hepatotoxic agent

A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.

ChEBI ID: 50908

Members (36)

Member	Definition	Class
2-dichlorobenzene	A dichlorobenzene carrying chloro substituents at positions 1 and 2.	1,2-dichlorobenzene
2-methylfuran	A member of the class of furans that is furan in which the hydrogen at position 2 is replaced by a methyl group.	2-methylfuran
2-nitropropane	A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC).	2-nitropropane
acetaminophen	A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.	paracetamol
azathioprine	A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.	azathioprine
benoxaprofen	A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.	benoxaprofen
bromobenzene	The simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30degreeC; b.p.760 156degreeC), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis.	bromobenzene
cadmium nitrate	An inorganic nitrate salt having Cd(2+) as the counterion.	cadmium nitrate
carbon tetrachloride	A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	tetrachloromethane
cp 724714	A 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide in which the double bond adopts a trans-configuration. It is a potent inhibitor of HER2/ErbB2 (IC50 = 10 nM) and exhibits anti-cancer activity.	CP-724714
diethylnitrosamine	A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	N-nitrosodiethylamine
dimethylformamide	A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.	N,N-dimethylformamide
droxicam	An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respectively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.	droxicam
ethylene dichloride	A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.	1,2-dichloroethane
flunoxaprofen	A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.	flunoxaprofen
furan	A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.	furan
genipin		Genipin
ibufenac	A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatotoxic side-effects.	ibufenac
indospicine	An alpha-amino acid that is 2,7-diaminoheptanoic acid substituted by a imino group at position 7 (the 2S stereoisomer).	L-indospicine
leflunomide	A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.	leflunomide
mepanipyrim	A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying additional methyl and 1-propynyl substituents at positions 4 and 6 respectively. A fungicide used to control a wide range of diseases including grey mould on strawberries, tomatoes and cucumabers, and scab on apples and pears.	mepanipyrim
methoxyflurane	An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.	methoxyflurane
mocetinostat	A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	mocetinostat
n-methylthiourea	A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a methyl group.	N-methylthiourea
nifurtoinol	An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group and at position 3 by a hydroxymethyl group.	nifurtoinol
nitrofurantoin	An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.	nitrofurantoin
paroxetine	A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.	paroxetine
paroxetine hydrochloride	The hydrochloride salt of paroxetine. It is an antidepressant drug.	paroxetine hydrochloride
paroxetine maleate	A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.	paroxetine maleate
polidocanol	A hydroxypolyether that is nonaethylene glycol in which one of the terminal hydroxy functions is substituted by a lauryl (dodecyl) group.	polidocanol
regorafenib	A pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy.	regorafenib
synthalin a	A member of the class of guanidines that is decane having guanidino groups at the 1- and 10-positions.	synthalin A
teriflunomide	An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.	teriflunomide
thioacetamide	A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.	thioacetamide
ticrynafen	An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.	tienilic acid
tosufloxacin, 4-toluene sulfonate	A racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate.	tosufloxacin tosylate

Research

Studies (85,092)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	21,234 (24.95)	18.7374
1990's	13,025 (15.31)	18.2507
2000's	19,028 (22.36)	29.6817
2010's	24,130 (28.36)	24.3611
2020's	7,675 (9.02)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	6,874 (7.50%)	5.53%
Reviews	6,327 (6.90%)	6.00%
Case Studies	7,252 (7.91%)	4.05%
Observational	417 (0.46%)	0.25%
Other	70,774 (77.23%)	84.16%

Protein Targets (709)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
67.9K protein	Vaccinia virus	Potency	13.6069	2	3
acetylcholinesterase	Homo sapiens (human)	Potency	61.3737	4	8
activating transcription factor 6	Homo sapiens (human)	Potency	36.7145	2	5
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	34.4454	1	4
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	30.1272	1	3
AR protein	Homo sapiens (human)	Potency	18.6031	11	78
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	22.5111	2	11
arylsulfatase A	Homo sapiens (human)	Potency	19.7800	1	3
ATAD5 protein, partial	Homo sapiens (human)	Potency	14.8794	4	10
Ataxin-2	Homo sapiens (human)	Potency	13.4742	2	8
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	0.8492	1	1
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	10.2075	2	10
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	14.6892	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	14.1916	2	4
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	50.1187	1	1
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	12.3677	1	3
caspase-3	Homo sapiens (human)	Potency	12.3677	1	3
Caspase-7	Homo sapiens (human)	Potency	31.6228	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	29.0341	3	12
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	9.7715	2	8
