Page last updated: 2024-08-05 14:23:52

hepatotoxic agent

A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals.

ChEBI ID: 50908

Members (36)

MemberDefinitionClass
2-dichlorobenzeneA dichlorobenzene carrying chloro substituents at positions 1 and 2.1,2-dichlorobenzene
2-methylfuranA member of the class of furans that is furan in which the hydrogen at position 2 is replaced by a methyl group.2-methylfuran
2-nitropropaneA secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC).2-nitropropane
acetaminophenA member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.paracetamol
azathioprineA thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.azathioprine
benoxaprofenA monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group. It was used as a non-steroidal anti-inflammatory drug until 1982 when it was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.benoxaprofen
bromobenzeneThe simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30degreeC; b.p.760 156degreeC), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis.bromobenzene
cadmium nitrateAn inorganic nitrate salt having Cd(2+) as the counterion.cadmium nitrate
carbon tetrachlorideA chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.tetrachloromethane
cp 724714A 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide in which the double bond adopts a trans-configuration. It is a potent inhibitor of HER2/ErbB2 (IC50 = 10 nM) and exhibits anti-cancer activity.CP-724714
diethylnitrosamineA nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.N-nitrosodiethylamine
dimethylformamideA member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.N,N-dimethylformamide
droxicamAn organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respectively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.droxicam
ethylene dichlorideA member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.1,2-dichloroethane
flunoxaprofenA monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.flunoxaprofen
furanA monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.furan
genipinGenipin
ibufenacA monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatotoxic side-effects.ibufenac
indospicineAn alpha-amino acid that is 2,7-diaminoheptanoic acid substituted by a imino group at position 7 (the 2S stereoisomer).L-indospicine
leflunomideA monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.leflunomide
mepanipyrimA member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying additional methyl and 1-propynyl substituents at positions 4 and 6 respectively. A fungicide used to control a wide range of diseases including grey mould on strawberries, tomatoes and cucumabers, and scab on apples and pears.mepanipyrim
methoxyfluraneAn ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.methoxyflurane
mocetinostatA benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).mocetinostat
n-methylthioureaA member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a methyl group.N-methylthiourea
nifurtoinolAn imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group and at position 3 by a hydroxymethyl group.nifurtoinol
nitrofurantoinAn imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.nitrofurantoin
paroxetineA benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.paroxetine
paroxetine hydrochlorideThe hydrochloride salt of paroxetine. It is an antidepressant drug.paroxetine hydrochloride
paroxetine maleateA maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.paroxetine maleate
polidocanolA hydroxypolyether that is nonaethylene glycol in which one of the terminal hydroxy functions is substituted by a lauryl (dodecyl) group.polidocanol
regorafenibA pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy.regorafenib
synthalin aA member of the class of guanidines that is decane having guanidino groups at the 1- and 10-positions.synthalin A
teriflunomideAn enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.teriflunomide
thioacetamideA thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.thioacetamide
ticrynafenAn aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.tienilic acid
tosufloxacin, 4-toluene sulfonateA racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate.tosufloxacin tosylate

Research

Studies (85,092)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199021,234 (24.95)18.7374
1990's13,025 (15.31)18.2507
2000's19,028 (22.36)29.6817
2010's24,130 (28.36)24.3611
2020's7,675 (9.02)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials6,874 (7.50%)5.53%
Reviews6,327 (6.90%)6.00%
Case Studies7,252 (7.91%)4.05%
Observational417 (0.46%)0.25%
Other70,774 (77.23%)84.16%

Protein Targets (709)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
67.9K proteinVaccinia virusPotency13.606923
acetylcholinesteraseHomo sapiens (human)Potency61.373748
activating transcription factor 6Homo sapiens (human)Potency36.714525
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency34.445414
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency30.127213
AR proteinHomo sapiens (human)Potency18.60311178
aryl hydrocarbon receptorHomo sapiens (human)Potency22.5111211
arylsulfatase AHomo sapiens (human)Potency19.780013
ATAD5 protein, partialHomo sapiens (human)Potency14.8794410
Ataxin-2Homo sapiens (human)Potency13.474228
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency0.849211
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency10.2075210
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency14.689211
Bloom syndrome protein isoform 1Homo sapiens (human)Potency14.191624
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency50.118711
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency12.367713
caspase-3Homo sapiens (human)Potency12.367713
Caspase-7Homo sapiens (human)Potency31.622811
Cellular tumor antigen p53Homo sapiens (human)Potency29.0341312
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency9.771528
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency14.125411
Chain A, Ferritin light chainEquus caballus (horse)Potency0.891311
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency35.125114
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.316214
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency22.482412
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency35.310415
chromobox protein homolog 1Homo sapiens (human)Potency52.611428
cytochrome P450 2C19 precursorHomo sapiens (human)Potency15.848911
cytochrome P450 2C9 precursorHomo sapiens (human)Potency31.622811
cytochrome P450 2C9, partialHomo sapiens (human)Potency11.497419
cytochrome P450 2D6Homo sapiens (human)Potency11.728918
