoma is chemoresistant to many anticancer drugs." | ( Chiang, PC; Guh, JH; Hsu, JL, 2009) |
"Hepatocellular carcinoma is the leading cause of death in cirrhosis." | ( Cabrera, R; Nelson, DR, 2010) |
"Hepatocellular carcinoma is dramatically increasing in incidence that is mostly attributed to chronic hepatitis C and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and its clinical phenotype diabetes and obesity." | ( Cabrera, R; Nelson, DR, 2010) |
"Hepatocellular carcinoma is the third leading cause of cancer mortality worldwide; current chemotherapeutic interventions for this disease are largely ineffective." | ( Graña, X; Knudsen, ES; Mayhew, CN; Reed, CA; Rivadeneira, DB; Sotillo, E; Thangavel, C, 2010) |
"Hepatocellular carcinoma is the most common primary cancer of the liver in Asian countries." | ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
"The hepatocellular carcinoma, is detected sooner due to the progress of the hepatic ultrasound scan allowing an accessibility to curative treatment." | ( Elloumi, H; Gargouri, D; Ghorbel, A; Hefaiedh, R; Kharrat, J; Kilani, A; Kochlef, A; Ouakaa, A; Romani, M, 2009) |
"The incidence of hepatocellular carcinoma is rising due to alcohol drinking, hepatitis C viral infection and metabolic syndrome." | ( Li, Y; Nie, Y; Wan, YJ; Yang, H, 2010) |
"Hepatocellular carcinoma is one of the most frequent malignant tumors in general and most common liver malignancy." | ( Bojanović, A; Bosnjaković, P; Marković, M; Mrvić, M; Radić, S; Radovanović, Z; Stojanović, M, 2009) |
"The occurrence of hepatocellular carcinoma is about 3-15 % in patients with alcoholic liver disease." | ( Fehér, J; Lengyel, G, 2010) |
"Hepatocellular carcinoma is the most common type of liver cancer and is highly metastatic." | ( Ho, CT; Huang, HW; Weng, CJ; Wu, CF; Yen, GC, 2010) |
"Hepatocellular carcinoma is a malignant tumor responsible for approximately 600,000-700,000 deaths worldwide, and is becoming more prevalent not only in South-East Asia and Africa, but also in Western countries; therefore, interest in hepatocellular carcinoma has mounted in recent years in the West, where little or no interest was evident 10-20 years ago." | ( Kudo, M, 2010) |
"Hepatocellular carcinoma is also one of the human cancer types in which aberrant promoter CpG island hypermethylation is frequently found." | ( Jang, JJ; Kang, GH; Kim, BH; Shin, SH; Suh, KS, 2010) |
"Liver cirrhosis and hepatocellular carcinomas are two major causes of morbidity and mortality worldwide, and can synergistically interact to expedite the tumor progression." | ( Chang, CP; Lei, HY; Yang, MC, 2010) |
"The incidence of hepatocellular carcinoma is increasing worldwide as well as the associated risk factors, some of which include exposure to aflatoxin B1, Hepatitis B (HBV) virus and hepatitis C (HCV) virus." | ( Azeez, OI; Oyagbemi, AA; Saba, AB, 2010) |
"Hepatocellular carcinoma is now a major public health concern." | ( Boucher, E; Edeline, J; Garin, E; Pracht, M; Raoul, JL; Rolland, Y, 2011) |
"As cells of hepatocellular carcinoma are morphologically different from healthy human hepatocytes, we hypothesized that plectin deficiency and cytoskeletal disorganization underlies this pleomorphic transformation." | ( Chao, WT; Cheng, CC; Ho, CC; Hsu, YH; Lai, YS; Liu, YH; Pei, RJ, 2011) |
"Fibrolamellar hepatocellular carcinoma is a subtype of hepatocellular carcinoma occurring in non-cirrhotic liver at a younger age." | ( Erdélyi-Belle, B; Kiss, A; Korompay, A; Kovalszky, I; Lotz, G; Patonai, A; Schaff, Z; Schirmacher, P; Somorácz, A; Straub, BK, 2011) |
"The incidence of hepatocellular carcinoma is rising in many countries, including the United States." | ( Aucejo, F; Byrne, MT; Kim, R; Tan, A, 2011) |
"Hepatocellular carcinoma is mainly associated with viral hepatitis B and C." | ( Ahmad, W; Asad, S; Fouzia, K; Gull, S; Hassan, S; Ijaz, B; Kausar, H; Nazar, N; Nazar, S; Sarwar, MT; Shabbiri, K; Shahid, I, 2011) |