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	14.1254	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	0.8913	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	35.1251	1	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	1.3162	1	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	22.4824	1	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	35.3104	1	5
chromobox protein homolog 1	Homo sapiens (human)	Potency	52.6114	2	8
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	15.8489	1	1
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	31.6228	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	11.4974	1	9
cytochrome P450 2D6	Homo sapiens (human)	Potency	11.7289	1	8
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	13.5221	2	12
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	8.8421	1	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	21.9553	1	9
D(1A) dopamine receptor	Homo sapiens (human)	Potency	11.2202	1	1
D(1A) dopamine receptor	Sus scrofa (pig)	Potency	26.1216	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	57.4176	1	4
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	31.6228	1	1
Endothelin receptor type B	Rattus norvegicus (Norway rat)	Potency	17.7828	1	1
Endothelin-1 receptor	Rattus norvegicus (Norway rat)	Potency	17.7828	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	23.0449	12	69
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	26.2039	3	8
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	14.2287	10	75
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	19.3306	1	6
EWS/FLI fusion protein	Homo sapiens (human)	Potency	12.0148	4	18
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	25.8910	3	6
flap endonuclease 1	Homo sapiens (human)	Potency	39.8107	1	1
Fumarate hydratase	Homo sapiens (human)	Potency	22.9127	1	6
G	Vesicular stomatitis virus	Potency	11.4974	1	9
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	13.5221	1	6
geminin	Homo sapiens (human)	Potency	11.6281	3	14
GLI family zinc finger 3	Homo sapiens (human)	Potency	28.5955	3	25
glp-1 receptor, partial	Homo sapiens (human)	Potency	11.0645	1	4
GLS protein	Homo sapiens (human)	Potency	17.1967	2	3
glucocerebrosidase	Homo sapiens (human)	Potency	39.8107	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	21.9288	4	11
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	27.2054	1	9
heat shock protein beta-1	Homo sapiens (human)	Potency	34.5181	2	6
hemoglobin subunit beta	Homo sapiens (human)	Potency	1.9377	5	8
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	27.9063	2	7
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	13.6185	2	5
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	126.0200	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	11.4974	1	9
huntingtin isoform 2	Homo sapiens (human)	Potency	13.8070	3	3
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	44.2386	1	2
IDH1	Homo sapiens (human)	Potency	16.5303	1	7
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	11.4974	1	18
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	6.3096	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	13.8753	1	3
Integrin beta-3	Homo sapiens (human)	Potency	13.8753	1	3
Interferon beta	Homo sapiens (human)	Potency	16.6522	3	25
interleukin 8	Homo sapiens (human)	Potency	70.9011	1	2
lamin isoform A-delta10	Homo sapiens (human)	Potency	7.6538	2	9
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	6.9440	1	4
Luciferase	Photinus pyralis (common eastern firefly)	Potency	25.8700	3	5
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	36.2932	1	3
Microtubule-associated protein tau	Homo sapiens (human)	Potency	31.5469	1	5
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	7.9444	1	2
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	9.8543	2	5
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	9.9150	1	2
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	0.0794	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	10.0000	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	31.6228	1	1
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	20.1486	1	3
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	26.0627	3	27
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	10.2080	1	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	33.5898	1	3
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	20.5908	1	7
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	20.1383	2	6
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	16.0825	1	2
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	11.9508	3	19
P53	Homo sapiens (human)	Potency	56.2341	1	2
Parkin	Homo sapiens (human)	Potency	1.6360	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	14.0355	2	6
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	37.5141	1	3
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	39.4549	5	12
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	35.3856	4	10
phosphopantetheinyl transferase	Bacillus subtilis	Potency	62.8410	1	7
plasminogen precursor	Mus musculus (house mouse)	Potency	8.1406	1	4
polyprotein	Zika virus	Potency	22.9127	1	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	25.1189	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	18.9556	1	4
PPM1D protein	Homo sapiens (human)	Potency	19.4548	1	10
pregnane X nuclear receptor	Homo sapiens (human)	Potency	16.6221	2	7
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	70.7946	1	1
progesterone receptor	Homo sapiens (human)	Potency	30.1926	2	8
pyruvate kinase	Leishmania mexicana mexicana	Potency	17.7828	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	20.0861	2	23
ras-related protein Rab-9A	Homo sapiens (human)	Potency	20.0637	1	3
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	44.6684	1	1
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	27.7231	3	26
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	21.9283	3	13
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	20.3239	4	4
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	26.6795	1	1