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency13.5221212
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency8.842118
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency21.955319
D(1A) dopamine receptorHomo sapiens (human)Potency11.220211
D(1A) dopamine receptorSus scrofa (pig)Potency26.121611
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency57.417614
DNA polymerase kappa isoform 1Homo sapiens (human)Potency31.622811
Endothelin receptor type BRattus norvegicus (Norway rat)Potency17.782811
Endothelin-1 receptorRattus norvegicus (Norway rat)Potency17.782811
estrogen nuclear receptor alphaHomo sapiens (human)Potency23.04491269
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency26.203938
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.22871075
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency19.330616
EWS/FLI fusion proteinHomo sapiens (human)Potency12.0148418
farnesoid X nuclear receptorHomo sapiens (human)Potency25.891036
flap endonuclease 1Homo sapiens (human)Potency39.810711
Fumarate hydrataseHomo sapiens (human)Potency22.912716
GVesicular stomatitis virusPotency11.497419
GABA theta subunitRattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency13.522116
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency13.522116
gemininHomo sapiens (human)Potency11.6281314
GLI family zinc finger 3Homo sapiens (human)Potency28.5955325
glp-1 receptor, partialHomo sapiens (human)Potency11.064514
GLS proteinHomo sapiens (human)Potency17.196723
glucocerebrosidaseHomo sapiens (human)Potency39.810711
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency21.9288411
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency27.205419
heat shock protein beta-1Homo sapiens (human)Potency34.518126
hemoglobin subunit betaHomo sapiens (human)Potency1.937758
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency27.906327
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.810711
histone deacetylase 9 isoform 3Homo sapiens (human)Potency13.618525
Histone H2A.xCricetulus griseus (Chinese hamster)Potency126.020011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency11.497419
huntingtin isoform 2Homo sapiens (human)Potency13.807033
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency44.238612
IDH1Homo sapiens (human)Potency16.530317
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency11.4974118
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency6.309611
Integrin alpha-IIbHomo sapiens (human)Potency13.875313
Integrin beta-3Homo sapiens (human)Potency13.875313
Interferon betaHomo sapiens (human)Potency16.6522325
interleukin 8Homo sapiens (human)Potency70.901112
lamin isoform A-delta10Homo sapiens (human)Potency7.653829
lethal factor (plasmid)Bacillus anthracis str. A2012Potency6.944014
LuciferasePhotinus pyralis (common eastern firefly)Potency25.870035
M-phase phosphoprotein 8Homo sapiens (human)Potency36.293213
Microtubule-associated protein tauHomo sapiens (human)Potency31.546915
mitogen-activated protein kinase 1Homo sapiens (human)Potency7.944412
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency9.854325
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency9.915012
neuropeptide S receptor isoform AHomo sapiens (human)Potency0.079411
NFKB1 protein, partialHomo sapiens (human)Potency10.000022
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency31.622811
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency20.148613
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency26.0627327
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency10.208012
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency33.589813
Nuclear receptor ROR-gammaHomo sapiens (human)Potency20.590817
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency20.138326
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency16.082512
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency11.9508319
P53Homo sapiens (human)Potency56.234112
ParkinHomo sapiens (human)Potency1.636011
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency14.035526
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency37.514113
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency39.4549512
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency35.3856410
phosphopantetheinyl transferaseBacillus subtilisPotency62.841017
plasminogen precursorMus musculus (house mouse)Potency8.140614
polyproteinZika virusPotency22.912716
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency25.118912
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency18.955614
PPM1D proteinHomo sapiens (human)Potency19.4548110
pregnane X nuclear receptorHomo sapiens (human)Potency16.622127
pregnane X receptorRattus norvegicus (Norway rat)Potency70.794611
progesterone receptorHomo sapiens (human)Potency30.192628
pyruvate kinaseLeishmania mexicana mexicanaPotency17.782822
RAR-related orphan receptor gammaMus musculus (house mouse)Potency20.0861223
ras-related protein Rab-9AHomo sapiens (human)Potency20.063713
regulator of G-protein signaling 4Homo sapiens (human)Potency44.668411
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency27.7231326
retinoid X nuclear receptor alphaHomo sapiens (human)Potency21.9283313
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency20.323944
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency26.679511
SMAD family member 2Homo sapiens (human)Potency20.211123
SMAD family member 3Homo sapiens (human)Potency20.211123
Smad3Homo sapiens (human)Potency27.498014
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency20.684427
survival motor neuron protein isoform dHomo sapiens (human)Potency14.6348212
TDP1 proteinHomo sapiens (human)Potency14.1435231
thioredoxin glutathione reductaseSchistosoma mansoniPotency30.059412
thioredoxin reductaseRattus norvegicus (Norway rat)Potency27.082949
ThrombopoietinHomo sapiens (human)Potency10.266324
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency23.5145314
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency11.476124
thyroid stimulating hormone receptorHomo sapiens (human)Potency12.3778416
tyrosine-protein kinase YesHomo sapiens (human)Potency4.873211
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency8.140614
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency8.140614
USP1 protein, partialHomo sapiens (human)Potency45.991913
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency30.457128
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency22.161733
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency89.125111
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency27.205419

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
10 kDa chaperonin Escherichia coliIC5075.750044