"Primary hepatocellular carcinoma is the third most common fatal cancer worldwide with more than 500,000 annual deaths." | ( Cuestas, ML; Mathet, VL; Sosnik, A, 2011) |
"The recurrence of hepatocellular carcinoma is still high even after surgery." | ( Hayami, S; Ozawa, S; Shigekawa, Y; Tani, M; Uchiyama, K; Ueno, M; Yamaue, H, 2011) |
"Hepatocellular carcinoma is the fifth most common malignant tumour, with a high mortality rate." | ( Iberer, F; Koestenbauer, S; Konrad, K; Leber, B; Mayrhauser, U; Portugaller, RH; Stadlbauer, V; Stiegler, P; Tscheliessnigg, K, 2011) |
"HCC (hepatocellular carcinoma) is among the most common and lethal cancers worldwide with a poor prognosis mainly due to a high recurrence rate and chemotherapy resistance." | ( Hong, DY; Huang, HS; Liu, ZM; Tseng, JT, 2011) |
"Hepatocellular carcinoma is a highly chemoresistant tumor with several genetic alterations." | ( Cervera, P; Fléjou, JF, 2011) |
"Hepatocellular carcinoma is the most common form of primary hepatic carcinoma." | ( Chan, SH; Chang, Y; Kung, HC; Lin, WJ; Lin, WY; Liu, SW; Luo, TY; Peng, CL; Tang, IC, 2011) |
"Hepatocellular carcinoma is the most common primary hepatic malignancy worldwide." | ( Das, N; Ghosh, A; Ghosh, D; Mandal, AK; Sarkar, S; Thakur Choudhury, S, 2012) |
"Hepatocellular carcinoma is a common malignancy." | ( Ahn, BC; Cho, JY; Lee, J; Lee, SW; Lee, Y; Lee, YL, 2011) |
"Hepatocellular carcinoma is becoming one of the most prominent types of cancer in the world." | ( Lee, J; Lim, KT, 2012) |
"Hepatocellular carcinoma is difficult to diagnose early, and most patients are already in the late stages of the disease when they are admitted to hospital." | ( Chen, QH; Gao, KP; Huang, T; Li, Q; Ma, JW; Qin, JM; Sa, ZQ; Shen, HB; Sheng, X; Yang, L; Yin, PH; Zhang, M, 2012) |
"Hepatocellular carcinoma is the sixth most prevalent cancer and the third most frequent cause of cancer-related death." | ( Bruix, J; Forner, A; Llovet, JM, 2012) |
"Hepatocellular carcinoma is one of the most common cancers in worldwide." | ( Dai, XY; Deng, Y; Han, YY; Lin, HJ; Mao, YQ; Peng, F; Xie, G; Xu, YZ; Yang, L; Yu, LT; Zeng, XX; Zhao, YL; Zhou, T, 2012) |
"Hepatocellular carcinoma is a common type of cancer that is usually associated with poor prognosis." | ( Binh, TV; Chang, HC; Chen, LM; Dung, TD; Huang, CY; Kuo, WW; Lee, MR; Tsai, CH; Tsai, FJ, 2012) |
"Hepatocellular carcinoma is the third most common cause of cancer-related death." | ( Francis, IR; Krishnamurthy, VN; Novelli, PM; Pandya, A; Vellody, R; Willatt, JM, 2012) |
"Hepatocellular carcinoma is one of the most common cancers and lethal diseases in the world." | ( Babu, LH; Balasubramanian, MP; Perumal, S, 2012) |
"Hepatocellular carcinoma is a primary malignant tumor of the liver that accounts for an important health problem worldwide." | ( Al Younis, I; Coenraad, MJ; Defreyne, L; Lam, MG; Lambert, B; Seinstra, BA; van den Bosch, MA; van Erkel, AR; van Erpecum, KJ; van Hoek, B; van Vlierberghe, H; Verkooijen, HM, 2012) |
"Hepatocellular carcinoma is one of the most malignant human cancers with high metastatic potential." | ( Feng, Y; Man, K; Tsao, SW; Wang, N; Zhang, Z; Zhu, M, 2012) |
"Annually, hepatocellular carcinoma is diagnosed in approximately a half-million people worldwide." | ( Grewal, P; Viswanathen, VA, 2012) |
"Hepatocellular carcinoma is one of the most common cancers worldwide." | ( Aizawa, K; Hata, K; Kato, N; Nakabayashi, K; Nakamura, K; Tanoue, A; Yamauchi, J, 2013) |
"Hepatocellular carcinoma is one of the most common cause of cancer related death." | ( Glodny, B; Henninger, B; Jaschke, W; Petersen, J, 2013) |
"Screening for hepatocellular carcinoma is reserved for those with hereditary hemochromatosis and cirrhosis." | ( Covey, CJ; Crownover, BK, 2013) |
