fibroblast growth factor receptor antagonist

An antagonist at the fibroblast growth factor receptor.

ChEBI ID: 63457

Members (8)

Member	Definition	Class
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	A member of the class of phenylureas that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-dichloro-3,5-dimethoxyphenyl group, while the hydrogens attached to the other nitrogen are replaced by a methyl group and a 6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl group. It is a potent and selective fibroblast growth factor receptor inhibitor.	BGJ-398
azd4547	A member of the class of benzamides that is a carboxamide resulting from the formal condensation of the carboxy group of 4-(cis-3,5-dimethylpiperazin-1-yl)benzoic acid with the amino substituent of 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-amine. It is an inhibitor of the fibroblast growth factor receptor (FGFR).	AZD4547
brivanib	A secondary alcohol resulting from the hydrolysis of the carboxylic ester group of brivanib alaninate. It is a dual VEGFR-2/FGFR-1 kinase inhibitor whose alanine prodrug, brivanib alaninate is currently under development as an oral agent for the treatment of cancer.	(2R)-1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol; brivanib
lenvatinib	A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.	lenvatinib
lucitanib	A naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine.	E-3810 free base
pd 173074	A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N(3) is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor.	PD173074
ssr128129e	An organic sodium salt having 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate as the counterion.	sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate
SU5402	An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 3-(2-carboxyethyl)-4-methyl-1H-pyrrol-2-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1.	SU5402

Research

Studies (1,397)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (0.21)	18.2507
2000's	52 (3.72)	29.6817
2010's	576 (41.23)	24.3611
2020's	766 (54.83)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	147 (9.77%)	5.53%
Reviews	196 (13.03%)	6.00%
Case Studies	149 (9.91%)	4.05%
Observational	18 (1.20%)	0.25%
Other	994 (66.09%)	84.16%

Protein Targets (539)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
67.9K protein	Vaccinia virus	Potency	12.6728	2	2
alpha-galactosidase	Homo sapiens (human)	Potency	31.6228	1	1
ATAD5 protein, partial	Homo sapiens (human)	Potency	29.0810	1	1
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	19.9526	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	0.7943	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	14.4900	1	3
cytochrome P450 2D6	Homo sapiens (human)	Potency	23.9185	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	9.5642	1	3
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	15.0030	1	1
EWS/FLI fusion protein	Homo sapiens (human)	Potency	17.2315	4	21
Fumarate hydratase	Homo sapiens (human)	Potency	28.1496	1	4
G	Vesicular stomatitis virus	Potency	14.4900	1	3
geminin	Homo sapiens (human)	Potency	8.0830	2	2
glp-1 receptor, partial	Homo sapiens (human)	Potency	4.4668	1	1
glucocerebrosidase	Homo sapiens (human)	Potency	25.2855	1	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	44.6684	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	14.4900	1	3
IDH1	Homo sapiens (human)	Potency	16.3601	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	14.4900	1	6
Interferon beta	Homo sapiens (human)	Potency	21.5266	2	18
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	23.1093	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	35.4813	1	1
plasminogen precursor	Mus musculus (house mouse)	Potency	7.0795	1	1
polyprotein	Zika virus	Potency	28.1496	1	4
PPM1D protein	Homo sapiens (human)	Potency	22.9339	1	10
serine-protein kinase ATM isoform a	Homo sapiens (human)	Potency	39.8107	1	1
Smad3	Homo sapiens (human)	Potency	22.3872	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	4.4772	2	2
TDP1 protein	Homo sapiens (human)	Potency	29.0929	2	2
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	4.9674	1	3
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	7.0795	1	1
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	7.0795	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Carbonic anhydrase 1	Homo sapiens (human)	Ki	10.0000	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Ki	10.0000	1	1
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	0.1327	1	1
Chain A, Protein (fibroblast Growth Factor (fgf) Receptor 1)	Homo sapiens (human)	Ki	0.0452	1	1
Coiled-coil domain-containing protein 6	Homo sapiens (human)	IC50	0.0100	1	1
Cytochrome P450 1A2	Homo sapiens (human)	IC50	40.0000	1	1
Cytochrome P450 2C19	Homo sapiens (human)	IC50	40.0000	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	40.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	40.0000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	19.0070	4	4
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	IC50	50.0000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	25.9500	2	2
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	1.0081	45	48
Fibroblast growth factor receptor 2	Homo sapiens (human)	IC50	0.4617	27	29
Fibroblast growth factor receptor 3	Homo sapiens (human)	IC50	0.5303	26	27
Fibroblast growth factor receptor 4	Homo sapiens (human)	IC50	0.7228	23	28
Fibroblast growth factor receptor 4	Mus musculus (house mouse)	IC50	0.4972	2	4
Gastrin/cholecystokinin type B receptor	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Insulin receptor	Homo sapiens (human)	IC50	50.0000	2	2
Kinesin-1 heavy chain	Homo sapiens (human)	IC50	0.0100	1	1
Nuclear receptor coactivator 4	Homo sapiens (human)	IC50	0.0100	1	1
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	IC50	0.0510	1	1
Platelet-derived growth factor receptor alpha	Rattus norvegicus (Norway rat)	IC50	17.0000	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	3.0195	2	2
Platelet-derived growth factor receptor beta	Mus musculus (house mouse)	IC50	12.0070	2	4
Platelet-derived growth factor receptor beta	Rattus norvegicus (Norway rat)	IC50	17.0000	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	18.0000	1	1
Protein kinase C alpha type	Homo sapiens (human)	IC50	25.0000	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	IC50	0.0162	4	4
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Ki	0.0015	1	1
Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (chicken)	IC50	20.0000	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	13.5070	2	4
Serine-protein kinase ATM	Homo sapiens (human)	IC50	17.6000	1	1
Smoothened homolog	Homo sapiens (human)	Ki	0.0465	1	1
Tyrosine-protein kinase CSK	Homo sapiens (human)	IC50	19.8000	1	1
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC50	50.0000	1	1
Tyrosine-protein kinase Lck	Homo sapiens (human)	IC50	2.5000	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	IC50	0.0821	7	8
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Ki	0.0600	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	0.0401	23	24
Vascular endothelial growth factor receptor 2	Mus musculus (house mouse)	IC50	0.0890	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Ki	0.0260	1	1
Vascular endothelial growth factor receptor 2	Mus musculus (house mouse)	Ki	0.0280	1	1
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50	0.0330	6	7