60 kDa chaperonin Escherichia coliIC5075.750044
Acid-sensing ion channel 1Rattus norvegicus (Norway rat)IC501,023.290011
Acid-sensing ion channel 3Rattus norvegicus (Norway rat)IC50416.869011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC502.358012
Aldo-keto reductase family 1 member B1Bos taurus (cattle)Ki0.000411
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki2.338512
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)Ki6.310011
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)Ki6.310011
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)Ki6.310011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC5020.696011
Angiopoietin-1 receptorHomo sapiens (human)IC500.156222
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)IC5010.429311
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)Ki8.544511
Arachidonate 5-lipoxygenase-activating proteinHomo sapiens (human)IC5044.000011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000016
ATP-dependent translocase ABCB1Homo sapiens (human)IC5029.800011
Beta-adrenergic receptor kinase 1Bos taurus (cattle)IC501.153333
Beta-adrenergic receptor kinase 1Homo sapiens (human)IC504.560066
Bifunctional epoxide hydrolase 2Homo sapiens (human)IC500.000511
Bile salt export pumpHomo sapiens (human)IC50391.9005420
Bile salt export pumpRattus norvegicus (Norway rat)IC50642.140015
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC503.000011
Calcium release-activated calcium channel protein 1Homo sapiens (human)IC504.300011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000016
Carbonic anhydrase 1Homo sapiens (human)Ki129.7000415
Carbonic anhydrase 12Homo sapiens (human)Ki147.6615213
Carbonic anhydrase 13Mus musculus (house mouse)Ki149.6769213
Carbonic anhydrase 14Homo sapiens (human)Ki148.1615213
Carbonic anhydrase 15Mus musculus (house mouse)Ki9.230011
Carbonic anhydrase 2Homo sapiens (human)Ki128.9400415
Carbonic anhydrase 3Homo sapiens (human)Ki147.8923213
Carbonic anhydrase 4Homo sapiens (human)Ki148.2231213
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki209.0385213
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki170.1154213
Carbonic anhydrase 6Homo sapiens (human)Ki197.9615213
Carbonic anhydrase 7Homo sapiens (human)Ki148.0462213
Carbonic anhydrase 9Homo sapiens (human)Ki146.9214314
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)IC5019.100011
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)Ki0.816011
Cytochrome P450 1A2Homo sapiens (human)IC500.500011
Cytochrome P450 2C19Homo sapiens (human)IC500.102011
Cytochrome P450 2C9 Homo sapiens (human)IC5050.000011
Cytochrome P450 2C9 Homo sapiens (human)Ki7.650022
Cytochrome P450 2D6Homo sapiens (human)IC502.775644
Cytochrome P450 2D6Homo sapiens (human)Ki4.850012
Cytochrome P450 2E1Homo sapiens (human)IC5011.000011
Cytochrome P450 2J2Homo sapiens (human)IC5050.000011
Cytochrome P450 3A4Homo sapiens (human)IC502.792534
Cytochrome P450 3A5Homo sapiens (human)IC500.300012
Dihydrofolate reductaseHomo sapiens (human)IC500.388011
Dihydroorotate dehydrogenase Plasmodium falciparum (malaria parasite P. falciparum)IC5098.872544
Dihydroorotate dehydrogenase Schistosoma mansoniIC5050.000022
Dihydroorotate dehydrogenase Plasmodium falciparum (malaria parasite P. falciparum)Ki22.675022
Dihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)IC501.58222323
Dihydroorotate dehydrogenase (quinone), mitochondrialMus musculus (house mouse)IC500.103045
Dihydroorotate dehydrogenase (quinone), mitochondrialRattus norvegicus (Norway rat)IC500.016067
Dihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)Ki0.920733
Epidermal growth factor receptorHomo sapiens (human)IC506.400022
Fibroblast growth factor receptor 1Homo sapiens (human)IC500.101822
G protein-coupled receptor kinase 5Bos taurus (cattle)IC50150.725044
G protein-coupled receptor kinase 5Homo sapiens (human)IC50100.000011
Histone deacetylase 1Homo sapiens (human)IC502.48921727
Histone deacetylase 1Homo sapiens (human)Ki0.009011
Histone deacetylase 11 Homo sapiens (human)IC504.9592413
Histone deacetylase 2Homo sapiens (human)IC503.5691918
Histone deacetylase 2Homo sapiens (human)Ki0.032411
Histone deacetylase 3Homo sapiens (human)IC503.41801121
Histone deacetylase 3Homo sapiens (human)Ki0.265011
Histone deacetylase 4Homo sapiens (human)IC506.2287515
Histone deacetylase 5Homo sapiens (human)IC507.3350514
Histone deacetylase 6Homo sapiens (human)IC508.6016919
Histone deacetylase 7Homo sapiens (human)IC507.3350514
Histone deacetylase 8Homo sapiens (human)IC5011.7306716
Integrin alpha-4Homo sapiens (human)IC5010.000011
Integrin beta-1Homo sapiens (human)IC5010.000011
Interleukin-8Homo sapiens (human)IC501.000011
Leukotriene A-4 hydrolaseHomo sapiens (human)IC5010.000022
Mast/stem cell growth factor receptor KitHomo sapiens (human)GI500.63821717
Mast/stem cell growth factor receptor KitHomo sapiens (human)IC500.504355
Mcl-1Homo sapiens (human)IC5054.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50114.316716
Muscarinic acetylcholine receptor M1Homo sapiens (human)IC500.145011
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)IC5054.000014
Muscarinic acetylcholine receptor M1Homo sapiens (human)Ki0.035011
Muscarinic acetylcholine receptor M2Homo sapiens (human)IC500.532011
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)IC5054.000013
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki0.189011
Muscarinic acetylcholine receptor M3Homo sapiens (human)IC500.179011
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)IC5054.000013
Muscarinic acetylcholine receptor M3Homo sapiens (human)Ki0.038011
Muscarinic acetylcholine receptor M4Homo sapiens (human)IC500.244011
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)IC5054.000013
Muscarinic acetylcholine receptor M4Homo sapiens (human)Ki0.034011
Muscarinic acetylcholine receptor M5Homo sapiens (human)IC500.123011
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)IC5054.000013
Muscarinic acetylcholine receptor M5Homo sapiens (human)Ki0.089011
MyeloperoxidaseHomo sapiens (human)IC500.020011
MyoglobinHomo sapiens (human)IC502.300011
Nuclear receptor corepressor 1Homo sapiens (human)IC500.022011
Nuclear receptor corepressor 2Homo sapiens (human)IC500.045011
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)IC5010.429311
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)Ki8.544511
P2X purinoceptor 4Homo sapiens (human)IC502.806733
P2X purinoceptor 4Rattus norvegicus (Norway rat)IC502.450022
Platelet-derived growth factor receptor alphaHomo sapiens (human)GI500.286522
Platelet-derived growth factor receptor betaHomo sapiens (human)GI500.029011
Platelet-derived growth factor receptor betaHomo sapiens (human)IC500.001511
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)IC5028.380011
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)IC5031.900011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC5023.476433
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)Ki8.544511
Prostaglandin G/H synthase 1Homo sapiens (human)IC50200.000011
Prostaglandin G/H synthase 1Ovis aries (sheep)IC50372.000011
Prostaglandin G/H synthase 2Mus musculus (house mouse)IC505.500011
Protein kinase C alpha typeHomo sapiens (human)IC50220.000011
Protein-arginine deiminase type-4Homo sapiens (human)IC505,250.000012
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)IC500.001522
Quinolone resistance protein NorAStaphylococcus aureusIC507.000011
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)IC500.002022
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)IC500.014066
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)IC500.082011
Rhodopsin kinase GRK1Bos taurus (cattle)IC50243.175044
Rhodopsin kinase GRK1Homo sapiens (human)IC50100.000011
Serine/threonine-protein kinase B-rafHomo sapiens (human)IC500.022666
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC505.366011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki2.255011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)IC500.849225
Sodium-dependent dopamine transporterMus musculus (house mouse)Ki0.460011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki0.400011
Sodium-dependent dopamine transporter Homo sapiens (human)IC501.778012
Sodium-dependent dopamine transporter Homo sapiens (human)Ki1.075023
Sodium-dependent noradrenaline transporterMus musculus (house mouse)Ki0.020011
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC501.605323
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki1.589023
Sodium-dependent serotonin transporterHomo sapiens (human)IC500.000744
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)IC500.000311
Sodium-dependent serotonin transporterHomo sapiens (human)Ki0.000299
Sodium-dependent serotonin transporterMus musculus (house mouse)Ki0.000411
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)Ki0.000534
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)Ki2,099.000011
Stromal interaction molecule 1Homo sapiens (human)IC504.300011
Substance-P receptorHomo sapiens (human)IC500.900011
TransporterRattus norvegicus (Norway rat)IC500.535011
TransporterRattus norvegicus (Norway rat)Ki0.659611
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50500.000011
Tyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)IC50500.000011
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)IC50500.000011
Vascular endothelial growth factor receptor 1 Homo sapiens (human)IC500.009233
Vascular endothelial growth factor receptor 2Homo sapiens (human)GI500.114011
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC500.004355
Vascular endothelial growth factor receptor 2Mus musculus (house mouse)IC500.001511
Vascular endothelial growth factor receptor 3Homo sapiens (human)IC500.046011
Vascular endothelial growth factor receptor 3Mus musculus (house mouse)IC500.001511
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC503.900011
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)IC503.900011
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)IC503.900011
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)IC503.900011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
26S proteasome regulatory subunit 6BHomo sapiens (human)Kd30.000012
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)Kd10.000011
5-hydroxytryptamine receptor 1AHomo sapiens (human)Kd30.811412
5'-AMP-activated protein kinase catalytic subunit alpha-1Homo sapiens (human)Kd23.333323
5'-AMP-activated protein kinase catalytic subunit alpha-2Homo sapiens (human)Kd10.000011
5'-AMP-activated protein kinase subunit gamma-1Homo sapiens (human)Kd30.000012
5'-AMP-activated protein kinase subunit gamma-2Homo sapiens (human)Kd30.000012
AarF domain-containing protein kinase 1Homo sapiens (human)Kd30.000012
Actin-related protein 2Homo sapiens (human)Kd30.000012
Actin-related protein 3Homo sapiens (human)Kd30.000012
Activated CDC42 kinase 1Homo sapiens (human)Kd23.333323
Activin receptor type-1Homo sapiens (human)Kd23.333323
Activin receptor type-1BHomo sapiens (human)Kd23.333323
Activin receptor type-2AHomo sapiens (human)Kd10.000011
Activin receptor type-2BHomo sapiens (human)Kd23.333323
Acyl-CoA dehydrogenase family member 10Homo sapiens (human)Kd30.000012
Acyl-CoA dehydrogenase family member 11Homo sapiens (human)Kd30.000012
Adenine phosphoribosyltransferaseHomo sapiens (human)Kd30.000012
Adenosine kinaseHomo sapiens (human)Kd30.000012
Adenylate kinase 2, mitochondrialHomo sapiens (human)Kd30.000012
ADP/ATP translocase 2Homo sapiens (human)Kd30.000012
ADP/ATP translocase 3Homo sapiens (human)Kd30.000012
ALK tyrosine kinase receptorHomo sapiens (human)Kd20.000022
Angiopoietin-1 receptorHomo sapiens (human)Kd10.000011
Ankyrin repeat and protein kinase domain-containing protein 1Homo sapiens (human)Kd10.000011
AP2-associated protein kinase 1Homo sapiens (human)Kd23.333323
ATP-dependent 6-phosphofructokinase, platelet typeHomo sapiens (human)Kd30.000012
ATP-dependent RNA helicase DDX1Homo sapiens (human)Kd30.000012
ATP-dependent RNA helicase DDX3XHomo sapiens (human)Kd30.000012
ATP-dependent RNA helicase DDX42Homo sapiens (human)Kd30.000013
ATP-dependent RNA helicase DHX30Homo sapiens (human)Kd30.000012
Atypical kinase COQ8A, mitochondrialHomo sapiens (human)Kd23.333323
Atypical kinase COQ8B, mitochondrialHomo sapiens (human)Kd10.000011
Aurora kinase AHomo sapiens (human)Kd23.333323
Aurora kinase BHomo sapiens (human)Kd23.333323
Aurora kinase CHomo sapiens (human)Kd10.000011
BDNF/NT-3 growth factors receptorHomo sapiens (human)Kd10.000011
Beta-adrenergic receptor kinase 1Homo sapiens (human)Kd20.993323
BMP-2-inducible protein kinaseHomo sapiens (human)Kd23.333323
Bone morphogenetic protein receptor type-1AHomo sapiens (human)Kd23.333323
Bone morphogenetic protein receptor type-1BHomo sapiens (human)Kd30.000012
Bone morphogenetic protein receptor type-2Homo sapiens (human)Kd23.333323
Breakpoint cluster region proteinHomo sapiens (human)Kd15.369512
Calcium/calmodulin-dependent protein kinase kinase 1Homo sapiens (human)Kd10.000011
Calcium/calmodulin-dependent protein kinase kinase 2Homo sapiens (human)Kd23.333323
Calcium/calmodulin-dependent protein kinase type 1Homo sapiens (human)Kd10.000011
Calcium/calmodulin-dependent protein kinase type 1DHomo sapiens (human)Kd10.000011
Calcium/calmodulin-dependent protein kinase type 1GHomo sapiens (human)Kd10.000011
Calcium/calmodulin-dependent protein kinase type II subunit alphaHomo sapiens (human)Kd10.000011
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)Kd10.000011
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)Kd23.333323
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)Kd23.333323
Calcium/calmodulin-dependent protein kinase type IVHomo sapiens (human)Kd23.333323
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)Kd23.333323
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)Kd23.333323
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)Kd30.000012
cAMP-dependent protein kinase catalytic subunit PRKXHomo sapiens (human)Kd10.000011
cAMP-dependent protein kinase type II-alpha regulatory subunitHomo sapiens (human)Kd30.000012
Casein kinase I isoform alphaHomo sapiens (human)Kd30.000012
Casein kinase I isoform alpha-likeHomo sapiens (human)Kd10.000011
Casein kinase I isoform deltaHomo sapiens (human)Kd23.333323
Casein kinase I isoform epsilonHomo sapiens (human)Kd23.333323
Casein kinase I isoform gamma-1Homo sapiens (human)Kd23.333323
Casein kinase I isoform gamma-2Homo sapiens (human)Kd25.000024
Casein kinase I isoform gamma-3Homo sapiens (human)Kd23.333323
Casein kinase II subunit alphaHomo sapiens (human)Kd10.000011
Casein kinase II subunit alpha'Homo sapiens (human)Kd23.333323
Cell division cycle 7-related protein kinaseHomo sapiens (human)Kd30.000011
cGMP-dependent protein kinase 1 Homo sapiens (human)Kd23.333323
cGMP-dependent protein kinase 2Homo sapiens (human)Kd10.000011
Choline-phosphate cytidylyltransferase AHomo sapiens (human)Kd30.000013
Chromodomain-helicase-DNA-binding protein 4Homo sapiens (human)Kd30.000012
Citron Rho-interacting kinaseHomo sapiens (human)Kd23.333323
Cyclin-dependent kinase 1Homo sapiens (human)Kd30.000013
Cyclin-dependent kinase 10Homo sapiens (human)Kd30.000011
Cyclin-dependent kinase 11AHomo sapiens (human)Kd10.000011
Cyclin-dependent kinase 11BHomo sapiens (human)Kd10.000011
Cyclin-dependent kinase 12Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 13Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 14Homo sapiens (human)Kd10.000011
Cyclin-dependent kinase 16Homo sapiens (human)Kd23.333323
Cyclin-dependent kinase 17Homo sapiens (human)Kd13.573023
Cyclin-dependent kinase 18Homo sapiens (human)Kd10.000011
Cyclin-dependent kinase 19Homo sapiens (human)Kd1.100011
Cyclin-dependent kinase 2Homo sapiens (human)Kd23.333323
Cyclin-dependent kinase 3Homo sapiens (human)Kd23.333323
Cyclin-dependent kinase 4Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 6Homo sapiens (human)Kd30.000012
Cyclin-dependent kinase 7Homo sapiens (human)Kd23.333323
Cyclin-dependent kinase 8Homo sapiens (human)Kd2.300022
Cyclin-dependent kinase 9Homo sapiens (human)Kd25.000024
Cyclin-dependent kinase-like 5Homo sapiens (human)Kd30.000011
Cyclin-dependent-like kinase 5 Homo sapiens (human)Kd23.333323
Cyclin-G-associated kinaseHomo sapiens (human)Kd23.333323
Cysteine--tRNA ligase, cytoplasmicHomo sapiens (human)Kd30.000012
Cytochrome c1, heme protein, mitochondrialHomo sapiens (human)Kd30.000012
Cytochrome P450 1A1Homo sapiens (human)Kd19.100011
Cytoplasmic tyrosine-protein kinase BMXHomo sapiens (human)Kd10.000011
dCTP pyrophosphatase 1Homo sapiens (human)Kd30.000012
Death-associated protein kinase 1Homo sapiens (human)Kd10.000011
Death-associated protein kinase 2Homo sapiens (human)Kd10.000011
Death-associated protein kinase 3Homo sapiens (human)Kd10.000022
Delta(24)-sterol reductaseHomo sapiens (human)Kd30.000012
Deoxycytidine kinaseHomo sapiens (human)Kd30.000012
Dihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)EC508.906312
Discoidin domain-containing receptor 2Homo sapiens (human)Kd13.473723
DNA replication licensing factor MCM4Homo sapiens (human)Kd30.000012
DNA topoisomerase 2-alphaHomo sapiens (human)Kd30.000012
DNA topoisomerase 2-betaHomo sapiens (human)Kd30.000012
DnaJ homolog subfamily A member 1Homo sapiens (human)Kd30.000012
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)Kd23.333323
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)Kd23.333323
Dual specificity mitogen-activated protein kinase kinase 3Homo sapiens (human)Kd23.333323
Dual specificity mitogen-activated protein kinase kinase 4Homo sapiens (human)Kd10.000011
Dual specificity mitogen-activated protein kinase kinase 5Homo sapiens (human)Kd15.627512
Dual specificity mitogen-activated protein kinase kinase 6Homo sapiens (human)Kd25.000024
Dual specificity protein kinase CLK1Homo sapiens (human)Kd14.035723
Dual specificity protein kinase CLK2Homo sapiens (human)Kd23.333323
Dual specificity protein kinase CLK3Homo sapiens (human)Kd20.000022
Dual specificity protein kinase CLK4Homo sapiens (human)Kd23.333323
Dual specificity protein kinase TTKHomo sapiens (human)Kd6.961522
Dual specificity testis-specific protein kinase 1Homo sapiens (human)Kd20.000022
Dual specificity testis-specific protein kinase 2Homo sapiens (human)Kd30.000012
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)Kd30.000012
Dual specificity tyrosine-phosphorylation-regulated kinase 1BHomo sapiens (human)Kd10.000011
Dynamin-like 120 kDa protein, mitochondrialHomo sapiens (human)Kd30.000012
eIF-2-alpha kinase GCN2Homo sapiens (human)Kd10.000011
EKC/KEOPS complex subunit TP53RKHomo sapiens (human)Kd30.000012
Electron transfer flavoprotein subunit betaHomo sapiens (human)Kd30.000012
Elongation factor Tu, mitochondrialHomo sapiens (human)Kd30.000012
Envelope glycoproteinEbola virus - Mayinga, Zaire, 1976Kd650.000011
Ephrin type-A receptor 1Homo sapiens (human)Kd13.335723
Ephrin type-A receptor 2Homo sapiens (human)Kd10.425234
Ephrin type-A receptor 3Homo sapiens (human)Kd10.000011
Ephrin type-A receptor 4Homo sapiens (human)Kd23.333323
Ephrin type-A receptor 5Homo sapiens (human)Kd13.707723
Ephrin type-A receptor 6Homo sapiens (human)Kd10.000011
Ephrin type-A receptor 7Homo sapiens (human)Kd20.000022
Ephrin type-A receptor 8Homo sapiens (human)Kd10.000011
Ephrin type-B receptor 1Homo sapiens (human)Kd10.000011
Ephrin type-B receptor 2Homo sapiens (human)Kd23.333323
Ephrin type-B receptor 3Homo sapiens (human)Kd23.333323
Ephrin type-B receptor 4Homo sapiens (human)Kd23.333323
Ephrin type-B receptor 6Homo sapiens (human)Kd30.000012
Epidermal growth factor receptorHomo sapiens (human)Kd3.03051112
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)Kd13.452723
Estrogen receptorRattus norvegicus (Norway rat)EC50150.000012
Estrogen receptor betaRattus norvegicus (Norway rat)EC50150.000012
Eukaryotic translation initiation factor 2-alpha kinase 1Homo sapiens (human)Kd30.000012
Eukaryotic translation initiation factor 5BHomo sapiens (human)Kd30.000012
Exosome RNA helicase MTR4Homo sapiens (human)Kd30.000012