"Hepatocellular carcinoma is one of the leading causes of death in cancer and yet no drug has proven to be a successful candidate for its treatment in advanced stages." | ( Afzal, M; Ahmad, A; Al-Abbasi, FA; Anwar, F; Kazmi, I; Narooka, AR; Singh, R, 2013) |
"Hepatocellular carcinoma is rare in Wilson's disease, especially in the absence of cirrhosis." | ( Dufour, JF; Thattil, R, 2013) |
"Hepatocellular carcinoma is generally diagnosed at advanced stages, for which only palliative treatments are possible by intra-arterial route or by targeted therapies." | ( Ardisson, V; Audrain, O; Boucher, E; Clement, B; Edeline, J; Garin, E; Lenoir, L; Lepareur, N; Pracht, M; Raoul, JL, 2013) |
"Hepatocellular carcinoma is the most common type of liver cancer." | ( Li, J; Li, Y; Liu, M; Wei, M; Zhu, W, 2013) |
"Hepatocellular carcinoma is highly chemoresistant, and ATP-binding cassette subfamily G member 2 (ABCG2) is thought to play a critical role in this drug resistance." | ( Chen, T; Ge, C; Hou, H; Li, H; Li, J; Lu, P; Sun, H; Tian, H; Yao, M; Zhang, L; Zhao, F, 2013) |
"Hepatocellular carcinoma is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide." | ( Akalın, G; Incesu, Z; Işcan, A; Kutlu, HM; Önder, NI; Özdemir, F; Şen, M, 2014) |
"Hepatocellular carcinoma is the fifth most common cancer worldwide." | ( Franke, A; Jakobsen, JC; Mössner, J; Schoppmeyer, K; Weis, S, 2013) |
"Hepatocellular carcinoma is the fifth most common cancer worldwide and the third most common cause of cancer mortality." | ( Abdel-Rahman, O; Fouad, M, 2014) |
"Hepatocellular carcinoma is a major cause of death among patients with cirrhosis." | ( Behnke, M; Bornstein, K; Cotterell, A; Fisher, RA; Fulcher, A; Lee, DD; Posner, MP; Ramanathan, R; Sharma, A; Stravitz, RT; Sydnor, M, 2014) |
"Hepatocellular carcinoma is the fifth most common cancer worldwide and shows a complex clinical course, poor response to pharmacological treatment, and a severe prognosis." | ( Capone, F; Castello, G; Colonna, G; Costantini, S; Guerriero, E; Pagliuca, J; Sorice, A; Storti, G, 2014) |
"Hepatocellular carcinoma is difficult to treat, primarily because the underlying molecular mechanisms driving clinical outcome are still poorly understood." | ( Cao, Y; Fabregat, I; Giannelli, G; Malfettone, A; Rani, B; Tomuleasa, C, 2014) |
"Hepatocellular carcinoma is a common malignancy with a poor prognosis." | ( Abou-Alfa, GK; Harding, JJ, 2014) |
"Hepatocellular carcinoma is the third most common cause of cancer death." | ( Bao, X; Chu, QC; Gao, M; Guan, X; Jiang, N; Liu, KX; Tian, Y; Xu, H; Zhang, CH, 2015) |
"Hepatocellular carcinomas are highly vascular tumors, showing progressive hypervascularity by the process of neoangiogenesis." | ( Bhargava, P; Bhosale, P; Choi, JI; Imagawa, DK; Lall, C; Seery, TE; Tirkes, T, 2014) |
"Hepatocellular carcinoma is the fifth most common solid cancer worldwide." | ( Chen, IT; Chen, KF; Hsu, CY; Li, YS; Liu, CY; Shiau, CW; Su, JC; Tai, WT; Tseng, PH; Wu, SH, 2014) |
"Hepatocellular carcinoma is one of the most frequent tumor types worldwide and oxidative stress represents a major risk factor in pathogenesis of liver diseases leading to HCC." | ( Calderon, PB; Dejeans, N; Glorieux, C; Najimi, M; Renard, P; Rommelaere, G; Sid, B; Valenzuela, M; Verrax, J, 2014) |
"Hepatocellular carcinoma is a difficult-to-treat cancer and, after numerous phase III trials assessing kinase inhibitors have failed to meet their end points, sorafenib is the only accepted treatment for advanced stages of the disease." | ( Llovet, JM, 2014) |
"Hepatocellular carcinoma is the third cause of cancer related death for which new treatment strategies are needed." | ( Chemin, I; Favaudon, V; Guillot, C; Hall, J; Herceg, Z; Merle, P; Sagne, C; Sauvaigo, S, 2014) |
"Hepatocellular carcinoma is related to various etiologies including hepatitis B, hepatitis C, high alcohol intake, aflatoxin B1 and metabolic syndrome." | ( Nault, JC, 2014) |
"Hepatocellular carcinoma is one of the most common malignancies worldwide and drug resistance is a major cause of treatment failure." | ( Qian, J; Wang, C; Wang, D; Ye, Y; Zhang, N; Zhu, Y, 2014) |
"Hepatocellular carcinoma is one of the most common cancers worldwide, and a leading cause of cancer-related death." | ( Chen, KF; Hung, MH; Shiau, CW; Tai, WT, 2014) |
"Hepatocellular carcinoma is becoming more common, and numerous treatment algorithms are available for this complex disease." | ( Narang-Master, J; Rizzolo, D, 2015) |
"Hepatocellular carcinoma is one of the most aggressive cancers with poor prognosis worldwide." | ( Feng, LY; Meng, ZQ; Wang, SY, 2015) |
"Hepatocellular carcinoma is one of the most common malignancies worldwide and evidence suggests that Ras signaling regulates various hallmarks of cancer via regulating several effector pathways such as ERK and PI3K." | ( Gopal, A; Halagowder, D; Iyer, SC, 2015) |
"Most patients with hepatocellular carcinoma are still diagnosed at intermediate or advanced disease stages, where curative approaches are often not feasible." | ( Llovet, JM; Torrecilla, S, 2015) |
"Hepatocellular carcinoma is the third most common cause of cancer-related deaths worldwide." | ( Di Pietro, A; Guterres, FA; Martinez, GR; Rocha, ME; Scoparo, CT; Valdameri, G; Winnischofer, SM; Worfel, PR, 2015) |
"Hepatocellular carcinoma is one of the most common cancers in adults and develops due to activation of oncogenes and inactivation of tumor suppressor genes." | ( Choi, HG; Choi, JY; Gupta, B; Hiep, TT; Kim, JO; Pathak, S; Poudel, BK; Thapa, RK; Yong, CS, 2015) |
"Hepatocellular carcinoma is the fifth most common cancer worldwide, with poor prognosis and resistance to chemotherapy." | ( Behmanesh, M; Najafi, F; Sadeghizadeh, M; Zamani, M, 2015) |
"Hepatocellular carcinoma is the first liver tumor worldwide." | ( Belhadj, N; Ben Nejma, H; Ennaifer, R; Gharbi, L; Hefaiedh, R; Khalfallah, MT; Romdhane, H; Sabbeh, M, 2015) |
"Hepatocellular carcinoma is a challenging malignancy of global importance." | ( Cabibbo, G; Cammà, C; Maida, M; Petta, S, 2015) |
"Hepatocellular carcinoma is one of the most common and deadly forms of human malignancies." | ( Liu, L; Wang, D; Wang, J; Wang, S, 2016) |
"Hepatocellular carcinoma is increasingly important in the United States as the incidence rate rose over the last 30 years." | ( Drinkwater, NR; Hanes, MA; Herbert, DC; Herzig, MC; Hildreth, K; McMahan, CA; Reddick, RL; Reddick, T; Street, K; Walter, CA; Zavadil, JA, 2016) |
"Hepatocellular carcinoma is a widely prevalent cancer, and hence, the development of radiopharmaceuticals for its management is an important issue." | ( El-Kawy, OA; Talaat, HM, 2016) |
"Hepatocellular carcinoma is the most common primary hepatic malignant tumor." | ( Kim, JW; Lee, CH; Park, CM; Park, YS; Shin, S, 2016) |
"Hepatocellular carcinoma is the second deadliest cancer with limited treatment options." | ( Calis, I; Cetin-Atalay, R; Durmaz, I; Ersahin, T; Guven, EB; Ozturk, M, 2016) |
"Hepatocellular carcinoma is the most common liver neoplasm and the fifth most common cancer worldwide." | ( Abdel-Rahman, OM; Elsayed, Z, 2016) |
"Hepatocellular carcinomas are frequently nonresponsive to systemically delivered drugs." | ( Exner, AA; Gangolli, M; Hernandez, C; Solorio, L; Wu, H, 2016) |
"Hepatocellular carcinoma is one of the most common lethal diseases worldwide and there is no effective treatment till date." | ( Ali, N; Ali, R; Hasan, SK; Nafees, S; Rashid, S; Shahid, A; Siddiqi, A; Sultana, S, 2016) |
"Hepatocellular carcinoma is one of the leading causes of malignancy-related death in China." | ( Jin, FX; Liu, JT; Liu, LJ; Lv, Q; Rong, N; Wang, CM; Xu, XL, 2016) |
"Hepatocellular carcinoma is the most common primary hepatic tumor in dogs and is amenable to surgical resection in many cases." | ( Cannon, CM; Conklin, GA; Constant, C; Craig, LE; Hecht, S; Lux, CN, 2016) |
"Hepatocellular carcinoma is among the leading causes of cancer-related deaths worldwide, and the development of new treatment regimens is urgently needed to improve therapeutic approach." | ( Cao, J; Chen, Y; Chen, ZB; Dai, XY; Han, YX; He, QJ; Luo, PH; Ma, J; Peng, Y; Sun, YH; Wang, DD; Yan, FJ; Yang, B; Ying, MD; Zhang, H; Zhu, H, 2016) |
"Hepatocellular carcinoma is the most prevalent type of tumor among primary tumors affecting the liver." | ( Basso, BS; da Silva, EF; de Oliveira, JR; Haute, GV; Krause, GC; Lima, KG; Mesquita, FC; Nunes, FB; Pedrazza, L; Velasquez, AC, 2016) |
"Hepatocellular carcinoma is a lethal cancer with high recurrence ratio and lacks effective therapeutics." | ( Chen, K; Chen, L; Huang, Z; Wang, Z; Zhang, H; Zhang, X; Zhou, J, 2016) |
"Hepatocellular carcinoma is the most common primary liver malignancy, commonly a sequelae of hepatitis C infection, but can complicate cirrhosis of any cause." | ( Kasmari, AJ; Leslie, D; Liu, G; McGarrity, T; Riley, T; Welch, A, 2017) |
"Hepatocellular carcinoma is the most common liver neoplasm, the sixth most common cancer worldwide, and the third most common cause of cancer mortality." | ( Abdel-Rahman, O; Elsayed, Z, 2017) |
"Hepatocellular carcinoma is the major form of primary liver cancer, which is the second and sixth leading cause of cancer-related death in men and women, respectively." | ( Ahsani, Z; Karimkhanloo, H; Mohammadi-Yeganeh, S; Paryan, M, 2017) |
"Hepatocellular carcinoma is one of the conditions in which HSR activation was shown to have the highest clinical significance." | ( Di Ianni, L; Di Stefano, G; Govoni, M; Manerba, M; Recanatini, M; Roberti, M, 2017) |
"Hepatocellular carcinoma is highly refractory cancer which is resistant to conventional chemotherapy and radiotherapy, carrying a dismal prognosis." | ( Badrinath, N; Heo, J; Woo, HY; Yoo, SY, 2017) |
"Hepatocellular carcinoma is one of the fastest growing causes of cancer-related mortality worldwide." | ( Ross, P; Srikandarajah, K; Thillai, K, 2017) |
"Prognosis of hepatocellular carcinoma is measured in months, with median overall survival reaching 10." | ( Abou-Alfa, GK; Dika, IE, 2017) |
"Hepatocellular carcinoma is known to exhibit highly heterogeneous molecular aberrations across the tumors, including somatic genetic and epigenetic alterations." | ( Bian, CB; Fuchs, BC; Higashi, T; Hirschfield, H; Hoshida, Y; Nair, VD; Nakagawa, S; Zeleke, TZ, 2018) |
"The hepatocellular carcinoma is one of the most common malignant tumour with high level of mortality rate due to its rapid progression and high resistance to conventional chemotherapies." | ( Basoli, V; Carta, P; Cruciani, S; Delogu, G; Dettori, MA; Fabbri, D; Maioli, M; Serra, PA, 2018) |
"Hepatocellular carcinoma is the main factor affecting their overall mortality, and is the only factor affecting liver-related mortality in this setting." | ( Berg, T; Buti, M; Calleja, JL; Chi, H; Colombo, M; Dalekos, G; de la Revilla, J; Esteban, R; Galanis, K; Gatselis, N; Goulis, J; Hansen, BE; Idilman, R; Janssen, HLA; Keskın, O; Kourikou, A; Lampertico, P; Lehretz, M; Loglio, A; Manolakopoulos, S; Papatheodoridis, GV; Savvidou, S; Siakavellas, S; Sypsa, V; van Boemmel, F; Vlachogiannakos, I; Yurdaydin, C, 2018) |
"Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis." | ( Fathy, M; Nikaido, T, 2018) |
"Hepatocellular carcinoma is the most common primary malignancy of the liver, with increasing incidence worldwide." | ( Dank, M; Padányi, P, 2018) |
"Hepatocellular carcinoma is the most frequent primary liver cancer worldwide." | ( Lu, J; Sun, X; Wang, R; Wang, X; Wen, Y; Xu, J; Yang, L; Zhang, M, 2018) |
"Pedunculated hepatocellular carcinoma is an unusual form of hepatocellular carcinoma protruding from the liver with or without a pedicle." | ( Dong, A; Wang, Y; Zhong, X, 2018) |
"Hepatocellular carcinoma is emerging as one of the most common forms of cancer resulting in thousands of death worldwide." | ( Afzal, M; Al-Abbasi, FA; Anwar, F; Bhardwaj, DP; Kazmi, I; Khan, R; Saleem, S, 2019) |