SMAD family member 2	Homo sapiens (human)	Potency	20.2111	2	3
SMAD family member 3	Homo sapiens (human)	Potency	20.2111	2	3
Smad3	Homo sapiens (human)	Potency	27.4980	1	4
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	20.6844	2	7
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	14.6348	2	12
TDP1 protein	Homo sapiens (human)	Potency	14.1435	2	31
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	30.0594	1	2
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	27.0829	4	9
Thrombopoietin	Homo sapiens (human)	Potency	10.2663	2	4
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	23.5145	3	14
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	11.4761	2	4
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	12.3778	4	16
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	4.8732	1	1
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	8.1406	1	4
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	8.1406	1	4
USP1 protein, partial	Homo sapiens (human)	Potency	45.9919	1	3
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	30.4571	2	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	22.1617	3	3
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	89.1251	1	1
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	27.2054	1	9

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
10 kDa chaperonin	Escherichia coli	IC50	75.7500	4	4
60 kDa chaperonin	Escherichia coli	IC50	75.7500	4	4
Acid-sensing ion channel 1	Rattus norvegicus (Norway rat)	IC50	1,023.2900	1	1
Acid-sensing ion channel 3	Rattus norvegicus (Norway rat)	IC50	416.8690	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	2.3580	1	2
Aldo-keto reductase family 1 member B1	Bos taurus (cattle)	Ki	0.0004	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	Ki	2.3385	1	2
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	6.3100	1	1
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	6.3100	1	1
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	Ki	6.3100	1	1
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	20.6960	1	1
Angiopoietin-1 receptor	Homo sapiens (human)	IC50	0.1562	2	2
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	10.4293	1	1
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	Ki	8.5445	1	1
Arachidonate 5-lipoxygenase-activating protein	Homo sapiens (human)	IC50	44.0000	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	6
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	29.8000	1	1
Beta-adrenergic receptor kinase 1	Bos taurus (cattle)	IC50	1.1533	3	3
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	IC50	4.5600	6	6
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	IC50	0.0005	1	1
Bile salt export pump	Homo sapiens (human)	IC50	391.9005	4	20
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50	642.1400	1	5
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	3.0000	1	1
Calcium release-activated calcium channel protein 1	Homo sapiens (human)	IC50	4.3000	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	6
Carbonic anhydrase 1	Homo sapiens (human)	Ki	129.7000	4	15
Carbonic anhydrase 12	Homo sapiens (human)	Ki	147.6615	2	13
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	149.6769	2	13
Carbonic anhydrase 14	Homo sapiens (human)	Ki	148.1615	2	13
Carbonic anhydrase 15	Mus musculus (house mouse)	Ki	9.2300	1	1
Carbonic anhydrase 2	Homo sapiens (human)	Ki	128.9400	4	15
Carbonic anhydrase 3	Homo sapiens (human)	Ki	147.8923	2	13
Carbonic anhydrase 4	Homo sapiens (human)	Ki	148.2231	2	13
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	209.0385	2	13
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	170.1154	2	13
Carbonic anhydrase 6	Homo sapiens (human)	Ki	197.9615	2	13
Carbonic anhydrase 7	Homo sapiens (human)	Ki	148.0462	2	13
Carbonic anhydrase 9	Homo sapiens (human)	Ki	146.9214	3	14
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens (human)	IC50	19.1000	1	1
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens (human)	Ki	0.8160	1	1
Cytochrome P450 1A2	Homo sapiens (human)	IC50	0.5000	1	1
Cytochrome P450 2C19	Homo sapiens (human)	IC50	0.1020	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	50.0000	1	1
Cytochrome P450 2C9	Homo sapiens (human)	Ki	7.6500	2	2
Cytochrome P450 2D6	Homo sapiens (human)	IC50	2.7756	4	4
Cytochrome P450 2D6	Homo sapiens (human)	Ki	4.8500	1	2
Cytochrome P450 2E1	Homo sapiens (human)	IC50	11.0000	1	1
Cytochrome P450 2J2	Homo sapiens (human)	IC50	50.0000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	2.7925	3	4
Cytochrome P450 3A5	Homo sapiens (human)	IC50	0.3000	1	2
Dihydrofolate reductase	Homo sapiens (human)	IC50	0.3880	1	1
Dihydroorotate dehydrogenase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	98.8725	4	4
Dihydroorotate dehydrogenase	Schistosoma mansoni	IC50	50.0000	2	2
Dihydroorotate dehydrogenase	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	22.6750	2	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	IC50	1.5822	23	23
Dihydroorotate dehydrogenase (quinone), mitochondrial	Mus musculus (house mouse)	IC50	0.1030	4	5
Dihydroorotate dehydrogenase (quinone), mitochondrial	Rattus norvegicus (Norway rat)	IC50	0.0160	6	7
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	Ki	0.9207	3	3
Epidermal growth factor receptor	Homo sapiens (human)	IC50	6.4000	2	2
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	0.1018	2	2
G protein-coupled receptor kinase 5	Bos taurus (cattle)	IC50	150.7250	4	4
G protein-coupled receptor kinase 5	Homo sapiens (human)	IC50	100.0000	1	1
Histone deacetylase 1	Homo sapiens (human)	IC50	2.4892	17	27
Histone deacetylase 1	Homo sapiens (human)	Ki	0.0090	1	1
Histone deacetylase 11	Homo sapiens (human)	IC50	4.9592	4	13
Histone deacetylase 2	Homo sapiens (human)	IC50	3.5691	9	18
Histone deacetylase 2	Homo sapiens (human)	Ki	0.0324	1	1
Histone deacetylase 3	Homo sapiens (human)	IC50	3.4180	11	21
Histone deacetylase 3	Homo sapiens (human)	Ki	0.2650	1	1
Histone deacetylase 4	Homo sapiens (human)	IC50	6.2287	5	15
Histone deacetylase 5	Homo sapiens (human)	IC50	7.3350	5	14
Histone deacetylase 6	Homo sapiens (human)	IC50	8.6016	9	19
Histone deacetylase 7	Homo sapiens (human)	IC50	7.3350	5	14
Histone deacetylase 8	Homo sapiens (human)	IC50	11.7306	7	16
Integrin alpha-4	Homo sapiens (human)	IC50	10.0000	1	1
Integrin beta-1	Homo sapiens (human)	IC50	10.0000	1	1
Interleukin-8	Homo sapiens (human)	IC50	1.0000	1	1
Leukotriene A-4 hydrolase	Homo sapiens (human)	IC50	10.0000	2	2
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	GI50	0.6382	17	17
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50	0.5043	5	5
Mcl-1	Homo sapiens (human)	IC50	54.0000	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	114.3167	1	6
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	IC50	0.1450	1	1
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	IC50	54.0000	1	4
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Ki	0.0350	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	IC50	0.5320	1	1
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	IC50	54.0000	1	3
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Ki	0.1890	1	1
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	IC50	0.1790	1	1
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	IC50	54.0000	1	3
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	Ki	0.0380	1	1
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	IC50	0.2440	1	1
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	IC50	54.0000	1	3
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	Ki	0.0340	1	1
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	IC50	0.1230	1	1
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	IC50	54.0000	1	3
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	Ki	0.0890	1	1
Myeloperoxidase	Homo sapiens (human)	IC50	0.0200	1	1
Myoglobin	Homo sapiens (human)	IC50	2.3000	1	1
Nuclear receptor corepressor 1	Homo sapiens (human)	IC50	0.0220	1	1
Nuclear receptor corepressor 2	Homo sapiens (human)	IC50	0.0450	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	IC50	10.4293	1	1
Nuclear receptor subfamily 3 group C member 3	Bos taurus (cattle)	Ki	8.5445	1	1
P2X purinoceptor 4	Homo sapiens (human)	IC50	2.8067	3	3
P2X purinoceptor 4	Rattus norvegicus (Norway rat)	IC50	2.4500	2	2
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	GI50	0.2865	2	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	GI50	0.0290	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	0.0015	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	IC50	28.3800	1	1
Potassium voltage-gated channel subfamily A member 3	Homo sapiens (human)	IC50	31.9000	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	23.4764	3	3
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	8.5445	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	200.0000	1	1
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	372.0000	1	1
Prostaglandin G/H synthase 2	Mus musculus (house mouse)	IC50	5.5000	1	1
Protein kinase C alpha type	Homo sapiens (human)	IC50	220.0000	1	1
Protein-arginine deiminase type-4	Homo sapiens (human)	IC50	5,250.0000	1	2
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	IC50	0.0015	2	2
Quinolone resistance protein NorA	Staphylococcus aureus	IC50	7.0000	1	1
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	IC50	0.0020	2	2
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	0.0140	6	6
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	0.0820	1	1
Rhodopsin kinase GRK1	Bos taurus (cattle)	IC50	243.1750	4	4
Rhodopsin kinase GRK1	Homo sapiens (human)	IC50	100.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	IC50	0.0226	6	6
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	IC50	5.3660	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	2.2550	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50	0.8492	2	5
Sodium-dependent dopamine transporter	Mus musculus (house mouse)	Ki	0.4600	1	1
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	Ki	0.4000	1	1
Sodium-dependent dopamine transporter	Homo sapiens (human)	IC50	1.7780	1	2
Sodium-dependent dopamine transporter	Homo sapiens (human)	Ki	1.0750	2	3
Sodium-dependent noradrenaline transporter	Mus musculus (house mouse)	Ki	0.0200	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	1.6053	2	3
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	1.5890	2	3
Sodium-dependent serotonin transporter	Homo sapiens (human)	IC50	0.0007	4	4
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	0.0003	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	0.0002	9	9
Sodium-dependent serotonin transporter	Mus musculus (house mouse)	Ki	0.0004	1	1
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Ki	0.0005	3	4
Solute carrier family 22 member 6	Rattus norvegicus (Norway rat)	Ki	2,099.0000	1	1
Stromal interaction molecule 1	Homo sapiens (human)	IC50	4.3000	1	1
Substance-P receptor	Homo sapiens (human)	IC50	0.9000	1	1
Transporter	Rattus norvegicus (Norway rat)	IC50	0.5350	1	1
Transporter	Rattus norvegicus (Norway rat)	Ki	0.6596	1	1
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50	500.0000	1	1
Tyrosine-protein phosphatase non-receptor type 11	Homo sapiens (human)	IC50	500.0000	1	1
Tyrosine-protein phosphatase non-receptor type 2	Homo sapiens (human)	IC50	500.0000	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	IC50	0.0092	3	3
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	GI50	0.1140	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	0.0043	5	5
Vascular endothelial growth factor receptor 2	Mus musculus (house mouse)	IC50	0.0015	1	1
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50	0.0460	1	1
Vascular endothelial growth factor receptor 3	Mus musculus (house mouse)	IC50	0.0015	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	IC50	3.9000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	IC50	3.9000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	IC50	3.9000	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	IC50	3.9000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	2