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	3
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	25.0000	2	4
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	1	1
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	3
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	3
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	3
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	3
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	3
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Activin receptor type-1	Homo sapiens (human)	Kd	25.0000	2	4
Activin receptor type-1B	Homo sapiens (human)	Kd	25.0000	2	4
Activin receptor type-2A	Homo sapiens (human)	Kd	10.0000	1	1
Activin receptor type-2B	Homo sapiens (human)	Kd	25.0000	2	4
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	3
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	3
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	4
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	1	3
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	3
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	3
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	1	1
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	0.4400	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	1	1
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	2
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	3
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	3
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	2
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	25.0000	2	4
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	10.0000	1	1
Aurora kinase A	Homo sapiens (human)	Kd	20.0762	3	5
Aurora kinase B	Homo sapiens (human)	Kd	16.1582	2	4
Aurora kinase C	Homo sapiens (human)	Kd	10.0000	1	1
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	1	1
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	3
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	25.0000	2	4
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	25.0000	2	4
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	25.0000	2	4
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	25.0000	2	4
Breakpoint cluster region protein	Homo sapiens (human)	Kd	23.5282	1	4
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	25.0000	2	4
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	25.0000	2	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	25.0000	2	4
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	25.0000	2	4
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	25.0000	2	4
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	25.0000	2	4
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	3
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	3
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	25.0000	2	4
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	10.0000	1	1
Casein kinase I isoform delta	Homo sapiens (human)	Kd	25.0000	2	4
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	25.0000	2	4
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	25.0000	2	4
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	23.3333	2	3
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	25.0000	2	4
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	25.0000	2	4
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	1
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	1
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	3
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	1	3
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	3
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	22.0000	3	5
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	3
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	25.0000	2	4
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	3
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	5
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	1	1
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	3
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	3
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	3
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	10.0780	2	4
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	3
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	2
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	3
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	3
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	26.0000	2	5
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	25.0000	2	4
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	16.5025	2	4
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	25.0000	2	4
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	25.0000	2	4
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	26.0000	2	5
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	25.0000	2	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	20.0000	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	1	1
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	3
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	4
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	23.3333	2	3
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	25.0000	2	4
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	10.0000	1	1
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	25.0000	2	4
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	25.0000	2	4
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	0.1900	1	1
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	20.5667	2	3
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	10.0000	1	1
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	10.0000	1	1
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	25.0000	2	4
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	25.0000	2	4
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	25.0000	2	4
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	22.8500	2	4
Epidermal growth factor receptor	Homo sapiens (human)	Kd	12.4000	13	15
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	0.3097	2	4
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	3
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	3
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	16.4765	2	4
Fibroblast growth factor receptor 1	Homo sapiens (human)	EC50	0.0210	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	22.5248	2	4
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	0.1100	1	1
Fibroblast growth factor receptor 3	Homo sapiens (human)	EC50	0.0300	1	1
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	0.1550	2	2
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	0.6000	1	1
Focal adhesion kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	3
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	3
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	4
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	4
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	3
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	25.0000	2	4
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	25.0000	2	4
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	3
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	3
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	3
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	20.0000	4	6
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	23.3333	2	3
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	25.0000	2	4
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	3
Insulin receptor	Homo sapiens (human)	Kd	26.6667	2	6
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	1	1
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	25.0000	2	4
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	3
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	26.0000	2	5
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	25.0000	2	4
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	25.0000	2	4
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	1	1
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	10.0000	1	1
LIM domain kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
LIM domain kinase 2	Homo sapiens (human)	Kd	25.0000	2	4
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	2
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	1.9000	1	1
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	25.0000	2	4
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	17.5158	2	4
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	25.0000	2	4
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	25.0000	2	4
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	25.0000	2	4