Ferrochelatase, mitochondrialHomo sapiens (human)Kd27.190023
Fibroblast growth factor receptor 1Homo sapiens (human)Kd25.000024
Fibroblast growth factor receptor 2Homo sapiens (human)Kd10.000011
Fibroblast growth factor receptor 3Homo sapiens (human)Kd10.000022
Fibroblast growth factor receptor 4Homo sapiens (human)Kd10.000011
Focal adhesion kinase 1Homo sapiens (human)Kd23.333323
G protein-coupled receptor kinase 6Homo sapiens (human)Kd30.000014
General transcription and DNA repair factor IIH helicase subunit XPDHomo sapiens (human)Kd30.000012
Glycine receptor subunit alpha-1Homo sapiens (human)EC501.800011
Glycine--tRNA ligaseHomo sapiens (human)Kd30.000012
Glycogen phosphorylase, brain formHomo sapiens (human)Kd30.000012
Glycogen phosphorylase, liver formHomo sapiens (human)Kd30.000012
Glycogen synthase kinase-3 alphaHomo sapiens (human)Kd23.333323
Glycogen synthase kinase-3 betaHomo sapiens (human)Kd25.000024
GTP-binding nuclear protein RanHomo sapiens (human)Kd30.000012
Guanine nucleotide-binding protein G(i) subunit alpha-2Homo sapiens (human)Kd30.000012
Heme oxygenase 2Homo sapiens (human)Kd30.000012
Hepatocyte growth factor receptorHomo sapiens (human)Kd23.333323
High affinity nerve growth factor receptorHomo sapiens (human)Kd25.000024
Inhibitor of nuclear factor kappa-B kinase subunit epsilonHomo sapiens (human)Kd23.333323
Inosine-5'-monophosphate dehydrogenase 2Homo sapiens (human)Kd30.000012
Insulin receptorHomo sapiens (human)Kd23.333323
Insulin receptor-related proteinHomo sapiens (human)Kd10.000011
Insulin-like growth factor 1 receptorHomo sapiens (human)Kd23.333323
Integrin-linked protein kinaseHomo sapiens (human)Kd30.000013
Interferon-induced, double-stranded RNA-activated protein kinaseHomo sapiens (human)Kd10.000011
Interleukin-1 receptor-associated kinase 1Homo sapiens (human)Kd30.000013
Interleukin-1 receptor-associated kinase 3Homo sapiens (human)Kd23.333323
Interleukin-1 receptor-associated kinase 4Homo sapiens (human)Kd30.000012
Isoleucine--tRNA ligase, mitochondrialHomo sapiens (human)Kd30.000012
Leukocyte tyrosine kinase receptorHomo sapiens (human)Kd10.000011
LIM domain kinase 1Homo sapiens (human)Kd13.538723
LIM domain kinase 2Homo sapiens (human)Kd23.333323
Long-chain-fatty-acid--CoA ligase 5Homo sapiens (human)Kd30.000012
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)Kd10.000011
Macrophage-stimulating protein receptorHomo sapiens (human)Kd30.000012
MAP kinase-activated protein kinase 2Homo sapiens (human)Kd13.560723
MAP kinase-activated protein kinase 3Homo sapiens (human)Kd30.000011
MAP kinase-activated protein kinase 5Homo sapiens (human)Kd23.333323
MAP kinase-interacting serine/threonine-protein kinase 1Homo sapiens (human)Kd10.000011
MAP kinase-interacting serine/threonine-protein kinase 2Homo sapiens (human)Kd0.840011
MAP/microtubule affinity-regulating kinase 3Homo sapiens (human)Kd23.333323
MAP/microtubule affinity-regulating kinase 4Homo sapiens (human)Kd23.333323
Mast/stem cell growth factor receptor KitHomo sapiens (human)Kd10.000077
Maternal embryonic leucine zipper kinaseHomo sapiens (human)Kd23.333323
matrix metalloproteinase 1, partialHomo sapiens (human)EC505.650011
Membrane-associated progesterone receptor component 1Homo sapiens (human)Kd30.000012
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseHomo sapiens (human)Kd23.333323
MidasinHomo sapiens (human)Kd30.000012
Mitogen-activated protein kinase 1Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase 10Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase 11Homo sapiens (human)Kd13.970323
Mitogen-activated protein kinase 12Homo sapiens (human)Kd10.000011
Mitogen-activated protein kinase 14Homo sapiens (human)Kd13.568323
Mitogen-activated protein kinase 15Homo sapiens (human)Kd25.000024
Mitogen-activated protein kinase 3 Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase 4Homo sapiens (human)Kd10.000011
Mitogen-activated protein kinase 6Homo sapiens (human)Kd10.000011
Mitogen-activated protein kinase 7Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase 8Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase 9Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase kinase kinase 1Homo sapiens (human)Kd15.232512
Mitogen-activated protein kinase kinase kinase 10Homo sapiens (human)Kd10.000011
Mitogen-activated protein kinase kinase kinase 11Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase kinase kinase 2Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 20Homo sapiens (human)Kd13.424723
Mitogen-activated protein kinase kinase kinase 3Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 4Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase kinase kinase 5Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase kinase kinase 6Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase 9Homo sapiens (human)Kd10.000011
Mitogen-activated protein kinase kinase kinase kinase 1Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase kinase kinase kinase 2Homo sapiens (human)Kd30.000012
Mitogen-activated protein kinase kinase kinase kinase 3Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase kinase kinase kinase 4Homo sapiens (human)Kd23.333323
Mitogen-activated protein kinase kinase kinase kinase 5Homo sapiens (human)Kd23.333323
Mitotic checkpoint serine/threonine-protein kinase BUB1Homo sapiens (human)Kd30.000012
Multifunctional protein ADE2Homo sapiens (human)Kd30.000012
Muscle, skeletal receptor tyrosine-protein kinaseHomo sapiens (human)Kd10.000011
Myosin light chain kinase 2, skeletal/cardiac muscleHomo sapiens (human)Kd10.000011
Myosin light chain kinase 3Homo sapiens (human)Kd30.000012
Myosin light chain kinase family member 4Homo sapiens (human)Kd10.000011
Myosin light chain kinase, smooth muscleGallus gallus (chicken)Kd10.000011
Myosin light chain kinase, smooth muscleHomo sapiens (human)Kd23.333323
Myosin-10Homo sapiens (human)Kd30.000012
Myosin-14Homo sapiens (human)Kd30.000012
Myosin-IIIaHomo sapiens (human)Kd10.000011
Myosin-IIIbHomo sapiens (human)Kd10.000011
Myotonin-protein kinaseHomo sapiens (human)Kd10.000011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Homo sapiens (human)Kd30.000012
Non-receptor tyrosine-protein kinase TNK1Homo sapiens (human)Kd23.333323
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)Kd23.333323
NT-3 growth factor receptorHomo sapiens (human)Kd10.000011
NUAK family SNF1-like kinase 1Homo sapiens (human)Kd10.000011
NUAK family SNF1-like kinase 2Homo sapiens (human)Kd23.333323
Nucleolar GTP-binding protein 1Homo sapiens (human)Kd30.000012
Obg-like ATPase 1Homo sapiens (human)Kd30.000012
PAS domain-containing serine/threonine-protein kinaseHomo sapiens (human)Kd30.000011
Peroxisomal acyl-coenzyme A oxidase 1Homo sapiens (human)Kd30.000011
Peroxisomal acyl-coenzyme A oxidase 3Homo sapiens (human)Kd30.000012
Phenylalanine--tRNA ligase beta subunitHomo sapiens (human)Kd30.000012
Phosphatidylethanolamine-binding protein 1Homo sapiens (human)Kd30.000012
Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaHomo sapiens (human)Kd10.000011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)Kd10.000022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaHomo sapiens (human)Kd30.000012
Phosphatidylinositol 5-phosphate 4-kinase type-2 betaHomo sapiens (human)Kd10.000011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaHomo sapiens (human)Kd30.000012
Phosphorylase b kinase gamma catalytic chain, liver/testis isoformHomo sapiens (human)Kd23.333323
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformHomo sapiens (human)Kd10.000011
Platelet-derived growth factor receptor alphaHomo sapiens (human)Kd10.000011
Platelet-derived growth factor receptor betaHomo sapiens (human)Kd23.333323
Probable ATP-dependent RNA helicase DDX6Homo sapiens (human)Kd30.000012
Protein kinase C alpha typeHomo sapiens (human)Kd30.000012
Protein kinase C beta typeHomo sapiens (human)Kd30.000012
Protein kinase C delta typeHomo sapiens (human)Kd23.333323
Protein kinase C epsilon typeHomo sapiens (human)Kd10.000011
Protein kinase C eta typeHomo sapiens (human)Kd10.000011
Protein kinase C iota typeHomo sapiens (human)Kd30.000012
Protein kinase C theta typeHomo sapiens (human)Kd23.333323
Protein kinase C zeta typeHomo sapiens (human)Kd30.000011
Protein-tyrosine kinase 2-betaHomo sapiens (human)Kd23.333323
Protein-tyrosine kinase 6Homo sapiens (human)Kd23.333323
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)Kd12.531534
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)Kd10.000011
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)Kd23.333323
Putative heat shock protein HSP 90-beta 2Homo sapiens (human)Kd30.000011
Pyridoxal kinaseHomo sapiens (human)Kd30.000012
Rab-like protein 3Homo sapiens (human)Kd30.000012
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)Kd23.333323
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)Kd23.333323
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)Kd23.333323
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)Kd10.000011
Ras-related protein Rab-10Homo sapiens (human)Kd30.000012
Ras-related protein Rab-27AHomo sapiens (human)Kd30.000012
Ras-related protein Rab-6AHomo sapiens (human)Kd30.000012
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)Kd0.043022
Receptor-interacting serine/threonine-protein kinase 1Homo sapiens (human)Kd10.000011
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)Kd13.589023
Receptor-interacting serine/threonine-protein kinase 3Homo sapiens (human)Kd15.184012
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)Kd11.508967
Rho-associated protein kinase 1Homo sapiens (human)Kd30.000012
Rho-associated protein kinase 2Homo sapiens (human)Kd30.000012
Ribosomal protein S6 kinase alpha-1Homo sapiens (human)Kd20.000034
Ribosomal protein S6 kinase alpha-2Homo sapiens (human)Kd10.000022
Ribosomal protein S6 kinase alpha-3Homo sapiens (human)Kd25.000024
Ribosomal protein S6 kinase alpha-4Homo sapiens (human)Kd22.000035
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)Kd22.000035
Ribosomal protein S6 kinase alpha-6Homo sapiens (human)Kd23.333336
Ribosomal protein S6 kinase beta-1Homo sapiens (human)Kd30.000012
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)Kd30.000012
RNA cytidine acetyltransferaseHomo sapiens (human)Kd30.000012
S-adenosylmethionine synthase isoform type-2Homo sapiens (human)Kd30.000012
Septin-9Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase 10Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase 16Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase 17AHomo sapiens (human)Kd10.000011
Serine/threonine-protein kinase 17BHomo sapiens (human)Kd10.000011
Serine/threonine-protein kinase 24Homo sapiens (human)Kd20.000022
Serine/threonine-protein kinase 25Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase 26Homo sapiens (human)Kd25.000024
Serine/threonine-protein kinase 3Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase 32BHomo sapiens (human)Kd10.000011
Serine/threonine-protein kinase 32CHomo sapiens (human)Kd10.000011
Serine/threonine-protein kinase 33Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase 36Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase 38-likeHomo sapiens (human)Kd20.000022
Serine/threonine-protein kinase 4Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase A-RafHomo sapiens (human)Kd30.000013
Serine/threonine-protein kinase ATRHomo sapiens (human)Kd30.000011
Serine/threonine-protein kinase B-rafHomo sapiens (human)Kd13.281234
Serine/threonine-protein kinase BRSK1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase BRSK2Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase Chk1Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase D1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase D2Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase D3Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase DCLK1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase DCLK2Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase DCLK3Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase ICKHomo sapiens (human)Kd30.000012
Serine/threonine-protein kinase LATS1Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase LATS2Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase MARK1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase MARK2Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase MRCK alphaHomo sapiens (human)Kd23.333323
Serine/threonine-protein kinase MRCK betaHomo sapiens (human)Kd23.333323
Serine/threonine-protein kinase MRCK gammaHomo sapiens (human)Kd23.333323
Serine/threonine-protein kinase N1Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase N2Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase N3Homo sapiens (human)Kd30.000013
Serine/threonine-protein kinase Nek1Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase Nek2Homo sapiens (human)Kd25.000024
Serine/threonine-protein kinase Nek3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase Nek5Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase Nek6Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase Nek7Homo sapiens (human)Kd20.000022
Serine/threonine-protein kinase Nek9Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase NLKHomo sapiens (human)Kd23.333323
Serine/threonine-protein kinase PAK 1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase PAK 2Homo sapiens (human)Kd25.000024
Serine/threonine-protein kinase PAK 3Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase PAK 4Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase PAK 5Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase PAK 6Homo sapiens (human)Kd20.000022
Serine/threonine-protein kinase pim-1Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase pim-2Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase pim-3Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase PLK1Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase PLK3Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase PLK4Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase receptor R3Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase RIO1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase RIO3Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase SIK1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase SIK2Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase SIK3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase STK11Homo sapiens (human)Kd23.333323
Serine/threonine-protein kinase TAO1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase TAO2Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase TAO3Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase TBK1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase TNNI3KHomo sapiens (human)Kd10.000011
Serine/threonine-protein kinase tousled-like 1Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase tousled-like 2Homo sapiens (human)Kd10.000011
Serine/threonine-protein kinase ULK1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase ULK3Homo sapiens (human)Kd30.000013
Serine/threonine-protein kinase/endoribonuclease IRE1Homo sapiens (human)Kd30.000012
Serine/threonine-protein kinase/endoribonuclease IRE2Homo sapiens (human)Kd30.000012
short transient receptor potential channel 6 isoform 1Mus musculus (house mouse)EC5044.670011
Signal recognition particle receptor subunit alphaHomo sapiens (human)Kd30.000012
Sodium-dependent dopamine transporter Homo sapiens (human)Kd0.490011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Kd0.040011
Sodium-dependent serotonin transporterHomo sapiens (human)Kd0.000111
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)Kd0.000111
SRSF protein kinase 1Homo sapiens (human)Kd10.000011
SRSF protein kinase 2Homo sapiens (human)Kd10.000011
STE20-like serine/threonine-protein kinase Homo sapiens (human)Kd23.333323
STE20-related kinase adapter protein alphaHomo sapiens (human)Kd30.000012
streptokinase A precursorStreptococcus pyogenes M1 GASEC5052.040323
Structural maintenance of chromosomes protein 1AHomo sapiens (human)Kd30.000012
Structural maintenance of chromosomes protein 2Homo sapiens (human)Kd30.000012
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrialHomo sapiens (human)Kd30.000012
Taste receptor type 2 member 38Homo sapiens (human)EC50600.000011
Testis-specific serine/threonine-protein kinase 1Homo sapiens (human)Kd10.000011
TGF-beta receptor type-1Homo sapiens (human)Kd23.333323
TGF-beta receptor type-2Homo sapiens (human)Kd23.333323
Thyroid hormone receptor-associated protein 3Homo sapiens (human)Kd30.000012
TRAF2 and NCK-interacting protein kinaseHomo sapiens (human)Kd23.333323
Tubulin alpha-1A chainRattus norvegicus (Norway rat)Kd0.260011
Tyrosine--tRNA ligase, cytoplasmicHomo sapiens (human)Kd30.000012
Tyrosine-protein kinase ABL1Homo sapiens (human)Kd11.194889
Tyrosine-protein kinase ABL2Homo sapiens (human)Kd23.333323
Tyrosine-protein kinase BlkHomo sapiens (human)Kd10.000011
Tyrosine-protein kinase BTKHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase CSKHomo sapiens (human)Kd26.000025
Tyrosine-protein kinase FerHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase Fes/FpsHomo sapiens (human)Kd25.000024
Tyrosine-protein kinase FgrHomo sapiens (human)Kd20.000022
Tyrosine-protein kinase FRKHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase FynHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase HCKHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase ITK/TSKHomo sapiens (human)Kd10.000011
Tyrosine-protein kinase JAK1Homo sapiens (human)Kd23.333323
Tyrosine-protein kinase JAK2Homo sapiens (human)Kd10.000011
Tyrosine-protein kinase JAK3Homo sapiens (human)Kd10.000011
Tyrosine-protein kinase LckHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase LynHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase MerHomo sapiens (human)Kd20.000022
Tyrosine-protein kinase receptor Tie-1Homo sapiens (human)Kd10.000011
Tyrosine-protein kinase receptor TYRO3Homo sapiens (human)Kd10.000011
Tyrosine-protein kinase receptor UFOHomo sapiens (human)Kd10.000011
Tyrosine-protein kinase SrmsHomo sapiens (human)Kd10.000011
Tyrosine-protein kinase SYKHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase TecHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase TXKHomo sapiens (human)Kd10.000011
Tyrosine-protein kinase YesHomo sapiens (human)Kd23.333323
Tyrosine-protein kinase ZAP-70Homo sapiens (human)Kd10.000011
U5 small nuclear ribonucleoprotein 200 kDa helicaseHomo sapiens (human)Kd30.000012
UMP-CMP kinase Homo sapiens (human)Kd30.000011
Uncharacterized aarF domain-containing protein kinase 5Homo sapiens (human)Kd30.000012
Uncharacterized protein FLJ45252Homo sapiens (human)Kd30.000012
Vascular endothelial growth factor receptor 1 Homo sapiens (human)Kd10.000011
Vascular endothelial growth factor receptor 2Homo sapiens (human)Kd10.000011
Vascular endothelial growth factor receptor 3Homo sapiens (human)Kd10.000011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrialHomo sapiens (human)Kd30.000012
Wee1-like protein kinaseHomo sapiens (human)Kd23.333323

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Beta-adrenergic receptor kinase 1Mus musculus (house mouse)MEC10.000011
Cytochrome P450 1A1Homo sapiens (human)Km803.000011
Cytochrome P450 1A1Rattus norvegicus (Norway rat)Ks870.000011
Cytochrome P450 1A2Homo sapiens (human)Km120.000011
Cytochrome P450 2B1Rattus norvegicus (Norway rat)Ks800.000011
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)Activity1.508055
Prostaglandin G/H synthase 2Homo sapiens (human)INH26.000011
protein AF-9 isoform aHomo sapiens (human)AC5014.655012
Sulfotransferase 1A1 Rattus norvegicus (Norway rat)Km92.000011
Taste receptor type 2 member 38Homo sapiens (human)Activity100.000012
toxin BClostridioides difficile 630AC5020.870011
UDP-glucuronosyltransferase 1-6Homo sapiens (human)Km2,200.000011
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)Km9,400.000011
UDP-glucuronosyltransferase 1A9Homo sapiens (human)Km20,900.000011