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Kd	30.8114	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	23.3333	2	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	1	1
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	2
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	2
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	2
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	2
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	2
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	23.3333	2	3
Activin receptor type-1	Homo sapiens (human)	Kd	23.3333	2	3
Activin receptor type-1B	Homo sapiens (human)	Kd	23.3333	2	3
Activin receptor type-2A	Homo sapiens (human)	Kd	10.0000	1	1
Activin receptor type-2B	Homo sapiens (human)	Kd	23.3333	2	3
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	2
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	2
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	2
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	1	2
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	2
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	2
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	20.0000	2	2
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	10.0000	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	1	1
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	23.3333	2	3
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	2
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	2
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	2
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	3
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	2
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	23.3333	2	3
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	10.0000	1	1
Aurora kinase A	Homo sapiens (human)	Kd	23.3333	2	3
Aurora kinase B	Homo sapiens (human)	Kd	23.3333	2	3
Aurora kinase C	Homo sapiens (human)	Kd	10.0000	1	1
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	1	1
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	20.9933	2	3
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	23.3333	2	3
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	23.3333	2	3
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	30.0000	1	2
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	23.3333	2	3
Breakpoint cluster region protein	Homo sapiens (human)	Kd	15.3695	1	2
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	23.3333	2	3
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	23.3333	2	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	23.3333	2	3
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	23.3333	2	3
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	23.3333	2	3
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	23.3333	2	3
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	2
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	2
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	30.0000	1	2
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	10.0000	1	1
Casein kinase I isoform delta	Homo sapiens (human)	Kd	23.3333	2	3
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	23.3333	2	3
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	23.3333	2	3
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	25.0000	2	4
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	23.3333	2	3
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	23.3333	2	3
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	23.3333	2	3
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	3
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	2
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	1	3
Cyclin-dependent kinase 10	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	2
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	30.0000	1	2
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	13.5730	2	3
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	1.1000	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	30.0000	1	2
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	2
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	2.3000	2	2
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	25.0000	2	4
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	23.3333	2	3
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	23.3333	2	3
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	2
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Cytochrome P450 1A1	Homo sapiens (human)	Kd	19.1000	1	1
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	1	1
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	2
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	2	2
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	2
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	EC50	8.9063	1	2
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	13.4737	2	3
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	2
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	2
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	2
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	2
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	15.6275	1	2
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	25.0000	2	4
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	14.0357	2	3
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	20.0000	2	2
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	23.3333	2	3
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	6.9615	2	2
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	20.0000	2	2
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	30.0000	1	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	10.0000	1	1
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	1	1
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	2