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	3.0192	8	8
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	25.0000	2	4
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	26.0000	2	5
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Midasin	Homo sapiens (human)	Kd	30.0000	1	3
Misshapen-like kinase 1	Homo sapiens (human)	Kd	20.1033	2	3
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	17.5542	2	4
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	26.0000	2	5
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	0.5000	1	1
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	17.8938	2	4
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	20.1156	2	5
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	20.8368	2	4
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	18.9034	2	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	3
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	3
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	10.0000	1	1
Myosin light chain kinase 3	Homo sapiens (human)	Kd	26.0000	2	5
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	23.3333	2	3
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	3
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	5
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	1	1
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	1	1
Myotonin-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	3
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	25.0000	2	4
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	22.0000	3	5
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	1	1
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	25.0000	2	4
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	3
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	3
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	2
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	10.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	3
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	3
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	3
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	3
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	10	10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	25.0000	2	4
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	25.0000	2	4
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	10.0000	1	1
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	0.0110	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	0.7952	2	4
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	3
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	3
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	3
Protein kinase C delta type	Homo sapiens (human)	Kd	26.0000	2	5
Protein kinase C epsilon type	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C iota type	Homo sapiens (human)	Kd	25.0000	2	4
Protein kinase C theta type	Homo sapiens (human)	Kd	25.0000	2	4
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	1
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	25.0000	2	4
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	17.5432	2	4
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	3.3749	5	7
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	22.9000	2	4
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	5
Pyridoxal kinase	Homo sapiens (human)	Kd	25.4680	1	3
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	2
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	25.0000	2	4
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	25.0000	2	4
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	25.0000	2	4
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	3
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	3
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	3
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	10.0000	1	1
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	10.0000	1	1
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	10.0000	1	1
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	8.2775	2	4
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	20.1053	1	3
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	16.0000	8	10
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	25.0000	2	4
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	25.0000	2	4
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	10.0000	1	1
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	10.0000	1	1
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	22.0000	3	5
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	2	2
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	25.0000	2	4
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	22.0000	3	5
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	22.0000	3	5
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	22.0000	3	5
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	23.3333	2	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	20.5077	1	3
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	3
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	3
Septin-9	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	10.2932	2	4
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	3.9000	1	1
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	3.2000	1	1
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	0.0260	1	1
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	23.3333	3	6
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	26.0000	2	5
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	18.0605	2	4
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	3
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	3
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	9.1905	2	4
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	20.3790	1	3
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	4
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	3
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
TGF-beta receptor type-1	Homo sapiens (human)	Kd	25.0000	2	4
TGF-beta receptor type-2	Homo sapiens (human)	Kd	25.0000	2	4
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	2
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	15.1812	2	4
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	3
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	5.5512	16	18
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	24.3600	2	5
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	2.0000	1	1
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	20.0000	2	2
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	26.0000	2	5
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	23.1750	2	4
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	22.0000	3	5
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	22.7750	2	4
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	20.5528	2	5
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	20.0000	2	2
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	1.1000	1	1
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	26.0000	2	5
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	3
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	4
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	2
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	3
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	0.0100	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	EC50	0.2500	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	0.0036	2	2
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	0.0560	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Wee1-like protein kinase	Homo sapiens (human)	Kd	25.0000	2	4
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Cholinesterase	Homo sapiens (human)	Activity	0.0400	1	1
Cytochrome P450 1A2	Homo sapiens (human)	Km	45.0000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	Km	32.7000	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	Activity	0.2760	1	1
Fibroblast growth factor receptor 2	Homo sapiens (human)	Activity	0.2760	1	1
Fibroblast growth factor receptor 3	Homo sapiens (human)	Activity	0.2760	1	1
Fibroblast growth factor receptor 4	Homo sapiens (human)	Activity	0.2760	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Activity	0.0400	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Activity	0.0400	1	1
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Activity	0.0400	1	1

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fibroblast growth factor receptor antagonist

Members (8)

Research

Studies (1,397)

Study Types

Protein Targets (539)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements