EC 2.7.11.22 (cyclin-dependent kinase) inhibitor

An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).

ChEBI ID: 82665

Members (19)

Member	Definition	Class
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)	A member of the class of benzodioxoles that is 1,3-benzodioxole substituted by a (2-anilino-5-oxo-1,5-dihydro-4H-imidazol-4-ylidene)methyl group at position 5. It is an inhibitor of DYRK1A, DYRK2, CLK1, and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 muM, respectively).	leucettine L41
(R)-DRF053	A member of the class of 2,6-diaminopurines that is 2,6-diamiopurine which is substituted by an isopropyl group at position 9 and in which the amino groups at positions 2 and 6 are substituted by a 1-hydroxybutan-2-yl and 3-(pyridin-2-yl)phenyl groups, respectively (the R enantiomer). A cyclin dependent kinase inhibitor, widely used as its hydrochloride hydrate.	(R)-DRF053
5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one	A member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol.	rohitukine
adapalene	A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.	adapalene
alsterpaullone	An organic heterotetracyclic compound that is 1,3-dihydro-2H-1-benzazepin-2-one which shares its 4-5 bond with the 3-2 bond of 5-nitro-1H-indole.	alsterpaullone
alvocidib	A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.	alvocidib
at 7519	A member of the class of pryrazoles that is 4-amino-1H-pyrazole-3-carboxylic acid in which the primary amino group has been acylated by a 2,6-dichlorobenzoyl group and in which the carboxylic acid has been converted into a carboxamide by formal condensation with the primary amino group of 4-aminopiperidine.	4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide
bms 387032	A secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties.	N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide
bohemine	Purine substituted on C-2, C-6 and N-9 with (3-hydroxypropyl)amino, benzylamino and isopropyl groups respectively; a synthetic, cell-permeable, cyclin-dependent kinase (CDK) inhibitor that is structurally similar to olomoucine and roscovitine.	bohemine
can 508	A member of the class of pyrazoles that is 1H-pyrazole substituted by amino, (4-hydroxyphenyl)diazenyl, and amino groups at positions 3, 4 and 5, respectively. It is a CDK9 inhibitor (IC50 = 0.35 muM) with 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes.	CAN-508
CCT251545	A chloropyridine that is 3-chloropyridine substituted by a 1-oxo-2,8-diazaspiro[4.5]decan-8-yl group and a 4-(1-methyl-1H-pyrazol-4-yl)phenyl group at positions 4 and 5, respectively. It is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM) and a potent and selective chemical probe for cyclin-dependent kinases CDK8 and CDK19.	CCT251545
cyc 202	2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.	seliciclib
hmr 1275	A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.	alvocidib hydrochloride
ldc4297	A pyrazolotriazine that is pyrazolo[1,5-a][1,3,5]triazine substituted by a piperidin-3-yloxy group, [2-(1H-pyrazol-1-yl)benzyl]nitrilo group and an isopropyl group at positions 2, 4 and 8 respectively. It is a potent and selective CDK7 inhibitor and exhibits antiviral activity.	LDC4297
nsc 664704	An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta).	kenpaullone
olomoucine	A 9H-purine that is substituted by a (2-hydroxyethyl)nitrilo, benzylnitrilo and a methyl group at positions 2,6 and 9, respectively. It is a cyclin-dependent kinase inhibitor.	olomoucine
palbociclib	A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.	palbociclib
paullone	An indolobenzazepine that is 5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepine carrying an oxo substituent at position 6.	paullone
THZ531	A member of the class of indoles that is 5-chloro-4-(1H-indol-3-yl)-N-[(3R)-piperidin-3-yl]pyrimidin-2-amine in which the piperidine NH group is substituted by a 4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}benzoyl group. It is a first-in-class CDK12 and CDK13 covalent kinase inhibitor with IC50 of 158 nM and 69 nM, respectively.	THZ531

Research

Studies (3,131)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	2 (0.06)	18.7374
1990's	169 (5.40)	18.2507
2000's	1,030 (32.90)	29.6817
2010's	1,336 (42.67)	24.3611
2020's	594 (18.97)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	352 (9.78%)	5.53%
Reviews	372 (10.34%)	6.00%
Case Studies	99 (2.75%)	4.05%
Observational	17 (0.47%)	0.25%
Other	2,758 (76.65%)	84.16%

Protein Targets (745)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-lipoxygenase, partial	Homo sapiens (human)	Potency	15.8489	1	1
67.9K protein	Vaccinia virus	Potency	8.5259	2	8
activating transcription factor 6	Homo sapiens (human)	Potency	3.0985	1	2
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	24.3506	1	3
AR protein	Homo sapiens (human)	Potency	6.4854	7	9
arylsulfatase A	Homo sapiens (human)	Potency	5.3582	1	1
ATAD5 protein, partial	Homo sapiens (human)	Potency	14.7459	2	2
Ataxin-2	Homo sapiens (human)	Potency	19.9138	2	2
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	15.8489	1	1
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	0.0168	1	1
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	37.9330	1	1
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	14.6892	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	46.8840	2	3
BRCA1	Homo sapiens (human)	Potency	18.6298	1	2
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	0.2371	1	1
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	0.2660	1	1
caspase-3	Homo sapiens (human)	Potency	0.2371	1	1
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	0.2660	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	1.6160	2	3
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	19.7830	2	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	25.1189	1	2
Chain A, Cruzipain	Trypanosoma cruzi	Potency	39.8107	1	2
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	25.1189	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	39.8107	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	22.3951	2	4
Chain B, HADH2 protein	Homo sapiens (human)	Potency	39.8107	1	1
chromobox protein homolog 1	Homo sapiens (human)	Potency	56.2341	1	1
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	10.0000	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	9.0810	1	2
cytochrome P450 2D6	Homo sapiens (human)	Potency	25.1097	1	3
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	1.6064	1	3
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	13.8931	2	5
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	11.4612	1	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	0.1123	1	2
D(1A) dopamine receptor	Homo sapiens (human)	Potency	1.6339	1	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	35.4813	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	23.7150	1	1
endonuclease IV	Escherichia coli	Potency	6.3096	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	2.1775	8	14
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	1.6785	1	1
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	6.4034	10	17
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	23.6677	1	3
EWS/FLI fusion protein	Homo sapiens (human)	Potency	8.3759	4	19
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	13.1450	2	3
flap endonuclease 1	Homo sapiens (human)	Potency	4.2284	1	1
Fumarate hydratase	Homo sapiens (human)	Potency	9.9503	1	4
G	Vesicular stomatitis virus	Potency	9.0810	1	2
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	13.6758	1	3
geminin	Homo sapiens (human)	Potency	9.0166	4	8
GLI family zinc finger 3	Homo sapiens (human)	Potency	0.0626	2	2
glp-1 receptor, partial	Homo sapiens (human)	Potency	2.5788	2	2
GLS protein	Homo sapiens (human)	Potency	22.3872	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	7.3461	2	3
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	0.3808	1	2
Glycoprotein hormones alpha chain	Homo sapiens (human)	Potency	0.7943	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	0.0521	1	1
heat shock protein beta-1	Homo sapiens (human)	Potency	26.7776	2	2
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	10.0000	1	3
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	35.7168	1	2
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	11.9845	2	2
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	9.0810	1	2
huntingtin isoform 2	Homo sapiens (human)	Potency	1.9293	2	3
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	16.0556	2	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	3.1623	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	9.0810	1	4
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	2.8184	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	31.6228	1	1
Integrin beta-3	Homo sapiens (human)	Potency	31.6228	1	1
Interferon beta	Homo sapiens (human)	Potency	7.4729	3	21
lamin isoform A-delta10	Homo sapiens (human)	Potency	12.2389	2	4
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	12.5893	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	15.8489	1	1
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	14.1254	1	1
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	25.1189	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	44.6684	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	7.0795	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	4.1524	2	4
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	0.5174	1	1
Nrf2	Homo sapiens (human)	Potency	18.3564	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	10.7651	2	4
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	1.8473	2	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	21.3138	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	30.3001	1	2
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	4.2812	2	4
Ornithine decarboxylase	Rattus norvegicus (Norway rat)	Potency	3.1623	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	32.7498	1	3
Parkin	Homo sapiens (human)	Potency	4.1988	2	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	55.0085	2	2
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	7.1144	2	2
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	19.0338	1	2
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	6.8547	3	4
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	6.8989	2	3
polyprotein	Zika virus	Potency	9.9503	1	4
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	35.4813	1	1
PPM1D protein	Homo sapiens (human)	Potency	7.6977	1	12
pregnane X nuclear receptor	Homo sapiens (human)	Potency	0.1059	1	1
progesterone receptor	Homo sapiens (human)	Potency	0.0841	1	1
pyruvate kinase	Leishmania mexicana mexicana	Potency	6.3096	2	2
pyruvate kinase PKM isoform b	Homo sapiens (human)	Potency	3.1623	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	2.8412	2	4
ras-related protein Rab-9A	Homo sapiens (human)	Potency	0.3663	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	31.7450	1	2
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	0.9421	3	5
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	0.0937	2	2
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	16.5111	3	3
SMAD family member 2	Homo sapiens (human)	Potency	0.6740	1	1
SMAD family member 3	Homo sapiens (human)	Potency	0.6740	1	1
Smad3	Homo sapiens (human)	Potency	1.4353	3	6
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	16.7006	1	2
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	15.4983	1	8
TDP1 protein	Homo sapiens (human)	Potency	22.4858	2	16
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	22.4510	3	5
Thrombopoietin	Homo sapiens (human)	Potency	0.1585	2	2
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	0.6647	3	5
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	59.8901	2	3
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	39.8107	2	2
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	25.5264	1	4
USP1 protein, partial	Homo sapiens (human)	Potency	79.4328	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	0.0617	2	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	10.4736	3	4
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	28.1838	1	1
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	0.3808	1	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Homo sapiens (human)	IC50	10.0000	1	1
[Tau protein] kinase	Sus scrofa (pig)	IC50	19.6200	9	10
10 kDa chaperonin	Escherichia coli	IC50	3.6000	2	2
10 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	2.3000	1	1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	40.0000	1	1
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	IC50	40.0000	1	1
5-hydroxytryptamine receptor 1D	Rattus norvegicus (Norway rat)	IC50	40.0000	1	1
5-hydroxytryptamine receptor 1F	Rattus norvegicus (Norway rat)	IC50	40.0000	1	1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	IC50	516.5000	1	4
60 kDa chaperonin	Escherichia coli K-12	IC50	250.0000	1	1
60 kDa chaperonin	Escherichia coli	IC50	3.6000	2	2
60 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	2.3000	1	1
Acetylcholinesterase	Mus musculus (house mouse)	IC50	0.0210	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.4370	1	2
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.4370	1	2
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.4370	1	2
Aspartate aminotransferase, cytoplasmic	Homo sapiens (human)	IC50	21.7900	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	1
Aurora kinase A	Homo sapiens (human)	IC50	10.0000	2	2
Bile salt export pump	Homo sapiens (human)	IC50	133.0000	1	1
cAMP-dependent protein kinase catalytic subunit alpha	Bos taurus (cattle)	IC50	357.9350	1	6
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	IC50	1,002.0000	4	5
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	IC50	1,002.0000	4	5
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	IC50	1,002.0000	4	5
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	1
Cannabinoid receptor 1	Homo sapiens (human)	IC50	0.3140	1	1
Cannabinoid receptor 2	Mus musculus (house mouse)	IC50	0.0620	1	1
Casein kinase I isoform alpha	Homo sapiens (human)	IC50	17.5035	4	4
Casein kinase I isoform alpha	Rattus norvegicus (Norway rat)	IC50	190.1300	2	12
Casein kinase I isoform alpha	Sus scrofa (pig)	IC50	10.0000	1	2
Casein kinase I isoform delta	Homo sapiens (human)	IC50	13.5000	2	2
Casein kinase I isoform epsilon	Homo sapiens (human)	IC50	17.0000	1	1
Casein kinase I isoform gamma-1	Homo sapiens (human)	IC50	17.0000	1	1
Casein kinase I isoform gamma-2	Homo sapiens (human)	IC50	17.0000	1	1
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	6.9433	3	3
Casein kinase II subunit alpha 3	Homo sapiens (human)	IC50	0.5100	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	0.4150	2	2
Casein kinase II subunit beta	Homo sapiens (human)	IC50	0.4150	2	2
CDK-activating kinase assembly factor MAT1	Homo sapiens (human)	IC50	3.2404	9	11
CDK-activating kinase assembly factor MAT1	Homo sapiens (human)	Ki	2.8000	1	1
cGMP-dependent protein kinase 1	Bos taurus (cattle)	IC50	357.9350	1	6
Chain A, Cyclin-dependent kinase 9	Homo sapiens (human)	IC50	0.7400	1	1
Chain A, Extracellular Regulated Kinase 2	Rattus norvegicus (Norway rat)	IC50	27.0000	1	2
Chain A, Glycogen Synthase Kinase-3 Beta	Homo sapiens (human)	IC50	0.0040	1	2
Chain A, Homo sapiens cyclin-dependent kinase 2	Homo sapiens (human)	IC50	0.4000	1	1
Chain A, MAP KINASE P38	Homo sapiens (human)	IC50	27.0000	1	1
Chain A, Protein (glycogen Phosphorylase)	Oryctolagus cuniculus (rabbit)	IC50	1.0000	1	1
Chain A, PROTEIN (MAP KINASE P38)	Homo sapiens (human)	IC50	27.0000	1	3
Chain B, Cell division protein kinase 6	Homo sapiens (human)	IC50	0.0150	1	2
Chain B, Glycogen Synthase Kinase-3 Beta	Homo sapiens (human)	IC50	0.0040	1	1
Chain C, Cell division protein kinase 2	Homo sapiens (human)	IC50	0.2100	1	2
Cyclin homolog	Herpesvirus saimiri (strain 11)	IC50	0.1850	1	4
Cyclin-A1	Homo sapiens (human)	IC50	6.6543	19	23
Cyclin-A1	Homo sapiens (human)	Ki	23.1467	1	3
Cyclin-A2	Homo sapiens (human)	IC50	5.6634	55	76
Cyclin-A2	Homo sapiens (human)	Ki	14.8968	3	5
Cyclin-C	Homo sapiens (human)	IC50	0.0530	2	2
Cyclin-C	Homo sapiens (human)	Ki	0.0090	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	30.7516	87	154
Cyclin-dependent kinase 1	Oryzias latipes (Japanese medaka)	IC50	5.6153	10	35
Cyclin-dependent kinase 1	Homo sapiens (human)	Ki	1.1560	4	5
Cyclin-dependent kinase 12	Homo sapiens (human)	IC50	2.1337	5	5
Cyclin-dependent kinase 13	Homo sapiens (human)	IC50	0.2650	3	3
Cyclin-dependent kinase 14	Homo sapiens (human)	IC50	0.0198	1	1
Cyclin-dependent kinase 19	Homo sapiens (human)	IC50	0.0055	2	2
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	11.0673	133	206
Cyclin-dependent kinase 2	Homo sapiens (human)	Ki	8.8562	7	10
Cyclin-dependent kinase 3	Homo sapiens (human)	IC50	0.3600	3	3
Cyclin-dependent kinase 4	Homo sapiens (human)	IC50	38.0201	65	107
Cyclin-dependent kinase 4	Homo sapiens (human)	Ki	0.2588	4	4
Cyclin-dependent kinase 5 activator 1	Homo sapiens (human)	IC50	29.8806	44	81
Cyclin-dependent kinase 5 activator 1	Homo sapiens (human)	Ki	0.0180	1	1
Cyclin-dependent kinase 6	Homo sapiens (human)	IC50	8.4338	31	38
Cyclin-dependent kinase 6	Homo sapiens (human)	Ki	0.0270	1	1
Cyclin-dependent kinase 7	Homo sapiens (human)	IC50	6.4475	41	62
Cyclin-dependent kinase 7	Homo sapiens (human)	Ki	3.9000	2	2
Cyclin-dependent kinase 8	Homo sapiens (human)	IC50	0.0377	4	4
Cyclin-dependent kinase 8	Homo sapiens (human)	Ki	0.0090	1	1
Cyclin-dependent kinase 9	Homo sapiens (human)	IC50	5.0959	59	86
Cyclin-dependent kinase 9	Homo sapiens (human)	Ki	0.2306	4	7
Cyclin-dependent-like kinase 5	Bos taurus (cattle)	IC50	0.2000	1	1
Cyclin-dependent-like kinase 5	Homo sapiens (human)	IC50	24.0132	56	102
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Ki	0.0180	1	1
Cyclin-H	Homo sapiens (human)	IC50	6.5655	31	43
Cyclin-H	Homo sapiens (human)	Ki	3.9000	2	2
Cyclin-K	Homo sapiens (human)	IC50	0.5213	8	8
Cyclin-T1	Homo sapiens (human)	IC50	5.3597	45	61
Cyclin-T1	Homo sapiens (human)	Ki	0.3214	3	5
Cyclin-Y	Homo sapiens (human)	IC50	0.0198	1	1
Cytochrome P450 1A2	Homo sapiens (human)	Ki	5.0000	1	1
Cytochrome P450 2C19	Homo sapiens (human)	Ki	5.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	Ki	5.0000	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	0.0710	1	1
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	IC50	10.0000	1	2
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	IC50	10.0000	1	1
Dual specificity protein kinase CLK1	Homo sapiens (human)	IC50	6.6903	2	3
Dual specificity protein kinase CLK1	Mus musculus (house mouse)	IC50	0.9920	7	7
Dual specificity protein kinase CLK2	Mus musculus (house mouse)	IC50	0.4700	4	4
Dual specificity protein kinase CLK3	Mus musculus (house mouse)	IC50	6.8400	5	5
Dual specificity protein kinase CLK4	Mus musculus (house mouse)	IC50	0.1845	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	IC50	9.3096	13	18
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Mus musculus (house mouse)	IC50	5.0000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	IC50	4.4843	6	7
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	IC50	0.2840	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	IC50	0.4084	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 3	Homo sapiens (human)	IC50	2.8125	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 4	Homo sapiens (human)	IC50	0.5200	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	103.1200	4	5
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	10.0000	1	1
Focal adhesion kinase 1	Homo sapiens (human)	IC50	40.0000	1	1
G1/S-specific cyclin-D1	Homo sapiens (human)	IC50	47.1142	50	73
G1/S-specific cyclin-D1	Homo sapiens (human)	Ki	0.0350	2	2
G1/S-specific cyclin-D2	Homo sapiens (human)	IC50	0.1680	7	7
G1/S-specific cyclin-D3	Homo sapiens (human)	IC50	14.5715	18	18
G1/S-specific cyclin-D3	Homo sapiens (human)	Ki	0.0270	1	1
G1/S-specific cyclin-E1	Homo sapiens (human)	IC50	21.0577	55	88
G1/S-specific cyclin-E1	Homo sapiens (human)	Ki	6.9050	2	2
G1/S-specific cyclin-E2	Homo sapiens (human)	IC50	22.2419	15	20
G1/S-specific cyclin-E2	Homo sapiens (human)	Ki	13.3000	1	1
G2/mitotic-specific cyclin-B	Marthasterias glacialis (spiny starfish)	IC50	5.6153	10	35
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	34.5515	66	112
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	Ki	2.5950	2	2
G2/mitotic-specific cyclin-B2	Homo sapiens (human)	IC50	8.5461	19	30
G2/mitotic-specific cyclin-B3	Homo sapiens (human)	IC50	8.5461	19	30
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus (rabbit)	IC50	1.2000	1	1
Glycogen synthase kinase 3	Plasmodium falciparum 3D7	IC50	10.0000	1	2
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	IC50	19.1758	9	10
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Ki	0.2310	1	1
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	9.0363	28	36
Glycogen synthase kinase-3 beta	Rattus norvegicus (Norway rat)	IC50	98.5770	4	22
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Ki	0.3450	1	1
Glycogen synthase kinase-3 beta	Sus scrofa (pig)	IC50	19.6200	9	10
Insulin receptor	Homo sapiens (human)	IC50	55.0000	2	2
Insulin-like growth factor 1 receptor	Homo sapiens (human)	IC50	25.0000	1	1
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	5.0355	2	2
La-related protein 7	Homo sapiens (human)	Ki	0.0030	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	IC50	10.0000	1	1
Mitogen-activated protein kinase 1	Homo sapiens (human)	IC50	23.1625	5	12
Mitogen-activated protein kinase 1	Rattus norvegicus (Norway rat)	IC50	52.3333	2	3
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	63.5000	1	2
Mitogen-activated protein kinase 3	Homo sapiens (human)	IC50	26.5000	4	6
Mitogen-activated protein kinase 8	Homo sapiens (human)	IC50	170.0000	1	1
MO15-related protein kinase Pfmrk	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	461.7143	2	7
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	133.0000	1	1
NAD-dependent protein deacetylase sirtuin-1	Homo sapiens (human)	IC50	29.0000	2	2
NAD-dependent protein deacetylase sirtuin-2	Homo sapiens (human)	IC50	48.9000	3	4
NUAK family SNF1-like kinase 1	Homo sapiens (human)	IC50	5.0000	1	1
nuclear receptor subfamily 0 group B member 1	Homo sapiens (human)	IC50	0.8335	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	IC50	10.0000	1	1
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	10.0000	1	1
Poly [ADP-ribose] polymerase tankyrase-1	Homo sapiens (human)	IC50	10.0000	1	1
Poly [ADP-ribose] polymerase tankyrase-2	Homo sapiens (human)	IC50	15.0000	1	1
Protein kinase C alpha type	Homo sapiens (human)	IC50	12.4667	6	6
Protein kinase C alpha type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein kinase C beta type	Homo sapiens (human)	IC50	23.2000	5	5
Protein kinase C beta type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein kinase C delta type	Homo sapiens (human)	IC50	7.9725	4	4
Protein kinase C delta type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein kinase C epsilon type	Homo sapiens (human)	IC50	7.8700	4	4
Protein kinase C epsilon type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein kinase C eta type	Homo sapiens (human)	IC50	19.0000	4	4
Protein kinase C eta type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein kinase C gamma type	Homo sapiens (human)	IC50	17.7500	4	4
Protein kinase C gamma type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein kinase C iota type	Homo sapiens (human)	IC50	10.3333	3	3
Protein kinase C theta type	Homo sapiens (human)	IC50	10.3333	3	3
Protein kinase C theta type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein kinase C theta type	Homo sapiens (human)	Ki	0.0610	1	1
Protein kinase C zeta type	Homo sapiens (human)	IC50	10.3333	3	3
Protein kinase C zeta type	Rattus norvegicus (Norway rat)	IC50	507.0000	1	2
Protein Wnt-3a	Homo sapiens (human)	IC50	0.0070	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	24.5000	2	2
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	20.4000	2	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	5.4933	3	3
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	1.5000	1	2
Retinoic acid receptor alpha	Homo sapiens (human)	Ki	1.1000	1	1
Retinoic acid receptor beta	Homo sapiens (human)	Ki	0.0340	1	1
Retinoic acid receptor gamma	Homo sapiens (human)	Ki	0.1300	1	1
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	IC50	10.0000	1	1
Ribosomal protein S6 kinase beta-2	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	IC50	40.0000	1	1
Serine/threonine-protein kinase D1	Homo sapiens (human)	IC50	10.3333	3	3
Serine/threonine-protein kinase D3	Homo sapiens (human)	IC50	10.3333	3	3
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	IC50	6.9000	1	1
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	IC50	2.0600	3	3
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	IC50	100.0000	1	1
Squalene synthase	Rattus norvegicus (Norway rat)	IC50	0.1700	1	1
steroidogenic factor 1	Homo sapiens (human)	IC50	67.5180	1	1
Synapsin-1	Bos taurus (cattle)	IC50	1.0000	1	1
Thiosulfate sulfurtransferase	Homo sapiens (human)	IC50	100.0000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	46.0000	5	5
Tyrosine-protein kinase Fyn	Homo sapiens (human)	IC50	10.0000	1	1
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	IC50	27.4250	2	2
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC50	0.0631	1	1
Tyrosine-protein kinase Lck	Homo sapiens (human)	IC50	11.7740	4	5
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	IC50	45.0000	2	2
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	35.8000	2	3
Vitamin K-dependent protein C	Homo sapiens (human)	IC50	0.6659	4	32
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	IC50	23.4000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	5
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	6
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	17.9000	4	12
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	2	6
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	6
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	5
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	5
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	5
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	5
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	20.7692	3	13
Activin receptor type-1	Homo sapiens (human)	Kd	18.6500	3	12
Activin receptor type-1B	Homo sapiens (human)	Kd	20.0000	3	12
Activin receptor type-2A	Homo sapiens (human)	Kd	8.8500	2	6
Activin receptor type-2B	Homo sapiens (human)	Kd	17.7091	3	11
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	5
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	5
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	3
Adenosine kinase	Homo sapiens (human)	Kd	24.4882	1	5
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	5
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	5
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	5
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	5.6067	2	6
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	10.0000	2	6
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	2	6
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	15.8924	3	11
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	5
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	5
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	5
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	3
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	3
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	19.0909	3	11
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	8.8167	2	6
Aurora kinase A	Homo sapiens (human)	Kd	18.6182	3	11
Aurora kinase B	Homo sapiens (human)	Kd	20.0000	3	12
Aurora kinase C	Homo sapiens (human)	Kd	9.1667	2	6
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	2	6
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	5
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	18.7696	3	11
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	19.0909	3	11
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	20.0643	2	7
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	19.0909	3	11
Breakpoint cluster region protein	Homo sapiens (human)	Kd	30.0000	1	5
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	10.0000	1	3
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	5.7396	3	7
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	12.9132	4	12
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	10.0000	2	6
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	2	6
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	10.0000	2	6
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	6.3857	3	7
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	8.1857	3	7
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	19.3000	3	12
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	18.4182	3	11
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	15.6236	3	11
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	19.0909	3	11
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	19.0909	3	11
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	6
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	2	6
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	5
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	20.5125	2	8
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	8.7333	2	6
Casein kinase I isoform delta	Homo sapiens (human)	Kd	14.3345	3	11
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	13.7324	4	12
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	17.0417	4	12
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	18.5692	4	13
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	19.4083	3	12
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	6
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	14.2791	3	11
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	7.7667	1	3
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	19.0909	3	11
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	6
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	3
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	4
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	14.0780	3	11
Cyclin-A1	Homo sapiens (human)	EC50	0.1510	1	1
Cyclin-A2	Homo sapiens (human)	EC50	0.1510	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	12.8300	1	5
Cyclin-dependent kinase 10	Homo sapiens (human)	Kd	30.0000	1	5
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	5.0169	2	6
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	5.0341	2	6
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	12.1148	1	5
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	7.8537	2	8
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	1.9360	2	6
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	0.3773	1	3
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	3.5428	4	13
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	3.8431	3	11
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	6.0431	3	7
Cyclin-dependent kinase 19	Mus musculus (house mouse)	EC50	0.0200	1	1
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	2.5523	2	6
Cyclin-dependent kinase 2	Homo sapiens (human)	EC50	0.1510	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	5.3445	4	13
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	14.6356	3	11
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	5.8951	3	11
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	6.9564	1	5
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	3.7594	3	11
Cyclin-dependent kinase 8	Mus musculus (house mouse)	EC50	0.0200	1	1
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	3.7733	2	6
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	2.2337	3	11
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	3
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	3.6803	1	3
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	7.1333	1	3
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	15.0019	2	6
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	5.5304	4	13
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	14.6200	4	12
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	2
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	4
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	2	6
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	7
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	6
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	6
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	3	9
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	5
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	6
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	19.0909	3	11
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	5
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	5
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	5
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	5
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	8.0667	1	3
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	20.0000	3	12
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	19.0909	3	11
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	18.2909	3	11
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	12.6168	3	9
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	21.2725	2	8
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	19.0909	3	11
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	3
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	5.5263	5	14
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	11.5164	5	14
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	8.6984	5	11
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	13.5975	5	12
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	15.7909	4	11
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	19.0909	3	11
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	8.4763	3	9
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	4.0122	4	8
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	4.3875	2	4
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	5
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	2	6
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	5
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	5
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	5
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	14.0375	3	8
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	17.7273	3	11
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	7.7667	2	6
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	19.0909	3	11
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	17.2917	4	12
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	10.0000	2	6
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	19.0909	3	11
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	10.0000	2	6
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	7.6714	3	7
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	19.0909	3	11
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	20.0000	3	12
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	19.0909	3	11
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	21.4286	2	7
Epidermal growth factor receptor	Homo sapiens (human)	Kd	9.8207	23	71
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	19.0909	3	11
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	17.6160	2	8
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	1
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	5
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	5
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	19.0909	3	11
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	2	6
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	4	12
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	10.0000	2	6
Focal adhesion kinase 1	Homo sapiens (human)	Kd	19.0909	3	11
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	1	3
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	2
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	14.8102	1	5
Glycine receptor subunit alpha-1	Homo sapiens (human)	EC50	1.3000	1	1
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	6
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	24.7138	1	5
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	25.3535	1	6
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	6.2022	4	12
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	6.6038	3	11
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	5
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	4
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	5
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	14.2155	5	17
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	16.6667	3	9
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	4.7050	2	4
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	5.2333	1	3
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	4.1325	2	4
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	7.3333	1	3
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	3
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	1	3
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	3
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	17.8364	3	11
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	4
Insulin receptor	Homo sapiens (human)	Kd	19.0909	3	11
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	2	6
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	19.0909	3	11
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	4
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	8.4000	2	6
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	19.0522	3	9
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	17.8000	3	11
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	21.4375	2	8
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	7.1667	2	6
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	7.4000	2	6
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	7.0667	1	3
LIM domain kinase 1	Homo sapiens (human)	Kd	19.0909	3	11
LIM domain kinase 2	Homo sapiens (human)	Kd	20.0000	3	12
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	3
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	7.6000	2	6
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	22.5000	2	8
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	19.0909	3	11
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	19.0909	3	11
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	7.9333	2	6
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	6.0857	3	7
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	19.0909	3	11
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	19.0909	3	11
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	9.5911	15	45
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	18.2909	3	11
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	3
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	3
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	20.0000	3	12
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	8.7333	1	3
Midasin	Homo sapiens (human)	Kd	30.0000	1	5
Misshapen-like kinase 1	Homo sapiens (human)	Kd	12.8250	2	4
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	17.9000	3	11
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	2	6
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	14.6382	3	11
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	8.0333	2	6
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	6.8333	2	6
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	9.7498	3	11
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	18.3273	3	11
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	16.6233	3	11
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	22.5000	2	8
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	8.4000	2	6
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	22.0125	2	8
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	22.4875	2	8
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	20.0000	3	12
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	22.5000	2	8
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	4.7667	1	3
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	8.5667	2	6
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	17.8727	3	11
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	21.2611	2	8
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	18.0909	3	11
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	19.0909	3	11
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	19.0909	3	11
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	3
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	5
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	6
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	6.9933	2	6
Myosin light chain kinase 3	Homo sapiens (human)	Kd	20.2429	2	7
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	8.7333	2	6
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	7.2333	1	3
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	20.0000	3	12
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	5
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	5
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	2	6
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	2	6
Myotonin-protein kinase	Homo sapiens (human)	Kd	5.4000	2	6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	5
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	19.0909	3	11