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	2
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Envelope glycoprotein	Ebola virus - Mayinga, Zaire, 1976	Kd	650.0000	1	1
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	13.3357	2	3
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	10.4252	3	4
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	10.0000	1	1
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	23.3333	2	3
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	13.7077	2	3
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	10.0000	1	1
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	20.0000	2	2
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	10.0000	1	1
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	10.0000	1	1
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	23.3333	2	3
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	23.3333	2	3
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	23.3333	2	3
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	30.0000	1	2
Epidermal growth factor receptor	Homo sapiens (human)	Kd	3.0305	11	12
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	13.4527	2	3
Estrogen receptor	Rattus norvegicus (Norway rat)	EC50	150.0000	1	2
Estrogen receptor beta	Rattus norvegicus (Norway rat)	EC50	150.0000	1	2
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	30.0000	1	2
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	2
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	2
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	27.1900	2	3
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	25.0000	2	4
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	1	1
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	2	2
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	10.0000	1	1
Focal adhesion kinase 1	Homo sapiens (human)	Kd	23.3333	2	3
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	4
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	2
Glycine receptor subunit alpha-1	Homo sapiens (human)	EC50	1.8000	1	1
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	2
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	2
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	2
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	23.3333	2	3
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	25.0000	2	4
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	2
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	2
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	2
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	23.3333	2	3
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	25.0000	2	4
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	23.3333	2	3
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	2
Insulin receptor	Homo sapiens (human)	Kd	23.3333	2	3
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	1	1
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	23.3333	2	3
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	3
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	30.0000	1	3
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	30.0000	1	2
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	1	1
LIM domain kinase 1	Homo sapiens (human)	Kd	13.5387	2	3
LIM domain kinase 2	Homo sapiens (human)	Kd	23.3333	2	3
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	2
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	10.0000	1	1
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	30.0000	1	2
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	13.5607	2	3
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	23.3333	2	3
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	0.8400	1	1
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	23.3333	2	3
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	10.0000	7	7
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	23.3333	2	3
matrix metalloproteinase 1, partial	Homo sapiens (human)	EC50	5.6500	1	1
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	23.3333	2	3
Midasin	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	13.9703	2	3
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	13.5683	2	3
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	25.0000	2	4
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	15.2325	1	2
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	13.4247	2	3
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	30.0000	1	2
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	23.3333	2	3
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	23.3333	2	3
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	2
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	2
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	10.0000	1	1
Myosin light chain kinase 3	Homo sapiens (human)	Kd	30.0000	1	2
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	1	1
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	23.3333	2	3
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	2
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	2
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	1	1
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	1	1
Myotonin-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	2
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	23.3333	2	3
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	23.3333	2	3
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	1	1
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	23.3333	2	3
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	2
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	2
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	2
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	2
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	30.0000	1	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	23.3333	2	3
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	10.0000	1	1
