A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.
ChEBI ID: 48354
| Member | Definition | Class |
|---|---|---|
| 1,1,1-trichloroethane | A member of the class of chloroethanes carrying three chloro substituents at position 1. | 1,1,1-trichloroethane |
| 2-pyrrolidone | The simplest member of the class of pyrrolidin-2-ones, consisting of pyrrolidine in which the hydrogens at position 2 are replaced by an oxo group. The lactam arising by the formal intramolecular condensation of the amino and carboxy groups of gamma-aminobutyric acid (GABA). | pyrrolidin-2-one |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 267 (38.47) | 18.7374 |
| 1990's | 111 (15.99) | 18.2507 |
| 2000's | 145 (20.89) | 29.6817 |
| 2010's | 138 (19.88) | 24.3611 |
| 2020's | 33 (4.76) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (0.40%) | 5.53% |
| Reviews | 31 (4.10%) | 6.00% |
| Case Studies | 48 (6.35%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 674 (89.15%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 24.7355 | 3 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 1.7783 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 43.2771 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 48.7680 | 2 | 2 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 24.3365 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 35.2534 | 5 | 7 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 54.4827 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 69.2877 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 49.0520 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 13.0636 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 55.5196 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 55.5196 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 0.7943 | 2 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 435,000.0000 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Olfactory receptor 51E2 | Homo sapiens (human) | EC50 | 0.0019 | 1 | 1 |