An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
| Member | Definition | Class |
|---|
| anabasine | A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3. | anabasine |
| carbachol | | carbachol |
| clothianidin | An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. | (E)-clothianidin; clothianidin |
| clothianidin | An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. | (E)-clothianidin; clothianidin |
| cytisine | An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking. | cytisine |
| decamethonium | A quaternary ammonium ion that is a depolarising muscle relaxant whose structure comprises a decane-1,10-diamine core in which each amino group carries three methyl substituents. | decamethonium |
| dimethylphenylpiperazinium iodide | | 1,1-dimethyl-4-phenylpiperazinium iodide |
| flupyradifurone | A tertiary amino compound that is ammonia in which the nitrogens have been replaced by (6-chloropyridin-3-yl)methyl, 2,2-difluoroethyl, and 5-oxo-2,5-dihydrofuran-3-yl groups, respectively. A nicotinic acetylcholine receptor (AChR) agonist, it is used as an insecticide to control sucking pests in a variety of crops. | flupyradifurone |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| lobeline | An optically active piperidine alkaloid having a 2-oxo-2-phenylethyl substituent at the 2-position and a 2-hydroxy-2-phenylethyl group at the 6-position. | (-)-lobeline |
| nicotine | A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. | (S)-nicotine |
| tilorone | A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug. | tilorone |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 10.8195 | 4 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 27.9478 | 1 | 3 |
| AR protein | Homo sapiens (human) | Potency | 14.7866 | 7 | 9 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 1.7089 | 1 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.4921 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0006 | 2 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 18.2834 | 3 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 18.2563 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 3.9152 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 100.0000 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 44.6684 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 79.4328 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.7164 | 2 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 4.7724 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.3450 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.9557 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.1458 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 29.8911 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 0.0178 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.0177 | 9 | 14 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 25.1566 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 17.2802 | 4 | 4 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 16.2547 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 37.2212 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 25.0163 | 3 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 48.7810 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 4.7724 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 13.0022 | 1 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 44.3741 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.0035 | 3 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 26.6032 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 35.4813 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 55.1965 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 4.7724 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 0.1949 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 4.7724 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 15.6730 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 9.0135 | 2 | 2 |
| interleukin 8 | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.8791 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 38.9018 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 27.3488 | 2 | 4 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 12.3807 | 2 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.6310 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 54.2192 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 12.6938 | 3 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 8.0875 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 30.1313 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 37.5751 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.0610 | 1 | 2 |
| polyprotein | Zika virus | Potency | 10.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 20.7585 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.5693 | 2 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 13.3260 | 1 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 25.3050 | 3 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 3.1623 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 16.7715 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.0698 | 2 | 14 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 16.2825 | 1 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 27.1496 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 16.3127 | 5 | 6 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 3.3786 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.0610 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.0610 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 99.1498 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 13.8324 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 15.6569 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 26.6032 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 7.4000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | IC50 | 107.3333 | 2 | 3 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | Ki | 2.7011 | 4 | 5 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | Ki | 5.5067 | 2 | 3 |
| Acetylcholine receptor subunit alpha-like 1 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit alpha-like 2 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | Ki | 2.7011 | 4 | 5 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | Ki | 5.5067 | 2 | 3 |
| Acetylcholine receptor subunit beta-like 1 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | IC50 | 1.0023 | 2 | 4 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | Ki | 0.9017 | 2 | 3 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | Ki | 2.7011 | 4 | 5 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | Ki | 5.5067 | 2 | 3 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | Ki | 2.7011 | 4 | 5 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | Ki | 5.5067 | 2 | 3 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Ki | 0.3390 | 7 | 10 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| Acetylcholinesterase | Torpedo marmorata (marbled electric ray) | IC50 | 1.0630 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 3,000.2300 | 2 | 2 |
| Acetylcholinesterase | Mus musculus (house mouse) | Ki | 1.9800 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 307.2000 | 3 | 5 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | IC50 | 30.2500 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4,100.0000 | 1 | 1 |
| Cytochrome P450 2A13 | Homo sapiens (human) | Ki | 72.0000 | 1 | 1 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 159.9560 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 210.6763 | 2 | 3 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 46.2667 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 26.3000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.4400 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3A isoform a | Homo sapiens (human) | IC50 | 1.9300 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 2.6200 | 1 | 1 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 38.0500 | 1 | 2 |
| Forkhead box protein A2-A | Xenopus laevis (African clawed frog) | Ki | 0.0019 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | IC50 | 0.8200 | 1 | 1 |
| Liver carboxylesterase B-1 | Rattus norvegicus (Norway rat) | IC50 | 7.0225 | 1 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.2260 | 2 | 2 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.4400 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | IC50 | 150.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor | Cavia porcellus (domestic guinea pig) | Ki | 67.5911 | 4 | 4 |