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	13.8345	4	14
NPYLR7B	Aedes aegypti (yellow fever mosquito)	EC50	20.0000	1	1
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	2	6
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	2	6
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	14.6200	3	10
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	5
Nucleoside diphosphate kinase B	Homo sapiens (human)	Kd	30.0000	1	1
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	4
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	5
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	3.4747	1	3
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	5
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	6
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	5
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	4
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	2	6
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	7.5333	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	12	36
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	24.0416	1	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	2	6
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	14.4295	2	8
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	15.6883	4	12
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	5.3333	2	6
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	9.3167	2	6
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	19.0909	3	11
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	6
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	3
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	5
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	5
Protein kinase C delta type	Homo sapiens (human)	Kd	14.7975	3	11
Protein kinase C epsilon type	Homo sapiens (human)	Kd	6.7933	2	6
Protein kinase C eta type	Homo sapiens (human)	Kd	6.7833	2	6
Protein kinase C iota type	Homo sapiens (human)	Kd	22.5000	2	8
Protein kinase C theta type	Homo sapiens (human)	Kd	17.3364	3	11
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	3
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	18.4636	3	11
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	19.0909	3	11
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	14.3478	7	23
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	2	6
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	19.0909	3	11
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	5
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	6
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	5
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.0909	3	11
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.0909	3	11
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.0909	3	11
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	6
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	5
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	5
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	4
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	10.0000	2	6
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	9.7333	1	3
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	8.3333	1	3
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	6
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	19.0909	3	11
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	5
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	3
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	10.9439	13	41
Retinoic acid receptor alpha	Homo sapiens (human)	EC50	0.0220	1	1
Retinoic acid receptor beta	Homo sapiens (human)	EC50	0.0020	1	1
Retinoic acid receptor gamma	Homo sapiens (human)	EC50	0.0031	1	1
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	21.4000	2	8
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	21.4375	2	8
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	6.8833	1	3
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	6.9933	1	3
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	12.2576	5	17
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	7.2929	5	14
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	18.2727	3	11
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	14.8588	5	17
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	15.0556	6	18
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	14.3353	5	17
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	21.7125	2	8
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	30.0000	1	5
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	6
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	5
Septin-9	Homo sapiens (human)	Kd	30.0000	1	5
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	17.2699	3	11
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	5.8300	2	6
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	6.9857	3	7
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	16.6667	3	9
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	18.9818	3	11
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	8.5000	1	3
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	7.2333	2	6
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	6.8167	1	3
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	6.7533	2	6
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	15.0000	2	4
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	12.8571	3	7
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	20.0000	3	12
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	5
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	14.8765	5	17
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	9.2667	2	6
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	3.9067	2	6
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	11.5399	3	11
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	9.2847	3	11
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	4.5667	2	6
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	5.7667	2	6
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	2.7500	2	6
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	18.7699	2	8
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	0.8083	1	3
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	17.5473	3	11
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	20.5504	3	12
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	17.2165	3	12
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	20.0000	3	12
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	22.5000	2	8
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	18.0000	3	10
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	15.0000	3	8
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	7.8333	2	6
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	16.8204	3	11
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	15.0000	3	8
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	15.9700	4	12