"Hepatocellular carcinoma is highly resistant to chemotherapy." | ( George, J; Patel, T; Yan, IK, 2018) |
"Hepatocellular carcinoma is a common primary malignancy of hepatocytes that has caused many fatalities globally." | ( Omwandho, C; Wasonga, C, 2018) |
"Hepatocellular carcinoma is one of most common solid cancers worldwide." | ( Chen, Y; Jiang, R; Lu, S; Shao, Q; Sun, J; Xu, G; Yao, Y; Zhang, Y; Zhou, C, 2018) |
"Hepatocellular carcinoma is associated with several chronic liver diseases, especially chronic hepatitis B virus, hepatitis C virus, and alcoholism." | ( Carr, BI; Caturelli, E; Farinati, F; Giannelli, G; Giannini, EG; Guerra, V; Marco, MD; Masotto, A; Rapaccini, GL; Sacco, R; Trevisani, F; Virdone, R; Zoli, M, 2018) |
"HCC (Hepatocellular carcinoma) is a most common type of malignant neoplasms in the digestive system." | ( Duan, X; He, J; He, K; Huang, R; Li, B; Xiang, G; Yang, X; Zhang, J, 2018) |
"Hepatitis and hepatocellular carcinoma are serious human diseases." | ( Fang, NY; Shen, JJ; Wan, LF; Wang, YH; Xue, BY; Yuan, X; Zhao, W, 2019) |
"Hepatocellular carcinoma is the most frequent kind of primary liver cancer and occurs mostly in patients with chronic liver disease and cirrhosis." | ( Cui, G; Shang, X; Wang, N; Yang, G; Zhao, H; Zhao, L, 2019) |
"Hepatocellular carcinoma is a serious health problem worldwide, especially in Asian countries, such as China." | ( Li, N; Liu, Z; Wu, M; Zhang, A, 2019) |
"Hepatocellular carcinoma is the most frequent primary malignant tumor of the liver and the third most common cause of all cancer-related mortalities." | ( Öcal, S; Özer Etik, D; Selçuk, H; Suna, N, 2019) |
"Hepatocellular carcinoma is the fourth leading cause of cancer death." | ( Boulin, M; Gehin, S; Guiu, B; Pistre, P, 2020) |
"Hepatocellular carcinoma is the most frequent and deadliest cancers worldwide." | ( Devaraj, E; Solai Prakash, AK, 2019) |
"Hepatocellular carcinoma is the most common liver malignancy and the third leading cause of cancer death worldwide." | ( Castronuovo, CC; Cuestas, ML; Davio, C; Gentile, EA; Gómez, N; Mathet, VL; Oubiña, JR, 2019) |
"Hepatocellular carcinoma is one of the most fatal cancers worldwide." | ( Sun, H; Sun, Y, 2020) |
"Hepatocellular carcinoma is the most common primary liver cancer and the fourth leading cause of cancer death worldwide." | ( Argentiero, A; Brunetti, O; Delcuratolo, S; Gnoni, A; Licchetta, A; Longo, V; Memeo, R; Solimando, AG, 2019) |
"Hepatocellular carcinoma is the most common liver neoplasm and the sixth most common cancer worldwide." | ( Abdel-Rahman, O; Elsayed, Z, 2020) |
"Hepatocellular carcinoma is cancer with many new cases and the highest mortality rate." | ( Du, G; Li, H; Pang, L; Yang, L; Zhan, Y, 2020) |
"Hepatocellular carcinoma is one of few cancer types that continues to grow in incidence and mortality worldwide." | ( Dewdney, B; George, J; Hebbard, L; Qiao, L; Roberts, A, 2020) |
"Hepatocellular carcinoma is a major cause of cancer mortality worldwide." | ( Eissa, LA; El-Mesery, ME; Habeeb, MR; Yousef, EH, 2020) |
"Hepatocellular carcinoma is known to be a common predominant cancer in adults, especially in eastern countries." | ( Guo, W; Huo, J; Liu, Q; Wei, F; Yu, L, 2020) |
"Hepatocellular carcinoma is one of the most prevalent malignant diseases and causes a third of cancer-related death." | ( Murata, T; Ramos, JW; Yamaguchi, M, 2020) |
"Hepatocellular carcinoma is the second leading cause of cancer-related mortality worldwide." | ( Devaraj, E; Thakur, RS, 2020) |
"Liver cancer or hepatocellular carcinoma is considered to be the third leading cause of death among all other cancers." | ( Bolla, SR; Chen, Y; Gong, G; Li, Y; Veeraraghavan, VP; Xu, C; Zhang, C; Zhang, M, 2020) |
"Hepatocellular carcinoma is a heterogenous group of disease with a spectrum of disease presentations that developed on the setting of liver cirrhosis, although the achievements made in the imaging techniques have enabled the early diagnosis in nearly 60% of the cases in cirrhotic patients." | ( Aydin, C; Yilmaz, S, 2020) |
"Hepatocellular carcinoma is rapidly becoming one of the leading causes of cancer-related deaths, largely due to the increasing incidence of non-alcoholic fatty liver disease." | ( Alanazy, M; Dewdney, B; George, J; Gillman, R; Hebbard, L; Qiao, L; Roberts, A; Walker, S; Wankell, M, 2020) |
"Hepatocellular carcinoma is one of the most common malignant tumors in the digestive tract, so it is necessary to find effective preventive and therapeutic measures." | ( Liu, YW; Niu, JQ; Xu, HQ; Zhou, Q, 2020) |
"HCC (hepatocellular carcinoma) is a major health threat for the Chinese population and has poor prognosis because of strong resistance to chemotherapy in patients." | ( Luo, J; Si, Z; Tan, X; Tong, JS; Yao, H; Zhang, Z, 2020) |
"Hepatocellular carcinoma is a relevant cause of mortality worldwide, mainly among patients who have a prior liver disease." | ( da Silva Yamashiro, F; Katsuda, L; Kawanami, GH; Pelafsky, L; Qi, X; Rocha, TB; Romeiro, FG, 2021) |
"Hepatocellular carcinoma is diagnosed in more than half of all cases at unresectable stage when no potentially curative treatments are feasible." | ( Battaglia, S; Busacca, A; Cabibbo, G; Cammà, C; Cannella, R; Celsa, C; Giuffrida, P; Grova, M; Rizzo, GEM; Spatola, F; Stornello, C, 2021) |
"Hepatocellular carcinoma is one of the most common malignancies and leading cancer-associated deaths worldwide." | ( He, X; Huang, Q; Li, J; Li, X; Tang, S; Zeng, T; Zhong, M, 2021) |
"Hepatocellular carcinoma is the fourth leading cause of cancer deaths in the world." | ( Abd El Fattah El Sayed, H; Atta, S; Elzayat, E; Hussein, T; Kamel, M; Mahmood, D; Mansour, W; Saber, S, 2022) |
"Hepatocellular carcinoma is the third-leading cause of cancer-related death worldwide." | ( Bennett, L; Breder, V; Fartoux, L; Hudgens, S; Kudo, M; López, C; Meier, G; Mody, K; Ohtsuka, T; Qin, S; Simon, K; Su, Y; Sung, M; Tamai, T; Vogel, A; Yamashita, T; Yoon, JH, 2021) |
"Although hepatocellular carcinoma is considered a highly lethal malignancy, recent therapeutic advances have been achieved during the last 10 years." | ( da Fonseca, LG; Piñero, F, 2021) |
"BACKGROUND Hepatocellular carcinoma is the third leading cause of cancer-associated mortality." | ( Ding, J; Fan, B; Huang, C; Li, J; Li, Y; Qi, C; Zhang, J; Zhang, Y, 2021) |
"Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality." | ( Balaraman, G; Krishnan, P; Mari, A; Salam, S; Sirajduddin, I; Subramaniam, N; Sundaram, J; Thiruvengadam, D, 2021) |
"Hepatocellular carcinoma is one of the most common malignant tumors in China and is also a major cause of cancer deaths worldwide." | ( Liu, X; Yi, Y, 2021) |
"Lay abstract Hepatocellular carcinoma is often found at intermediate or advanced stages and thus often has a poor outcome." | ( Liu, X; Yi, Y, 2021) |
"Hepatocellular carcinoma is among the leading causes of cancer-related deaths worldwide and needs efficient and feasible approach of treatment." | ( Chaudhary, A; Haque, R; Khan, A; Mishra, AK; Sarkar, A; Singh, P; Srivastava, A, 2022) |
"Hepatocellular carcinoma is insensitive to many chemotherapeutic agents." | ( Du, YZ; Lu, YF; Wang, XJ; Yang, XY; Yu, JN; Yu, RS; Zhou, JP; Zhou, QM, 2021) |
"Hepatocellular carcinoma is a malignancy with poor clinical prognosis." | ( Cai, X; He, T; Huang, D; Liu, Y; Lu, D; Luo, L; Tang, W; Wang, X; Wang, Y; Xue, J; Yang, F, 2022) |
"Hepatocellular carcinoma is one of the major causes of cancer-related deaths worldwide and is associated with several inflammatory mediators, since 90% of HCCs occur based on chronic hepatitis B or C, alcoholism or increasingly metabolic syndrome-associated inflammation." | ( Alotaibi, H; Carr, BI; Sengez, B, 2023) |
"Hepatocellular carcinoma is the most common primary liver cancer and the fifth most frequently diagnosed cancer worldwide." | ( Cortez, A; Du, Y; Josefsson, A; Krimins, R; Liapi, E; Nedrow, JR; Zarisfi, M, 2022) |
"Hepatocellular carcinoma is the second most cause of death among the various cancers worldwide." | ( Amudha, P; Jayalakshmi, M; Poojitha, BN; Vidya, R, 2023) |
"Hepatocellular carcinoma is one of the most common primary hepatic malignancy." | ( Chen, GY; Geng, JJ; Gu, YC; Hai, Y; Hou, XM; Li, PJ; Liu, M; Ma, WP; Shao, CL; Wang, CF; Wei, MY, 2022) |
"Fibrolamellar hepatocellular carcinoma is a rare type of hepatocellular carcinoma with unclear etiology." | ( Ahmed, A; Ata, F; Gaber, M; Hashim, A; Mahfouz, A; Musa, S; Petkar, M; Schirmacher, P, 2022) |
"Sarcomatoid hepatocellular carcinoma is a rare subtype of hepatocellular carcinoma." | ( Jiao, J; Yang, T; Zhang, Y; Zou, MH; Zou, Q, 2022) |
"Hepatocellular carcinoma is one of the most common malignant tumors in the world." | ( Liu, W; Xiong, S, 2022) |
"Hepatocellular carcinoma is a leading public health concern in sub-Saharan Africa, and it is most prevalent in young adults (median 45 years [IQR 35-57])." | ( Abdo, A; Afihene, M; Cunha, L; Desalegn, H; Dusheiko, G; Jonas, E; Kassianides, C; Katsidzira, L; Kramvis, A; Lam, P; Lesi, OA; Micah, EA; Musabeyezu, E; Ndow, G; Nnabuchi, CV; Ocama, P; Okeke, E; Rwegasha, J; Shewaye, AB; Some, FF; Sonderup, MW; Spearman, CW; Tzeuton, C, 2022) |
"Hepatocellular carcinoma is a common cancer type, especially among men." | ( Baysar, A; Çiğremiş, Y; Tosun, E; Türköz, Y; Üremiş, MM; Üremiş, N, 2022) |
"Hepatocellular carcinoma is the most common primary malignancy of the liver." | ( Cao, Z; Deng, X; Ding, W; Dong, F; Han, M; Hao, P; Jin, L; Li, J; Liu, D; Liu, G; Liu, H; Luo, W; Mu, J; Pan, L; Pang, Y; Wang, T; Wei, Y; Zeng, G; Zhang, H; Zhang, Y; Zhen, C, 2022) |
"Hepatocellular carcinoma is the most prevalent form of primary liver cancer with a multifactorial aetiology comprising genetic, environmental, and behavioural factors." | ( Ajoolabady, A; Kroemer, G; Ren, J; Tang, D, 2023) |
"Hepatocellular carcinoma is one of the deadliest neoplasms around the world, and a major proportion of patients are diagnosed in an advanced state not amenable to curative treatment." | ( Lu, Z; Wang, H; Yang, X; Zhang, G; Zhao, H, 2023) |
"Hepatocellular carcinoma is one of the deadliest neoplasms around the world, and a major proportion of patients are diagnosed in an advanced state not amenable to curative treatment." | ( Lu, Z; Wang, H; Yang, X; Zhang, G; Zhao, H, 2023) |
"Hepatocellular carcinoma is one of the deadliest neoplasms around the world, and a major proportion of patients are diagnosed in an advanced state not amenable to curative treatment." | ( Lu, Z; Wang, H; Yang, X; Zhang, G; Zhao, H, 2023) |
"Hepatocellular carcinoma is one of the most common types of primary liver cancer in adults and also it is the third leading cause of cancer-related deaths worldwide." | ( Cataklı, D; Dogan, HK; Erzurumlu, Y, 2023) |
"Hepatocellular carcinoma is the third most deadly malignant tumor in the world with a poor prognosis." | ( Liu, R; Liu, Y; Wei, J; Wu, L; Zhang, F, 2023) |
"Hepatocellular carcinoma is a primary liver cancer and 6th most common cancer globally." | ( Bibi, K; Fatima, T; Haider, G; Ilyas, A; Sohrab, S; Zarina, S, 2023) |
"Hepatocellular carcinoma is characterized by a high infiltration of myeloid-derived suppressor cells (MDSC), which are key drivers of maintaining the immunosuppressive tumor microenvironment." | ( Chen, J; Chen, S; Deng, X; Huang, X; Li, X; Luo, X; Wang, C; Wu, H; Zhong, J, 2023) |
"Hepatocellular carcinoma is a major contributor to cancer-related deaths in China and ranks among the most prevalent malignant tumors." | ( Hu, Y; Huang, L; Xu, Z, 2023) |
"Hepatocellular carcinoma is a common malignancy with a low survival rate, despite the available treatment options." | ( Bakar-Ates, F; Ozkan, E, 2023) |