| Muscarinic acetylcholine receptor DM1 | Drosophila melanogaster (fruit fly) | Ki | 100.0000 | 2 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 41.1368 | 4 | 4 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 60.5354 | 8 | 15 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 135.4539 | 18 | 18 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | Ki | 4.7822 | 5 | 5 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 10.8368 | 12 | 16 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 17.6728 | 7 | 7 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 40.0259 | 9 | 12 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 1.2977 | 15 | 15 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 25.4284 | 10 | 13 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 4.9900 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 168.5437 | 9 | 11 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 30.1886 | 10 | 10 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 13.8161 | 28 | 31 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 2.0626 | 4 | 4 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 47.4210 | 8 | 10 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 6.8330 | 13 | 13 |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | Ki | 2.1100 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 13.3053 | 10 | 13 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 25.2000 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 52.6645 | 7 | 9 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 37.6948 | 13 | 13 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 16.8249 | 7 | 10 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | Ki | 0.1173 | 3 | 10 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-2 | Homo sapiens (human) | Ki | 0.0595 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0671 | 29 | 39 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 2.8766 | 5 | 6 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 5.0025 | 4 | 4 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | Ki | 0.4775 | 23 | 27 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | Ki | 0.0841 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.3112 | 39 | 57 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | IC50 | 2.6000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 2.2998 | 12 | 14 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 0.8703 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0207 | 4 | 4 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | Ki | 0.4860 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.2935 | 32 | 38 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.1605 | 86 | 116 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.1173 | 3 | 10 |
| Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 0.0848 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.1173 | 3 | 10 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | IC50 | 99.5333 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | IC50 | 0.0087 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | Ki | 5.5252 | 18 | 24 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | Ki | 0.2406 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 2.7616 | 22 | 33 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | IC50 | 0.0041 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | Ki | 0.1173 | 3 | 10 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | IC50 | 2.1522 | 13 | 15 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0207 | 4 | 4 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.2900 | 32 | 38 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | Ki | 0.0024 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.1373 | 90 | 119 |
| Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (human) | IC50 | 0.0848 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.1173 | 3 | 10 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | IC50 | 1.0433 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | IC50 | 5.0025 | 4 | 4 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | Ki | 0.4477 | 25 | 29 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | Ki | 0.0572 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Ki | 0.2708 | 57 | 79 |
| Nicotinic acetyl choline receptor alpha-subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 3 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 4 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 5 subunit | Musca domestica (house fly) | Ki | 0.0046 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha3, isoform B | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha4, isoform D | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha5, isoform B | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha6, isoform E | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor beta 3 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor Dalpha7 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha5 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha7-1 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha7-2 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 245.0807 | 5 | 6 |
| Putative nicotinic acetylcholine receptor subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 4.0900 | 1 | 1 |
| Soluble acetylcholine receptor | Aplysia californica (California sea hare) | Ki | 0.6323 | 3 | 5 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 64.3000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 50.5000 | 1 | 1 |
| Synaptic vesicular amine transporter | Homo sapiens (human) | IC50 | 4.2000 | 1 | 1 |
| Synaptic vesicular amine transporter | Homo sapiens (human) | Ki | 4.5967 | 3 | 3 |
| Synaptic vesicular amine transporter | Rattus norvegicus (Norway rat) | Ki | 2.5023 | 6 | 6 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 2.2402 | 2 | 8 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 5.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | EC50 | 19.0028 | 4 | 4 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | EC50 | 21.7528 | 4 | 4 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | EC50 | 22.0037 | 3 | 3 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | EC50 | 106.6667 | 2 | 3 |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | EC50 | 65.0000 | 1 | 1 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | EC50 | 22.0037 | 3 | 3 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Kd | 0.2931 | 3 | 5 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC50 | 0.0004 | 1 | 1 |
| Cytochrome P450 2A13 | Homo sapiens (human) | Kd | 54.0000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Kd | 470.0000 | 1 | 1 |
| Glycoprotein IIb | Oryctolagus cuniculus (rabbit) | EC50 | 1.5068 | 1 | 4 |
| Integrin beta | Oryctolagus cuniculus (rabbit) | EC50 | 1.5068 | 1 | 4 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 1,108,477,796.2420 | 18 | 18 |
| Muscarinic acetylcholine receptor M1 | Mus musculus (house mouse) | EC50 | 40.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 | 0.6500 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 1,936,025,008.0114 | 8 | 8 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 5,568,744,447.3554 | 9 | 9 |
| Muscarinic acetylcholine receptor M3 | Mus musculus (house mouse) | EC50 | 9.9000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 | 0.7027 | 21 | 21 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | EC50 | 9.6071 | 7 | 7 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | EC50 | 9,120,110,011.0422 | 10 | 10 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Kd | 17.0000 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | EC50 | 33.0000 | 2 | 4 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | EC50 | 27.0000 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | EC50 | 22.7837 | 16 | 19 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | EC50 | 25.2039 | 8 | 10 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | EC50 | 4.6696 | 24 | 29 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | EC50 | 0.7222 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | EC50 | 12.6341 | 12 | 14 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-5 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | EC50 | 27.0000 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (human) | EC50 | 0.1270 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | EC50 | 27.0000 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | EC50 | 52.8661 | 8 | 9 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | EC50 | 3,342.2246 | 11 | 13 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | Kd | 0.0011 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | EC50 | 27.0000 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | EC50 | 11.4680 | 27 | 33 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | EC50 | 0.7222 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | EC50 | 12.6341 | 12 | 14 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (human) | EC50 | 10.5635 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | EC50 | 27.0000 | 2 | 3 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | EC50 | 13.9368 | 16 | 18 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | EC50 | 25.2039 | 8 | 10 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | EC50 | 19,952,600,000.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 152,369.0000 | 2 | 3 |
| Transient receptor potential cation channel subfamily A member 1 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | EC50 | 51.0000 | 1 | 1 |