Roles > polar solvent
Page last updated: 2024-08-05 15:29:22

polar solvent

A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.

ChEBI ID: 48354

Members (2)

MemberDefinitionClass
1,1,1-trichloroethaneA member of the class of chloroethanes carrying three chloro substituents at position 1.1,1,1-trichloroethane
2-pyrrolidoneThe simplest member of the class of pyrrolidin-2-ones, consisting of pyrrolidine in which the hydrogens at position 2 are replaced by an oxo group. The lactam arising by the formal intramolecular condensation of the amino and carboxy groups of gamma-aminobutyric acid (GABA).pyrrolidin-2-one

Research

Studies (694)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990267 (38.47)18.7374
1990's111 (15.99)18.2507
2000's145 (20.89)29.6817
2010's138 (19.88)24.3611
2020's33 (4.76)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials3 (0.40%)5.53%
Reviews31 (4.10%)6.00%
Case Studies48 (6.35%)4.05%
Observational0 (0.00%)0.25%
Other674 (89.15%)84.16%

Protein Targets (30)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency24.735533
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.778311
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency43.277111
estrogen nuclear receptor alphaHomo sapiens (human)Potency48.768022
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency24.336511
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency35.253457
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency54.482711
pregnane X nuclear receptorHomo sapiens (human)Potency69.287711
RAR-related orphan receptor gammaMus musculus (house mouse)Potency49.052011
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency13.063622
SMAD family member 2Homo sapiens (human)Potency55.519611
SMAD family member 3Homo sapiens (human)Potency55.519611
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.794323

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
GABA theta subunitRattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)IC50435,000.000012
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)IC50435,000.000012

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Olfactory receptor 51E2Homo sapiens (human)EC500.001911
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