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	10.0000	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	23.3333	2	3
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	2
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	2
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	2
Protein kinase C delta type	Homo sapiens (human)	Kd	23.3333	2	3
Protein kinase C epsilon type	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C iota type	Homo sapiens (human)	Kd	30.0000	1	2
Protein kinase C theta type	Homo sapiens (human)	Kd	23.3333	2	3
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	1
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	23.3333	2	3
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	23.3333	2	3
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	12.5315	3	4
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	23.3333	2	3
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	1
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	2
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	2
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	23.3333	2	3
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	23.3333	2	3
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	23.3333	2	3
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	2
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	2
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	2
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	0.0430	2	2
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	13.5890	2	3
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	15.1840	1	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	11.5089	6	7
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	2
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	2
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	20.0000	3	4
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	2	2
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	25.0000	2	4
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	22.0000	3	5
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	22.0000	3	5
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	23.3333	3	6
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	30.0000	1	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	30.0000	1	2
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	2
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	2
Septin-9	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	13.2812	3	4
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	25.0000	2	4
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	23.3333	2	3
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	2
short transient receptor potential channel 6 isoform 1	Mus musculus (house mouse)	EC50	44.6700	1	1
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	2
Sodium-dependent dopamine transporter	Homo sapiens (human)	Kd	0.4900	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Kd	0.0400	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	Kd	0.0001	1	1
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Kd	0.0001	1	1
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	23.3333	2	3
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	2
streptokinase A precursor	Streptococcus pyogenes M1 GAS	EC50	52.0403	2	3
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	2
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Taste receptor type 2 member 38	Homo sapiens (human)	EC50	600.0000	1	1
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
TGF-beta receptor type-1	Homo sapiens (human)	Kd	23.3333	2	3
TGF-beta receptor type-2	Homo sapiens (human)	Kd	23.3333	2	3
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	2
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	23.3333	2	3
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	0.2600	1	1
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	2
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	11.1948	8	9
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	26.0000	2	5
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	25.0000	2	4
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	20.0000	2	2
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	20.0000	2	2
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	10.0000	1	1
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	23.3333	2	3
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	2
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	1
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	2
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	2
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	10.0000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	1	1
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Wee1-like protein kinase	Homo sapiens (human)	Kd	23.3333	2	3

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Beta-adrenergic receptor kinase 1	Mus musculus (house mouse)	MEC	10.0000	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Km	803.0000	1	1
Cytochrome P450 1A1	Rattus norvegicus (Norway rat)	Ks	870.0000	1	1
Cytochrome P450 1A2	Homo sapiens (human)	Km	120.0000	1	1
Cytochrome P450 2B1	Rattus norvegicus (Norway rat)	Ks	800.0000	1	1
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)	Activity	1.5080	5	5
Prostaglandin G/H synthase 2	Homo sapiens (human)	INH	26.0000	1	1
protein AF-9 isoform a	Homo sapiens (human)	AC50	14.6550	1	2
Sulfotransferase 1A1	Rattus norvegicus (Norway rat)	Km	92.0000	1	1
Taste receptor type 2 member 38	Homo sapiens (human)	Activity	100.0000	1	2
toxin B	Clostridioides difficile 630	AC50	20.8700	1	1
UDP-glucuronosyltransferase 1-6	Homo sapiens (human)	Km	2,200.0000	1	1
UDP-glucuronosyltransferase 1A1	Homo sapiens (human)	Km	9,400.0000	1	1
UDP-glucuronosyltransferase 1A9	Homo sapiens (human)	Km	20,900.0000	1	1

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