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	16.0158	4	12
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	6.8667	2	6
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	10.0000	1	3
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	16.6667	3	9
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	18.5769	4	13
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	12.0714	3	7
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	7.1667	1	3
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	23.3333	2	9
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	19.0909	3	11
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	10.8287	3	9
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	15.1012	2	8
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	10.9168	2	8
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	19.1577	2	9
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	6.6850	2	6
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	8.7333	2	6
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	2	6
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	22.5333	2	9
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	6.8233	1	3
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	23.3333	2	9
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	6.6877	1	3
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	23.3333	2	9
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	6
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	6
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	3
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	6
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	6
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	3
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	18.7182	3	11
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	25.4678	1	6
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	3
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	3
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	5
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	6
TGF-beta receptor type-1	Homo sapiens (human)	Kd	20.0000	3	12
TGF-beta receptor type-2	Homo sapiens (human)	Kd	16.9091	3	11
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	4
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	20.0000	3	12
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	3
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	10.0000	1	3
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	5
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	10.0914	23	71
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	10.0000	2	6
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	15.0000	3	8
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	18.2909	3	11
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	2	6
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	17.1429	4	14
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	18.6818	3	11
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	8.6000	2	6
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	20.0000	3	12
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	11.9429	3	7
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	10.0000	2	6
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	2	6
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	7.8333	2	6
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	7.1333	2	6
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	10.0000	2	6
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	19.0909	3	11
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	2	6
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	5
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	4
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	2
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	29.5557	1	6
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	3
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	9.9833	2	6
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	2	6
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	2	6
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	6
Voltage-dependent N-type calcium channel subunit alpha-1B	Homo sapiens (human)	EC50	675.8600	1	3
Wee1-like protein kinase	Homo sapiens (human)	Kd	19.0909	3	11
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	3

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Cannabinoid receptor 1	Homo sapiens (human)	Kb	2.2000	1	1
Casein kinase I isoform alpha	Homo sapiens (human)	EC	4.9800	2	2
Casein kinase I isoform delta	Homo sapiens (human)	EC	4.9800	2	2
Cyclin-A1	Homo sapiens (human)	ID50	0.1000	1	1
Cyclin-A2	Homo sapiens (human)	ID50	0.1000	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	ID50	2.2171	2	7
Cyclin-dependent kinase 1	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 10	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 11B	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 12	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 13	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 14	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 15	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 16	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 17	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 18	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 19	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Cell cycle	0.0210	10	10
Cyclin-dependent kinase 2	Homo sapiens (human)	ID50	3.5500	2	2
Cyclin-dependent kinase 2	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 20	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 3	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 4	Homo sapiens (human)	ID50	0.4000	1	1
Cyclin-dependent kinase 4	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 6	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 7	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 8	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent kinase 9	Homo sapiens (human)	INH	24.5000	1	1
Cyclin-dependent-like kinase 5	Homo sapiens (human)	INH	24.5000	1	1
G1/S-specific cyclin-D1	Homo sapiens (human)	ID50	0.4000	1	1
G1/S-specific cyclin-D2	Homo sapiens (human)	ID50	0.4000	1	1
G1/S-specific cyclin-D3	Homo sapiens (human)	ID50	0.4000	1	1
G1/S-specific cyclin-E1	Homo sapiens (human)	ID50	7.0000	1	1
G1/S-specific cyclin-E2	Homo sapiens (human)	ID50	7.0000	1	1
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	ID50	2.2171	2	7
G2/mitotic-specific cyclin-B2	Homo sapiens (human)	ID50	2.2171	2	7
G2/mitotic-specific cyclin-B3	Homo sapiens (human)	ID50	2.2171	2	7
UDP-glucuronosyltransferase 1A9	Homo sapiens (human)	Km	37.0000	1	1

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EC 2.7.11.22 (cyclin-dependent kinase) inhibitor

Members (19)

Research

Studies (3,131)

Study Types

Protein Targets (745)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements