Roles > insulin secretagogue
Page last updated: 2024-08-05 15:06:42

insulin secretagogue

A secretagogue that causes the secretion of insulin.

ChEBI ID: 90415

Members (5)

MemberDefinitionClass
acetohexamideAn N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a p-acetylphenylsulfonyl group, while a hydrogen attached to the other nitrogen is replaced by a cyclohexyl group.acetohexamide
chlorpropamideAn N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.chlorpropamide
gliclazidegliclazide
glipizideAn N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.glipizide
tolbutamideAn N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.tolbutamide

Research

Studies (7,879)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19905,202 (66.02)18.7374
1990's941 (11.94)18.2507
2000's888 (11.27)29.6817
2010's691 (8.77)24.3611
2020's157 (1.99)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials739 (7.91%)5.53%
Reviews432 (4.62%)6.00%
Case Studies431 (4.61%)4.05%
Observational8 (0.09%)0.25%
Other7,734 (82.77%)84.16%

Protein Targets (101)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency41.275212
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency33.437215
AR proteinHomo sapiens (human)Potency22.609034
aryl hydrocarbon receptorHomo sapiens (human)Potency23.235422
arylsulfatase AHomo sapiens (human)Potency26.854511
ATAD5 protein, partialHomo sapiens (human)Potency32.629411
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency10.691011
Bloom syndrome protein isoform 1Homo sapiens (human)Potency25.060724
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency40.216412
Chain A, Beta-lactamaseEscherichia coli K-12Potency12.672812
Chain A, Ferritin light chainEquus caballus (horse)Potency0.251211
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency89.125111
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency3.546012
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency8.912511
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency30.258612
chromobox protein homolog 1Homo sapiens (human)Potency41.260823
cytochrome P450 2C19 precursorHomo sapiens (human)Potency20.155912
cytochrome P450 2C9 precursorHomo sapiens (human)Potency19.783012
cytochrome P450 2C9, partialHomo sapiens (human)Potency12.824814
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency14.219124
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency0.123011
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
estrogen nuclear receptor alphaHomo sapiens (human)Potency37.650837
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency7.654115
EWS/FLI fusion proteinHomo sapiens (human)Potency21.576448
farnesoid X nuclear receptorHomo sapiens (human)Potency3.440822
flap endonuclease 1Homo sapiens (human)Potency1.122011
Fumarate hydrataseHomo sapiens (human)Potency37.221211
GVesicular stomatitis virusPotency12.824814
GABA theta subunitRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency14.219112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency14.219112
gemininHomo sapiens (human)Potency2.197123
GLI family zinc finger 3Homo sapiens (human)Potency22.094527
GLS proteinHomo sapiens (human)Potency20.552322
glucocerebrosidaseHomo sapiens (human)Potency20.552312
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency25.118911
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency19.783016
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.622811
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency12.824814
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency1.068211
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency12.824818
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency5.011911
Interferon betaHomo sapiens (human)Potency13.237626
lamin isoform A-delta10Homo sapiens (human)Potency3.610914
lethal factor (plasmid)Bacillus anthracis str. A2012Potency3.981111
Microtubule-associated protein tauHomo sapiens (human)Potency44.668411
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency7.076822
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency63.095711
neuropeptide S receptor isoform AHomo sapiens (human)Potency5.011911
NFKB1 protein, partialHomo sapiens (human)Potency0.229024
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency60.645734
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency30.512312
phosphopantetheinyl transferaseBacillus subtilisPotency35.716812
polyproteinZika virusPotency37.221211
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency35.481311
pregnane X nuclear receptorHomo sapiens (human)Potency44.965512
RAR-related orphan receptor gammaMus musculus (house mouse)Potency21.133012
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency37.734125
retinoid X nuclear receptor alphaHomo sapiens (human)Potency37.684235
SMAD family member 2Homo sapiens (human)Potency38.351812
SMAD family member 3Homo sapiens (human)Potency38.351812
survival motor neuron protein isoform dHomo sapiens (human)Potency1.367613
thioredoxin reductaseRattus norvegicus (Norway rat)Potency1.075112
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.998912
thyroid stimulating hormone receptorHomo sapiens (human)Potency10.345529
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency25.118911
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency58.196511

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AlbuminHomo sapiens (human)Ki39,810,700,000.000012
Aldo-keto reductase family 1 member C1Homo sapiens (human)IC50300.000011
Aldo-keto reductase family 1 member C2 Homo sapiens (human)IC501,000.000011
Aldo-keto reductase family 1 member C3Homo sapiens (human)IC5019.620011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000014
Bile salt export pumpHomo sapiens (human)IC50502.1385413
Bile salt export pumpRattus norvegicus (Norway rat)IC501,000.000013
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000014
Cytochrome P450 2C9 Homo sapiens (human)IC500.392022
Cytochrome P450 2C9 Homo sapiens (human)Ki70.000011
Cytochrome P450 3A4Homo sapiens (human)IC507.447311
Lanosterol 14-alpha demethylaseHomo sapiens (human)IC50200.000012
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000014
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)Ki47.500024
UDP-glucuronosyltransferase 1-6Homo sapiens (human)IC50296.200015
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)IC50296.200015
UDP-glucuronosyltransferase 1A4Homo sapiens (human)IC50296.200015
UDP-glucuronosyltransferase 2B10 Homo sapiens (human)IC50296.200015
UDP-glucuronosyltransferase 2B7Homo sapiens (human)IC50296.200015

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AlbuminHomo sapiens (human)Kd6.025611
AlbuminRattus norvegicus (Norway rat)Kd7.970011
Potassium channel subfamily K member 2Homo sapiens (human)EC50784.000011